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Written By Lakshmithulasi Yarragunta , Pharm-D (PB)
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
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Composition :

ENALAPRILAT-1.25MG

Manufacturer/Marketer :

Cadila Pharmaceuticals Ltd

Consume Type :

PARENTERAL

Return Policy :

Not Returnable

Expires on or after :

About Envas Injection 1 ml

Envas Injection 1 ml is an anti-hypertensive medicine primarily used in the treatment of Hypertension. It is used when the oral treatment is not effective. Hypertension (high blood pressure) is a serious condition in which the force exerted by the blood against the artery walls becomes high, and this hardens the heart to pump blood.

Envas Injection 1 ml contains Enalaprilat, which belongs to the class of Angiotensin-converting enzyme (ACE) inhibitors. It works by decreasing the production of certain substances responsible for increased blood pressure.

Envas Injection 1 ml may cause certain common side effects such as cough, dizziness, headache, nausea, light-headedness, difficulty breathing, vomiting, confusion, sore throat, chest pain, abdominal pain, diarrhoea, decreased blood pressure, nervousness, injection site reactions, and hoarseness. These side effects do not require medical attention and usually resolve after some time. Envas Injection 1 ml will be administered by a trained healthcare professional. Do not self-administer.

Avoid receiving Envas Injection 1 ml and inform your doctor if you are allergic to it. Envas Injection 1 ml is contraindicated in patients with angioedema related to previous treatment with an angiotensin-converting enzyme inhibitor and hereditary or idiopathic angioedema. This medicine should be used with caution if you have/had any conditions such as congestive heart failure, liver or kidney disease, and peripheral oedema (swelling of hands/legs). It is not recommended to take this medicine during pregnancy and breastfeeding.

Uses of Envas Injection 1 ml

Hypertension.

Directions for Use

Envas Injection 1 ml will be administered by a trained healthcare professional. Hence, do not self-administer.

Medicinal Benefits

Envas Injection 1 ml contains Enalaprilat, which belongs to the Angiotensin-converting enzyme (ACE) inhibitors class. It works by reducing the production of certain substances that cause an increase in blood pressure. It allows the blood to flow more smoothly and makes the heart more efficient at pumping blood throughout the body. Envas Injection 1 ml helps reduce high BP and the risk of heart attack, stroke and angina (chest pain).

Storage

Keep Envas Injection 1 ml out of the sight and reach of children.
Side effects of Envas Injection 1 ml
  • Reduce salt intake to minimize fluid buildup.
  • Use compression stockings, sleeves, or gloves.
  • Gently massage the affected area towards the heart.
  • Protect the swollen area from injury and keep it clean.
  • Use lotion or cream to keep the skin moisturized.

Drug Warnings

Avoid receiving Envas Injection 1 ml and inform your doctor if an allergic reaction occurs. Envas Injection 1 ml is contraindicated in patients with angioedema related to previous treatment with an angiotensin-converting enzyme inhibitor and hereditary or idiopathic angioedema. Envas Injection 1 ml is not recommended for use in children as the safety and efficacy are not established. On rare occasions, ACE inhibitors have been linked to a syndrome that begins with cholestatic jaundice, advances to fulminant hepatic necrosis, and occasionally results in death. When jaundice or significant elevations in hepatic enzymes occur in patients taking ACE inhibitors, the medication should be stopped, and appropriate medical attention should be given. Before receiving Envas Injection 1 ml, caution should be exercised in patients with congestive heart failure, liver disease, kidney disease, hyperkalaemia, angioedema, cough, and peripheral oedema (swelling of hands/legs). In some patients, this medicine may cause head and neck angioedema, severe anaphylactic reactions, hypotension, hepatic failure, and neutropenia. Hence, inform your doctor about your complete medication and medical history. Avoid consumption of alcohol during the treatment. If you are pregnant or breastfeeding, inform your doctor beforehand.

Drug-Drug Interactions

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Drug-Drug Interactions

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How does the drug interact with Envas Injection 1 ml:
Using aliskiren together with Envas Injection 1 ml may increase the risk of serious side effects such as kidney problems, low blood pressure, and high potassium levels in the blood.

How to manage the interaction:
Taking Envas Injection 1 ml with aliskiren is not recommended, but it can be taken together if your doctor advises. However, contact your doctor if you experience nausea, vomiting, weakness, confusion, tingling of the hands and feet, or feelings of heaviness in the legs. Do not stop taking any medications without consulting a doctor.
How does the drug interact with Envas Injection 1 ml:
Due to the additive effect, the coadministration of Envas Injection 1 ml and Amiloride (potassium-sparing diuretic) may increase blood potassium levels. The risk is increased if you are elderly, dehydrated, or have a history of kidney or heart disease.

How to manage the interaction:
Although taking Envas Injection 1 ml together with Allopurinol may possibly result in an interaction, they can be taken together if prescribed by your doctor. However, if you experience any signs and symptoms of hyperkalemia like, weakness, confusion, numbness or tingling, and uneven heartbeats, consult your doctor immediately. Do not discontinue any medication without consulting your doctor.
How does the drug interact with Envas Injection 1 ml:
Envas Injection 1 ml has the potential to cause liver damage; this effect can be increased by the coadministration of medications that affect the liver, such as Leflunomide. This effect can be seen even long after discontinuing leflunomide as it stays in your blood longer.

How to manage the interaction:
Although taking Envas Injection 1 ml together with Leflunomide may possibly result in an interaction, they can be taken together if prescribed by your doctor. However, contact your doctor immediately if you experience signs and symptoms of liver damage like fever, chills, unusual bleeding, dark-coloured urine, light colour stools, yellowish discolouration of skin and eyes, and abdominal pain. It is advised not to consume alcohol while using these medications as it may increase the damage o the liver. Do not discontinue any medications without consulting your doctor.
How does the drug interact with Envas Injection 1 ml:
Coadministration of Envas Injection 1 ml with Telmisartan may increase the risk of hyperkalemia (high potassium levels in the blood), hypotension, syncope (fainting), and renal failure due to additive or synergistic effects. If you are elderly, dehydrated, or have a history of renal or heart illness, your risk is enhanced.

How to manage the interaction:
Although taking Envas Injection 1 ml together with Telmisartan may possibly result in an interaction, they can be taken together if prescribed by your doctor. However, contact your doctor immediately if you experience signs and symptoms of hyperkalemia, such as nausea, vomiting, confusion, numbness, tingling in hands and feet, and irregular heartbeat. It is advised to limit the intake of potassium-rich foods like tomatoes, bananas, papayas, mangoes, beans, and potassium-containing supplements. Do not discontinue any medication without consulting your doctor.
EnalaprilPotassium iodide
Severe
How does the drug interact with Envas Injection 1 ml:
Taking Envas Injection 1 ml with Potassium iodide increases the potassium levels in the blood, which may lead to hyperkalemia. In severe cases, hyperkalemia may lead to muscular paralysis, kidney damage, and cardiac problems. The risk is increased if you are elderly, dehydrated, or have a history of kidney or heart disease.

How to manage the interaction:
Although taking Envas Injection 1 ml together with Potassium iodide may possibly result in an interaction, they can be taken together if prescribed by your doctor. However, contact your doctor immediately if you experience signs and symptoms of hyperkalemia, such as nausea, vomiting, confusion, numbness, tingling in hands and feet, and irregular heartbeat. It is advised to limit the intake of potassium-rich foods like tomatoes, bananas, mangoes, beans, coconut and potassium-containing supplements. Do not discontinue any medication without consulting your doctor.
EnalaprilEprosartan
Severe
How does the drug interact with Envas Injection 1 ml:
Coadministration of Envas Injection 1 ml with Eprosartan may raise the risk of hyperkalemia, hypotension, syncope, and renal failure due to additive or synergistic effects. The risk is increased if you are elderly, dehydrated, or have a history of kidney or heart disease.

How to manage the interaction:
Although taking Envas Injection 1 ml together with Eprosartan may result in an interaction, they can be taken together if prescribed by your doctor. However, contact your doctor immediately if you experience signs and symptoms of hyperkalemia, such as nausea, vomiting, confusion, numbness, tingling in hands and feet, and irregular heartbeat. It is advised to limit the intake of potassium-rich foods like tomatoes, bananas, mangoes, beans, and potassium-containing supplements. Do not discontinue any medication without consulting your doctor.
How does the drug interact with Envas Injection 1 ml:
Using Envas Injection 1 ml together with amiloride may increase the levels of potassium in your blood, especially if you are dehydrated or have kidney disease or diabetes.

How to manage the interaction:
Although taking amiloride and Envas Injection 1 ml together can result in an interaction, it can be taken if a doctor has prescribed it. However, consult the doctor if you experience weakness, confusion, numbness or tingling, and uneven heartbeats. Do not discontinue any medications without a doctor's advice.
EnalaprilTriamterene
Severe
How does the drug interact with Envas Injection 1 ml:
Taking Envas Injection 1 ml together with triamterene may increase the levels of potassium in your blood (hyperkalemia), especially if you are dehydrated or have kidney disease or diabetes.

How to manage the interaction:
Although taking Envas Injection 1 ml with Triamterene may result in an interaction, they can be taken together if your doctor prescribes it. However, contact your doctor immediately if you experience weakness, confusion, numbness or tingling. Do not discontinue any medication without consulting your doctor.
How does the drug interact with Envas Injection 1 ml:
Due to additive or synergistic effects, coadministration of Envas Injection 1 ml with candesartan may raise the risk of hyperkalemia, hypotension, syncope, and renal failure. The risk is increased if you are elderly, dehydrated, or have a history of kidney or heart disease.

How to manage the interaction:
Although taking Envas Injection 1 ml together with Candesartan may result in an interaction, they can be taken together if prescribed by your doctor. However, contact your doctor immediately if you experience signs and symptoms of hyperkalemia, such as nausea, vomiting, confusion, numbness, tingling in hands and feet, and irregular heartbeat. It is advised to limit the intake of potassium-rich foods like tomatoes, bananas, mangoes, beans and potassium-containing supplements. Do not discontinue any medication without consulting your doctor.
How does the drug interact with Envas Injection 1 ml:
Envas Injection 1 ml combined with Trimethoprim can cause hyperkalemia by elevating blood potassium levels. In severe cases, hyperkalemia can induce muscle paralysis, renal damage, and cardiac problems. The risk is increased if you are elderly, dehydrated, or have a history of renal or cardiovascular disease.

How to manage the interaction:
Although taking Envas Injection 1 ml together with Trimethoprim may possibly result in an interaction, they can be taken together if prescribed by your doctor. However, contact your doctor immediately if you experience signs and symptoms of hyperkalemia, such as nausea, vomiting, confusion, numbness, tingling in hands and feet, and irregular heartbeat. It is advised to limit the intake of potassium-rich foods like tomatoes, bananas, mangoes, beans, and potassium-containing supplements. Do not discontinue any medication without consulting your doctor.

Drug-Food Interactions

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ENALAPRILAT-1.25MGPotassium rich foods
Moderate

Drug-Food Interactions

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ENALAPRILAT-1.25MGPotassium rich foods
Moderate
Common Foods to Avoid:
Lentils, Orange Juice, Oranges, Raisins, Potatoes, Salmon Dried, Spinach, Sweet Potatoes, Tomatoes, Coconut Water, Beans, Beetroot, Broccoli, Bananas, Apricots, Avocado, Yogurt

How to manage the interaction:
Consuming a high-potassium diet while taking Envas Injection 1 ml can cause hyperkalemia (elevated blood potassium levels). Hyperkalemia may lead to dizziness, lightheadedness, fainting, or a rapid heartbeat. Avoid the consumption of potassium-rich foods.

Diet & Lifestyle Advise

  • Try to maintain your weight under control with a BMI of 19.5-24.9.
  • Doing regular physical activity or exercise for at least 30 minutes most days of the week can help you lower your raised blood pressure.
  • Opt for a diet rich in whole grains, fruits, veggies and low-fat dairy products. 
  • Reduce the intake of table salt in your daily diet to 2300 mg per day for better results.
  • Quitting smoking and alcohol consumption is the best strategy to lower the risk of heart disease. 
  • Avoid chronic stress, as it can raise your blood pressure.
  • Monitor your blood pressure daily, and if there is too much fluctuation, then immediately contact your doctor. 

Side Effects of Envas Injection 1 ml

  • Headache
  • Diarrhoea
  • Dizziness
  • Nausea
  • Cough
  • Hoarseness
  • Abdominal pain
  • Nervousness
  • Pain at the site of injection
  • Chest pain
  • Upper respiratory tract infections

Habit Forming

No

Therapeutic Class

ACE INHIBITORS

Drug-Diseases Interactions

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No Drug - Disease interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Diseases Interactions

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FAQs

Envas Injection 1 ml contains Enalaprilat, which works by reducing the production of certain substances that cause an increase in blood pressure. This allows the blood to flow more smoothly and makes the heart more efficient at pumping blood throughout the body.

It is advised to continue your medicine even after your blood pressure is controlled or becomes normal, as it can shoot up at any time. If you have a persistent headache, please consult your doctor immediately.

The chances of missing a dose of Envas Injection 1 ml are very low. If you forget to take a dose or miss the appointment, consult your doctor and receive your next dose on time.

Drug-Drug Interactions Checker List

  • ALISKIREN
  • SITAGLIPTIN
  • METFORMIN
  • INSULIN
  • FUROSEMIDE
  • IBUPROFEN
  • ASPIRIN
  • SACUBITRIL
  • VALSARTAN

Special Advise

  • Sudden withdrawal may worsen angina (chest pain). However, if you experience chest pain, consult your doctor immediately.
  • Frequent monitoring of blood pressure is important while receiving this medicine.
  • Abnormal liver and kidney tests must be reported to the doctor.
  • Your doctor may suggest a blood test for serum electrolytes (sodium, potassium), and a CBC to check for the occurrence of hyponatremia and hypokalaemia.

Disease/Condition Glossary

Hypertension: Also called high blood pressure, is a serious condition in which the force exerted by the blood against the artery walls becomes high. This hardens the heart to pump blood. Raised blood pressure can cause chest pain (angina), heart attack (when the blood supply to the heart is blocked), stroke (brain damage) and kidney failure. Envas Injection 1 ml is used in treating hypertension and thus helps reduce further risk. The blood pressure can be diagnosed with the help of a blood pressure monitor called a sphygmomanometer.

Have a query?

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Alcohol

Unsafe

Do not consume alcohol while on treatment with Envas Injection 1 ml as it may worsen the side effects like dizziness and also may increase blood pressure.

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Pregnancy

Unsafe

The use of Envas Injection 1 ml is contraindicated during the second and third trimester of pregnancy. It may cause harm to the developing fetus. Inform your doctor if you are pregnant before receiving Envas Injection 1 ml.

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Breast Feeding

Unsafe

Envas Injection 1 ml may be excreted in human milk. Therefore, it is not recommended for breastfeeding mothers as it may be unsafe for the baby. Inform your doctor if you are breastfeeding before receiving Envas Injection 1 ml. Your doctor will decide whether you stop breastfeeding or discontinue the use of Envas Injection 1 ml based on the benefits and risks.

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Driving

Caution

Envas Injection 1 ml may cause dizziness. Hence, do not drive or operate machines after receiving this medicine.

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Liver

Caution

If you have a pre-existing or a history of liver disease, inform your doctor before receiving Envas Injection 1 ml. Your doctor may adjust the dose of this medicine or prescribe a suitable alternative based on your condition. Elderly patients with liver impairment should start the treatment with a lower dose.

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Kidney

Caution

If you have a pre-existing or a history of kidney disease, inform your doctor before receiving Envas Injection 1 ml. Envas Injection 1 ml may cause renal failure in some patients. Hence, inform your doctor if the patient develops any symptoms. Your doctor may adjust the dose of this medicine or prescribe a suitable alternative based on your condition. Elderly patients with renal impairment should start the treatment with a lower dose.

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Children

Unsafe

Envas Injection 1 ml is not recommended for use in children as the safety and efficacy are not established for this age group.

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