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  3. Farabine 20 mg Injection 20 ml

Written By Lakshmithulasi Yarragunta , Pharm-D (PB)
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
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Whats That

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Composition :

CLOFARABINE-20MG

Manufacturer/Marketer :

Intas Pharmaceuticals Ltd

Consume Type :

PARENTERAL

Return Policy :

Not Returnable

Expires on or after :

About Farabine 20 mg Injection 20 ml

Farabine 20 mg Injection 20 ml is an anti-cancer medicine used in pediatric patients aged 1 - 21 years for the treatment of acute lymphoblastic leukaemia, a blood cancer that primarily affects the blood and bone marrow. Farabine 20 mg Injection 20 ml is used in patients with relapsed or refractory acute lymphoblastic leukaemia (ALL) after receiving at least two prior therapies.

Farabine 20 mg Injection 20 ml contains Clofarabine as an active ingredient in the class of antimetabolites. It works by inhibiting the DNA polymerase enzyme responsible for DNA elongation, synthesis, and repair.

Farabine 20 mg Injection 20 ml may cause certain side effects, such as skin rash, fatigue, headache, decreased platelet count, nausea, vomiting, diarrhoea, fever, anxiety, flushing, and injection site reactions. These side effects do not require medical attention and gradually resolve over time. A trained oncologist will administer Farabine 20 mg Injection 20 ml. Do not self-administer.

Farabine 20 mg Injection 20 ml should be avoided if you are allergic to it or any other components present in it. It should be used with caution in patients with a pre-existing or history of liver/kidney disease, gastrointestinal disorders, skin problems, and bleeding disorders, as it may cause serious side effects or worsen such conditions. This medicine is known to cause embryo-fetal toxicity. It is not recommended for use in pregnancy or breastfeeding.

Uses of Farabine 20 mg Injection 20 ml

Acute lymphocytic leukemia (ALL).

Directions for Use

A trained and experienced oncologist will administer Farabine 20 mg Injection 20 ml.

Medicinal Benefits

Farabine 20 mg Injection 20 ml contains Clofarabine, which is used in the treatment of acute lymphoblastic leukemia (ALL). It works by inhibiting the DNA polymerase enzyme that is responsible for DNA elongation, synthesis, and repair. In general, it inhibits the production of genetic material (DNA) in the cancer cells that are essential for cell growth, repair and multiplication. Thus, Farabine 20 mg Injection 20 ml stops the multiplication of abnormal cells, leads to the growth of cells in an unbalanced way and causes the death of cells.

Storage

Keep Farabine 20 mg Injection 20 ml out of the sight and reach of children.

Drug Warnings

Farabine 20 mg Injection 20 ml should be avoided if you are allergic to it or any other components present in it. Before receiving, if the child has/had any history of liver/kidney disease, gastrointestinal disorders, skin problems, and bleeding disorders, as it may cause serious side effects or worsen such conditions. This medicine is known to cause embryo-fetal toxicity. Hence, inform your doctor if you are pregnant or are planning to become pregnant before starting the treatment. Breastfeeding should be discontinued in nursing mothers during the treatment. Farabine 20 mg Injection 20 ml is given in children above one year of age only if prescribed by the doctor. Farabine 20 mg Injection 20 ml may cause myelosuppression, QT prolongation, hepatotoxicity, renal toxicity, cerebral, gastrointestinal and pulmonary haemorrhage, Tumor Lysis syndrome, severe infections, Systemic Inflammatory Response Syndrome (SIRS), enterocolitis, and skin reactions in some patients. Hence, inform your doctor about your complete medical and medication history before receiving this medicine.

Drug-Drug Interactions

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Drug-Drug Interactions

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How does the drug interact with Farabine 20 mg Injection 20 ml:
When Etanercept is used with Farabine 20 mg Injection 20 ml, the likelihood or severity of infection may increase.

How to manage the interaction:
Although taking Etanercept and Farabine 20 mg Injection 20 ml together can cause an interaction, it can be taken if a doctor has suggested it. However, if you develop fever, chills, diarrhea, sore throat, muscular pains, shortness of breath, blood in phlegm, weight loss, red or irritated skin, body sores, or discomfort or burning during urination, consult a doctor immediately. Do not discontinue any medications without a doctor's advice.
How does the drug interact with Farabine 20 mg Injection 20 ml:
Coadministration of Farabine 20 mg Injection 20 ml with Baricitinib can increase the risk of developing serious infections.

How to manage the interaction:
Taking Baricitinib with Farabine 20 mg Injection 20 ml together can result in an interaction, but it can be taken if your doctor has advised it. However, if you experience fever, chills, diarrhea, sore throat, muscle pains, breathing difficulty, blood in your coughing fluid, weight loss, red or irritated skin, body sores, and discomfort or burning when you urinate, consult a doctor. Do not stop using any medications without a doctor's advice.
How does the drug interact with Farabine 20 mg Injection 20 ml:
Combining Farabine 20 mg Injection 20 ml with Leflunomide can increase the risk of negative side effects.

How to manage the interaction:
Although taking Leflunomide and Farabine 20 mg Injection 20 ml together can evidently cause an interaction, it can be taken if your doctor has suggested it. If you notice any of these symptoms - such as fever, diarrhea, or muscle aches - contact your doctor immediately. Do not stop using any medications without talking to your doctor.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

  • After beginning your treatment, several dietary adjustments can help you control side effects.
  • Anyone suffering from a chronic illness, including cancer, should consume foods high in protein, healthy fats, whole grains, and vitamins and minerals.
  • Plant-based proteins are among the greatest meals to take during chemotherapy or other cancer treatments. They have the highest concentrations of vitamins and minerals, such as nuts, seeds, beans, and legumes.
  • Eat a healthy diet and exercise regularly to maintain proper weight.
  • Include leafy vegetables, citrus fruits, fatty fish, berries, yoghurt, apples, peaches, cauliflower, cabbage, broccoli, beans, and herbs.
  • Get optimal sleep; rest well.
  • Avoid fast and fried food, processed meats, refined carbs and added sugars.

Side Effects of Farabine 20 mg Injection 20 ml

  • Nausea
  • Diarrhoea
  • Fatigue
  • Vomiting
  • Headache
  • Abdominal pain
  • Flusing
  • Skin rash
  • Fever
  • Rash
  • Itching
  • Pain at the site of injection
  • Injection site reactions

Habit Forming

No

Therapeutic Class

ANTINEOPLASTIC

Drug-Diseases Interactions

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No Drug - Disease interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Diseases Interactions

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FAQs

Farabine 20 mg Injection 20 ml contains Clofarabine, which works by inhibiting the DNA transcription that is essential for cancer cell growth. This helps prevent the growth and further spread of cancerous or non-cancerous cells.

Farabine 20 mg Injection 20 ml is used only in children and adolescents 1-21 years. It is not recommended for adults.

Treatment with Farabine 20 mg Injection 20 ml may result in cerebral, gastric, and pulmonary hemorrhage that is severe and fatal. Keep track of platelets and coagulation parameters and treat as needed.

Drug-Drug Interactions Checker List

  • ADALIMUMAB
  • NATALIZUMAB
  • INFLIXIMAB
  • EFAVIRENZ
  • HALOPERIDOL

Special Advise

  • A blood test, such as LFT and RFT, should be performed to check for liver/kidney function.
  • Weekly blood tests should be done during the treatment to check for CBC (Complete blood count).
  • It is advised to use contraceptive pills while using Farabine 20 mg Injection 20 ml to prevent pregnancy.

Disease/Condition Glossary

Acute Lymphoblastic Leukemia (ALL): Leukemia, also known as blood cancer, is a cancer of blood cells or blood-forming tissues. It causes excessive production of immature white blood cells by the bone marrow and reduces the body’s ability to fight infections. There are different types of blood cancers. ALL is a type of blood cancer that primarily affects your blood and bone marrow. It mainly targets the white blood cells, which can interfere with your body’s ability to combat infections. Symptoms may include fever, weight loss, abnormal blood cell count, bruising, and loss of appetite.

Have a query?

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Alcohol

Unsafe

Avoid consuming alcohol while on treatment with Farabine 20 mg Injection 20 ml as it may cause severe side effects.

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Pregnancy

Unsafe

Farabine 20 mg Injection 20 ml is not recommended for use in pregnancy as it may cause embryo-fetal toxicity and harm your foetus. Hence, if you are under 21 and pregnant or planning pregnancy, inform your doctor before receiving Farabine 20 mg Injection 20 ml. You should not become pregnant while you are taking Farabine 20 mg Injection 20 ml. Using effective birth control methods while on treatment is suggested.

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Breast Feeding

Unsafe

There are no data on the presence of clofarabine in human milk, its effects on breastfed children, or its impact on milk supply; due to the possibility of serious adverse events in breastfed children, including genotoxicity, patients are advised not to breastfeed during therapy and for at least two weeks following the final dosage.

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Driving

Not applicable

Farabine 20 mg Injection 20 ml is administered to hospitalized patients.

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Liver

Caution

Farabine 20 mg Injection 20 ml has not been studied in patients with liver impairment. However, inform your doctor if you have liver problems.

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Kidney

Caution

If you have a history of kidney disease or have a pre-existing condition, notify your doctor before getting Farabine 20 mg Injection 20 ml. Based on your situation, your doctor may adjust the dose of this medication or prescribe a suitable alternative. Farabine 20 mg Injection 20 ml has the potential to cause renal toxicity, which presents as high creatinine levels and sudden renal failure. Monitor renal function and adjust or discontinue Clolar as needed.

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Children

Safe if prescribed

Farabine 20 mg Injection 20 ml is recommended for children and adolescents below 21 years of age only if prescribed by the oncologist.

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