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Reviewed By Sunny S , MBBS
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ORAL

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Not Returnable

About Ediflam Plus Tablet

Ediflam Plus Tablet belongs to a class of painkillers called a non-steroidal anti-inflammatory drugs (NSAIDs). Pain can be temporary (acute) or long-lasting (chronic) in nature. Acute pain is for a short time caused by damage to the tissues of the muscle, bone, or other organs. While, chronic pain lasts for a long duration and is  caused due to pathologies like nerve damage, osteoarthritis etc. Besides this it is also useful for dental pain which can occur due to damage to the tooth nerve, infection, decay, extraction, or injury.

Ediflam Plus Tablet is composed of three medicines: Ibuprofen, Paracetamol and Caffeine. Together it relieves symptoms of arthritis, dysmenorrhea (painful periods or menstrual cramps) and reduces fever. Ibuprofen is known to have an analgesic and anti-inflammatory effect for reducing mild to moderate pain. It works by blocking the effect of a chemical known as prostaglandin responsible for inducing pain and inflammation in our body. Paracetamol acts as a mild analgesic and antipyretic (fever reducer). It lowers the elevated body temperature and mild pain by inhibiting the synthesis of a chemical messenger (prostaglandin) and by promoting heat loss (through sweating) that helps reset the hypothalamic thermostat. Caffeine acts as a common stimulant, added to speed up the action of ibuprofen and paracetamol in relieving pain and reducing inflammation. Together all these three medicines help in reducing mild to moderate pain in a shorter duration.

Ediflam Plus Tablet can be taken with or after the meal. If stomach upset or irritation occurs, it is advisable to take Ediflam Plus Tablet with food or milk. It should be swallowed whole with a glass of water. Do not crush or chew the tablets. Do not take Ediflam Plus Tablet if your pain lasts for more than ten days or fever lasting for more than three days. Do not take double dose if you missed one dose. Like all medicines, Ediflam Plus Tablet may cause side effects, although not everybody gets them. Stop taking this medicine if you experience symptoms like tightness of the chest, breathing difficulties, fever, skin rashes, increased heart rate and or in case of any signs of hypersensitivity. 

Do not take Ediflam Plus Tablet if you are allergic to painkillers like aspirin, ibuprofen, naproxen or diclofenac. It is not recommended for use in children, people with liver disease, heart disease, or gastric ulcers/bleeding problems. Ediflam Plus Tablet may be associated with a small increase in the risk of heart attack (myocardial infarction). Avoid consumption of alcohol as it may damage your liver and cause increased side effects on taking this drug. Consult your doctor if your symptoms of pain, inflammation, and fever do not disappear even after ten days.

Uses of Ediflam Plus Tablet

Headache, Migraine, Muscle aches, Arthritis, Backache, Dental pain, Cold and Fever.

Directions for Use

Take it with food or milk to avoid upsetting of the stomach. Do not chew, crush or break the tablet.

Medicinal Benefits

Ediflam Plus Tablet is composed of ibuprofen, caffeine and paracetamol primarily used to treat mild to moderate pain. Ediflam Plus Tablet is prescribed mainly to treat pain and get relief from discomfort cause in conditions like tooth pain, arthritis, period pain and other type of short term pains. It helps in treating pain by blocking the chemical messenger in the brain responsible for causing pain. Ibuprofen works by blocking the effect of a chemical known as prostaglandin responsible for inducing pain and inflammation in our body. On the other hand, Paracetamol lowers the elevated body temperature and mild pain by inhibiting the synthesis of prostaglandin by promoting heat loss (through sweating) that helps reset the hypothalamic thermostat and caffeine helps in reducing drowsiness caused due to paracetamol. Paracetamol has got the advantage of producing less gastric irritation compared to other painkillers like aspirin.

Storage

Keep out of the sight and reach of children.
Side effects of Ediflam Plus Tablet
  • Drink water or other clear fluids.
  • To prevent worsening of pain, limit intake of tea, coffee, or alcohol.
  • Include bland foods like rice, toast, crackers, and rice in your diet.
  • Avoid lying down immediately after eating as it may cause indigestion or heartburn.
  • Avoid acidic and spicy food as it may cause indigestion.
Here are the 7 steps to manage Dizziness caused by medication:
  • Inform your doctor about dizziness symptoms. They may adjust your medication regimen or prescribe additional medications to manage symptoms.
  • Follow your doctor's instructions for taking medication, and take it at the same time every day to minimize dizziness.
  • When standing up, do so slowly and carefully to avoid sudden dizziness.
  • Avoid making sudden movements, such as turning or bending quickly, which can exacerbate dizziness.
  • Drink plenty of water throughout the day to stay hydrated and help alleviate dizziness symptoms.
  • If you're feeling dizzy, sit or lie down and rest until the dizziness passes.
  • Track when dizziness occurs and any factors that may trigger it, and share this information with your doctor to help manage symptoms.
  • Skin rash caused by allergies is due to irritants or allergens. Therefore, avoid contact with such irritants.
  • Consult your doctor for proper medication and apply an anti-itch medication. Follow the schedule and use the medication whenever needed.
  • Protect your skin from extreme heat and try to apply wet compresses.
  • Soak in the cool bath, which gives a soothing impact to the affected area.
  • Get enough sleep. Maintain a regular sleep cycle.
  • Eat a healthy diet and exercise regularly.
  • Manage stress with yoga or meditation.
  • Limit alcohol and caffeine.
  • Avoid driving or operating machinery unless you are alert.
Overcome Medication-Induced Nausea: A 9-Step Plan
  • Inform your doctor about the nausea and discuss possible alternatives to the medication or adjustments to the dosage.
  • Divide your daily food intake into smaller, more frequent meals to reduce nausea.
  • Opt for bland, easily digestible foods like crackers, toast, plain rice, bananas, and applesauce.
  • Avoid certain foods that can trigger nausea, such as fatty, greasy, spicy, and smelly foods.
  • Drink plenty of fluids, such as water, clear broth, or electrolyte-rich beverages like coconut water or sports drinks.
  • Use ginger (tea, ale, or candies) to help relieve nausea.
  • Get adequate rest and also avoid strenuous activities that can worsen nausea.
  • Talk to your doctor about taking anti-nausea medication if your nausea is severe.
  • Record when your nausea occurs, what triggers it, and what provides relief to help you identify patterns and manage your symptoms more effectively.
To prevent, manage, and treat Constipation caused by medication usage, follow these steps:
  • Preventing Vomiting (Before it Happens)
  • Take medication exactly as prescribed by your doctor. This can help minimize side effects, including vomiting.
  • Having a small meal before taking your medication can help reduce nausea and vomiting.
  • Talk to your doctor about taking anti-nausea medication along with your prescribed medication.
  • Managing Vomiting (If it Happens)
  • Try taking ginger in the form of tea, ale, or candy to help alleviate nausea and vomiting.
  • What to Do if Vomiting Persists
  • Consult your doctor if vomiting continues or worsens, consult the doctor for guidance on adjusting your medication or additional treatment.
Here are the steps to cope with constipation as a side effect of medication:
  • Inform your doctor about your constipation symptoms. They may adjust your medication or advise alternative treatments.
  • Stay hydrated by drinking sufficient of water (at least 8-10 glasses a day) to help soften stool and promote bowel movements.
  • Increase fibre intake by eating foods high in fibre, such as fruits, whole grains, vegetables and legumes, to help bulk up the stool.
  • Establish a bowel routine by trying to go to the bathroom at the same time each day to train your bowels.
  • Engaging in regular exercise, like walking or yoga, can support in bowel movement stimulation.
  • Consult your doctor if constipation persists, and discuss alternative treatments or adjustments to your medication.

Drug Warnings

Ediflam Plus Tablet should be taken with caution if you have an active stomach ulcer, recent gastrointestinal bleeding, asthma, recent bypass heart surgery, heart disease, or a history of allergy to any painkillers or analgesics. Caffeine can pass in the breast milk which may have a stimulating effect on the breastfed child. Therefore, Ediflam Plus Tablet should be avoided in pregnant or breastfeeding females.

Drug-Drug Interactions

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Drug-Drug Interactions

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How does the drug interact with Ediflam Plus Tablet:
Taking Ketorolac and Ediflam Plus Tablet can increase the risk of side effects in the gastrointestinal tract such as inflammation, bleeding and ulceration.

How to manage the interaction:
Taking Ketorolac and Ediflam Plus Tablet together is not recommended as it can lead to an interaction, it can be taken if advised by your doctor. However, if you experience any symptoms like dizziness, lightheadedness, red or black, dark stools, coughing or vomiting fresh or dried blood that looks like coffee grounds, severe headache, and weakness, consult the doctor immediately. Do not stop using any medications without a doctor's advice.
How does the drug interact with Ediflam Plus Tablet:
Combining Meloxicam and Ediflam Plus Tablet can increase the risk of side effects in the gastrointestinal tract such as inflammation, bleeding, ulceration, and rarely, perforation.

How to manage the interaction:
Taking Meloxicam and Ediflam Plus Tablet together is not recommended as it can lead to an interaction, it can be taken if advised by your doctor. However, if you experience any symptoms like dizziness, lightheadedness, red or black, dark stools, coughing or vomiting fresh or dried blood that looks like coffee grounds, severe headache, and weakness, consult the doctor immediately. Do not stop using any medications without a doctor's advice.
CaffeineIsocarboxazid
Critical
How does the drug interact with Ediflam Plus Tablet:
Taking these two together can cause your blood pressure to rise, a condition known as a hypertensive crisis.

How to manage the interaction:
Taking Ediflam Plus Tablet with Isocarboxazid is not recommended, please consult your doctor before taking it. It can be taken if your doctor prescribes it. Do not stop taking any medication without consulting your doctor.
Critical
How does the drug interact with Ediflam Plus Tablet:
Coadministration of tranylcypromine with Ediflam Plus Tablet can in cause severe high blood pressure.

How to manage the interaction:
Taking Ediflam Plus Tablet with Tranylcypromine is not recommended, but it can be taken together if prescribed by a doctor. However, consult your doctor if you experience headache, confusion, blurred vision, problems with speech or balance, nausea, vomiting, chest pain, convulsions, and sudden numbness or weakness (especially on one side of the body). Do not discontinue any medications without consulting a doctor.
CaffeineLinezolid
Critical
How does the drug interact with Ediflam Plus Tablet:
Taking these two together can cause your blood pressure to rise, a condition known as a hypertensive crisis.

How to manage the interaction:
Taking Ediflam Plus Tablet with Linezolid is not recommended, please consult your doctor before taking it. It can be taken if your doctor prescribes it. Do not stop taking any medication without consulting your doctor.
CaffeinePhenelzine
Critical
How does the drug interact with Ediflam Plus Tablet:
Taking these two together can cause your blood pressure to rise, a condition known as a hypertensive crisis.

How to manage the interaction:
Taking Ediflam Plus Tablet with Phenelzine is not recommended, please consult your doctor before taking it. They can be taken if your doctor advises it. Do not stop taking any medication without consulting your doctor.
How does the drug interact with Ediflam Plus Tablet:
Co-administration of Rivaroxaban and Ediflam Plus Tablet can increase the risk of bleeding problems.

How to manage the interaction:
Co-administration of Rivaroxaban and Ediflam Plus Tablet can lead to an interaction, it can be taken if advised by your doctor. However, if you experience any symptoms like unusual bleeding or bruising, dizziness, lightheadedness, red or black, tarry stools, coughing up or vomiting fresh or dried blood that looks like coffee grounds, severe headache, and weakness, consult the doctor immediately. Do not stop using any medications without a doctor's advice.
How does the drug interact with Ediflam Plus Tablet:
Taking risedronic acid with Ediflam Plus Tablet can increase the risk of developing kidney problems, gastrointestinal bleeding, and ulcers.

How to manage the interaction:
Co-administration of Risedronic acid and Ediflam Plus Tablet can lead to an interaction but it can be taken if your doctor has advised it. However, consult your doctor if you experience abdominal pain, bloating, sudden dizziness or lightheadedness, nausea, vomiting (especially with blood), loss of appetite, and/or black, tarry stools. Do not discotinue any medications without consulting a doctor.
How does the drug interact with Ediflam Plus Tablet:
Coadministration of Tenofovir disoproxil and Ediflam Plus Tablet can increase the risk of developing kidney problems.

How to manage the interaction:
Co-administration of Tenofovir disoproxil and Ediflam Plus Tablet can lead to an interaction, it can be taken if advised by your doctor. However, if you experience any symptoms like nausea, vomiting, irregular urination, sudden weight gain or weight loss, shortness of breath, muscle cramps, weakness, and irregular heart rhythm, consult the doctor immediately. Do not stop using any medications without a doctor's advice.
How does the drug interact with Ediflam Plus Tablet:
Taking cidofovir and Ediflam Plus Tablet can increase the risk of Kidney problems.

How to manage the interaction:
Taking Cidofovir and Ediflam Plus Tablet can lead to an interaction, it can be taken if advised by your doctor. However, if you experience any symptoms like nausea, vomiting, loss of hunger, increased or decreased urination, sudden weight gain or weight loss , swelling, shortness of breath, bone pain, muscle cramps, tiredness, weakness, dizziness, confusion, consult the doctor immediately. Do not stop using any medications without a doctor's advice.

Drug-Food Interactions

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CAFFEINE-30MG+IBUPROFEN-400MG+PARACETAMOL-325MGFruit juices, Fruits
Mild

Drug-Food Interactions

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CAFFEINE-30MG+IBUPROFEN-400MG+PARACETAMOL-325MGFruit juices, Fruits
Mild
Common Foods to Avoid:
Grapefruit Juice, Grapefruit

How to manage the interaction:
Consumption of grape juice increases the effect of caffeine. Limit your consumption of grapefruit and grapefruit juice during treatment with caffeine.

Diet & Lifestyle Advise

  • Include more glucosamine, chondroitin sulphate, vitamin D, calcium enriched supplements. Besides this, turmeric and fish oils can help in reducing inflammation in the tissue. 
  • Do not go for heavy exercise as it may increase your joint pain in arthritis. Instead, you can do stretching, low impact aerobic exercise like walking on treadmill, bike riding and swimming. You can also strengthen your muscles by lifting light weights. 
  • In chronic condition of arthritis or joint pain try to include fish like salmon, trout, tuna, and sardines. These fishes are enriched with omega-3 fatty acids that minimize level of chemical called cytokines, which ramp up inflammation.
  • Your sitting posture is important especially when you have pain and inflammation. Try to sit as little as possible, and only for a short duration of time. Long term immobility is harmful in conditions like arthritis. Use back support like a rolled up towel at the back of your spine curve to minimize pain. Keep your knees and hips at a right angle. Besides this, you can also use a foot rest if required.

Side Effects of Ediflam Plus Tablet

  • Nausea
  • Indigestion
  • Stomach pain
  • Restlessness

Habit Forming

No

Therapeutic Class

ANALGESICS

Drug-Diseases Interactions

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No Drug - Disease interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Diseases Interactions

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FAQs

No, Ediflam Plus Tablet should not be taken as a long term medication as it may lead to stomach ulcers/bleeding and kidney problems. For best results of Ediflam Plus Tablet, take it in doses and duration mentioned by your doctor.

No, it is not advisable to take Ediflam Plus Tablet with depression medication. Please inform your doctor if you are taking depression medicine before starting Ediflam Plus Tablet.

Yes, Ediflam Plus Tablet is a short term medication and if you feel better you can stop taking Ediflam Plus Tablet, but only after consulting your doctor.

Ediflam Plus Tablet is known to be contra-indicated in patients with allergy to painkillers (NSAIDs) or any of the components or excipients of this medicine. Its use should also be avoided in patients with history of stomach ulcer and kidney/liver disease.

Yes, Ediflam Plus Tablet is known to cause dizziness. If you feel dizzy, please take rest and also avoid driving while you take Ediflam Plus Tablet as it can be harmful.

No, Ediflam Plus Tablet is not indicated for stomach pain. Also, If you have stomach pain post ingestion it may be a sign of stomach ulcer, or gastric bleeding. Do not take Ediflam Plus Tablet in this condition. It is better to inform your doctor in case of stomach pain post ingestion of this medication.

It depends on whether your cough and cold pills contain ibuprofen, paracetamol and caffeine or not. If it contains these three medicines, do not take it. It may lead to over dosage, thereby producing unpleasant side effects. Consult your doctor before taking it in such cases.

Drug-Drug Interactions Checker List

  • LITHIUM
  • METHOTREXATE
  • WARFARIN
  • COUMADIN
  • JANTOVEN
  • METOCLOPRAMIDE
  • DOMPERIDONE
  • FUROSEMIDE
  • PREDNISONE
  • CIPROFLOXACIN
  • THEOPHYLLINE
  • EPHEDRINE
  • CHOLESTYRAMINE
  • DULOXETINE

Special Advise

  • Ediflam Plus Tablet is commonly prescribed for relieving pain in both acute and chronic conditions and in cases of fever. Do not take the drug beyond its suggested dose and frequency.
  • Avoid driving while consuming Ediflam Plus Tablet as it can cause dizziness in some individuals and hamper your focus and reflexes.
  • Avoid concomitant consumption of drugs containing the same chemicals as Ediflam Plus Tablet as it can lead to overdosage and unwanted side effects.
  • Immediately consult your doctor in case of persistent side effects like stomach pain on consumption of Ediflam Plus Tablet.
  • Avoid consuming alcohol while you are on Ediflam Plus Tablet.

Disease/Condition Glossary

Pain can be short term (acute) or long term (chronic) in nature. Acute pain is for a short time caused by damage to the tissues of the muscle, bone, or organs. While, chronic pain lasts for a longer duration and is caused due to pathologies like nerve damage, osteoarthritis and dental pain due to damage to the tooth nerve, infection, decay, extraction, or injury. Many women have painful periods known as dysmenorrhea most often menstrual cramps. On the other hand, Osteoarthritis is a degenerative disease that results in chronic pain in joints (especially knee) and stiffness making daily tasks difficult.

Have a query?

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Alcohol

Caution

Taking Ediflam Plus Tablet with alcohol may cause dizziness or drowsiness. Besides this, it can also damage your liver if taken for a longer duration. So, avoid or limit intake of alcoholic beverages with Ediflam Plus Tablet.

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Pregnancy

Unsafe

Use of Ediflam Plus Tablet during pregnancy is not recommended as taking this medicine during the last 3 months of pregnancy may harm the unborn baby.

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Breast Feeding

Unsafe

Caffeine can pass in the breast milk which may have stimulating effect on breastfed child. Therefore, Ediflam Plus Tablet should be avoided in the breastfeeding stage.

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Driving

Caution

After taking Ediflam Plus Tablet you may notice dizziness, sleepiness, drowsiness or fatigue as it contain caffeine as stimulant. So, in this you should stop taking Ediflam Plus Tablet and contact your doctor.

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Liver

Caution

Ediflam Plus Tablet to be taken with caution, especially if you have a history of liver disease. Dose may have to be adjusted by your doctor.

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Kidney

Caution

Ediflam Plus Tablet to be taken with caution, especially if you have a history of Kidney diseases/conditions. Dose may have to be adjusted by your doctor.

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Children

Caution

Ediflam Plus Tablet is contraindicated in children below 20 kg body weight or younger than 6 years of age. It may cause kidney problems in children and adolescents who are dehydrated.

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