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Reviewed By Bayyarapu Mahesh Kumar , M Pharmacy
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Composition :

DULOXETINE-60MG

Manufacturer/Marketer :

Icon Life Sciences

Consume Type :

ORAL

Return Policy :

Not Returnable

Expires on or after :

About Dulotin-60 Tablet

Dulotin-60 Tablet belongs to a group of medicines known as Antidepressants. It is primarily used for the treatment of depression and anxiety. Besides this, it is also used to treat neuropathic pain such as fibromyalgia associated with diabetic peripheral neuropathy and can be used to treat stress urinary incontinence in women. Depression is a mental illness or disorder characterised by persistently depressed mood or loss of interest in activities, causing significant impairment in daily life. Anxiety is a feeling of unease, such as worry or fear, that can be mild or severe. Fibromyalgia, also called fibromyalgia syndrome (FMS), is a long-term condition that causes pain all over the body. Urinary incontinence is the unintentional passing of urine. It's a common problem thought to affect millions of people.

Dulotin-60 Tablet contains Duloxetine. It works by enhancing the amount of mood-enhancing chemicals serotonin and noradrenaline in the brain. This action of Dulotin-60 Tablet balances out negative emotions, improves mood, sleep, and makes a person live a better life. In this way, Dulotin-60 Tablet relieves depressive disorder, anxiety disorder, neuropathic pain, fibromyalgia, and many more.

Common side effects of the medicine include feeling sick, a dry mouth, headache, constipation and feeling sleepy. Most of these side effects of Dulotin-60 Tablet do not require medical attention and gradually resolve over time. However, if the side effects are persistent, reach out to your doctor. A person taking this drug is not allowed to stop or reduce the dosage even if they start noticing an improvement in their condition without asking their doctor, as it may cause unpleasant symptoms including vomiting, agitation, confusion, etc.

Before taking the Dulotin-60 Tablet , let your doctor know about all your allergic or hypersensitivity reactions to medicines or food. Inform your doctor if you are suffering from kidney, liver, or heart disease. If you are pregnant or breastfeeding, please tell your doctor so that your doctor will weigh the benefits and any potential risks before prescribing it to you. Keep your doctor informed about your health condition and all the medicines you are taking before taking the Dulotin-60 Tablet to rule out any side effects.

Uses of Dulotin-60 Tablet

Depression, anxiety disorder, neuropathic pain associated with diabetes, chronic muscle or joint pain, fibromyalgia.

Directions for Use

Tablet/capsule: Swallow it as a whole with water; do not crush, break or chew it.

Medicinal Benefits

Dulotin-60 Tablet is used in the treatment of depression and anxiety disorders. This medicine is also used to relieve nerve pain associated with diabetic neuropathy or chronic pain associated with arthritis or back pain. This medicine acts by restoring the balance of serotonin and norepinephrine, a natural chemical present in the brain. In this way, this drug improves mood, appetite, sleep, and energy levels in patients and gives a sense of calmness in the body. Besides this, it can be used to treat stress urinary incontinence in women.

Storage

Store in a cool and dry place away from sunlight
Side effects of Dulotin-60 Tablet
Dealing with Medication-Induced Headache:
  • Hydrate your body: Drink enough water to prevent dehydration and headaches.
  • Calm Your Mind: Deep breathing and meditation can help you relax and relieve stress.
  • Rest and Recharge: Sleep for 7-8 hours to reduce headache triggers.
  • Take rest: lie down in a quiet, dark environment.
  • Cold or warm compresses can help reduce tension.
  • Stay Upright: Maintain good posture to keep symptoms from getting worse.
  • To treat headaches naturally, try acupuncture or massage therapy.
  • Over-the-counter pain relievers include acetaminophen and ibuprofen.
  • Prescription Assistance: Speak with your doctor about more substantial drug alternatives.
  • Severe Headaches: Seek emergency medical assistance for sudden, severe headaches.
  • Frequent Headaches: If you get reoccurring headaches, consult your doctor.
  • Headaches with Symptoms: Seek medical attention if your headaches include fever, disorientation, or weakness.
  • Avoid driving or operating machinery or activities that require high focus until you know how the medication affects you.
  • Maintain a fixed sleeping schedule, create a relaxing bedtime routine and ensure your sleeping space is comfortable to maximize your sleep quality.
  • Limit alcohol and caffeine as these may worsen drowsiness and disturb sleep patterns.
  • Drink plenty of water as it helps with alertness and keeps you hydrated and for overall well-being.
  • Moderate physical activity can improve energy levels, but avoid intense workouts right before bedtime.
Overcome Medication-Induced Nausea: A 9-Step Plan
  • Inform your doctor about the nausea and discuss possible alternatives to the medication or adjustments to the dosage.
  • Divide your daily food intake into smaller, more frequent meals to reduce nausea.
  • Opt for bland, easily digestible foods like crackers, toast, plain rice, bananas, and applesauce.
  • Avoid certain foods that can trigger nausea, such as fatty, greasy, spicy, and smelly foods.
  • Drink plenty of fluids, such as water, clear broth, or electrolyte-rich beverages like coconut water or sports drinks.
  • Use ginger (tea, ale, or candies) to help relieve nausea.
  • Get adequate rest and also avoid strenuous activities that can worsen nausea.
  • Talk to your doctor about taking anti-nausea medication if your nausea is severe.
  • Record when your nausea occurs, what triggers it, and what provides relief to help you identify patterns and manage your symptoms more effectively.
Here are the steps to Dry Mouth (xerostomia) caused by medication:
  • Inform your doctor about dry mouth symptoms. They may adjust your medication regimen or prescribe additional medications to manage symptoms.
  • Drink plenty of water throughout the day to help keep your mouth moist and alleviate dry mouth symptoms.
  • Chew sugar-free gum or candies to increase saliva production and keep your mouth moisturized.
  • Use saliva substitutes, such as mouthwashes or sprays, only if your doctor advises them to help moisturize your mouth and alleviate dry mouth symptoms.
  • Avoid consuming smoking, alcohol, spicy or acidic foods, and other irritants that may aggravate dry mouth symptoms.
  • Schedule regular dental check-ups to keep track of your oral health and handle any dry mouth issues as they arise.
  • Drink water or other clear fluids.
  • To prevent worsening of pain, limit intake of tea, coffee, or alcohol.
  • Include bland foods like rice, toast, crackers, and rice in your diet.
  • Avoid lying down immediately after eating as it may cause indigestion or heartburn.
  • Avoid acidic and spicy food as it may cause indigestion.
To prevent, manage, and treat Constipation caused by medication usage, follow these steps:
  • Preventing Vomiting (Before it Happens)
  • Take medication exactly as prescribed by your doctor. This can help minimize side effects, including vomiting.
  • Having a small meal before taking your medication can help reduce nausea and vomiting.
  • Talk to your doctor about taking anti-nausea medication along with your prescribed medication.
  • Managing Vomiting (If it Happens)
  • Try taking ginger in the form of tea, ale, or candy to help alleviate nausea and vomiting.
  • What to Do if Vomiting Persists
  • Consult your doctor if vomiting continues or worsens, consult the doctor for guidance on adjusting your medication or additional treatment.
  • Weight loss without physical activity needs immediate medical attention.
  • Get a physical examination and blood tests done to identify factors causing weight loss that could be related to metabolism and thyroid function.
  • Avoid smoking and alcohol intake as it can alter your liver condition and increase your weight loss.
  • Practice meditation and yoga to avoid anxiety, which can be one of the leading causes of weight loss.
  • Talk to your dietician and consume food which can maintain ideal weight.

Drug Warnings

Dulotin-60 Tablet should not be allowed to be used within 5 days before or 14 days after taking an MAO inhibitor such as rasagiline, selegiline, or linezolid as it may result in serious drug interaction. Don't stop taking Dulotin-60 Tablet without consulting with a doctor as it may cause serious drug with drawl symptoms. At the time of consultation, tell your doctor about heart problems, high blood pressure, liver or kidney disease, slow digestion, and a seizure. You should tell your doctor if you are pregnant or breastfeeding with your doctor.  Avoid doing any hazardous activity as these medicines cause sleepiness in the body, so rest only.

Drug-Drug Interactions

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Drug-Drug Interactions

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How does the drug interact with Dulotin-60 Tablet:
Taking Dulotin-60 Tablet with procarbazine can increase the risk of serotonin syndrome(a condition in which a chemical called serotonin increase in your body).

How to manage the interaction:
Taking Dulotin-60 Tablet with Procarbazine is not recommended, but they can be taken together if prescribed by a doctor. However, consult a doctor if you experience confusion, fever, excessive sweating, shivering or shaking, pain in the muscles, stomach cramps, nausea, vomiting, and diarrhoea. Do not discontinue any medications without consulting your doctor.
How does the drug interact with Dulotin-60 Tablet:
Coadministration of metoclopramide with Dulotin-60 Tablet increase the risk of serotonin syndrome(a condition in which a chemical called serotonin increase in your body).

How to manage the interaction:
Taking Metoclopramide with Dulotin-60 Tablet is not recommended, they can be taken together if prescribed by a doctor. However, consult a doctor if you experience any unusual symptoms. Do not discontinue any medications without consulting a doctor.
How does the drug interact with Dulotin-60 Tablet:
Coadministration of safinamide with Dulotin-60 Tablet can increase the risk of serotonin syndrome (a condition in which a chemical called serotonin increases in your body).

How to manage the interaction:
Taking Safinamide with Dulotin-60 Tablet is not recommended as it can result in an interaction, but they can be taken together if prescribed by a doctor. However, consult a doctor if you experience confusion, fever, excessive sweating, shivering, pain in the muscles, stomach cramps, nausea, vomiting, and loose stools. Do not discontinue any medications without consulting a doctor.
DuloxetineEliglustat
Critical
How does the drug interact with Dulotin-60 Tablet:
Coadministration of eliglustat and Dulotin-60 Tablet can significantly increase the blood levels of eliglustat. This may increase the risk of irregular heart rhythm.

How to manage the interaction:
Taking Dulotin-60 Tablet with Eliglustat is not recommended, but they can be taken together if prescribed by a doctor. However, consult a doctor if you experience sudden dizziness, lightheadedness, fainting, shortness of breath, slow heart rate, or weak pulse. Do not discontinue any medications without consulting your doctor.
How does the drug interact with Dulotin-60 Tablet:
Taking Dulotin-60 Tablet with Linezolid can increase the risk of serotonin syndrome(a condition in which a chemical called serotonin increase in your body).

How to manage the interaction:
Although taking Dulotin-60 Tablet with Linezolid is not recommended, they can be taken together if prescribed by a doctor. However, consult a doctor if you experience confusion, fever, excessive sweating, shivering, blurred vision, pain in the muscles, stomach cramps, nausea, vomiting, and diarrhoea. Do not discontinue any medications without consulting a doctor.
How does the drug interact with Dulotin-60 Tablet:
Taking Tranylcypromine with Dulotin-60 Tablet can increase the risk of serotonin syndrome(a condition in which a chemical called serotonin increase in your body).

How to manage the interaction:
Taking Tranylcypromine with Dulotin-60 Tablet is not recommended but can be taken together if prescribed by a doctor. However, consult a doctor if you experience confusion, fever, excessive sweating, shivering, pain in the muscles or stiffness, stomach cramps, nausea, vomiting, and diarrhoea. Do not discontinue any medications without consulting your doctor.
DuloxetinePhenelzine
Critical
How does the drug interact with Dulotin-60 Tablet:
Taking phenelzine with Dulotin-60 Tablet can increase the risk of serotonin syndrome(a condition in which a chemical called serotonin increase in your body).

How to manage the interaction:
Taking Dulotin-60 Tablet with Phenelzine is not recommended, but they can be taken together if prescribed by a doctor. However, consult a doctor if you experience confusion, fever, excessive sweating, shivering, blurred vision, pain in the muscles, stomach cramps, nausea, vomiting, and diarrhoea. Do not discontinue any medications without consulting your doctor.
How does the drug interact with Dulotin-60 Tablet:
Taking Dulotin-60 Tablet with selegiline may increase the risk of serotonin syndrome (a condition in which a chemical called serotonin increases in your body).

How to manage the interaction:
Although there is an interaction between Dulotin-60 Tablet and Selegiline, they can be taken together if prescribed by a doctor. However, consult a doctor if you experience confusion, fever, excessive sweating, shivering, blurred vision, pain in the muscles, stomach cramps, nausea, vomiting, and diarrhoea. Do not discontinue any medications without consulting your doctor.
How does the drug interact with Dulotin-60 Tablet:
Taking Rasagiline with Dulotin-60 Tablet can increase the risk of serotonin syndrome (a condition in which a chemical called serotonin increases in your body).

How to manage the interaction:
Taking Rasagiline and Dulotin-60 Tablet is not recommended as they can possibly result in an interaction, but they can be taken together if prescribed by a doctor. However, consult a doctor if you experience confusion, fever, excessive sweating, shivering, pain in the muscles, stomach cramps, nausea, vomiting, and loose stools. Do not discontinue any medications without consulting a doctor.
How does the drug interact with Dulotin-60 Tablet:
Coadministration of Dulotin-60 Tablet with amitriptyline can increase the risk of serotonin syndrome. (a condition in which a chemical called serotonin builds up in your body)

How to manage the interaction:
Although using Dulotin-60 Tablet and Amitriptyline together may cause an interaction, they can be taken if prescribed by a doctor. Consult a doctor if you have symptoms such as confusion, fever, excessive sweating, shivering or shaking, pain in the muscles or stiffness, stomach cramps, nausea, vomiting, and diarrhea. Do not discontinue any medications without consulting a doctor.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

  • Eat healthy foods that can improve the overall mood. The easiest way to do so is to cut out junk food. Avoid food high in saturated fats and include Omega-3s and omega-6-rich food such as fish, nuts, fresh fruits and vegetables, and olive oil in your diet.
  • Neurotransmitters are responsible for keeping good mental health, so these neurotransmitters are made up of amino acids. Include amino acids in your diet as these food play an important role in improving mental health.
  • Exercise is the best way to relax the body as it helps the body to produce more antidepressants which in turn alleviate depression.
  • Losing weight is an important step that improves overall self-esteem and health so if you are overweight, then try to lose weight and manage it according to body mass index.
  • Meditation is the best way to relax the body and relieve stress.
  • Try to do deep breathing exercises, which help to calm down your mind and let you sleep better.
  • Lying awake in bed does not calm down the brain, so it is important to have a good night's sleep. Thus take 7- 8 hours of sound sleep.

Habit Forming

Yes

Therapeutic Class

ANTIDEPRESSANT

Drug-Diseases Interactions

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No Drug - Disease interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Diseases Interactions

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FAQs

Dulotin-60 Tablet work by increasing the amount of mood-enhancing chemicals serotonin and noradrenaline in the brain.

Although Dulotin-60 Tablet is not addictive in nature taking it higher or for prolonged use of time may cause drug dependence. Thus one should only take this medicine or the time suggested by the doctor. Do not try to increase the dose for fast results as it may worsen the side effects.

No, the person having a liver problem facing us, symptoms like itching, dark urine, right-sided upper stomach pain, jaundice is not allowed to use this medicine.

Duloxetine has been used safely for a long time. Long-term negative effects are not present.

Report it to your doctor on an urgent basis, as they will either change the dosing strength or change the medicine.

The use of Dulotin-60 Tablet is restricted if a patient has used an MAO inhibitor (Selegiline etc), within 5 days before or 14 days as it may result in serious drug interaction.

There's no evidence to suggest that duloxetine will reduce fertility in either men or women. But speak to your doctor before taking it if you're trying to get pregnant.

If you have been feeling better for six months or more, your doctor may suggest coming off Dulotin-60 Tablet . Your doctor will probably recommend reducing your dose gradually over several weeks or longer if you have been taking Dulotin-60 Tablet for a long time. This is to help prevent any extra side effects you might get as a reaction to coming off the medicine.

Drug-Drug Interactions Checker List

  • CLOPIDOGREL
  • WARFARIN
  • IBUPROFEN
  • CIPROFLOXACIN
  • LINEZOLID

Special Advise

  •  Do not make any change in your dosing schedule without asking the doctor.

Disease/Condition Glossary

Major depressive disorder: Major depressive disorder is a mental disorder that affects the mood, behaviour, and physical activities of a person. The common symptoms of depression include reduced interest in daily activities, changes in appetite, sudden weight loss or gain, changes in sleeping patterns, restlessness, slowed movement, and speech and tiredness.

Generalized anxiety disorder or GAD: Generalized anxiety disorder is a mental illness that makes a person worry more than normal. Common signs and symptoms of GAD include Fatigue, Shaking, restlessness, problems in focusing, trouble in sleeping, feeling jumpy or dizzy, nausea, vomiting, diarrhoea, or shortness of breath.

Diabetic neuropathy: In this condition, nerves of the body get damaged by the high blood sugar in the body. This condition especially affects the nerves of the legs and feet. The common symptoms of this disease include bloating, diarrhoea, constipation, heartburn, nausea, vomiting, and dizziness.

Fibromyalgia: Fibromyalgia is a long-term condition that causes musculoskeletal pain, followed by sleeping issues, fatigue, memory, and mood issues. It can start at any age and is more seen in women than in men. The pain may be triggered by physical injury, hormonal change, or emotional trauma. The common symptoms of fibromyalgia include pain for at least three months, tiredness, trouble falling or staying asleep, shortness of breath, headaches, memory problems, difficulty in concentrating, or anxiety.

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