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Written By Lakshmithulasi Yarragunta , Pharm-D (PB)
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
Non returnable*
COD available

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Composition :

DASATINIB-70MG

Manufacturer/Marketer :

Hetero Drugs Ltd

Consume Type :

ORAL

Return Policy :

Not Returnable

Expires on or after :

About Dyronib 70 Tablet

Dyronib 70 Tablet is an anti-cancer medicine used in the treatment of Leukemia. Leukemia, also known as blood cancer, is a cancer of blood cells or blood-forming tissues. It causes excessive production of immature white blood cells by the bone marrow and reduces the body’s ability to fight infections. There are different types of blood cancers. Dyronib 70 Tablet is used in the treatment of chronic myelogenous leukemia (CML) in patients with chronic, accelerated, or blast phase Ph+ (Philadelphia chromosome-positive) who are resistant or intolerant to prior therapy, in patients with newly diagnosed chronic Ph+ chronic myelogenous leukemia (CML). This medicine is also used in the treatment of Philadelphia chromosome-positive (Ph+) acute lymphoblastic leukemia (ALL).

Dyronib 70 Tablet contains Dasatinib, which belongs to the class of kinase inhibitors. It works by inhibiting the action of abnormal proteins that cause the multiplication of cancerous cells. This helps stop the abnormal growth of cancer cells and thus reduce the further spread to other parts of the body.

Dyronib 70 Tablet may cause certain side effects, such as skin rash, fatigue, headache, musculoskeletal pain, decreased platelet count, nausea, vomiting, diarrhea, abdominal pain, dizziness, GI bleeding, muscle inflammation, myalgia, and difficulty breathing. These side effects do not require medical attention and gradually resolve over time. However, if the side effects persist or worsen, please consult your doctor. Dyronib 70 Tablet should be taken as advised by your doctor. Do not take more than the recommended dose of medicine. Your doctor will decide the dose of Dyronib 70 Tablet based on the severity of your condition.

Dyronib 70 Tablet should be avoided if you are allergic to it or any other components present in it. Before taking Dyronib 70 Tablet , caution should be exercised if you have/had liver/kidney disease, gastrointestinal disorders, cardiac problems, and myelosuppression as may cause serious side effects or worsen such conditions. This medicine is known to cause embryo-fetal toxicity. Hence, inform your doctor if you are pregnant or are planning to become pregnant before starting the treatment with Dyronib 70 Tablet . Breastfeeding should be discontinued in nursing mothers during the treatment.

Uses of Dyronib 70 Tablet

Philadelphia chromosome-positive chronic myeloid leukemia, Philadelphia chromosome-positive acute lymphoblastic leukemia.

Directions for Use

Take Dyronib 70 Tablet as advised by your doctor. Do not take more than the prescribed dose of medicine. Swallow the medicine as a whole with a glass of water. Do not chew, crush, or break the medicine.

Medicinal Benefits

Dyronib 70 Tablet contains Dasatinib, which belongs to the class of kinase inhibitors. It works by inhibiting the action of abnormal proteins (BCR-ABL tyrosine kinase) that cause the multiplication of cancerous cells. This helps stop the abnormal growth of cancer cells and thus reduce the further spread to other parts of the body. Dyronib 70 Tablet is used in the treatment of Philadelphia chromosome-positive chronic myeloid leukemia and acute lymphoblastic leukemia.

Storage

Store in a cool and dry place away from sunlight

Drug Warnings

Dyronib 70 Tablet should be avoided if you are allergic to it or any other components present in it. Let your doctor know about your complete medical history, including current medication, to rule out any side effects/interactions. Before taking, inform your doctor if you have liver/kidney disease, diabetes, cardiac problems, increased blood pressure, or gastrointestinal disorders, as the use of Dyronib 70 Tablet in these patients may cause serious side effects. Dyronib 70 Tablet may cause myelosuppression, fluid retention, gastrointestinal haemorrhage, QT prolongation, congestive heart failure, Left ventricular dysfunction and Myocardial infarction. This medicine is known to cause embryo-fetal toxicity. Hence, inform your doctor if you are pregnant or are planning to become pregnant before starting the treatment. Breastfeeding should be discontinued in nursing mothers during the treatment. Dyronib 70 Tablet is given in children above one year of age only if prescribed by the doctor. Avoid alcohol consumption and smoking, as it can lead to serious adverse effects.

Drug-Drug Interactions

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DasatinibMesoridazine
Critical

Drug-Drug Interactions

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How does the drug interact with Dyronib 70 Tablet:
Using Pimozide together with Dyronib 70 Tablet can increase the risk of an irregular heart rhythm.

How to manage the interaction:
Taking Dyronib 70 Tablet with Pimozide is not recommended, please consult your doctor before taking it. You should seek immediate medical attention if you develop sudden dizziness, lightheadedness, fainting, shortness of breath, or heart palpitations. Do not stop any medication without talking to a doctor.
DasatinibMesoridazine
Critical
How does the drug interact with Dyronib 70 Tablet:
Using Mesoridazine together with Dyronib 70 Tablet can increase the risk of an irregular heart rhythm.

How to manage the interaction:
Taking Mesoridazine with Dyronib 70 Tablet is not recommended, please consult your doctor before taking it. You should seek immediate medical attention if you develop sudden dizziness, lightheadedness, fainting, shortness of breath, or heart palpitations. Do not stop any medication without talking to a doctor.
How does the drug interact with Dyronib 70 Tablet:
Using dronedarone together with Dyronib 70 Tablet can increase the risk of an irregular heart rhythm.

How to manage the interaction:
Taking Dyronib 70 Tablet with Dronedarone is not recommended, please consult a doctor before taking it. You should seek immediate medical attention if you develop sudden dizziness, lightheadedness, fainting, shortness of breath, or heart palpitations. Do not stop using any medication without doctor's advice.
DasatinibHalofantrine
Critical
How does the drug interact with Dyronib 70 Tablet:
Using Halofantrine together with Dyronib 70 Tablet can increase the risk of an irregular heart rhythm.

How to manage the interaction:
Taking Dyronib 70 Tablet with Halofantrine is not recommended, consult a doctor before taking it. You should seek immediate medical attention if you develop sudden dizziness, lightheadedness, fainting, shortness of breath, or heart palpitations. Do not stop any medication without doctor's advice.
How does the drug interact with Dyronib 70 Tablet:
Taking Dyronib 70 Tablet with Phenobarbital may significantly reduce the blood levels of Dyronib 70 Tablet.

How to manage the interaction:
Taking Phenobarbital with Dyronib 70 Tablet together can result in an interaction, but it can be taken if a doctor has advised it. In case of any unusual side effects, contact a doctor. Do not stop using any medications without a doctor's advice.
How does the drug interact with Dyronib 70 Tablet:
Coadministration of Dyronib 70 Tablet with Streptokinase can increase the risk of bleeding.

How to manage the interaction:
Co-administration of Streptokinase with Dyronib 70 Tablet can result in an interaction, but it can be taken if a doctor has advised it. You should seek immediate medical attention if you experience bruising, dizziness; red or black, tarry stools; severe headache; and weakness. Do not discontinue any medications without consulting a doctor.
How does the drug interact with Dyronib 70 Tablet:
Co-administration of Dyronib 70 Tablet with Amiodarone may increase the risk of abnormal heart rhythm.

How to manage the interaction:
Although taking Dyronib 70 Tablet with Amiodarone may cause an interaction, it is safe if a doctor has prescribed it. If you develop dizziness, fainting, shortness of breath, or a rapid heartbeat, consult a doctor. Do not stop taking any medications without visiting a doctor.
How does the drug interact with Dyronib 70 Tablet:
Coadministration of Dyronib 70 Tablet with Dipyridamole can increase the risk of bleeding tendencies.

How to manage the interaction:
Co-administration of Dyronib 70 Tablet with Dipyridamole can result in an interaction, but it can be taken if a doctor has advised it. If you notice any symptoms like bruising, feeling dizzy or lightheaded, having dark stools, headaches, weakness, - make sure to contact a doctor right away. Do not discontinue any medications without consulting a doctor.
How does the drug interact with Dyronib 70 Tablet:
Using Dyronib 70 Tablet with Naproxen may increase the risk or severity of bleeding problems.

How to manage the interaction:
Taking Dyronib 70 Tablet with Naproxen together can result in an interaction, it can be taken if a doctor has advised it. However, if you experience dizziness, red or black tarry stools, severe headache, and weakness, you should contact a doctor immediately. Do not stop using any medications without talking to a doctor.
How does the drug interact with Dyronib 70 Tablet:
Coadministration of Dyronib 70 Tablet with Dalteparin can increase the risk of bleeding.

How to manage the interaction:
Although taking Dalteparin and Dyronib 70 Tablet together can cause an interaction, it can be taken if a doctor has suggested it. If you have any of these symptoms - bruising, dizziness, severe headache, or weakness - make sure to contact a doctor. Do not discontinue any medications without consulting a doctor.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

  • After beginning your treatment, several dietary adjustments can help you control side effects.
  • Anyone suffering from a chronic illness, including cancer, should consume foods high in protein, healthy fats, whole grains, and vitamins and minerals.
  • Plant-based proteins are among the greatest meals to take during chemotherapy or other cancer treatments. They have the highest concentrations of vitamins and minerals, such as nuts, seeds, beans, and legumes.
  • Eat a healthy diet and exercise regularly to maintain proper weight.
  • Include leafy vegetables, citrus fruits, fatty fish, berries, yoghurt, apples, peaches, cauliflower, cabbage, broccoli, beans, and herbs.
  • De-stress yourself by meditating, reading books, taking a warm bubble bath or listening to soothing music.
  • Get optimal sleep; rest well.
  • Avoid smoking and alcohol consumption.
  • Avoid fast and fried food, processed meats, refined carbs and added sugars.

Habit Forming

No

Therapeutic Class

ANTINEOPLASTIC

Dyronib 70 Tablet Substitute

Substitutes safety advice
  • Spnib 70 Tablet 60's

    by Others

    60.00per tablet
  • Daslemia 70 mg Tablet 60's

    by Others

    68.27per tablet
  • Dasamyl 70 mg Tablet 60's

    by Others

    66.90per tablet
  • Invista 70 Tablet 10's

    by Others

    87.75per tablet
  • Beedan 70Mg Tablet 60's

    by Others

    186.55per tablet

Drug-Diseases Interactions

verifiedApollotooltip
No Drug - Disease interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Diseases Interactions

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FAQs

Dyronib 70 Tablet contains Dasatinib, which works by inhibiting the action of abnormal proteins that cause the multiplication of cancerous cells.

Dyronib 70 Tablet is known to cause embryo-fetal toxicity; hence, it is contraindicated for use in pregnancy. A woman needs to have a negative pregnancy test before starting treatment with this medicine. It is better to use effective birth control methods to prevent pregnancy while taking this medicine or at least six months after completion of the treatment.

Take antacids such as aluminium hydroxide/magnesium hydroxide, calcium carbonate, calcium carbonate, and magnesium 2 hours before or after taking Dyronib 70 Tablet as antacids may alter the absorption of this medicine.

Drug-Drug Interactions Checker List

  • PANTOPRAZOLE
  • KETOCONAZOLE
  • ESOMEPRAZOLE
  • RITONAVIR
  • CLARITHROMYCIN
  • ERYTHROMYCIN
  • PHENYTOIN
  • RIFAMPICIN
  • CARBAMAZEPINE
  • ALUMINIUM HYDROXIDE

Special Advise

  • A blood test, such as LFT and RFT, should be performed to check for liver/kidney function.
  • Weekly blood tests should be done during the treatment to check for CBC (Complete blood count).
  • An ECG and ECHO should be done in patients taking Dyronib 70 Tablet to check for any signs of cardiac problems.

Disease/Condition Glossary

Philadelphia chromosome-positive (Ph+) chronic myeloid leukemia: Leukemia, also known as blood cancer, is a cancer of blood cells or blood-forming tissues. It causes excessive production of immature white blood cells by the bone marrow and reduces the body’s ability to fight infections. Chronic Myelogenous Leukemia is a type of blood cancer that originates in the myeloid cells or stem cells in your bone marrow. Ph+ chronic myeloid leukemia is a common form of CML that occurs when specific chromosomes swap position. This causes a chromosome abnormality, creating the Philadelphia chromosome. The abnormal chromosomes produce an abnormal protein called Bcr-Abl tyrosine kinase, which then triggers a signal to produce abnormal white blood cells in the bone marrow. Symptoms may include fatigue, fever, weight loss, and loss of appetite.

Philadelphia chromosome-positive (Ph+) Acute Lymphoblastic Leukemia (ALL): ALL is a type of blood cancer that primarily affects your blood and bone marrow. It mainly targets the white blood cells which can interfere with your body’s ability to combat infections. Ph+ Acute Lymphoblastic Leukemia is a form of ALL that occurs when specific chromosomes swap position. This causes a chromosome abnormality, creating the Philadelphia chromosome. The abnormal chromosomes produce a BCR-ABL tyrosine kinase protein, which triggers a signal to produce abnormal white blood cells in the bone marrow. Symptoms may include fever, weight loss, abnormal blood cell count, bruising, and loss of appetite.

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