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  3. Fludabine 50 mg Injection 1's

Fludabine 50 mg Injection 1's, Pack of 1 INJECTION
Fludabine 50 mg Injection 1's, Pack of 1 INJECTION
Written By Lakshmithulasi Yarragunta , Pharm-D (PB)
Reviewed By Santoshini Reddy G , M Pharmacy
Non returnable*
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Whats That

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Synonym :

FLUDARABINE PHOSPHATE

Composition :

FLUDARABINE-50MG

Manufacturer/Marketer :

Dr Reddy's Laboratories Ltd

Consume Type :

PARENTERAL

Return Policy :

Not Returnable

Expires on or after :

About Fludabine 50 mg Injection

Fludabine 50 mg Injection belongs to a group of anticancer medicines called purine analogue used in the treatment of chronic lymphocytic leukaemia. Leukaemia, also known as blood cancer, is a cancer of blood cells or blood-forming tissues. It causes excessive production of immature white blood cells by the bone marrow and reduces the body’s ability to fight infections. 

Fludabine 50 mg Injection contains Fludarabine, which works by inhibiting DNA synthesis (responsible for DNA elongation, synthesis, and repair) in cancer cells by interfering with the ribonucleotide reductase and DNA polymerase enzymes. Thus, Fludabine 50 mg Injection slows or stops the growth of cancer cells in the body.

Fludabine 50 mg Injection may cause certain side effects such as fever, chills, hair loss, depression, fatigue, vomiting, nausea, headache, cough, constipation, oedema, weakness, and pain at the site of injection. Most of these side effects of Fludabine 50 mg Injection do not require medical attention and gradually resolve over time. However, if the side effects persist or worsen, please seek medical help. A trained healthcare professional will administer Fludabine 50 mg Injection. Hence, do not self-administer.

If you are allergic to Fludabine 50 mg Injection, inform your doctor and avoid taking it. Inform your doctor about your complete medical and medication history before starting treatment with Fludabine 50 mg Injection. Fludabine 50 mg Injection is contraindicated for pregnant women and breastfeeding women due to serious embryo-fetal toxicity. Hence, consult your doctor if you are pregnant, planning to become pregnant or breastfeeding. Let the doctor know if you have/had kidney or liver disease, hemolytic anaemia, severe bone marrow suppression, thrombocytopenia, or neutropenia before starting the treatment, as it may worsen your condition. Inform your doctor if you have received any vaccination before starting the treatment.

Uses of Fludabine 50 mg Injection

Chronic lymphocytic leukemia.

Directions for Use

An oncology doctor will administer Fludabine 50 mg Injection. Self-administration is not recommended.

Medicinal Benefits

Fludabine 50 mg Injection contains Fludarabine, which belongs to the class of purine analogues. It works by inhibiting DNA synthesis (responsible for DNA elongation, synthesis, and repair) in cancer cells by interfering with the ribonucleotide reductase and DNA polymerase enzymes. Thus, Fludabine 50 mg Injection stops the multiplication of abnormal cells and causes the death of cancer cells.

Storage

Store in a cool and dry place away from sunlight
Side effects of Fludabine 50 mg Injection
  • Eat well-cooked food to minimize infection risk.
  • Practice good hand hygiene to prevent infections.
  • Avoid crowds and people with illnesses to reduce exposure.
  • Wear a mask when necessary to lower infection risk.
  • Rest adequately to support your body's healing process.
  • Stay hydrated by drinking plenty of water.
  • Regularly monitor blood cell counts for changes.
  • Seek immediate medical help if symptoms like fever, chills, or fatigue occur.
  • Consult your doctor right away if concerning symptoms arise.
  • Follow your doctor's guidance on managing myelosuppression and infection prevention.
Here's a comprehensive approach to managing medication-triggered fever:
  • Inform your doctor immediately if you experience a fever after starting a new medication.
  • Your doctor may adjust your medication regimen or dosage as needed to minimize fever symptoms.
  • Monitor your body temperature to monitor fever progression.
  • Drink plenty of fluids, such as water or electrolyte-rich beverages, to help your body regulate temperature.
  • Get plenty of rest and engage in relaxation techniques, such as deep breathing or meditation, to help manage fever symptoms.
  • Under the guidance of your doctor, consider taking medication, such as acetaminophen or ibuprofen, to help reduce fever.
  • If your fever is extremely high (over 103°F), or if you experience severe symptoms such as confusion, seizures, or difficulty breathing, seek immediate medical attention.
  • Rest well; get enough sleep.
  • Wear comfortable layers of clothes and get to a warm place.
  • Drink warm fluids like coffee, tea or hot chocolate.
  • Warm up using a blanket or heating pad.
  • Rest well; get enough sleep.
  • Eat a balanced diet and drink enough water.
  • Manage stress with yoga and meditation.
  • Limit alcohol and caffeine.
  • Physical activities like walking or jogging might help boost energy and make you feel less tired.
  • Rest well; get enough sleep.
  • Eat a balanced diet and drink enough water.
  • Manage stress with yoga and meditation.
  • Limit alcohol and caffeine.
  • Physical activities like walking or jogging might help boost energy and make you feel less tired.
  • Wash your hands regularly with soap and water or use a hand sanitizer to prevent the spread of infections.
  • Wear masks, gloves and other protective clothing.
  • Cover sneezes and coughs with a medical mask or tissue or your elbow.
  • Take vaccinations to enhance your immunity to specific diseases.
  • Clean your utensils, linen and surfaces regularly.
Here are the steps to manage the medication-triggered Cough:
  • Tell your doctor about the cough symptoms you're experiencing, which may be triggered by your medication.
  • Your doctor may adjust your treatment plan by changing your medication, adding new medications, or providing guidance on managing your cough symptoms.
  • Practice good hygiene, including frequent handwashing, avoiding close contact with others, and avoiding sharing utensils or personal items.
  • Stay hydrated by drinking plenty of fluids, such as water, tea, or soup, to help thin out mucus and soothe your throat.
  • Get plenty of rest and engage in stress-reducing activities to help your body recover. If your cough persists or worsens, consult your doctor for further guidance.

Drug Warnings

If you are allergic to Fludabine 50 mg Injection, inform your doctor and avoid taking it. Inform your doctor about your complete medical and medication history before starting treatment with Fludabine 50 mg Injection. Fludabine 50 mg Injection is contraindicated for pregnant women and breastfeeding women due to serious embryo-fetal toxicity. Hence, consult your doctor if you are pregnant, planning to become pregnant or breastfeeding. Let the doctor know if you have/had kidney or liver disease, haemolytic anaemia, severe bone marrow suppression, thrombocytopenia (low number of platelets), or neutropenia (low white blood cells) before starting the treatment, as it may worsen your condition. If you are about to receive any vaccinations, inform your doctor that you are taking Fludabine 50 mg Injection as it may cause infection.

Drug-Drug Interactions

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FludarabineEtanercept
Severe
FludarabineInfliximab
Severe

Drug-Drug Interactions

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FludarabineEtanercept
Severe
How does the drug interact with Fludabine 50 mg Injection:
When Etanercept is used with Fludabine 50 mg Injection, the likelihood or severity of infection may increase.

How to manage the interaction:
Co-administration of Etanercept with Fludabine 50 mg Injection can result in an interaction, but it can be taken if a doctor has advised it. However, if you develop fever, chills, diarrhea, sore throat, muscular pains, shortness of breath, blood in phlegm, weight loss, red or irritated skin, body sores, or discomfort or burning during urination, consult a doctor immediately. Do not discontinue any medications without a doctor's advice.
FludarabineInfliximab
Severe
How does the drug interact with Fludabine 50 mg Injection:
Combining Infliximab with Fludabine 50 mg Injection can increase the risk or severity of developing serious infections.

How to manage the interaction:
There may be a possibility of interaction between Fludabine 50 mg Injection and Infliximab, but it can be taken if prescribed by a doctor. If you have any of these symptoms like fever, chills, diarrhea, sore throat, muscle pain, difficulty breathing, losing weight, and pain or burning when you pee, it's important to contact a doctor right away. Do not stop using any medications without a doctor's advice.
FludarabineBaricitinib
Severe
How does the drug interact with Fludabine 50 mg Injection:
Coadministration of baricitinib and Fludabine 50 mg Injection can raise the risk of developing serious infections.

How to manage the interaction:
Although there is an interaction, baricitinib can be taken with Fludabine 50 mg Injection if prescribed by the doctor. However, if you experience fever, chills, diarrhea, sore throat, muscle pains, breathing difficulty, blood in your coughing fluid, red or irritated skin, body sores, and discomfort or burning when you urinate, consult a doctor. Do not discontinue any medication without consulting a doctor.
FludarabineCladribine
Severe
How does the drug interact with Fludabine 50 mg Injection:
Taking Cladribine with Fludabine 50 mg Injection can increase the risk of developing serious infections.

How to manage the interaction:
Co-administration of Fludabine 50 mg Injection with Cladribine can possibly result in an interaction, but it can be taken if your doctor has advised it. However, if you experience fever, chills, diarrhea, sore throat, muscle pains, breathing difficulty, blood in your coughing fluid, weight loss, red or irritated skin, body sores, and discomfort or burning sensation when you urinate, consult a doctor. Do not stop using any medications without a doctor's advice.
FludarabineClozapine
Severe
How does the drug interact with Fludabine 50 mg Injection:
Co-administration of Fludabine 50 mg Injection with Clozapine can increase the risk of neutropenia (low levels of neutrophils in blood).

How to manage the interaction:
There may be a possibility of interaction between Fludabine 50 mg Injection and Clozapine, but it can be taken if prescribed by a doctor. If you experience any symptoms such as infection, fever, chills, diarrhea, sore throat, muscle aches, shortness of breath, weight loss, or pain or burning during urination, it is important to contact a doctor right away. Do not stop using any medications without a doctor's advice.
FludarabineThalidomide
Severe
How does the drug interact with Fludabine 50 mg Injection:
Taking thalidomide together with Fludabine 50 mg Injection may increase the risk of blood clots and other complications.

How to manage the interaction:
Although taking thalidomide and Fludabine 50 mg Injection together can possibly result in an interaction, it can be taken if your doctor has prescribed it. However, consult the doctor immediately if you experience symptoms such as chest pain, shortness of breath, difficulty breathing, coughing up blood, sudden loss of vision, pain, redness or swelling in an arm or leg, and numbness or weakness on one side of the body. Do not discontinue any medications without consulting a doctor.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

  • Maintain a balanced diet including fruits and vegetables rich in nutrients and low-fat proteins like lean meats, fish and poultry.
  • Drink plenty of water daily while taking the medication, as some cancer therapies may cause dehydration.
  • Exercise regularly and maintain a healthy body weight.
  • Regularly wash your hands and avoid contact with people having infections.
  • Quit smoking.

Habit Forming

No

Therapeutic Class

ANTINEOPLASTIC

Fludabine 50 mg Injection Substitute

Substitutes safety advice

  • Fludocyte 50 Injection 2 ml

    by Others

    ₹5256.60per tablet

  • Fludacel 50 Injection 1's

    by Others

    ₹6396.00per tablet

  • Fludarither 50 Injection 2 ml

    by Others

    ₹2886.40per tablet

  • Naprobin 50mg Injection

    by Others

    ₹6150.00per tablet

Product Substitutes

Author Details

Lakshmithulasi YarraguntaDoctor badge

Written By

Lakshmithulasi Yarragunta

Pharm-D (PB)

Santoshini Reddy GDoctor badge

Reviewed By

Santoshini Reddy G

M Pharmacy

Last Updated

Aug 20, 2024 | 1:17 PM IST

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Drug-Diseases Interactions

verifiedApollotooltip
No Drug - Disease interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Diseases Interactions

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FAQs

Fludabine 50 mg Injection contains Fludarabine, which works by inhibiting the production of genetic material (DNA) in cancer cells by interfering with the ribonucleotide reductase and DNA polymerase enzymes.

If you are about to receive any vaccinations, it is advised to inform your doctor that you are on treatment with Fludabine 50 mg Injection as it may cause infections.

Fludabine 50 mg Injection may interfere with the normal menstrual cycle in women and may stop sperm production in men. Therefore, please consult a doctor if you plan to have a baby.

Drug-Drug Interactions Checker List

  • PENTOSTATIN

Special Advise

  • Regular blood tests are recommended while receiving Fludabine 50 mg Injection to monitor any signs of anemia, neutropenia and thrombocytopenia
  • Fludabine 50 mg Injection is contraindicated for use in combination with pentostatin due to the increased risk of severe pulmonary toxicity.

Disease/Condition Glossary

Chronic lymphocytic leukaemia: It is a type of cancer that occurs in the bone marrow and blood. It increases the number of lymphocytes (a type of white blood cell). The symptoms include fever, enlarged liver, bone or joint pain, shortness of breath, weakness, and bleeding from gums or bruises.

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