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Reviewed By Hari Kumar , MBBS
Non returnable*
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Manufacturer/Marketer :

Burot Pharmaceutical

Consume Type :

ORAL

Return Policy :

Not Returnable

About Estradien Tablet 21's

Estradien Tablet 21's belongs to the group of combined oral contraceptives. It is a hormonal combination that contains both female reproductive hormones oestrogen and progestin. It is used as a means of birth control in women who wish to prevent unwanted pregnancy. It is also used in the treatment of irregular menstrual cycles. It also finds use in the treatment of moderate to severe acne. A combined oral contraceptive (COCP) is nothing but a birth-control pill, colloquially referred to as the ‘’pill,’’ and it is used as a means of oral birth control by women. Menorrhagia is heavy menstrual bleeding lasting longer than seven days, whereas dysmenorrhea is painful periods. Acne vulgaris is a skin condition characterized by pimples, blackheads and whiteheads on the skin of the face.
Estradien Tablet 21's is composed of ‘’Ethinyl estradiol and Dienogest.’’ It is essentially an ovulation inhibitor, which inhibits the release of potent eggs from the ovary, thereby preventing pregnancy. It also changes the cervical (cervix is the connection between the uterus and vagina) ambience, making cervical secretions thicker and hostile to any incoming sperm. Hence, it is a very potent contraceptive. In addition, the dienogest component inhibits gonadotropin (sex hormone) production and also suppresses the growth of uterine cells. Therefore, Estradien Tablet 21's helps prevent pregnancy. 
In some cases, Estradien Tablet 21's may cause certain common side effects such as nausea, breast soreness, headache and irregular periods. Most of these side effects do not require medical attention and will resolve gradually over time. However, you are advised to talk to your doctor if you experience these side effects consistently.
 If you are allergic to Estradien Tablet 21's or any of its components, please inform the doctor before using Estradien Tablet 21's. Keep the doctor informed if you are on treatment for any cardiovascular disease, mental health disorder, liver disease, gallbladder disease or breast/uterine/cervical cancer. Before taking Estradien Tablet 21's, inform your doctor of your entire medical and surgical history. Please consult your doctor before taking Estradien Tablet 21's during pregnancy or if you are breastfeeding. Do not consume Estradien Tablet 21's with alcohol. 

Uses of Estradien Tablet 21's

Contraception, Menorrhagia, Acne vulgaris 

Directions for Use

Swallow it as a whole with water; do not crush, break or chew it.

Medicinal Benefits

Estradien Tablet 21's is a combined oral contraceptive and birth control pill. It contains Ethinyl estradiol and Dienogest. Estradien Tablet 21's is used to prevent pregnancy by suppressing ovulation and changing the consistency of cervical secretions. In patients suffering from menorrhagia, Estradien Tablet 21's reduces the intensity and duration of menstrual bleeding. It also relieves pain during periods (dysmenorrhea). Estradien Tablet 21's reduces hair and skin greasiness, providing relief to blackhead/whitehead and acne-prone skin. 

Storage

Store in a cool and dry place away from sunlight

Side Effects of Estradien Tablet 21's

  • Headache
  • Nausea and vomiting
  • Irregular menstrual cycles
  • Cramps 
  • Abdominal bloating
  • Breast tenderness
  • Hypertension

Drug Warnings

Estradien Tablet 21's is not recommended for use in women over 35 who smoke. Estradien Tablet 21's should not be used in case of any known allergy to either of the components. Estradien Tablet 21's is not advisable for use in case of high risk or previous history of any mental health disorders, arterial or thrombotic disorders, cardiovascular health disorders, liver disease, gallbladder disease, history of breast/uterine/cervical cancer or any hormone-sensitive cancer. Women with a history of angioedema should exercise caution while taking $drug as it may worsen the angioedema. Please consult the doctor before using Estradien Tablet 21's during pregnancy or breastfeeding. It is advisable not to consume Estradien Tablet 21's with alcohol. Inform the doctor right away if you notice any dark urine, yellowing of the eyes/skin, severe mood changes or any sudden heavy bleeding. Women with a tendency for chloasma/melasma (skin condition commonly seen in middle-aged women) should avoid sun exposure after taking Estradien Tablet 21's.

Drug-Drug Interactions

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EthinylestradiolTranexamic acid
Critical
DienogestEfavirenz
Critical

Drug-Drug Interactions

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EthinylestradiolTranexamic acid
Critical
How does the drug interact with Estradien Tablet:
Taking Estradien Tablet with Tranexamic acid may increase the risk of blood clot formation.

How to manage the interaction:
Taking Estradien Tablet with Tranexamic acid is not recommended, as it can lead to an interaction, but can be taken if a doctor has prescribed it. However, if you suffer from chest discomfort, shortness of breath, blood in the urine, blood in the cough, sudden loss of vision, and pain, redness, or swelling in your arm or leg, consult doctor immediately. Do not stop using any medications without talking to a doctor.
DienogestEfavirenz
Critical
How does the drug interact with Estradien Tablet:
When Efavirenz is taken with Estradien Tablet, it can lower the metabolism of Estradien Tablet and increase the risk or severity of side effects.

How to manage the interaction:
Taking Efavirenz with Estradien Tablet can possibly result in an interaction, however, it can be taken when advised by a doctor. Do not stop using any medications without talking to a doctor.
EthinylestradiolPhenytoin
Severe
How does the drug interact with Estradien Tablet:
Coadministration of Phenytoin and Estradien Tablet may reduce the blood levels and effects of Estradien Tablet.

How to manage the interaction:
Although taking Phenytoin and Estradien Tablet together can result in an interaction, it can be taken if your doctor has prescribed it. If you use Estradien Tablet as hormone replacement therapy for menopause, let your doctor know if your symptoms stop being controlled by your medication or if you start bleeding abnormally. Do not discontinue any medication without consulting a doctor.
EthinylestradiolCarfilzomib
Severe
How does the drug interact with Estradien Tablet:
Carfilzomib can cause serious blood clots and taking it with ethinyl estradiol may enhance the risk.

How to manage the interaction:
There may be a possibility of interaction between Carfilzomib and Estradien Tablet, but it can be taken if prescribed by a doctor. However, if you experience chest pain, shortness of breath, difficulty breathing, coughing up blood, sudden loss of vision, pain, redness, or swelling in an arm or leg, or numbness or weakness on one side of the body, you should consult a doctor. Do not stop using any medications without a doctor's advice.
EthinylestradiolExemestane
Severe
How does the drug interact with Estradien Tablet:
When used with Estradien Tablet, the effectiveness of Exemestane might be reduced.

How to manage the interaction:
Although taking Exemestane and Estradien Tablet together can cause an interaction, it can be taken if a doctor has suggested it. Do not stop using any medications without a doctor's advice.
EthinylestradiolRifabutin
Severe
How does the drug interact with Estradien Tablet:
Taking rifabutin with ethinyl estradiol it may significantly reduces the blood levels.

How to manage the interaction:
There may be a possibility of interaction between Estradien Tablet and Rifabutin, but it can be taken if prescribed by a doctor. If you use hormone replacement therapy for menopause, inform a doctor if experience any unusual symptoms or if you develop unusual bleeding. Do not stop using any medications without talking to a doctor.
EthinylestradiolThalidomide
Severe
How does the drug interact with Estradien Tablet:
Taking thalidomide together with Estradien Tablet may increase the risk of blood clots and that may lead to serious complications.

How to manage the interaction:
Although taking thalidomide and Estradien Tablet together can result in an interaction, it can be taken if a doctor has prescribed it. However, consult the doctor immediately if you experience symptoms such as chest pain, shortness of breath, difficulty breathing, coughing up blood, sudden loss of vision, pain, redness or swelling in an arm or leg, and numbness or weakness on one side of the body. Do not discontinue any medications without consulting a doctor.
EthinylestradiolGriseofulvin
Severe
How does the drug interact with Estradien Tablet:
Taking ethinyl estradiol with griseofulvin may reduce blood levels and the effects of ethinyl estradiol.

How to manage the interaction:
Although taking Estradien Tablet and Griseofulvin together can cause an interaction, it can be taken if a doctor has suggested it. However, if you use hormone replacement therapy (ethinyl estradiol) for menopause, inform a doctor if your symptoms are no longer controlled or if you deal with unusual bleeding. Do not stop using any medications without a doctor's advice.
EthinylestradiolPhenobarbital
Severe
How does the drug interact with Estradien Tablet:
When Estradien Tablet is taken with phenobarbital, Estradien Tablet may become les effective.

How to manage the interaction:
Although taking phenobarbital and Estradien Tablet together can result in an interaction, it can be taken if a doctor has prescribed it. However, if you use hormone replacement therapy for menopause, inform a doctor if your symptoms are no longer controlled or if you experience unusual bleeding. Do not stop using any medications without talking to a doctor.
EthinylestradiolPrimidone
Severe
How does the drug interact with Estradien Tablet:
Coadministration of Estradien Tablet with primidone may decrease the blood levels of Estradien Tablet and reduce its effectiveness.

How to manage the interaction:
Although there is an interaction between primidone with Estradien Tablet, it can be taken if prescribed by a doctor. However, if you experience abnormal bleeding, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

  • As nausea and vomiting may occur with the use of Estradien Tablet 21's, make sure to take it on light, small meals. 
  • Let your doctor know if you are planning to get pregnant. 
  • After starting Estradien Tablet 21's, use another alternative non-hormonal contraceptive for at least ten days.
  • Maintaining a healthy weight can go a long way in promoting healthy female reproductive health. Make sure you exercise for at least 30 minutes every day. However, do not engage in very strenuous physical exercise as this can worsen bleeding. 
  • Regularly working night shifts can affect hormone production. Try to avoid night shifts. 
  • Maintain good sexual hygiene and prevent any sexually transmitted diseases by practising only safe sex.
  • Limit your intake of caffeine and alcohol. 
  • Avoid smoking. 
  • Avoid grapefruit juice while taking Estradien Tablet 21's as this may interact with Estradien Tablet 21's and affect its absorption. 
  • Increase your intake of red vegetables, fruits, dry fruits, spinach, nuts and beans as these help in new blood formation. 
  • Keeping your skin hydrated by drinking enough water can also do wonders for the overall quality of your skin. 
  • Always wash your makeup before sleeping. Never go to bed with makeup on.
  • Exfoliate your skin lightly but regularly. This helps wash away dry and dead cells, cleansing the skin. 
  • Severe nausea or vomiting following the use of the tablet can be considered a missed dose. In this case, additional contraceptive measures are advised. 

Habit Forming

No

Therapeutic Class

CONTRACEPTIVES

Estradien Tablet 21's Substitute

Substitutes safety advice
  • Estro Plus Tablet 21's

    by AYUR

    24.21per tablet
  • Dienoplus Tablet 21's

    by Others

    23.31per tablet
  • Dienille Tablet 21's

    by Others

    26.96per tablet
  • Deereg Tablet 21's

    by Others

    23.31per tablet
  • Dinesys Plus Tablet 21's

    by Others

    34.24per tablet

Drug-Diseases Interactions

verifiedApollotooltip
No Drug - Disease interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Diseases Interactions

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FAQs

Estradien Tablet 21's works by suppressing ovulation and by changing cervical mucous thickness, thereby preventing pregnancy and acting as an effective birth control method.

Estradien Tablet 21's is advisable not to use atleast for a minimum of 4 weeks after delivery after which you can resume its use. Please consult your doctor.

Estradien Tablet 21's is not known to affect conception rates as it’s been found that women got pregnant pretty soon after discontinuing Estradien Tablet 21's. Please consult your doctor.

Estradien Tablet 21's is not recommended or indicated in the treatment of any breast tumours or cancers.

This is not one of the indicated uses of Estradien Tablet 21's. For any concerns, please consult your gynaecologist.

Drug-Drug Interactions Checker List

  • RIFAMPICIN
  • CARBAMAZEPINE
  • PHENYTOIN
  • RIFABUTIN
  • GRISEOFULVIN
  • RITONAVIR
  • NELFINAVIR
  • FELBAMATE
  • TOPIRAMATE

Special Advise

  • Do not skip tablets or delay intake by more than 12 hours. In case of a missed dose, try to catch up as early as possible. However, if the time for the second dose has come too close, revert to your original schedule. 
  • Chart your menstrual cycle and take Estradien Tablet 21's on Day 1 of your cycle, i.e. Day 1 of your period. 
  • Use a condom or any non-hormonal contraceptive for the first ten days after starting Estradien Tablet 21's.
  • Please inform the doctor immediately if you notice any breast lump, dark urine, yellowing of the skin, mood changes, headache, palpitations, severe fatigue or any alarming changes in vaginal bleeding. 
  • Call for the doctor right away in case of any stroke symptoms such as breathlessness, confusion, dizziness, left arm pain, jaw pain or sudden vision changes or any pulmonary embolism symptoms such as cough, leg pain and warmth, pain in calf etc.

Disease/Condition Glossary

Oral Contraception: It is birth control taken by mouth by women to prevent pregnancy. It is commonly referred to as the ‘’pill’’. Oral contraceptives contain hormonal preparations of female sex hormones for birth control. 

Menorrhagia: Severe loss of blood during a period lasting more than seven days is called menorrhagia. It is a form of dysfunctional uterine bleeding. Common signs and symptoms include having to use two pads at once, frequent spotting of clothes, blood clots the size of a coin or larger, having to change pads during the night, soakiness of pads and spillage. 

Dysmenorrhoea: Abdominal and uterine pain during periods is referred to as dysmenorrhea. This includes abdominal cramps and pelvic pain during periods. It can be caused by a variety of disorders ranging from more organic diseases such as endometriosis, fibroids and cysts, to psychological conditions such as pre-menstrual dysmorphic disorder. However, in most cases, cramps are common and are a usual symptom of pre-menstrual syndrome. 

Acne vulgaris: Acne is a skin condition in which pores get blocked or clogged, leading to the appearance of whiteheads, blackheads, pimples and greasy skin. It is caused by a bacterium called Propionibacterium acnes. In advanced stages, it can even cause a nose deformity called rhinophyma. 

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