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Reviewed By Hari Kumar , MBBS
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Consume Type

ORAL

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About Estofol 2 mg Tablet 28's

Estofol 2 mg Tablet 28's is a hormone replacement therapy used in the treatment of the symptoms of menopause, osteoporosis, hypoestrogenism due to hypogonadism, and advanced androgen-dependent carcinoma of the prostate. Menopause is the stopping of a woman’s period for life and is marked after an entire span of 12 months without periods.

Estofol 2 mg Tablet 28's is composed of Estradiol valerate that works by enhancing the lowered levels of the sex hormone oestrogen in the peri or post-menopausal female body. This helps combat the various symptoms of menopause such as vaginal dryness, hot flashes (hot face, neck and chest) and weak bones. 

Take Estofol 2 mg Tablet 28's as prescribed. In some cases, Estofol 2 mg Tablet 28's may cause certain common side effects such as nausea, vomiting, breast soreness, headache and bloating. Most of these side effects do not require medical attention and will resolve gradually over time. However, you are advised to talk to your doctor if you experience these side effects consistently.

Keep your doctor informed if you are allergic to any medicines. Discuss with the doctor if you have/had cardiovascular disease, thrombotic disorders, pulmonary embolism, mental health disorders, liver disease, gall bladder disease, anaemia, bleeding disorders, or breast/uterine/cervical cancer. Estofol 2 mg Tablet 28's is intended for post-menopausal women; therefore, do not take Estofol 2 mg Tablet 28's if you are pregnant or breastfeeding.

Uses of Estofol 2 mg Tablet 28's

Post-menopausal symptoms, Osteoporosis, Hypoestrogenism, Advanced androgen-dependent carcinoma of the prostate.

Directions for Use

Swallow it as a whole with a glass of water. Do not crush, chew or break it.

Medicinal Benefits

Estofol 2 mg Tablet 28's is a hormone replacement therapy (HRT) used in the treatment of the symptoms of menopause, osteoporosis, hypoestrogenism due to hypogonadism, and advanced androgen-dependent carcinoma of the prostate. Estofol 2 mg Tablet 28's helps in the synthesis and maintenance of sex hormone oestrogen in the body, by acting as its precursor. It acts directly on plasma membrane receptors and promotes the conversion of oestradiol to its most potent counterpart, thereby enhancing the body’s levels of oestrogen and helping fight the symptoms of menopause.

Storage

Store in a cool and dry place away from sunlight

Side Effects of Estofol 2 mg Tablet 28's

  • Headache
  • Irregular vaginal bleeding/spotting
  • Stomach cramps
  • Bloating
  • Breast pain
  • Nausea
  • Vomiting
  • Hair loss

Drug Warnings

Estofol 2 mg Tablet 28's should not be used in case of any known allergy to any of the components. Inform your doctor if you have/had arterial or thrombotic disorders, cardiovascular health disorders, porphyria, anaemia, hypertension, diabetes, asthma, epilepsy, bleeding disorders, liver problem, kidney problem, depression, gallbladder disease, breast/uterine/cervical cancer or any hormone-sensitive cancer. Estofol 2 mg Tablet 28's is intended for use in postmenopausal women, do not take Estofol 2 mg Tablet 28's if you are pregnant or breastfeeding. Estofol 2 mg Tablet 28's should be used with caution if you are on any anti-epileptic, anti-tuberculosis, anti-hypertensive, cardiac, antifungal, antibiotic, anti-depressant or anti-retroviral therapy. Women with a tendency for chloasma/melasma (skin condition commonly seen in middle-aged women), should avoid sun exposure after taking Estofol 2 mg Tablet 28's. Women with a history of angioedema should exercise caution while taking Estofol 2 mg Tablet 28's as it may worsen the angioedema.

Drug-Drug Interactions

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EstradiolBivalirudin
Critical
EstradiolDantrolene
Severe

Drug-Drug Interactions

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EstradiolBivalirudin
Critical
How does the drug interact with Estofol 2 mg Tablet:
When Etodolac is taken with Bivalirudin, the risk or severity of bleeding and haemorrhage increases.

How to manage the interaction:
Taking Bivalirudin with Estofol 2 mg Tablet can cause an interaction, consult a doctor before taking it. Do not discontinue any medications without a doctor's advice.
EstradiolDantrolene
Severe
How does the drug interact with Estofol 2 mg Tablet:
The usage of Estofol 2 mg Tablet with dantrolene might have significant adverse effects on your liver.

How to manage the interaction:
Taking Estofol 2 mg Tablet with Dantrolene together can result in an interaction, but it can be taken if a doctor has advised it. However, if you have a fever, chills, joint pain or swelling, severe fatigue or weakness, unusual bleeding or bruising, skin rash or itching, lack of appetite, nausea, vomiting, or yellowing of the skin or whites of your eyes, consult the doctor immediately. Do not discontinue any medications without consulting a doctor.
EstradiolLetrozole
Severe
How does the drug interact with Estofol 2 mg Tablet:
Letrozole may have a negative effect when used with Estofol 2 mg Tablet, making it less effective in treating your disease.

How to manage the interaction:
Although taking Letrozole and Estofol 2 mg Tablet together can result in an interaction, it can be taken if a doctor has prescribed it. Do not discontinue any medications without a doctor's advice.
EstradiolAnastrozole
Severe
How does the drug interact with Estofol 2 mg Tablet:
Estofol 2 mg Tablet may interfere with anastrozole's function and make it less effective in treating your condition.

How to manage the interaction:
Co-administration of Anastrozole with Estofol 2 mg Tablet can result in an interaction, but it can be taken if a doctor has advised it. Do not stop using any medications without a doctor's advice.
EstradiolCarfilzomib
Severe
How does the drug interact with Estofol 2 mg Tablet:
Carfilzomib can cause serious blood clots and taking it alongside Estofol 2 mg Tablet may enhance the risk.

How to manage the interaction:
Co-administration of Estofol 2 mg Tablet with Carfilzomib can result in an interaction, but it can be taken if a doctor has advised it. However, if you experience symptoms like chest pain, shortness of breath, difficulty breathing, coughing up blood, sudden loss of vision, pain, redness, or swelling in an arm or leg, or numbness or weakness on one side of the body, consult a doctor immediately. Do not discontinue any medications without consulting a doctor.
EstradiolClindamycin
Severe
How does the drug interact with Estofol 2 mg Tablet:
When taken in combination, clindamycin can lower the amount or action of Estofol 2 mg Tablet.

How to manage the interaction:
Co-administration of Estofol 2 mg Tablet with Clindamycin can result in an interaction, but it can be taken if a doctor has advised it. Do not stop using any medications without a doctor's advice.
EstradiolThalidomide
Severe
How does the drug interact with Estofol 2 mg Tablet:
Taking thalidomide together with Estofol 2 mg Tablet may increase the risk of blood clots and other complications.

How to manage the interaction:
Although taking Estofol 2 mg Tablet and thalidomide together can result in an interaction, it can be taken if a doctor has prescribed it. However, consult the doctor immediately if you experience symptoms such as chest pain, shortness of breath, difficulty breathing, coughing up blood, sudden loss of vision, pain, redness or swelling in an arm or leg, and numbness or weakness on one side of the body. Do not discontinue any medications without consulting a doctor.
EstradiolExemestane
Severe
How does the drug interact with Estofol 2 mg Tablet:
Using Estofol 2 mg Tablet with Exemestane may interfere with Exemestane's activity and make it less effective in treating the condition.

How to manage the interaction:
Although there is a possible interaction between Exemestane and Estofol 2 mg Tablet, you can take these medicines together if prescribed by a doctor. Do not stop using any medications without talking to a doctor.
EstradiolPomalidomide
Severe
How does the drug interact with Estofol 2 mg Tablet:
Co-administration of Estofol 2 mg Tablet and Pomalidomide can increase the risk of serious blood clots.

How to manage the interaction:
There may be a possibility of interaction between Estofol 2 mg Tablet and Pomalidomide, but it can be taken if prescribed by a doctor. However, if you experience symptoms like chest pain, difficulty breathing, coughing up blood, sudden loss of vision, pain, redness, or swelling in an arm or leg, or numbness or weakness on one side of the body, consult a doctor immediately. Do not discontinue any medications without a doctor's advice.
EstradiolLenalidomide
Severe
How does the drug interact with Estofol 2 mg Tablet:
Coadministration of Estofol 2 mg Tablet and Lenalidomide can increase the risk of blood clots.

How to manage the interaction:
Although there is an interaction between lenalidomide and Estofol 2 mg Tablet, it can be taken if your doctor has advised it. However, if you experience chest pain, shortness of breath, difficulty breathing, coughing up blood, sudden loss of vision, pain, redness or swelling in an arm or leg, and numbness or weakness on one side of the body, contact your doctor immediately. Do not discontinue any medications without consulting a doctor.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

  • As nausea and vomiting may occur with the use of Estofol 2 mg Tablet 28's, make sure to take it on light, small meals. 
  • Avoid grapefruit juice while taking Estofol 2 mg Tablet 28's as this may interact with Estofol 2 mg Tablet 28's and affect its absorption. 
  • Avoid smoking as it increases the risk of stroke. 
  • Keep your meals balanced and invest in a healthy diet to avoid any cardiovascular problems. 
  • Load up on meats, fatty fish, oranges and strawberries, sesame seeds, soybean and canola oil and pistachios to enhance anti-oxidation and overall health during menopause.

Habit Forming

No

Therapeutic Class

HORMONES

Estofol 2 mg Tablet 28's Substitute

Substitutes safety advice
  • Estravian Tablet 28's

    by Others

    14.88per tablet

Drug-Diseases Interactions

verifiedApollotooltip
No Drug - Disease interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Diseases Interactions

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Drug-Drug Interactions Checker List

  • CARBAMAZEPINE
  • PHENYTOIN
  • RIFAMPICIN
  • CLARITHROMYCIN
  • ERYTHROMYCIN
  • ITRACONAZOLE
  • FLUCONAZOLE
  • GRISEOFULVIN
  • VERAMAPIL
  • RITONAVIR
  • NELFINAVIR
  • NEVIRAPINE
  • DILTIAZEM

Special Advise

  • Your doctor may recommend regular breast examinations/screenings and routine cervical smears while you are on Estofol 2 mg Tablet 28's, just to be on the safe side. Be sure to attend the check-ups.
  • Regularly check your breasts at home in front of a mirror, for any changes such as skin dimpling, nipple discharge, or any lumps.  
  • Inform the doctor immediately if you notice any breast lump, dark urine, yellowing of the skin, mood changes, headache, palpitations, severe fatigue or any alarming changes in vaginal bleeding. 
  • Call for the doctor right away in case of any stroke symptoms such as breathlessness, confusion, dizziness, left arm pain, jaw pain or sudden vision changes and pulmonary embolism symptoms such as cough, leg pain and warmth, pain in calf etc.

Disease/Condition Glossary

Post-Menopausal Syndrome: Menopause is the ceasing of a woman’s menstrual cycle around the age of 45-51. It is marked by an absence of periods for a consecutive time of at least 12 months. It is characterised by hot flashes, mood changes, decreased libido, changes in the skin, vaginal dryness and osteoporosis.  

Osteoporosis: It is a bone disease that weakens and thins the bones by decreasing bone density. As the density of bones decreases, they weaken and are more likely to break. Post-menopausal women are more likely to develop osteoporosis than men because, at menopause, women's ovaries stop producing oestrogen (a female hormone) that is essential to keep bones healthy. Following menopause, bone loss occurs, making bones weak and more likely to break. Signs and symptoms include back pain caused by a fractured or collapsed vertebra, loss of height over time, a stooped posture, a bone that breaks much more easily than expected.

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