ESPOGEN 2000IU INJECTION belongs to the class of medication called 'blood-forming agent'  primarily used to treat anaemia (low red blood cell count) in persons with chronic kidney disease (CKD), patients affected with HIV, and those receiving chemotherapy for cancer (except for bone marrow or blood cells' cancer). Anaemia occurs when the body has a lower amount of red blood cells or haemoglobin. In chronic kidney disease, the kidney gets damaged and doesn't filter the blood, leading to anaemia.

ESPOGEN 2000IU INJECTION contains a human-made protein known as 'Epoetin alfa' which works by providing signals to the bone marrow to make more red blood cells (RBCs). ESPOGEN 2000IU INJECTION helps to reverse anaemia and reduce the need for blood transfusion. ESPOGEN 2000IU INJECTION is a biologic response modifier and erythropoiesis-stimulating protein. In chronic kidney disease, when the kidney fails to produce sufficient 'erythropoietin protein' which aids in the formation of red blood cells, ESPOGEN 2000IU INJECTION stimulates the production of this protein in the bone marrow. 

ESPOGEN 2000IU INJECTION will be administered by a healthcare professional; do not self-administer. The most common side effects of ESPOGEN 2000IU INJECTION are shortness of breath,  cough, low blood pressure during dialysis, headache, body aches, diarrhoea, injection site pain and abdominal pain. Most of these side effects of ESPOGEN 2000IU INJECTION do not require medical attention and gradually resolve over time. However, if the side effects are persistent, reach out to your doctor.

If you have uncontrolled/untreated high blood pressure or red cell aplasia (a type of anaemia) due to epoetin alfa or darbepoetin alfa, please inform your doctor before taking ESPOGEN 2000IU INJECTION to avoid any complications. Inform your doctor immediately, if you feel weak, lightheaded, tired, or short of breath, or if your skin looks pale as it may be a sign that the body has stopped responding to ESPOGEN 2000IU INJECTION. It is not known whether ESPOGEN 2000IU INJECTION will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant and breastfeeding before starting treatment with this medicine. ESPOGEN 2000IU INJECTION is a cold chain medicine, and so it has to be stored in the refrigerator between 2-8 degrees Celsius else its efficiency might be lost. Do not store in the freezer or the fridge.

ESPOGEN 2000IU INJECTION is a human-made form of naturally occurring erythropoiesis-stimulating protein or erythropoietin (a hormone produced by the kidney's specialized cells and is responsible for protecting red blood cells against destruction and also stimulates the cells of bone marrow to produce more amount of red blood cells). Deficiency of erythropoietin happens when a person is suffering from chronic kidney diseases, which in turn causes low red blood cells count causing anemia.  This medicine is primarily indicated for treating anemia (low red blood cell count) in persons with long-term serious (chronic) kidney disease, persons receiving chemotherapy for some types of cancer except for bone marrow or blood cells cancer, and persons taking zidovudine to treat HIV(human immunodeficiency virus). ESPOGEN 2000IU INJECTION is also used to reduce the need for red blood cell transfusions in adults having certain types of surgery. ESPOGEN 2000IU INJECTION contains a protein 'Epoetin alfa' which works by providing signals to the bone marrow to make more red blood cells. 

• Shortness of breath Cough
• Hypertension (high blood pressure)
• High blood sugar
• Headache
• Body aches
• Diarrhoea
• Injection site pain 
• Abdominal pain (stomach pain) 

ESPOGEN 2000IU INJECTION can enhance the risk of blood clots and serious heart problems including heart attack so tell your doctor immediately if you notice shortness of breath, sudden numbness or weakness, chest pain, or trouble speaking or understanding. This medicine may speed up tumor growth, or shorten remission or survival time in some people with certain types of cancer. Inform your doctor before taking ESPOGEN 2000IU INJECTION if you have heart disease, high blood pressure, kidney disease, stroke, heart attack, blood clot, seizure, or latex allergy. Do not take ESPOGEN 2000IU INJECTION if you are pregnant or breastfeeding unless prescribed by the doctor. ESPOGEN 2000IU INJECTION should not be given to children below 1 month of age, as safety and effectiveness have not been established. Do not use ESPOGEN 2000IU INJECTION from a multi-dose vial when giving medicine to a baby. The multi-dose vial contains an ingredient (benzyl alcohol) that can cause serious side effects or death in very young infants or premature babies. ESPOGEN 2000IU INJECTION may affect a person's ability to drive as it may cause convulsions during the initial days of treatment, so a person taking ESPOGEN 2000IU INJECTION should avoid driving or operating any machine. Avoid consuming alcohol along with ESPOGEN 2000IU INJECTION as it could lead to increased dizziness and sleepiness. 

Drug-Drug Interactions: ESPOGEN 2000IU INJECTION may have interaction with other chemotherapy drugs (thalidomide, carfilzomib, lenalidomide, pomalidomide),  immunosuppressant medication (cyclosporine),  antihypertensive medicines (captopril, benazepril, enalapril, lisinopril, moexipril). 

Drug-Food Interactions: Avoid alcohol consumption while taking ESPOGEN 2000IU INJECTION as it might cause increased dizziness and sleepiness.

Drug-Disease Interactions: ESPOGEN 2000IU INJECTION may have interactions with disease conditions such as seizures, hemodialysis, hypertension, porphyria (liver disorders) and thrombotic events.

• THALIDOMIDE
• LENALIDOMIDE
• CYCLOSPORINE
• CAPTOPRIL
• ENALAPRIL
• LISINOPRIL
• CARFILZOMIB
• POMALIDOMIDE
• MOEXIPRIL

• Limit the consumption of fluids, salt, potassium, phosphorous, and other electrolytes.
• Eat a low-protein diet, and get enough calories from the foods if you are losing weight.
• Eat foods that are high in vitamin B12, iron, and folic acid can fulfill the deficiencies of happed in kidney disease.
• Include a little number of healthy fats in your diet that gives you enough energy to be active during the day; however, try to limit fats that make you fat. Try to include olive oil, peanut oil, and corn oil in your diet.
• Rest well, and get plenty of sleep.
• Avoid smoking and alcohol consumption.
• Using essential oils for massages can help increase circulation.

• Certain diagnostic tests like Complete blood count (CBC) can help check the count of red blood cells.
• Have regular hemoglobin tests to check whether there is an improvement in the level of red blood cells after taking ESPOGEN 2000IU INJECTION or not.
• You should not use ESPOGEN 2000IU INJECTION if you have uncontrolled high blood pressure (hypertension), or if you have ever had pure red cell aplasia (PRCA, a type of anemia) caused by using ESPOGEN 2000IU INJECTION. 
• Call your doctor at once if you experience any sign of a blood clot, sudden numbness or weakness, blur vision, speech problem, chest pain, trouble breathing, pain or cold feeling in leg or arm. 
• Discard any leftover medicine in a multi-dose vial of ESPOGEN 2000IU INJECTION 21 days after the first use.

Anaemia: It occurs when the body has a lower amount of red blood cells or haemoglobin than normal haemoglobin (iron-rich protein responsible for allowing red blood cells to carry more oxygen from the lungs to the rest of the body).  In chronic kidney disease, the kidney gets damaged and doesn't filter the blood, leading to anaemia. Symptoms of anaemia in chronic kidney disease include fatigue or tiredness, shortness of breath, ashen skin, weakness, body aches, chest pain, dizziness, fainting, fast or irregular heartbeat, headache, sleep problems, and trouble concentrating.