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Written By Lakshmithulasi Yarragunta , Pharm-D (PB)
Reviewed By Santoshini Reddy G , M Pharmacy
Non returnable*
COD available

Online payment accepted

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Whats That

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Synonym

FLUDARABINE PHOSPHATE

Composition

FLUDARABINE-50MG

Consume Type

PARENTERAL

Return Policy

Not Returnable

Expires on or after

Apr-24

for this medicine

About Fludabine 50 mg Injection 1's

Fludabine 50 mg Injection 1's belongs to a group of anticancer medicines called purine analogue used in the treatment of chronic lymphocytic leukaemia. Leukaemia, also known as blood cancer, is a cancer of blood cells or blood-forming tissues. It causes excessive production of immature white blood cells by the bone marrow and reduces the body’s ability to fight infections. 

Fludabine 50 mg Injection 1's contains Fludarabine, which works by inhibiting DNA synthesis (responsible for DNA elongation, synthesis, and repair) in cancer cells by interfering with the ribonucleotide reductase and DNA polymerase enzymes. Thus, Fludabine 50 mg Injection 1's slows or stops the growth of cancer cells in the body.

Fludabine 50 mg Injection 1's may cause certain side effects such as fever, chills, hair loss, depression, fatigue, vomiting, nausea, headache, cough, constipation, oedema, weakness, and pain at the site of injection. Most of these side effects of Fludabine 50 mg Injection 1's do not require medical attention and gradually resolve over time. However, if the side effects persist or worsen, please seek medical help. A trained healthcare professional will administer Fludabine 50 mg Injection 1's. Hence, do not self-administer.

If you are allergic to Fludabine 50 mg Injection 1's, inform your doctor and avoid taking it. Inform your doctor about your complete medical and medication history before starting treatment with Fludabine 50 mg Injection 1's. Fludabine 50 mg Injection 1's is contraindicated for pregnant women and breastfeeding women due to serious embryo-fetal toxicity. Hence, consult your doctor if you are pregnant, planning to become pregnant or breastfeeding. Let the doctor know if you have/had kidney or liver disease, hemolytic anaemia, severe bone marrow suppression, thrombocytopenia, or neutropenia before starting the treatment, as it may worsen your condition. Inform your doctor if you have received any vaccination before starting the treatment.

Uses of Fludabine 50 mg Injection 1's

Chronic lymphocytic leukemia.

Directions for Use

An oncology doctor will administer Fludabine 50 mg Injection 1's. Self-administration is not recommended.

Medicinal Benefits

Fludabine 50 mg Injection 1's contains Fludarabine, which belongs to the class of purine analogues. It works by inhibiting DNA synthesis (responsible for DNA elongation, synthesis, and repair) in cancer cells by interfering with the ribonucleotide reductase and DNA polymerase enzymes. Thus, Fludabine 50 mg Injection 1's stops the multiplication of abnormal cells and causes the death of cancer cells.

Storage

Store in a cool and dry place away from sunlight

Side Effects of Fludabine 50 mg Injection 1's

  • Vomiting
  • Nausea
  • Mouth ulcers
  • Loss of appetite
  • Constipation
  • Weakness
  • Injection site reactions
  • Pain at the site of injection
  • Headache
  • Hair loss

Drug Warnings

If you are allergic to Fludabine 50 mg Injection 1's, inform your doctor and avoid taking it. Inform your doctor about your complete medical and medication history before starting treatment with Fludabine 50 mg Injection 1's. Fludabine 50 mg Injection 1's is contraindicated for pregnant women and breastfeeding women due to serious embryo-fetal toxicity. Hence, consult your doctor if you are pregnant, planning to become pregnant or breastfeeding. Let the doctor know if you have/had kidney or liver disease, haemolytic anaemia, severe bone marrow suppression, thrombocytopenia (low number of platelets), or neutropenia (low white blood cells) before starting the treatment, as it may worsen your condition. If you are about to receive any vaccinations, inform your doctor that you are taking Fludabine 50 mg Injection 1's as it may cause infection.

Drug-Drug Interactions

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FludarabineCladribine
Severe
FludarabineEtanercept
Severe

Drug-Drug Interactions

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FludarabineCladribine
Severe
How does the drug interact with Fludabine 50 mg Injection:
Taking Cladribine with Fludabine 50 mg Injection can increase the risk of developing serious infections.

How to manage the interaction:
Co-administration of Fludabine 50 mg Injection with Cladribine can possibly result in an interaction, but it can be taken if your doctor has advised it. However, if you experience fever, chills, diarrhea, sore throat, muscle pains, breathing difficulty, blood in your coughing fluid, weight loss, red or irritated skin, body sores, and discomfort or burning sensation when you urinate, consult a doctor. Do not stop using any medications without a doctor's advice.
FludarabineEtanercept
Severe
How does the drug interact with Fludabine 50 mg Injection:
When Etanercept is used with Fludabine 50 mg Injection, the likelihood or severity of infection may increase.

How to manage the interaction:
Co-administration of Etanercept with Fludabine 50 mg Injection can result in an interaction, but it can be taken if a doctor has advised it. However, if you develop fever, chills, diarrhea, sore throat, muscular pains, shortness of breath, blood in phlegm, weight loss, red or irritated skin, body sores, or discomfort or burning during urination, consult a doctor immediately. Do not discontinue any medications without a doctor's advice.
FludarabineInfliximab
Severe
How does the drug interact with Fludabine 50 mg Injection:
Combining Infliximab with Fludabine 50 mg Injection can increase the risk or severity of developing serious infections.

How to manage the interaction:
There may be a possibility of interaction between Fludabine 50 mg Injection and Infliximab, but it can be taken if prescribed by a doctor. If you have any of these symptoms like fever, chills, diarrhea, sore throat, muscle pain, difficulty breathing, losing weight, and pain or burning when you pee, it's important to contact a doctor right away. Do not stop using any medications without a doctor's advice.
FludarabineThalidomide
Severe
How does the drug interact with Fludabine 50 mg Injection:
Taking thalidomide together with Fludabine 50 mg Injection may increase the risk of blood clots and other complications.

How to manage the interaction:
Although taking thalidomide and Fludabine 50 mg Injection together can possibly result in an interaction, it can be taken if your doctor has prescribed it. However, consult the doctor immediately if you experience symptoms such as chest pain, shortness of breath, difficulty breathing, coughing up blood, sudden loss of vision, pain, redness or swelling in an arm or leg, and numbness or weakness on one side of the body. Do not discontinue any medications without consulting a doctor.
FludarabineBaricitinib
Severe
How does the drug interact with Fludabine 50 mg Injection:
Coadministration of baricitinib and Fludabine 50 mg Injection can raise the risk of developing serious infections.

How to manage the interaction:
Although there is an interaction, baricitinib can be taken with Fludabine 50 mg Injection if prescribed by the doctor. However, if you experience fever, chills, diarrhea, sore throat, muscle pains, breathing difficulty, blood in your coughing fluid, red or irritated skin, body sores, and discomfort or burning when you urinate, consult a doctor. Do not discontinue any medication without consulting a doctor.
FludarabineClozapine
Severe
How does the drug interact with Fludabine 50 mg Injection:
Co-administration of Fludabine 50 mg Injection with Clozapine can increase the risk of neutropenia (low levels of neutrophils in blood).

How to manage the interaction:
There may be a possibility of interaction between Fludabine 50 mg Injection and Clozapine, but it can be taken if prescribed by a doctor. If you experience any symptoms such as infection, fever, chills, diarrhea, sore throat, muscle aches, shortness of breath, weight loss, or pain or burning during urination, it is important to contact a doctor right away. Do not stop using any medications without a doctor's advice.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

  • Maintain a balanced diet including fruits and vegetables rich in nutrients and low-fat proteins like lean meats, fish and poultry.
  • Drink plenty of water daily while taking the medication, as some cancer therapies may cause dehydration.
  • Exercise regularly and maintain a healthy body weight.
  • Regularly wash your hands and avoid contact with people having infections.
  • Quit smoking.

Habit Forming

No

Therapeutic Class

ANTINEOPLASTIC

Fludabine 50 mg Injection 1's Substitute

Substitutes safety advice
  • Fludacel 50 Injection 1's

    by Others

    6396.00per tablet
  • Fludocyte 50 Injection 2 ml

    by Others

    5256.60per tablet
  • Fludarither 50 Injection 2 ml

    by Others

    2886.40per tablet

Drug-Diseases Interactions

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No Drug - Disease interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Diseases Interactions

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Drug-Drug Interactions Checker List

  • PENTOSTATIN

Special Advise

  • Regular blood tests are recommended while receiving Fludabine 50 mg Injection 1's to monitor any signs of anemia, neutropenia and thrombocytopenia
  • Fludabine 50 mg Injection 1's is contraindicated for use in combination with pentostatin due to the increased risk of severe pulmonary toxicity.

Disease/Condition Glossary

Chronic lymphocytic leukaemia: It is a type of cancer that occurs in the bone marrow and blood. It increases the number of lymphocytes (a type of white blood cell). The symptoms include fever, enlarged liver, bone or joint pain, shortness of breath, weakness, and bleeding from gums or bruises.

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