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Reviewed By Sureshvarma D , MPharma
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Composition :

ENTACAPONE-200MG

Manufacturer/Marketer :

Intas Pharmaceuticals Ltd

Consume Type :

ORAL

Return Policy :

Not Returnable

Expires on or after :

About Entacom Tablet

Entacom Tablet belongs to a group known as antiparkinson’s medicines. It is used alone or in combination with other drugs, such as levodopa, for the treatment of the signs and symptoms of Parkinson's disease. This drug can improve symptoms such as tremors, stiffness, poor muscle control and muscle spasms. Parkinson's disease is a medical disorder that affects the ability of a person to do regular tasks. This disease affects the nervous system of the body, which in turn, affects the person's ability to move or do the normal activities of the day. This is a chronic and progressive disorder, so if the right treatment is not provided to the patient at the initial stage of this disease, their symptoms may worsen with time.

Entacom Tablet contains entacapone which is given in combination with levodopa. It works by inhibiting a chemical messenger that supports increasing the amount of dopamine (other chemical messengers) in the body. Thereby, enough dopamine controls the brain to organize body movements. This is how it works to survive Parkinson's disease.

Take Entacom Tablet as prescribed by your doctor. You are advised to take Entacom Tablet for as long as your doctor has prescribed it for you, depending on your medical conditions. You may experience nausea, fatigue, vomiting, confusion, constipation, increased sweating, falls, urine discolouration, dizziness Insomnia (difficulty in sleeping), diarrhea, impaired muscle coordination, heart disease, heart attack, dryness in the mouth and abdominal pain. Most of these side effects of Entacom Tablet do not require medical attention and gradually resolve over time. However, if the side effects persist or worsen, please consult your doctor.

Do not take Entacom Tablet if you are allergic to it or any other ingredients present in it. Avoid taking Entacom Tablet if you have heart disease or heart attack. Entacom Tablet causes low blood pressure, drowsiness and dizziness. It is advisable not to drive unless you are alert. Avoid drinking alcohol as it may cause drowsiness and dizziness and decrease the efficacy of Entacom Tablet . It is not recommended for use in children under 18 years of age as limited data are available. Tell your doctor if you are pregnant or breastfeeding.

Uses of Entacom Tablet

Parkinson’s disease

Directions for Use

Entacom Tablet is taken together with medicines containing levodopa and carbidopa. Entacom Tablet can be taken with or without food or as suggested by your doctor. It should be swallowed as a whole with a glass of water, do not chew or crush the tablet. The doctor will decide the dose after checking the severity of the medical disorder, reaction to treatment and different drugs a person might be taking.

Medicinal Benefits

Entacom Tablet increases levels of levodopa in the body. Entacom Tablet  is used together with levodopa and carbidopa to treat 'wearing-off' symptoms of Parkinson's disease, such as tremors, stiffness, poor muscle control and muscle spasms. It works by inhibiting a chemical messenger, which supports increasing the amount of dopamine (other chemical messengers) in the body. Thereby, enough dopamine controls the brain to organize body movements. This is how it works to survive Parkinson's disease.

Storage

Store in a cool and dry place away from sunlight

Side Effects of Entacom Tablet

  • Nausea
  • Fatigue
  • Vomiting
  • Confusion
  • Constipation
  • Increased sweating
  • Urine discolouration
  • Dizziness
  • Insomnia (difficulty in sleeping)
  • Diarrhoea
  • Impaired muscle coordination
  • Heart disease
  • Heart attack
  • Dry mouth
  • Abdominal pain

 

Drug Warnings

Avoid taking Entacom Tablet if you are allergic to Entacom Tablet or any other ingredients in it. If you have heart disease, heart attack, muscle pain, or weakness, consult your doctor before taking Entacom Tablet . Avoid taking Entacom Tablet if you experience diarrhea. Immediately inform your doctor if you notice weakness, loss of appetite and weight loss within a relatively short period. Entacom Tablet causes low blood pressure, drowsiness and dizziness. Do not drive unless you are alert. Avoid drinking alcohol as it may cause drowsiness and dizziness and decrease the efficacy of Entacom Tablet . It is not recommended for use in children under 18 years of age as limited data are available. Tell your doctor if you are pregnant or breastfeeding before taking Entacom Tablet .

Drug-Drug Interactions

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EntacaponePhenelzine
Critical
EntacaponeIsocarboxazid
Critical

Drug-Drug Interactions

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EntacaponePhenelzine
Critical
How does the drug interact with Entacom Tablet:
Combining Entacom Tablet with Phenelzine can increase the risk of serious condition called the serotonin syndrome.

How to manage the interaction:
Taking Entacom Tablet with Phenelzine is not recommended as it can possibly result in an interaction, but it can be taken if your doctor has advised it. However, if you experience extreme changes in blood pressure, increased heart rate, fever, excessive sweating, shivering or shaking, blurred vision, muscle spasm or stiffness, tremor, incoordination, stomach cramp, nausea, vomiting, and diarrhea. contact your doctor immediately. Do not discontinue any medications without consulting a doctor.
EntacaponeIsocarboxazid
Critical
How does the drug interact with Entacom Tablet:
Combining Entacom Tablet with Isocarboxazid can increase the risk of serious condition called the serotonin syndrome.

How to manage the interaction:
Taking Entacom Tablet with Isocarboxazid is not recommended as it can result in an interaction; it can be taken if your doctor has advised it. However, if you experience sudden extreme changes in blood pressure, increased heart rate, fever, excessive sweating, shivering or shaking, blurred vision, muscle spasm or stiffness, tremor, incoordination, stomach cramp, nausea, vomiting, and diarrhea, Contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
EntacaponeLinezolid
Critical
How does the drug interact with Entacom Tablet:
Coadministration of Entacom Tablet with Linezolid might raise serotonin hormone levels in the body, affecting the brain and nerve cells.

How to manage the interaction:
Taking Entacom Tablet with Linezolid is not recommended as it can result in an interaction, it can be taken if a doctor has advised it. However, if you experience confusion, hallucination, seizure, extreme changes in blood pressure, increased heart rate, fever, excessive sweating, shivering or shaking, blurred vision, muscle spasm or stiffness, tremors, incoordination, stomach cramps, nausea, vomiting, and diarrhea, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
EntacaponeTranylcypromine
Critical
How does the drug interact with Entacom Tablet:
Coadministration of Entacom Tablet with Tranylcypromine can increase the risk of high blood pressure and also increase the risk of serotonin syndrome(a condition in which a chemical called serotonin increase in your body).

How to manage the interaction:
Taking Entacom Tablet with Tranylcypromine can result in an interaction, but can be taken together if prescribed by a doctor. However, consult a doctor if you experience confusion, hallucination(seeing and hearing things that do not exist), fits, blood pressure alteration, increased heart rate, fever, excessive sweating, shivering or shaking, blurred vision, pain in the muscles or stiffness, incoordination, stomach cramps, nausea, vomiting, and diarrhea. Do not discontinue any medications without consulting your doctor.
EntacaponeFurazolidone
Severe
How does the drug interact with Entacom Tablet:
Combining Entacom Tablet with Furazolidone can increase the risk of CNS depression (a physiological state that can result in a decreased rate of breathing, decreased heart rate, and loss of consciousness).

How to manage the interaction:
Although there is a possible interaction between Entacom Tablet and Furazolidone, you can take these medicines together if prescribed by your doctor. It's important to keep an eye on your health. If you notice any of these signs - very high blood pressure, feeling really unwell, confusion, seeing or hearing things that aren't there, having a seizure, a faster heartbeat, fever, sweating a lot, shivering or shaking, trouble seeing clearly, muscle spasms or stiffness, difficulty moving, stomach cramps, feeling sick, throwing up, or having diarrhea - make sure to call a doctor right away. Do not stop using any medications without a doctor's advice.
EntacaponeMethylene blue
Severe
How does the drug interact with Entacom Tablet:
Combining Entacom Tablet with Methylene blue can increase the risk of CNS depression (a physiological state that can result in a decreased rate of breathing, decreased heart rate, and loss of consciousness).

How to manage the interaction:
Taking Entacom Tablet with Methylene blue together can result in an interaction, but it can be taken if your doctor has advised it. It's important to keep an eye on your health. If you notice any of these signs - very high blood pressure, feeling confused or hallucinating, having a seizure, a fast heartbeat, fever, sweating a lot, shivering or shaking, trouble seeing clearly, muscle spasms or stiffness, difficulty coordinating movements, stomach cramps, feeling sick, throwing up, or having diarrhea - make sure to call a doctor right away. Do not discontinue any medications without consulting a doctor.
EntacaponeSodium oxybate
Severe
How does the drug interact with Entacom Tablet:
Taking Entacom Tablet with Sodium oxybate can increase the risk or severity of side effects like decreased rate of breathing, decreased heart rate, and loss of consciousness.

How to manage the interaction:
Although taking Entacom Tablet and Sodium oxybate together can cause an interaction, it can be taken if your doctor has suggested it. If you notice any symptoms like fatigue, dizziness, lightheaded, drowsiness, confusion, shortness of breath, chest pain or tightness, make sure to call a doctor right away. Do not stop using any medications without a doctor's advice.
EntacaponeEsketamine
Severe
How does the drug interact with Entacom Tablet:
Combining Entacom Tablet with Esketamine can increase the risk and severity of side effects (drowsiness, confusion, difficulty concentrating, and impairment in thinking, judgment, reaction speed, and motor coordination).

How to manage the interaction:
Although taking Entacom Tablet and Esketamine together can cause an interaction, it can be taken if your doctor has suggested it. If you're having any of these symptoms like feeling sleepy, having trouble concentrating, or feeling confused, it's important to let a doctor know right away. Do not stop using any medications without talking to a doctor.
EntacaponeProcarbazine
Severe
How does the drug interact with Entacom Tablet:
Combining Entacom Tablet with Procarbazine can increase the risk or severity of side effects like decreased rate of breathing, decreased heart rate, and loss of consciousness.

How to manage the interaction:
Although taking Entacom Tablet and Procarbazine together can cause an interaction, it can be taken if your doctor has suggested it. If you notice any symptoms like confusion, hallucinations, seizures, fast heartbeat, fever, sweating, shivering, blurred vision, muscle spasms, stiffness, trouble moving, cramps, feeling sick, throwing up, or having diarrhea - make sure to call a doctor right away. Do not stop using any medications without a doctor's advice.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

  • A balanced diet is essential to show improvement in Parkinson's disease that includes grains and leafy foods as this food is rich in vitamins, fibre and minerals. With this food, one should also include dairy items, protein-rich nourishments, for example, meat and beans and solid fats found in nuts, olive oil, fish and eggs in their diet. However, limit the consumption of sugar.
  • Constipation is a common issue for individuals with Parkinson's disease. Drinking more liquid and increasing the intake of fibre admission helps in overcoming this issue.
  • Parkinson's sickness is often caused by decreased bone thickness. In this manner, taking calcium and nutrient D enhancements may help. However, do not take any supplements before counselling a doctor.
  • One should drink a lot of water as a person dealing with this disease often feel dehydrated.

Habit Forming

No

Therapeutic Class

ANTIPARKINSON AGENTS

Entacom Tablet Substitute

Substitutes safety advice
  • Adcapone Tablet 10's

    by Others

    8.73per tablet
  • Entocom Tablet 10's

    by Others

    6.12per tablet

Drug-Diseases Interactions

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No Drug - Disease interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Diseases Interactions

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FAQs

Yes, Entacom Tablet may result in urine discolouration to a brownish-orange colour. This effect is common and is not dangerous.

The combined use of Entacom Tablet and levodopa has been related to unnecessary daytime sleepiness and unexpected sleep onset episodes. If you experience these symptoms, you should neither drive nor use other machinery. Inform your doctor if it becomes difficult.

If you take more than the prescribed doses of Entacom Tablet , you may experience confusion, sleepiness, decreased activity, decreased muscle tone, urticaria (skin rashes caused by a reaction of medicine) and skin discolouration. If such symptoms happen, you should take urgent medical attention in a nearby hospital or inform your doctor.

No, Entacom Tablet does not affect fertility. However, Entacom Tablet should be avoided by pregnant and breastfeeding women because there is not enough data to help the safety of this patient group.

No, the Entacom Tablet should not be crushed or split. Take it as a whole with a full glass of water.

Drug-Drug Interactions Checker List

  • ISOPRENALINE
  • AMITRIPTYLINE
  • DESIPRAMINE
  • MOCLOBEMIDE
  • WARFARIN
  • ISOCARBOXAZID
  • LINEZOLID
  • METHYLENE BLUE
  • PHENELZINE
  • PROCARBAZINE
  • TRANYLCYPROMINE
  • CETIRIZINE
  • DIPHENHYDRAMINE
  • ALPRAZOLAM
  • DIAZEPAM
  • ZOLPIDEM

Special Advise

  • Entacom Tablet may cause diarrhea, if you experience diarrhea, drink plenty of water; if symptoms persist, consult your doctor immediately. Do not take anti-diarrhea medicine on your own.

Disease/Condition Glossary

Parkinson’s disease (PD): It is also known as a movement disorder that mainly affects a person's ability to perform regular activities. It is a chronic and progressive disorder that can worsen with time if proper treatment is not provided at the right time. Some common symptoms include tremors at rest, stiffness of the limbs and slowness of movement, difficulty in movement or walking and impaired balance. Other motor symptoms include trouble solving problems, small handwriting, stooped posture, etc. This disease also affects the brain's ability to work properly, such as sleep disturbances, reduced ability to smell, depression, fatigue and anxiety. However, the symptoms of this disease vary from person to person. There are certain neurons present in the brain that are responsible for making dopamine. This neurotransmitter helps to regulate the movement of the body. Loss of dopamine is supposed to be the primary reason for the occurrence of Parkinson's disease.

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