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About Esentra 120 mg Injection
Esentra 120 mg Injection belongs to a group of medicines called RANK ligand inhibitors used to treat osteoporosis in postmenopausal women and men who have an increased risk of fracture. Esentra 120 mg Injection is also used to treat bone loss due to reduced testosterone level caused by surgery, due to the treatment with medicines such as glucocorticoids and in patients with prostate cancer. Esentra 120 mg Injection may also be used to reduce the risk of fractures in people with multiple myeloma, giant cell tumour of the bone, and to treat high calcium levels caused due to cancer.
Esentra 120 mg Injection contains ‘denosumab’, which works by blocking a receptor in the body that causes bone loss, thereby treats bone loss. Esentra 120 mg Injection treats giant cell tumour of bone (GCTB) by blocking certain receptors in the tumour cells, thereby slowing the tumour growth. Esentra 120 mg Injection helps treat high calcium levels by decreasing bone breakdown as a breakdown of the bones releases calcium. Esentra 120 mg Injection makes the bones stronger and less likely to break.
Esentra 120 mg Injection will be administered by a healthcare professional; do not self-administer. In some cases, you may experience common side-effects such as bone/joint/muscle pain, arm/leg pain, abdominal discomfort, constipation, and painful/frequent urination. You are advised to talk to your doctor if the side effects persist or worsen.
Esentra 120 mg Injection might cause osteonecrosis of the jaw; therefore, maintain good dental hygiene and receive regular dental check-ups whilst on treatment with Esentra 120 mg Injection . Avoid taking Esentra 120 mg Injection if you are pregnant. Consult your doctor before taking Esentra 120 mg Injection if you are breastfeeding. Esentra 120 mg Injection is not recommended for children below 18 years as safety and effectiveness have not been established. Keep your doctor informed about your health condition and medicines to rule out any interactions.
Uses of Esentra 120 mg Injection
Directions for Use
Medicinal Benefits
Esentra 120 mg Injection belongs to a group of medicines called RANK ligand inhibitors used to treat osteoporosis in postmenopausal women and men who have an increased risk of fracture. Esentra 120 mg Injection is also used to treat bone loss due to reduced hormone levels caused by surgery or due to treatment with medicines in patients with prostate cancer. It is also used to treat bone loss occurring due to long-term treatment with glucocorticoids in patients who are at an increased risk of fractures. Esentra 120 mg Injection may also be used to reduce the risk of fractures in people with multiple myeloma, giant cell tumours of the bone and to treat high calcium levels caused due to cancer. Esentra 120 mg Injection binds to a protein on RANK ligand on osteoclast (cells that cause bone breakdown) and inhibits their formation, functioning and survival. Thereby decreases bone breakdown, increases bone density, and strengthens the bone. Esentra 120 mg Injection treats giant cell tumour of bone (GCTB) by blocking certain receptors in the tumour cells, thereby slows the tumour growth. Esentra 120 mg Injection helps treat high calcium levels by decreasing bone breakdown as the breakdown of the bones releases calcium. Esentra 120 mg Injection makes the bones stronger and less likely to break.
Storage
Drug Warnings
Do not take Esentra 120 mg Injection if you are allergic to any of its components; if you have hypocalcaemia (low levels of calcium in the blood). Inform your doctor if you have low levels of calcium, kidney dysfunction, liver problems, poor dental health, gum problems, weak immune system, hypoparathyroidism (decreased function of the parathyroid gland), malabsorption, latex allergy, undergone thyroid surgery, planned dental procedure, if you are taking glucocorticoids, or cannot take calcium and vitamin D supplements. Avoid taking Esentra 120 mg Injection if you are pregnant. Consult your doctor if you are breastfeeding. Esentra 120 mg Injection is not recommended for children below 18 years as safety and effectiveness have not been established.
Drug-Drug Interactions
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Side Effects of Esentra 120 mg Injection
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Esentra 120 mg Injection binds to a protein on RANK ligand on osteoclast (cells that cause bone breakdown) and inhibits their formation, functioning and survival. Thereby decreases bone breakdown, increases bone density, and strengthens the bone. Esentra 120 mg Injection makes the bones stronger and less likely to break.
Osteonecrosis of the jaw (bone damage in the jaw) might be a side-effect of Esentra 120 mg Injection . The risk increases in people taking Esentra 120 mg Injection for longer durations. It might also occur upon discontinuation of the treatment. Maintain good dental hygiene and receive regular dental check-ups whilst on treatment with Esentra 120 mg Injection . Inform your doctor if you have dental problems, gum disease, planned tooth extractions, cancer, if you smoke, or are taking bisphosphonates or corticosteroids.
Breakdown of bones releases calcium and causes hypercalcemia (high calcium levels in the blood). Esentra 120 mg Injection helps treat high calcium levels by decreasing bone breakdown.
Unusual thigh bone fractures might occur whilst on treatment with Esentra 120 mg Injection . Consult your doctor if you experience new or unusual pain in the thigh, hip, or groin.
Esentra 120 mg Injection treats giant cell tumour of bone (GCTB) by blocking certain receptors in the tumour cells, thereby slows the tumour growth. Giant cell tumour of the bone is a non-cancerous tumour that typically grows at the ends of long bones.
Esentra 120 mg Injection might cause skin infections. Consult your doctor immediately if you notice symptoms such as swollen skin, redness, cellulitis (hot and tender skin), commonly in the lower leg with feverish symptoms.
Drug-Drug Interactions Checker List
Special Advise
Disease/Condition Glossary
Osteoporosis: It is a bone disease that weakens and thins the bones by decreasing bone density. As the density of bones decreases, they weaken and are more likely to break. Postmenopausal women are more likely to develop osteoporosis than men because, at menopause, women’s ovaries stop producing oestrogen (a female hormone) that is essential to keep bones healthy. Following menopause, bone loss occurs, making bones weak and more likely to break. Osteoporosis can also occur in men due to ageing and/or low levels of testosterone hormone. Signs and symptoms include back pain caused by a fractured or collapsed vertebra, loss of height over time, a stooped posture, bones that break much more easily than expected.
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Alcohol
Caution
It is not known if alcohol interacts with Esentra 120 mg Injection , so please consult a doctor.
Pregnancy
Unsafe
Esentra 120 mg Injection is not recommended during pregnancy as it might cause foetal harm. If you are a woman of child-bearing potential, use effective contraception during the treatment with Esentra 120 mg Injection and for 5 months after discontinuation. Inform your doctor if you are pregnant, think you are pregnant or planning for pregnancy.
Breast Feeding
Caution
Consult your doctor if you are breastfeeding; your doctor will decide if breastfeeding mothers can take Esentra 120 mg Injection or not.
Driving
Safe if prescribed
Esentra 120 mg Injection generally does not affect your ability to drive. However, drive or operate machinery only if you are alert.
Liver
Caution
Please consult your doctor if you have a liver impairment or any concerns regarding this.
Kidney
Caution
Please consult your doctor if you have kidney impairment or any concerns regarding this.
Children
Unsafe
Esentra 120 mg Injection is not recommended for children below 18 years as safety and effectiveness were not established.