Estofol 2 mg Tablet 28's is a hormone replacement therapy used in the treatment of the symptoms of menopause, osteoporosis, hypoestrogenism due to hypogonadism, and advanced androgen-dependent carcinoma of the prostate. Menopause is the stopping of a woman’s period for life and is marked after an entire span of 12 months without periods.

Estofol 2 mg Tablet 28's is composed of Estradiol valerate that works by enhancing the lowered levels of the sex hormone oestrogen in the peri or post-menopausal female body. This helps combat the various symptoms of menopause such as vaginal dryness, hot flashes (hot face, neck and chest) and weak bones. 

Take Estofol 2 mg Tablet 28's as prescribed. In some cases, Estofol 2 mg Tablet 28's may cause certain common side effects such as nausea, vomiting, breast soreness, headache and bloating. Most of these side effects do not require medical attention and will resolve gradually over time. However, you are advised to talk to your doctor if you experience these side effects consistently.

Keep your doctor informed if you are allergic to any medicines. Discuss with the doctor if you have/had cardiovascular disease, thrombotic disorders, pulmonary embolism, mental health disorders, liver disease, gall bladder disease, anaemia, bleeding disorders, or breast/uterine/cervical cancer. Estofol 2 mg Tablet 28's is intended for post-menopausal women; therefore, do not take Estofol 2 mg Tablet 28's if you are pregnant or breastfeeding.

Estofol 2 mg Tablet 28's is a hormone replacement therapy (HRT) used in the treatment of the symptoms of menopause, osteoporosis, hypoestrogenism due to hypogonadism, and advanced androgen-dependent carcinoma of the prostate. Estofol 2 mg Tablet 28's helps in the synthesis and maintenance of sex hormone oestrogen in the body, by acting as its precursor. It acts directly on plasma membrane receptors and promotes the conversion of oestradiol to its most potent counterpart, thereby enhancing the body’s levels of oestrogen and helping fight the symptoms of menopause.

• Headache
• Irregular vaginal bleeding/spotting
• Stomach cramps
• Bloating
• Breast pain
• Nausea
• Vomiting
• Hair loss

Estofol 2 mg Tablet 28's should not be used in case of any known allergy to any of the components. Inform your doctor if you have/had arterial or thrombotic disorders, cardiovascular health disorders, porphyria, anaemia, hypertension, diabetes, asthma, epilepsy, bleeding disorders, liver problem, kidney problem, depression, gallbladder disease, breast/uterine/cervical cancer or any hormone-sensitive cancer. Estofol 2 mg Tablet 28's is intended for use in postmenopausal women, do not take Estofol 2 mg Tablet 28's if you are pregnant or breastfeeding. Estofol 2 mg Tablet 28's should be used with caution if you are on any anti-epileptic, anti-tuberculosis, anti-hypertensive, cardiac, antifungal, antibiotic, anti-depressant or anti-retroviral therapy. Women with a tendency for chloasma/melasma (skin condition commonly seen in middle-aged women), should avoid sun exposure after taking Estofol 2 mg Tablet 28's. Women with a history of angioedema should exercise caution while taking Estofol 2 mg Tablet 28's as it may worsen the angioedema.

Drug-Drug Interactions:  Estofol 2 mg Tablet 28's is known to interact with antiepileptics (carbamazepine, phenytoin), anti-depressant (St. John’s wort), anti-tuberculosis drug (rifampicin), antibiotics (clarithromycin, erythromycin), antifungals (itraconazole, fluconazole, griseofulvin), cardiac medications(verapamil, diltiazem) and anti-retroviral drugs (ritonavir, nelfinavir, nevirapine)

Drug-Food Interactions: Grapefruit juice may interfere with the absorption of Estofol 2 mg Tablet 28's. Proceed with caution.

Drug-Disease Interactions: Inform your doctor if you have/had breast cancer, cervical cancer, stroke, epilepsy, porphyria, thrombosis, pulmonary embolism, cardiovascular disturbances, gallstones, migraine or any severe headaches, anaemias, bleeding disorders, liver problem, kidney problem, depression, and any other hormone-dependent cancers.

• CARBAMAZEPINE
• PHENYTOIN
• RIFAMPICIN
• CLARITHROMYCIN
• ERYTHROMYCIN
• ITRACONAZOLE
• FLUCONAZOLE
• GRISEOFULVIN
• VERAMAPIL
• RITONAVIR
• NELFINAVIR
• NEVIRAPINE
• DILTIAZEM

• As nausea and vomiting may occur with the use of Estofol 2 mg Tablet 28's, make sure to take it on light, small meals. 
• Avoid grapefruit juice while taking Estofol 2 mg Tablet 28's as this may interact with Estofol 2 mg Tablet 28's and affect its absorption. 
• Avoid smoking as it increases the risk of stroke. 
• Keep your meals balanced and invest in a healthy diet to avoid any cardiovascular problems. 
• Load up on meats, fatty fish, oranges and strawberries, sesame seeds, soybean and canola oil and pistachios to enhance anti-oxidation and overall health during menopause.

• Your doctor may recommend regular breast examinations/screenings and routine cervical smears while you are on Estofol 2 mg Tablet 28's, just to be on the safe side. Be sure to attend the check-ups.
• Regularly check your breasts at home in front of a mirror, for any changes such as skin dimpling, nipple discharge, or any lumps.  
• Inform the doctor immediately if you notice any breast lump, dark urine, yellowing of the skin, mood changes, headache, palpitations, severe fatigue or any alarming changes in vaginal bleeding. 
• Call for the doctor right away in case of any stroke symptoms such as breathlessness, confusion, dizziness, left arm pain, jaw pain or sudden vision changes and pulmonary embolism symptoms such as cough, leg pain and warmth, pain in calf etc.

Post-Menopausal Syndrome: Menopause is the ceasing of a woman’s menstrual cycle around the age of 45-51. It is marked by an absence of periods for a consecutive time of at least 12 months. It is characterised by hot flashes, mood changes, decreased libido, changes in the skin, vaginal dryness and osteoporosis.  

Osteoporosis: It is a bone disease that weakens and thins the bones by decreasing bone density. As the density of bones decreases, they weaken and are more likely to break. Post-menopausal women are more likely to develop osteoporosis than men because, at menopause, women's ovaries stop producing oestrogen (a female hormone) that is essential to keep bones healthy. Following menopause, bone loss occurs, making bones weak and more likely to break. Signs and symptoms include back pain caused by a fractured or collapsed vertebra, loss of height over time, a stooped posture, a bone that breaks much more easily than expected.