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Written By Bayyarapu Mahesh Kumar , M Pharmacy
Reviewed By Santoshini Reddy G , M Pharmacy
Non returnable*
COD available

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Composition :

CLONAZEPAM-0.25MG

Manufacturer/Marketer :

Emcure Pharmaceuticals Ltd

Consume Type :

ORAL

Return Policy :

Not Returnable

Expires on or after :

NPPA :

Regulated

About EPITRIL 0.25MG TABLET

EPITRIL 0.25MG TABLET belongs to the group of medications called benzodiazepines, primarily used to treat seizures or fits due to epilepsy, panic disorder and involuntary muscle spasms. EPITRIL 0.25MG TABLET may also be used to treat restless leg syndrome. Epilepsy is a common neurological disorder that produces recurrent seizures. Seizures occur due to a sudden burst of electrical activity in the brain that disrupts its normal functioning. Panic disorder is an anxiety disorder characterised by frequent episodes of panic or fear.

EPITRIL 0.25MG TABLET contains clonazepam, which works by increasing the level of a calming chemical known as gamma-aminobutyric acid (GABA) in the brain. This helps relieve anxiety and seizures (fits). It also helps relax the tense muscles. Thereby, EPITRIL 0.25MG TABLET aids in the treatment of seizures, panic disorder, and involuntary muscle spasms.

Your doctor will advise you on how often you need to take this medicine based on your medical condition. In some cases, EPITRIL 0.25MG TABLET may cause side effects such as drowsiness, dizziness, fatigue, and problems with memory, walking, and coordination. Most of these side effects do not require medical attention and gradually resolve over time. However, please contact your doctor if the side effects are persistent.

EPITRIL 0.25MG TABLET is a habit-forming drug. Therefore, before stopping this medicine, consult your doctor as it may cause withdrawal symptoms like seizures that do not stop, hallucinations (hearing or seeing things that are not there), shaking, and stomach and muscle cramps. If you are pregnant or breastfeeding, consult your doctor before taking EPITRIL 0.25MG TABLET . Avoid drinking alcohol while taking EPITRIL 0.25MG TABLET as it may cause increased dizziness and drowsiness. It is recommended not to drive or operate any machinery as EPITRIL 0.25MG TABLET may cause dizziness, drowsiness, and problems with walking and coordination.

Uses of EPITRIL 0.25MG TABLET

Seizures, Panic disorder, Involuntary muscle spasms, Restless leg syndrome

Directions for Use

Tablet/capsule: Swallow it as a whole with water; do not crush, break or chew it.Dispersible Tablet: Check the label for directions before use. Disperse the tablet in the prescribed amount of water and swallow the contents. Do not crush, chew or swallow as a whole.Oral Solution: Shake the bottle well before use. Check the label for directions and take it in dose as prescribed by your doctor with the help of a measuring cup/dropper provided by the pack.Orally disintegrating strip/Orally disintegrating tablet: Keep the strip/tablet in the mouth and allow it to disintegrate. Do not swallow as a whole. Avoid handling the strip/tablet with wet hands.

Medicinal Benefits

EPITRIL 0.25MG TABLET belongs to the group of medications called benzodiazepines, primarily used to treat seizures or fits due to epilepsy, panic disorder and involuntary muscle spasms. EPITRIL 0.25MG TABLET may also be used to treat restless leg syndrome. EPITRIL 0.25MG TABLET contains clonazepam, which works by increasing the level of a calming chemical known as gamma-aminobutyric acid (GABA) in the brain. It decreases the feeling of nervousness, stress, and anxiety, which leads to a state of calmness and relaxation. EPITRIL 0.25MG TABLET benefits people who struggle with anxiety and worries in daily life. Regular intake of the prescribed dose of EPITRIL 0.25MG TABLET improves social life and the ability and performance at work, and general wellbeing.

Storage

Store in a cool and dry place away from sunlight
Side effects of Epitril 0.25mg Tablet
  • Avoid triggers like alcohol, caffeine, and energy drinks.
  • Try relaxation techniques such as yoga, meditation, or deep breathing.
  • Exercise regularly as it helps maintain heart health.
  • Follow a nutritious and balanced diet.
  • Eat protein-rich foods like fish, poultry, eggs, and legumes.
  • Include foods with minerals and vitamins essential for hair health.
  • Join a support group to connect with others experiencing hair loss.
  • Openly discuss your feelings about hair loss.
  • Consider covering up with wigs, hats, or scarves.
  • Be patient and avoid seeking miracle cures.
  • Skin rash caused by allergies is due to irritants or allergens. Therefore, avoid contact with such irritants.
  • Consult your doctor for proper medication and apply an anti-itch medication. Follow the schedule and use the medication whenever needed.
  • Protect your skin from extreme heat and try to apply wet compresses.
  • Soak in the cool bath, which gives a soothing impact to the affected area.
Here are the steps to Dry Mouth (xerostomia) caused by medication:
  • Inform your doctor about dry mouth symptoms. They may adjust your medication regimen or prescribe additional medications to manage symptoms.
  • Drink plenty of water throughout the day to help keep your mouth moist and alleviate dry mouth symptoms.
  • Chew sugar-free gum or candies to increase saliva production and keep your mouth moisturized.
  • Use saliva substitutes, such as mouthwashes or sprays, only if your doctor advises them to help moisturize your mouth and alleviate dry mouth symptoms.
  • Avoid consuming smoking, alcohol, spicy or acidic foods, and other irritants that may aggravate dry mouth symptoms.
  • Schedule regular dental check-ups to keep track of your oral health and handle any dry mouth issues as they arise.
  • Avoid consuming spicy, acidic, or sharp foods that can irritate gums.
  • Limit intake of citrus fruits and juices.
  • Restrict excessive alcohol consumption.
  • Opt for soft, easy-to-chew foods.
  • Use a soft-bristled toothbrush for gentle oral hygiene.
  • Floss daily to remove trapped food particles.
  • To alleviate gum soreness, try rinsing with warm salt water several times daily.
  • Apply a cold compress to reduce swelling and ease pain.
  • Consult a dentist if your gum soreness is severe, persistent, or accompanied by bleeding or swelling.

Drug Warnings

Do not take EPITRIL 0.25MG TABLET if you are allergic to clonazepam or any benzodiazepine class of drugs (diazepam, chlordiazepoxide, bromazepam, or flurazepam). Inform your doctor if you have lung disease, glaucoma, muscle weakness (myasthenia gravis), sleep apnoea (difficulty in sleeping), depression, mood problems, suicidal behaviour/thoughts, liver or kidney problems. Taking EPITRIL 0.25MG TABLET with opioid medicines can cause severe drowsiness, breathing problems, coma, and death. EPITRIL 0.25MG TABLET should be taken with extreme caution in patients with a history of alcohol or drug abuse. Do not stop taking EPITRIL 0.25MG TABLET suddenly as it may cause withdrawal symptoms.

Drug-Drug Interactions

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ClonazepamSodium oxybate
Critical

Drug-Drug Interactions

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ClonazepamSodium oxybate
Critical
How does the drug interact with Epitril 0.25mg Tablet:
Taking Epitril 0.25mg Tablet with Sodium oxybate can enhance the sedative effects on the central nervous system.

How to manage the interaction:
Taking Epitril 0.25mg Tablet and Tramadol together can result in an interaction, it can be taken if a doctor has advised it. However, if you experience any symptoms such as dizziness, drowsiness, difficulty concentrating, numbness and tingling of extremities, or hypersensitivity to light and noise, consult a doctor immediately. Do not discontinue any medications without consulting a doctor.
How does the drug interact with Epitril 0.25mg Tablet:
Co-administration of Epitril 0.25mg Tablet with Tramadol may significantly lead to adverse effects such as respiratory difficulties (a condition in which fluid builds up in the lungs).

How to manage the interaction:
Taking Epitril 0.25mg Tablet and Tramadol together can result in an interaction, it can be taken if a doctor has advised it. However, if you experience any symptoms such as dizziness, drowsiness, difficulty concentrating, numbness and tingling of extremities, or hypersensitivity to light and noise, consult a doctor immediately. Do not discontinue any medications without consulting a doctor.
ClonazepamRemifentanil
Severe
How does the drug interact with Epitril 0.25mg Tablet:
Co-administration of Remifentanil with Epitril 0.25mg Tablet can increase the risk of side effects.

How to manage the interaction:
Taking Epitril 0.25mg Tablet with Remifentanil together can possibly result in an interaction, but it can be taken if a doctor has advised it. If you notice any symptoms like feeling dizzy, having trouble breathing, or feeling very tired, make sure to call a doctor right away. Do not stop using any medications without a doctor's advice.
ClonazepamDezocine
Severe
How does the drug interact with Epitril 0.25mg Tablet:
Co-administration of Epitril 0.25mg Tablet with Dezocine may increase the risk or severity of respiratory distress.

How to manage the interaction:
Although there is a possible interaction between Epitril 0.25mg Tablet and Dezocine, you can take these medicines together if prescribed by a doctor. If you notice any symptoms like feeling tired, dizzy, or having trouble focusing, make sure to contact a doctor right away. Do not stop using any medications without a doctor's advice.
ClonazepamSufentanil
Severe
How does the drug interact with Epitril 0.25mg Tablet:
Co-administration of Sufentanil with Epitril 0.25mg Tablet can increase the risk of side effects.

How to manage the interaction:
Taking Epitril 0.25mg Tablet with Sufentanil together can possibly result in an interaction, but it can be taken if a doctor has advised it. If you notice any of these symptoms - feeling tired or sleepy, having trouble breathing, or a slower heartbeat - make sure to contact a doctor right away. Do not discontinue any medications without consulting a doctor.
How does the drug interact with Epitril 0.25mg Tablet:
Using Morphine together with Epitril 0.25mg Tablet can cause central nervous system depression (a physiological state that can result in a decreased rate of breathing, decreased heart rate, and loss of consciousness).

How to manage the interaction:
Taking Morphine with Epitril 0.25mg Tablet can result in an interaction, but it can be taken if a doctor has advised it. However, if you experience any symptoms like shortness of breath, feeling tired, having a cough, dizziness, drowsiness, difficulty concentrating, impaired judgment, reaction speed, and motor coordination, make sure to contact a doctor immediately. Do not stop using any medications without consulting a doctor.
ClonazepamAlfentanil
Severe
How does the drug interact with Epitril 0.25mg Tablet:
Co-administration of Alfentanil with Epitril 0.25mg Tablet can increase the risk of adverse effects.

How to manage the interaction:
Although there is a possible interaction between Epitril 0.25mg Tablet and Alfentanil, you can take these medicines together if prescribed by a doctor. If you notice any symptoms like feeling dizzy, having trouble breathing, or feeling very tired, make sure to call a doctor right away. Do not stop using any medications without talking to a doctor.
How does the drug interact with Epitril 0.25mg Tablet:
When Buprenorphine is used with Epitril 0.25mg Tablet, it may lead to significant adverse effects such as respiratory difficulties.

How to manage the interaction:
Co-administration of Buprenorphine alongside Epitril 0.25mg Tablet can result in an interaction, it can be taken if a doctor has advised it. Do not exceed the doses, frequency, or duration of usage advised by a doctor. You should avoid driving or operating hazardous machinery until you know how these drugs affect you. Do not discontinue any medications without consulting a doctor.
How does the drug interact with Epitril 0.25mg Tablet:
Co-administration of Tapentadol together with Epitril 0.25mg Tablet can increase the risk or severity of side effects like decreased breathing rate, irregular heart rhythms, or problems with movement and memory.

How to manage the interaction:
Taking Epitril 0.25mg Tablet with Tapentadol can result in an interaction, it can be taken if your doctor has advised it. Contact a doctor immediately if you experience signs such as drowsiness, lightheadedness, palpitations, confusion, severe weakness, or difficulty breathing. Do not discontinue any medications without consulting a doctor.
ClonazepamHydromorphone
Severe
How does the drug interact with Epitril 0.25mg Tablet:
Co-administration of Epitril 0.25mg Tablet with Hydromorphone may cause serious side effects like respiratory depression (a condition in which fluid builds up in the lungs).

How to manage the interaction:
Consult the doctor if you are taking Epitril 0.25mg Tablet with Hydromorphone. Until you know how these medicines affect you, avoid driving or operating hazardous machinery as these medications may cause dizziness, drowsiness, difficulty concentrating, and impairment in judgment, reaction speed, and motor coordination. Do not exceed the dose and duration prescribed by a doctor. Do not discontinue the medication without consulting a doctor.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

  • Do regular exercise, which can help lower anxiety by releasing endorphins and improving your sleep and self-image.
  • Find humor in your daily life. Try to watch light-hearted shows to help relieve stress.
  • You can increase your mindfulness by including yoga, meditation, mindfulness-based cognitive therapy, and mindfulness-based stress reduction.
  • Drink enough water to stay hydrated, and limit or avoid alcohol and caffeine to relieve anxiety.
  • Include a diet rich in whole grains, vegetables, and fruits.
  • Herbs like turmeric, ginger, and chamomile contain anti-inflammatory properties. Including this stuff in meals can reduce inflammation caused due to anxiety disorder.
  • Reduce alcohol, caffeine, added sugar, high salt, and high fat intake. Especially trans-fat may also help reduce inflammation.
  • You can include antioxidants in your daily diet like ashwagandha, omega-3 fatty acids, green tea and lemon.
  • Try to spend time with your friends and family. Having a strong social network may help you lower the risk of anxiety.

Habit Forming

Yes

Therapeutic Class

ANTICONVULSANT

Author Details

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Drug-Diseases Interactions

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CLONAZEPAM-0.25MGGlaucoma
Severe
CLONAZEPAM-0.25MGMental and behavioural disorders due to multiple drug use and use of other psychoactive substances
Severe

Drug-Diseases Interactions

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CLONAZEPAM-0.25MGGlaucoma
Severe
How does the disease interact with Epitril 0.25mg Tablet:
Benzodiazepines should not be used by people who have open-angle glaucoma or acute angle-closure glaucoma. While these drugs have very rarely being associated with increased intraocular pressure, they do not have anticholinergic effect.

How to manage the interaction:
Epitril 0.25mg Tablet is contraindicated in patients with acute angle-closure glaucoma or untreated open-angle glaucoma.
CLONAZEPAM-0.25MGMental and behavioural disorders due to multiple drug use and use of other psychoactive substances
Severe
How does the disease interact with Epitril 0.25mg Tablet:
Benzodiazepines have the potential to cause abuse and dependency. Particularly during extended usage and/or high dosages, tolerance as well as physical and psychological dependency might form.

How to manage the interaction:
Benzodiazepines have the potential to cause dependence and abuse. If dependency is suspected, withdrawal of benzodiazepine therapy should be done by gradual dose reduction.
CLONAZEPAM-0.25MGAbnormalities of breathing
Severe
How does the disease interact with Epitril 0.25mg Tablet:
When administered in large doses and/or by intravenous administration, benzodiazepines have the potential to cause respiratory depression and apnea. However, some individuals, such as the elderly, the very ill, those who are impaired or taking other CNS depressants, as well as those who have a limited ventilatory reserve, chronic pulmonary insufficiency, or other respiratory diseases, may be susceptible even at regularly prescribed dosages. In these individuals, benzodiazepine therapy should be used with caution.

How to manage the interaction:
When given in high dosages and/or by intravenous administration, benzodiazepines may cause respiratory depression and apnea. Therapy with benzodiazepines should be administered cautiously in patients including elderly, debilitated or severely ill patients, those receiving other CNS depressants, those with limited ventilatory reserve, chronic pulmonary insufficiency or other respiratory disorders.
CLONAZEPAM-0.25MGEpilepsy
Severe
How does the disease interact with Epitril 0.25mg Tablet:
The use of benzodiazepines for patients with seizure disorders may increase the frequency of generalised tonic-clonic seizures (grand mal) or accelerate the onset of them. The dosage of an appropriate anticonvulsant drug may need to be raised. Particularly after lengthy usage and/or high dosages, abruptly stopping benzodiazepine medication can cause seizures and other withdrawal symptoms. Patients with a history of seizures who discontinue benzodiazepine medication suddenly may experience status epilepticus.

How to manage the interaction:
Benzodiazepines in patients with seizure disorders may increase the incidence of fits. Dose adjustment or appropriate anticonvulsant medication might need to be initiated. Do not discontinue medication without first consulting with the physician.
CLONAZEPAM-0.25MGPoisoning by diuretics and other and unspecified drugs, medicaments and biological substances
Severe
How does the disease interact with Epitril 0.25mg Tablet:
Benzodiazepines in paediatric and psychiatric patients with aggressive hyperactivity problems. During benzodiazepine medication for such individuals, it is important to keep monitoring out for any indications of paradoxical stimulation.

How to manage the interaction:
Use of benzodiazepines with alcohol is not recommended. Therapy with benzodiazepines should be administered cautiously in patients who might be prone to acute alcohol intake.
CLONAZEPAM-0.25MGDepressive episode
Moderate
How does the disease interact with Epitril 0.25mg Tablet:
The central nervous system is depressed by benzodiazepines, which can also result in or aggravate mental depression as well as suicidal behaviour and ideas. Patients who were being treated for depression with some of these medications have also reported experiencing episodes of mania and hypomania. In individuals with a history of depression or other mental illnesses, the use of benzodiazepines should be provided with caution. Patients should be watched for any changes in attitude or behaviour. It could be wise to hold off on giving these people a lot of medicine.

How to manage the interaction:
Benzodiazepines may cause or exacerbate mental depression and cause suicidal behavior and ideation. Therapy with benzodiazepines should be administered cautiously in patients with a history of depression or other psychiatric disorders. Monitoring is advised in patients for any changes in mood or behavior.

FAQs

Drug-Drug Interactions Checker List

  • ALFENTANIL
  • BUPRENORPHINE
  • CODEINE
  • HYDROMORPHONE
  • DROPERIDOL
  • OLANZAPINE
  • KETAMINE
  • SODIUM OXYBATE
  • ENALAPRIL
  • AMLODIPINE
  • FELODIPINE
  • INDAPAMIDE
  • CIMETIDINE
  • RIFAMPICIN
  • FLUCONAZOLE
  • DIAZEPAM
  • LORAZEPAM

Special Advise

  • EPITRIL 0.25MG TABLET can cause dependance and abuse. Therefore, take EPITRIL 0.25MG TABLET only in prescribed doses and as directed by your doctor. Do not self-medicate.
  • EPITRIL 0.25MG TABLET may cause suicidal thoughts. Consult your doctor immediately if you notice suicidal behaviour.

Disease/Condition Glossary

Seizures: Fits/Seizure is a sudden rush of electrical activity in the brain. It is of two types: Generalized seizure (affects the entire brain) and Partial seizures (affects one part of the brain). A mild seizure might be difficult to recognize as it lasts for only a few seconds, during which one lacks awareness. Stronger seizures cause uncontrollable muscle twitches and spasms, lasting for a few seconds to several minutes. Lack of sleep, high fever, stress, bright lights, caffeine, certain medicines, alcohol, and skipping meals/overeating are a few of the most common triggers for seizures.

Panic disorder: Panic disorder is an anxiety disorder characterised by frequent episodes of panic or dread. At times, everyone feels sensations of anxiety and panic. It is a natural reaction to stressful or potentially harmful conditions. However, someone suffering from panic disorder experiences worries, stress, and panic on a regular basis and at any moment, frequently for no apparent cause.

Involuntary muscle spasm: When the nerve impulses that control muscle movements are damaged or interrupted, it could lead to muscle spasms. The sudden involuntary contractions of the muscle can be painful and uncomfortable. Symptoms include muscle tightness, joint stiffness, unusual posture, difficulty in movement, and pain in affected muscles and joints. Fatigue (weakness), stress, extreme heat or cold, infection and tight clothing can trigger muscle spasms.

Restless leg syndrome: Restless leg syndrome, also known as Willis-Ekbom illness, is a common nervous system disorder characterised by an intense, irresistible urge to move the legs. The primary symptom of restless leg syndrome is a strong need to move the legs. It can also induce a creeping or crawling sensation in the feet, calves, and thighs. The sensation is frequently exacerbated in the evening or at night. The arms are occasionally affected as well.

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