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  3. Febrex Plus Syrup 100 ml

Febrex Plus Syrup 100 ml, Pack of 1 Syrup
Febrex Plus Syrup 100 ml, Pack of 1 Syrup
Written By Veda Maddala , M Pharmacy
Reviewed By Sunny S , MBBS
Non returnable*
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Whats That

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Composition :

CHLORPHENIRAMINE-1MG + PARACETAMOL-125MG + PHENYLEPHRINE-5MG

Manufacturer/Marketer :

Indoco Remedies Ltd

Consume Type :

ORAL

Return Policy :

Not Returnable

Expires on or after :

About Febrex Plus Syrup

Febrex Plus Syrup belongs to the class of medication called 'cough and cold medications' primarily used to treat symptoms of the common cold and allergies like sneezing, runny/stuffy nose, fever, headache, body pains, congestion, or watery eyes. The common cold is a respiratory illness affecting the nose and throat. It is mostly caused by viruses known as 'rhinovirus'. The virus enters the body through nose, mouth or eyes and spreads easily through droplets in the air when the person who is sick sneezes, coughs or talks.

Febrex Plus Syrup is a combination of three drugs, namely: Paracetamol (mild analgesic and antipyretic), Phenylephrine (decongestant) and Chlorpheniramine (antihistamine/antiallergic). Paracetamol is an analgesic (relieves pain) and antipyretic (reduces fever) that works by inhibiting the production of certain chemical messengers in the brain known as prostaglandins that are responsible for pain and fever. Phenylephrine belongs to the class of decongestants that works by shrinking the blood vessels in the nasal passage. Thereby, provides relief from congestion and decreases the excess mucus production. Chlorpheniramine belongs to the class of antihistamines (anti-allergic drugs) that works by blocking the action of histamine, a substance responsible for causing allergic reactions.  It helps to provide relief from symptoms of allergy such as sneezing, running nose, watery eyes, itching, swelling, and nasal congestion.

Take Febrex Plus Syrup as prescribed. Your doctor will recommend you how often you take Febrex Plus Syrup based on your medical condition. Some people may experience drowsiness, nervousness, headache, dizziness, insomnia (difficulty in falling or staying asleep), blurred vision, constipation and dry mouth. Most of these side effects of Febrex Plus Syrup do not require medical attention and gradually resolve over time. However, if the side effects persist or worsen, please consult your doctor.

If you are allergic to Febrex Plus Syrup or any other medicines, please tell your doctor. If you are pregnant, it is advised to inform your doctor before using Febrex Plus Syrup . Do not use Febrex Plus Syrup in breastfeeding mothers without doctor’s advice as it may be excreted in breast milk and cause harm to the baby. Febrex Plus Syrup is not recommended for children below 4 years. Please do not take more than the prescribed dose of Febrex Plus Syrup as it may cause liver damage and can be lethal.  If you have high blood pressure, diabetes, glaucoma, hyperthyroidism (overactive thyroid), chronic bronchitis, asthma, chronic obstructive pulmonary disease (COPD), blockage in stomach or intestines, enlarged prostate gland, pheochromocytoma (tumour in the adrenal glands), kidney, liver, heart or urinary problems, inform your doctor before taking Febrex Plus Syrup .

Uses of Febrex Plus Syrup

Common cold, Allergies

Directions for Use

Tablet/capsule: Take it with or without food as advised by a doctor. Swallow it as a whole with a glass of water. Do not crush, chew or break it. Syrup/Drops: Shake the bottle well before use. Check the label for directions and take it with or without food in doses as prescribed by a doctor with the help of a measuring cup/dropper.

Medicinal Benefits

Febrex Plus Syrup is a combination of three drugs, namely: Paracetamol, Phenylephrine and Chlorpheniramine. Paracetamol is a mild analgesic (relieves pain) and antipyretic (reduces fever) that works by inhibiting the production of certain chemical messengers in the brain known as prostaglandins that are responsible for pain and fever. Phenylephrine belongs to the class of decongestants that works by contracting and narrowing the blood vessels. Thereby, provides relief from congestion and decreases the mucus production. Chlorpheniramine is an antihistamine (anti-allergic drug) that works by blocking the action of histamine, a substance responsible for causing allergic reactions.  It helps to provide relief from symptoms of allergy such as sneezing, running nose, watery eyes, itching, swelling, and congestion or stiffness.

Storage

Store in a cool and dry place away from sunlight

Drug Warnings

If you are allergic to Febrex Plus Syrup or any other medicines, please tell your doctor. If you are pregnant, it is advised to inform your doctor before using Febrex Plus Syrup . Do not use Febrex Plus Syrup in breastfeeding mothers without doctor’s advice as it may be excreted in breast milk and cause harm to the baby. Febrex Plus Syrup is not recommended for children below 4 years. Please do not take more than the prescribed dose of Febrex Plus Syrup as it may cause liver damage and can be lethal.  If you have high blood pressure, diabetes, glaucoma, hyperthyroidism (overactive thyroid), chronic bronchitis, asthma, chronic obstructive pulmonary disease (COPD), blockage in stomach or intestines, enlarged prostate gland, pheochromocytoma (tumour in the adrenal glands), kidney, liver, heart or urinary problems, inform your doctor before taking Febrex Plus Syrup .

Drug-Drug Interactions

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PhenylephrineTranylcypromine
Critical
PhenylephrineFurazolidone
Critical

Drug-Drug Interactions

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PhenylephrineTranylcypromine
Critical
How does the drug interact with Febrex Plus Syrup 100 ml:
Taking Tranylcypromine with Febrex Plus Syrup 100 ml can increase the risk of high blood pressure.

How to manage the interaction:
Taking Tranylcypromine with Febrex Plus Syrup 100 ml is not recommended, but can be taken together if prescribed by a doctor. However, consult a doctor if you experience severe headache, blurred vision, confusion, seizures, chest pain, nausea or vomiting, sudden numbness or weakness (especially on one side of the body), speech difficulties, fever, sweating, lightheadedness, and fainting Do not discontinue any medications without consulting a doctor.
PhenylephrineFurazolidone
Critical
How does the drug interact with Febrex Plus Syrup 100 ml:
Taking Furazolidone with Febrex Plus Syrup 100 ml can cause an increase in high blood pressure.

How to manage the interaction:
Taking Furazolidone with Febrex Plus Syrup 100 ml is not recommended, it can be taken if prescribed by the doctor. However, if you experience sudden and severe headache, blurred vision, confusion, seizures, chest pain, nausea or vomiting, sweating, lightheadedness, fainting, sudden numbness or weakness (especially on one side of the body), speech difficulties, fever, consult the doctor immediately. It is advised to use Febrex Plus Syrup 100 ml only after 14 days of stopping Furazolidone.
PhenylephrineSelegiline
Critical
How does the drug interact with Febrex Plus Syrup 100 ml:
Co-administration of Selegiline with Febrex Plus Syrup 100 ml together can raise blood pressure.

How to manage the interaction:
Taking Selegiline with Febrex Plus Syrup 100 ml is not recommended, it can be taken together if prescribed by a doctor. However, consult a doctor immediately if you experience any symptoms such as severe headache, blurred vision, confusion, fits, chest pain, nausea or vomiting, sudden numbness or weakness (especially on one side of the body), speech difficulties, fever, sweating, lightheadedness, and/or fainting Do not discontinue any medications without consulting a doctor.
PhenylephrineSevoflurane
Critical
How does the drug interact with Febrex Plus Syrup 100 ml:
Co-administration of Febrex Plus Syrup 100 ml with Sevoflurane can increase the levels of Febrex Plus Syrup 100 ml and lead to side effects.

How to manage the interaction:
Taking Febrex Plus Syrup 100 ml with Sevoflurane is not recommended, it can be taken if prescribed by the doctor. Do not discontinue the medications without consulting a doctor.
PhenylephrinePropofol
Critical
How does the drug interact with Febrex Plus Syrup 100 ml:
Taking Febrex Plus Syrup 100 ml with Propofol may lead to increased levels of Febrex Plus Syrup 100 ml leading to side effects like high blood pressure.

How to manage the interaction:
Taking Febrex Plus Syrup 100 ml with Propofol is not recommended, but it can be taken if prescribed by the doctor. Do not discontinue the medications without consulting a doctor.
ChlorpheniraminePotassium citrate
Critical
How does the drug interact with Febrex Plus Syrup 100 ml:
Taking Febrex Plus Syrup 100 ml and Potassium citrate (in tablet or capsule form) together can increase the risk of stomach ulcers, bleeding, and gastrointestinal injury.

How to manage the interaction:
Taking Febrex Plus Syrup 100 ml with Potassium citrate is not recommended as it can lead to an interaction, it can be taken if prescribed by the doctor. However, if you experience any symptoms such as severe stomach pain, bloating, lightheadedness or dizziness, nausea, vomiting (especially with blood), decreased hunger, or dark, tarry stools, consult the doctor immediately. Do not discontinue any medications without a doctor's advice.
ChlorpheniraminePotassium chloride
Critical
How does the drug interact with Febrex Plus Syrup 100 ml:
Taking Febrex Plus Syrup 100 ml and Potassium chloride (in tablet or capsule form) together can increase the risk of stomach ulcers, bleeding, and gastrointestinal injury.

How to manage the interaction:
Taking Febrex Plus Syrup 100 ml with Potassium chloride it not recommended as it can lead to an interaction, it can be taken if your doctor has prescribed it. However, if you experience any symptoms such as severe stomach pain, bloating, lightheadedness or dizziness, nausea, vomiting (especially with blood), decreased hunger, or dark, tarry stools, consult the doctor. Do not discontinue any medications without a doctor's advice.
PhenylephrineDoxepin
Severe
How does the drug interact with Febrex Plus Syrup 100 ml:
Taking Doxepin and Febrex Plus Syrup 100 ml together may lead to side effects like increased blood pressure.

How to manage the interaction:
Although taking Doxepin and Febrex Plus Syrup 100 ml together can result in an interaction, it can be taken if a doctor has prescribed it. However, if you experience any symptoms, contact your doctor immediately. Regular monitoring of blood pressure is advised. Do not discontinue any medications without a doctor's advice.
PhenylephrineAmitriptyline
Severe
How does the drug interact with Febrex Plus Syrup 100 ml:
Co-administration of Amitriptyline with Febrex Plus Syrup 100 ml together may lead to side effects like increased blood pressure.

How to manage the interaction:
Febrex Plus Syrup 100 ml and amitriptyline could interact, but they can still be taken if they are prescribed by a doctor. It is advised to monitor blood pressure regularly. Without consulting a doctor, never stop taking any medications.
PhenylephrineDesipramine
Severe
How does the drug interact with Febrex Plus Syrup 100 ml:
Taking Desipramine and Febrex Plus Syrup 100 ml together may lead to side effects like increased blood pressure.

How to manage the interaction:
Although taking Desipramine and Febrex Plus Syrup 100 ml together can result in an interaction, it can be taken if a doctor has prescribed it. However, if you experience any unusual symptoms, consult the doctor. Regular monitoring of blood pressure is advised. Do not discontinue any medications without a doctor's advice.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

  • Wash your hands with soap and water regularly to prevent the spread of germs.
  • Eat plenty of foods rich in good bacteria like yoghurt to improve overall health.
  • Drink plenty of fluids to avoid dehydration.
  • Gargle with salt water for relief from sore throat.
  • Avoid consumption of alcohol with Febrex Plus Syrup as it may cause tiredness, drowsiness or lack of concentration.

Habit Forming

No

Therapeutic Class

ANTIALLERGIC

Febrex Plus Syrup Substitute

Substitutes safety advice

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Author Details

Veda MaddalaDoctor badge

Written By

Veda Maddala

M Pharmacy

Sunny S

Reviewed By

Sunny S

MBBS

Last Updated

Jul 8, 2025 | 9:31 AM IST

Doctor imageWe provide you with authentic, trustworthy and relevant information

Drug-Diseases Interactions

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No Drug - Disease interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Diseases Interactions

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FAQs

Febrex Plus Syrup contains Paracetamol, Phenylephrine and Chlorpheniramine. Paracetamol is an analgesic (relieves pain) and antipyretic (reduces fever) that works by inhibiting the production of certain chemical messengers in the brain known as prostaglandins that are responsible for pain and fever. Phenylephrine is a decongestant that works by contracting and narrowing the blood vessels. Thereby, provides relief from congestion and decreases the mucus production. Chlorpheniramine is an antihistamine (anti-allergic drug) that works by blocking the action of histamine, a substance responsible for causing allergic reactions. It helps to provide relief from symptoms of allergy such as sneezing, running nose, watery eyes, itching, swelling, and congestion or stiffness.

Yes, Febrex Plus Syrup contains paracetamol which acts as mild pain killer (analgesic) and fever reducer (antipyretic). It works by inhibiting the production of certain chemical messengers in the brain known as prostaglandins responsible for pain and fever.

No, you are not recommended to consume alcohol with Febrex Plus Syrup as it may increase the risk of liver damage and cause increased drowsiness, dizziness and lack of concentration.

Febrex Plus Syrup is excreted in breast milk and may affect the health of baby. Therefore, if you are breastfeeding, please inform your doctor before taking Febrex Plus Syrup so that the doctor may prescribe Febrex Plus Syrup if the benefits are greater than risks.

Yes, Febrex Plus Syrup may cause drowsiness. It is not necessary for everyone taking Febrex Plus Syrup to experience this side effect. Therefore, avoid driving or operate heavy machinery if you feel drowsy after taking Febrex Plus Syrup .

No, you are not recommended to take Febrex Plus Syrup with Cetirizine as co-administration of these two medicines may increase sedation and can cause drowsiness, dizziness and difficulty in concentrating. However, please consult a doctor before taking Febrex Plus Syrup with other medicines.

No, you are not recommended to stop taking Febrex Plus Syrup without consulting your doctor as it may worsen the condition or cause recurring symptoms. Therefore, take Febrex Plus Syrup for as long as your doctor has prescribed it, and if you experience any difficulty while taking Febrex Plus Syrup , please consult your doctor.

Do not use Febrex Plus Syrup if you have used an MAO inhibitor in the past 14 days, like isocarboxazid, linezolid, phenelzine, rasagiline, selegiline, or tranylcypromine. Tell your doctor before taking Febrex Plus Syrup if you have nausea, stomach pain, itchy skin, loss of appetite, dark urine, clay-coloured stools, or jaundice (yellowing of your skin or eyes). In rare cases, paracetamol present in Febrex Plus Syrup may cause a severe skin allergic reaction. So, if you observe any skin blisters or redness or rash, immediately contact your doctor and stop taking Febrex Plus Syrup .

Drug-Drug Interactions Checker List

  • DIPHENHYDRAMINE
  • CETIRIZINE
  • DULOXETINE
  • ESCITALOPRAM
  • CLONAZEPAM
  • ALPRAZOLAM
  • CYCLOBENZAPRINE
  • DEXTROMETHORPHAN
  • ALBUTEROL
  • PARACETAMOL
  • IBUPROFEN
  • RAMELTEON

Special Advise

  • Do not give Febrex Plus Syrup to children below 4 years of age.
  • Do not take Febrex Plus Syrup for longer than 7 days in a row (for adults) and 5 days (for the children above 4 years).
  • If you have allergic skin reactions like skin redness o rash that spreads and causes blistering and peeling, immediately contact a doctor.

Disease/Condition Glossary

Common cold: The common cold is an infection caused by the virus, mainly known as ‘rhinoviruses’ affecting the nose and throat (upper respiratory tract). Children younger than 6 years are at the most significant risk of colds, but healthy adults can also be affected to have 2-3 colds annually. In most cases, cold symptoms are recovered within a week or ten days. However, symptoms might last longer in people who smoke or are exposed to allergens like pollutants, dust, etc. The symptoms of the common cold include sneezing, sore throat, cough, congestion, mild body pains, low fever, mild headache, feeling unwell, and stuffy or runny nose. In some cases, the discharge from the nose may become thicker and yellow or green, which is not an indication of bacterial infection.

Allergies: It occurs when foreign elements which cause allergy-causing agents (allergens) attack and invade our body thereby causing the release of histamines. This chemical messenger 'histamines' causes swelling, inflammation, redness, itchiness, itchy/watery nose and throat, and watery eyes. Allergies generally occur due to chemicals, air pollution, pet danders, dust, pollen hairs, seasonal allergies like hay fever, etc.

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