DUOTAX INJECTION 1.5GM belongs to the class of medications called ‘antibiotics’ used to treat bacterial infections. Bacterial infections are caused by the multiplication of harmful bacteria inside or on the body. These harmful bacteria produce chemicals known as toxins, which can damage tissue and make you sick. Symptoms of bacterial infection vary depending on the organ affected by bacteria.

DUOTAX INJECTION 1.5GM is a combination of two medicines: Cefotaxime and Sulbactam. Cefotaxime is a cephalosporin antibiotic. It has bactericidal action (kills bacteria). It works by preventing the formation of the cell wall (the outer protective layer of bacteria, which is essential for its survival) by preventing protein synthesis. Sulbactam inhibits the action of beta-lactamase. Beta-lactamase is an enzyme produced by bacteria that can destroy antibiotics (cefotaxime).

DUOTAX INJECTION 1.5GM will be administered by a healthcare professional; do not self-administer. The common side effects of DUOTAX INJECTION 1.5GM are pain and swelling at the injection site, skin rash, diarrhoea, nausea and vomiting. These side effects are usually mild and temporary. However, if any of these side effects persist or get worse, inform your doctor immediately.

It is not recommended to take DUOTAX INJECTION 1.5GM if you are allergic to penicillin, any cephalosporin antibiotic or its contents. Before taking DUOTAX INJECTION 1.5GM, inform your doctor if you have kidney problems, are on a low-salt diet, have diabetes or using other antibiotics. Do not discontinue or abruptly stop using DUOTAX INJECTION 1.5GM as it may lead to antibiotic resistance (bacteria become resistant to antibiotics). DUOTAX INJECTION 1.5GM is probably safe when used in children, pregnant women, breastfeeding mothers and elderly people. DUOTAX INJECTION 1.5GM may not interact with alcohol. DUOTAX INJECTION 1.5GM may cause dizziness, so do not drive or operate heavy machinery if you feel dizzy.

DUOTAX INJECTION 1.5GM contains Cefotaxime and Sulbactam. Cefotaxime is a cephalosporin antibiotic, whereas Sulbactam is a beta-lactamase inhibitor. DUOTAX INJECTION 1.5GM has broad-spectrum activity and is effective against both gram-positive and gram-negative bacteria. It makes the drug effective in multiple serious bacterial infections including infections of the bloodstream (septicemia), bones (osteomyelitis), the heart valves (endocarditis), the membranes protecting the brain (meningitis) and the lining of the abdomen (peritonitis) and to prevent and treat infections following surgeries.

• Pain at the injection site
• Swelling at the injection site
• Skin rash
• Diarrhoea
• Nausea
• Vomiting
• Colitis (inflammation of the intestine)

DUOTAX INJECTION 1.5GM may cause false-positive results when a urine test is performed to determine glucose levels, so let your doctor know that you are taking this medicine before undergoing laboratory tests. DUOTAX INJECTION 1.5GM may contain sodium, so this medicine should be used with caution in people who are on a low-sodium diet. In individuals who were prescribed DUOTAX INJECTION 1.5GM for more than ten days, blood counts should be regularly monitored. DUOTAX INJECTION 1.5GM may cause a skin reaction called Steven-Johnson syndrome. So, stop taking DUOTAX INJECTION 1.5GM and inform your doctor immediately if you notice a rash, blistering of the skin or itching while using DUOTAX INJECTION 1.5GM. Do not discontinue or abruptly stop the medication as it may lead to antibiotic resistance, a condition in which bacteria become resistant to antibiotics.

Drug-Drug Interactions:  DUOTAX INJECTION 1.5GM may interact with penicillin antibiotics (mezlocillin and azlocillin), aminoglycoside antibiotics (streptomycin, neomycin, and gentamicin), diuretic or water pill (furosemide), and medicine used to treat gout (probenecid).

Drug-Food Interactions: No interactions found.

Drug-Disease Interactions: DUOTAX INJECTION 1.5GM should be used with caution in patients with kidney problems and diabetes.

• MEZLOCILLIN
• AZLOCILLIN
• STREPTOMYCIN
• NEOMYCIN
• GENTAMICIN
• FUROSEMIDE
• PROBENECID

• Probiotics should be taken after taking the full course of DUOTAX INJECTION 1.5GM to restore some healthy bacteria in the intestines that may have been killed. Taking probiotics after antibiotic treatment can reduce the risk of antibiotic-associated diarrhoea. Certain fermented foods like yogurt, cheese, sauerkraut, kombucha and kimchi can help restore the intestine's good bacteria.
• Include more fiber-enriched food in your diet, as it can be easily digested by your gut bacteria, which helps stimulate their growth. Thus, fiber-rich foods may help restore healthy gut bacteria after a course of antibiotics. Whole grains like whole-grain bread and brown rice should be included in your diet.
• Avoid alcoholic beverages with DUOTAX INJECTION 1.5GM as they can make you dehydrated and may affect your sleep.  This can make it harder for your body to aid the DUOTAX INJECTION 1.5GM in fighting off infections.

• If you are taking aminoglycoside antibiotics such as streptomycin and gentamicin, your kidney function should be regularly monitored.
• Inform your doctor if you are allergic to penicillin or other antibiotics.

Bacterial infections: A bacterial infection is a condition in which harmful bacteria enter, multiply and infect the body. It can target any organ of the body and multiply very quickly. Many give off chemicals called toxins, which can damage tissue and make you sick. Bacterial infections vary from minor illnesses (like sore throat and ear infections) to severe brain infections (like meningitis and encephalitis). When you get infected with bacteria, you can experience generalized symptoms, like fevers, chills and fatigue. A few harmful bacteria that commonly cause infections include Streptococcus, Staphylococcus and E. coli. Anyone can get a bacterial infection but people with a weak immune system or taking immunosuppressive medicines like steroids are more prone to infections.