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Written By Santoshini Reddy G , M Pharmacy
Reviewed By Veda Maddala , M Pharmacy
Non returnable*
COD available

Online payment accepted

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Manufacturer/Marketer

Ipca Laboratories Ltd

Consume Type

ORAL

Return Policy

Not Returnable

Expires on or after

Apr-24

for this medicine

About Folitrax-2.5 Tablet 10's

Folitrax-2.5 Tablet 10's belongs to the class of medicines called 'anti-metabolites and immunosuppressants' used to treat active rheumatoid arthritis, including polyarticular juvenile rheumatoid arthritis, severe psoriasis, and severe psoriatic arthritis. Folitrax-2.5 Tablet 10's is used alone or in combination with other medicines to treat breast cancer, lung cancer, head and neck cancer, mycosis fungoides (type of blood cancer), and advanced stage non-Hodgkin's lymphomas (cancer that starts in the lymphatic system).

Folitrax-2.5 Tablet 10's contains 'Methotrexate' that works by interrupting the processes of the immune system that cause inflammation in the joint tissues. It reduces pain and inflammation and delays joint damage and disease progression over time. Besides this, Folitrax-2.5 Tablet 10's prevents and stops the growth of cancer cells, thereby helps treat cancer. Folitrax-2.5 Tablet 10's treats psoriasis by suppressing the overactive immune system that is responsible for causing psoriasis.

In some cases, Folitrax-2.5 Tablet 10's may cause common side-effects such as nausea, vomiting, diarrhoea, unusual fatigue, dizziness, headache, loss of appetite, lowered resistance to infections, tingling sensation, leukopenia (decreased number of white blood cells), and soreness of mouth and lips. You are advised to talk to your doctor if you experience these side effects persistently.

Take Folitrax-2.5 Tablet 10's exactly as prescribed by the doctor; daily intake of Folitrax-2.5 Tablet 10's could lead to serious toxic effects. Do not take Folitrax-2.5 Tablet 10's if you are pregnant or breastfeeding. Folitrax-2.5 Tablet 10's may cause dizziness and fatigue, so drive only if you are alert. Avoid consuming alcohol whilst on treatment with Folitrax-2.5 Tablet 10's. Your doctor may advise you to undergo regular blood tests, kidney and liver tests to monitor your condition. Inform your doctor about your medications and health condition to rule out any unpleasant side effects/interactions.

Uses of Folitrax-2.5 Tablet 10's

Rheumatoid arthritis, Psoriatic arthritis, Psoriasis, Cancer

Directions for Use

Folitrax-2.5 Tablet 10's should be taken exactly as prescribed by the doctor. Tablet/capsule: Take it one hour after food in the evening or as advised by the doctor. Swallow the tablet/capsule as a whole with a glass of water whilst standing or sitting upright; do not break or chew it. Oral solution: Take the prescribed quantity by mouth using the dosing syringe.

Medicinal Benefits

Folitrax-2.5 Tablet 10's belongs to the class of medicines called 'anti-metabolites and immunosuppressants' used to treat active rheumatoid arthritis, including polyarticular juvenile rheumatoid arthritis (arthritis in children), severe psoriasis, and severe psoriatic arthritis. Folitrax-2.5 Tablet 10's helps treat rheumatoid arthritis and psoriatic arthritis by interrupting the processes of the immune system that cause inflammation in the joint tissues. It reduces pain and inflammation and delays joint damage and disease progression over time. Folitrax-2.5 Tablet 10's treats psoriasis by suppressing the overactive immune system that is responsible for causing psoriasis. Folitrax-2.5 Tablet 10's is used alone or in combination with other medicines to treat breast cancer, lung cancer, head and neck cancer, mycosis fungoides (type of blood cancer), and advanced stage non-Hodgkin's lymphomas (cancer that starts in the lymphatic system). Folitrax-2.5 Tablet 10's prevents and stops the growth of cancer cells by interfering with DNA production. Folitrax-2.5 Tablet 10's may also be used to treat inflammatory bowel disease.

Storage

Store in a cool and dry place away from sunlight

Side Effects of Folitrax-2.5 Tablet 10's

  • Nausea
  • Vomiting
  • Diarrhoea
  • Unusual fatigue
  • Dizziness
  • Headache
  • Loss of appetite
  • Elevated liver enzymes
  • Lowered resistance to infections
  • Tingling sensation
  • Leukopenia (decreased number of white blood cells)
  • Soreness of mouth and lips

Drug Warnings

Do not take Folitrax-2.5 Tablet 10's if you are allergic to any of its contents; if you have immunodeficiency conditions, bone marrow problems, low white blood cell count, low platelet count, serious anaemia, liver problems due to alcohol abuse, chronic liver disease; if you are pregnant or breastfeeding. Talk to your doctor before taking Folitrax-2.5 Tablet 10's if you have/had liver or kidney problems, ulceration in the stomach or bowels, poor general condition, received any vaccinations or if you are due to have any vaccinations, diabetes, ascites (fluid in the stomach area), lung problems or fluid in the lungs. Folitrax-2.5 Tablet 10's may cause dizziness and fatigue, so drive only if you are alert. Take Folitrax-2.5 Tablet 10's exactly as directed by the doctor as it may cause serious problems if not taken in the dose and duration prescribed by the doctor. Stop taking Folitrax-2.5 Tablet 10's and consult your doctor immediately if you have mouth sores, diarrhoea, a fever, dehydration, cough, bleeding, shortness of breath, any signs of infection, or a skin rash.

Drug-Drug Interactions

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MethotrexateEtretinate
Critical
MethotrexateDicloxacillin
Severe

Drug-Drug Interactions

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MethotrexateEtretinate
Critical
How does the drug interact with Folitrax-2.5 Tablet:
Co-administration of Etretinate with Folitrax-2.5 Tablet may increase the risk or severity of liver problems.

How to manage the interaction:
Taking Etretinate with Folitrax-2.5 Tablet is generally avoided as it can possibly result in an interaction, it can be taken if a doctor has advised it. Do not stop using any medications without talking to a doctor.
MethotrexateDicloxacillin
Severe
How does the drug interact with Folitrax-2.5 Tablet:
Co-administration of Folitrax-2.5 Tablet with dicloxacillin can increase the levels and effects of Folitrax-2.5 Tablet. This can increase the risk or severity of serious infections.

How to manage the interaction:
Although there is a possible interaction between Folitrax-2.5 Tablet and dicloxacillin, you can take these medicines together if prescribed by your doctor. However, if you experience any symptoms such as nausea, vomiting, mouth ulcers, paleness, fatigue, dizziness, fainting, unusual bleeding or bruising, fever, chills, sore throat, body aches. Consult a doctor immediately. Do not stop using medications without a doctor's advice.
MethotrexateThalidomide
Severe
How does the drug interact with Folitrax-2.5 Tablet:
Using thalidomide together with Folitrax-2.5 Tablet can increase the risk of developing blood clots.

How to manage the interaction:
Although there is a possible interaction between thalidoamide and Folitrax-2.5 Tablet, you can take these medicines together if prescribed by your doctor. However, if you experience any symptoms such as chest pain, difficulty breathing, coughing up blood, sudden loss of vision, and/or pain, redness or swelling in an arm or leg, consult your doctor. Do not stop using any medications without consulting to a doctor.
MethotrexateAcitretin
Severe
How does the drug interact with Folitrax-2.5 Tablet:
Co-administration of Acitretin with Folitrax-2.5 Tablet may increase the risk or severity of liver problems.

How to manage the interaction:
Although there is a possible interaction between Acitretin with Folitrax-2.5 Tablet, you can take these medicines together if only when prescribed by a doctor. Do not discontinue any medications without talking to a doctor.
MethotrexateEverolimus
Severe
How does the drug interact with Folitrax-2.5 Tablet:
Coadministration of Everolimus with Folitrax-2.5 Tablet can increase the risk or severity of kidney disorders.

How to manage the interaction:
Taking Everolimus with Folitrax-2.5 Tablet together can result in an interaction, but it can be taken if a doctor has advised it. However, if you experience nausea, vomiting, loss of appetite, increased or decreased urination, sudden weight gain or loss, fluid retention, swelling, shortness of breath, muscle cramps, tiredness, weakness, dizziness, confusion, or an irregular heart rhythm, consult a doctor. Do not stop using any medications without talking to a doctor.
MethotrexateHydroxychloroquine
Severe
How does the drug interact with Folitrax-2.5 Tablet:
Combine use of hydroxychloroquine with Folitrax-2.5 Tablet may increase the effectiveness of everolimus.

How to manage the interaction:
Although there is a possible interaction between hydroxychloroquine and Folitrax-2.5 Tablet, you can take these medicines together if prescribed by your doctor. However, if you experience any symptoms such as nausea, vomiting, loss of appetite, increased or decreased urination, sudden weight gain or weight loss, fluid retention, swelling, shortness of breath, tiredness, weakness, dizziness. Consult your doctor. Do not stop using any medications without first consulting to your doctor.
MethotrexateFlucytosine
Severe
How does the drug interact with Folitrax-2.5 Tablet:
Combine use of entecavir with Folitrax-2.5 Tablet may increase the effectiveness of everolimus.

How to manage the interaction:
Although there is a possible interaction between everolimus and Folitrax-2.5 Tablet, you can take these medicines together if prescribed by your doctor. However, if you experience any symptoms such as nausea, vomiting, loss of appetite, increased or decreased urination, sudden weight gain or weight loss, fluid retention, swelling, shortness of breath, tiredness, weakness, dizziness. Consult your doctor. Do not stop using any medications without first consulting to your doctor.
MethotrexateSirolimus
Severe
How does the drug interact with Folitrax-2.5 Tablet:
Co-administration of Sirolimus with Folitrax-2.5 Tablet can increase the risk or severity of kidney damage.

How to manage the interaction:
Although there is a possible interaction between sirolimus and Folitrax-2.5 Tablet, you can take these medicines together if prescribed by a doctor. However, if you experience nausea, vomiting, a decrease in hunger, increased or decreased urine, weight gain or loss that occurs suddenly, fluid retention, swelling, difficulty breathing, muscle pain, fatigue, weakness, dizziness, confusion, and irregular heartbeat, consult a doctor. Do not discontinue any medications without a doctor's advice.
MethotrexateNaproxen
Severe
How does the drug interact with Folitrax-2.5 Tablet:
Coadministration of Folitrax-2.5 Tablet with Naproxen can increase the levels and side effects of Folitrax-2.5 Tablet.

How to manage the interaction:
Taking Folitrax-2.5 Tablet with Naproxen together can possibly result in an interaction, it can be taken if your doctor has advised it. However, if you experience any symptoms such as mouth ulcers or sores, vomiting, fever, chills, body aches, sore throat, muscle weakness, diarrhea, rash, loss of appetite, joint pain or swelling, yellow discoloration of skin and eyes, dark urine, breathing difficulty, dry cough, paleness, dizziness or fainting, unusual bruising or bleeding, seizures(fits), Consult a doctor. Do not stop using any medications without consulting a doctor.
MethotrexateNitrous oxide
Severe
How does the drug interact with Folitrax-2.5 Tablet:
Combine use of nitrous oxide with Folitrax-2.5 Tablet may increase the levels and side effects of nitrous oxide.

How to manage the interaction:
Although there is a possible interaction between nitrous oxide and Folitrax-2.5 Tablet, you can take these medicines together if prescribed by your doctor. However, if you experience any symptoms such as nausea, vomiting, pale skin, easy bruising or bleeding, unusual weakness, mouth sores, black or bloody stools, and decreased urine output, consult the doctor. Do not discontinue any medications without doctors advice.

Drug-Food Interactions

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METHOTREXATE-2.5MGCaffeine containing foods/drinks
Moderate

Drug-Food Interactions

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METHOTREXATE-2.5MGCaffeine containing foods/drinks
Moderate
Common Foods to Avoid:
Cocoa, Coffee, Dark Chocolate, Energy Drinks With Caffeine, Green Tea, Kola Nut, Tea, Tiramisu

How to manage the interaction:
Caffeine may reduce the effectiveness of Folitrax-2.5 Tablet. Avoid taking caffeine while taking Folitrax-2.5 Tablet. This can increase the risk or severity of side effects.

Diet & Lifestyle Advise

Arthritis:

  • Physical activity helps in strengthening muscles and relieves joint stiffness. Gentle exercises like 20-30minutes of walking or swimming would be helpful.
  • Performing yoga may also help in improving joint flexibility and pain management.
  • Maintain a healthy weight by performing regular low-strain exercises and eating healthy food.
  • Get adequate sleep as resting the muscles can help reduce inflammation and swelling.
  • De-stress yourself by meditating, reading books, taking a warm bubble bath or listening to soothing music.
  • Acupuncture, massage and physical therapy may also be helpful.
  • Eat food rich in antioxidants such as berries, spinach, kidney beans, dark chocolate, etc.
  • Foods containing flavonoids help in reducing inflammation. These include soy, berries, broccoli, grapes and green tea.
  • Avoid smoking and alcohol consumption.

Psoriasis:

  • Include foods such as cherries, berries, leafy vegetables, salmon, sardines, and fish rich in omega-3 fatty acids.
  • Consume antioxidant-rich spices and herbs like cumin, ginger, sage and thyme.
  • Avoid processed foods, refined sugars, and fatty foods.
  • Limit intake of food that might trigger allergies, such as dairy products, soy, eggs, and nuts.
  • Include fruits, vegetables, whole grains, healthy fats and fish in your diet.
  • Reducing stress and maintaining a good sleep cycle would be helpful.
  • Avoiding getting in contact with harsh soaps, detergents and rough fabrics.

Cancer:

  • Consume a healthy diet and exercise regularly to maintain proper weight.
  • Avoid smoking and alcohol consumption.
  • Include leafy vegetables, citrus fruits, fatty fish, berries, yoghurt, apples, peaches, cauliflower, cabbage, broccoli, beans, herbs, and spices in your diet.
  • Avoid fast food, fried food, processed meats, refined carbs, and added sugar.
  • Get optimal sleep; rest well.

Habit Forming

No

Therapeutic Class

IMMUNOSUPPRESSANTS

Folitrax-2.5 Tablet 10's Substitute

Substitutes safety advice
  • Mexate 2.5 mg Tablet 10's

    by Others

    5.00per tablet
  • Dermotrex 2.5 Tablet 10's

    by Others

    5.00per tablet
  • Imotrax-2.5 Tablet 10's

    by Others

    5.04per tablet
  • Imutrex 2.5 Tablet 10's

    by Others

    4.23per tablet
  • MEXATE 2.5MG TABLET

    by Others

    4.39per tablet

Author Details

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Drug-Diseases Interactions

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No Drug - Disease interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Diseases Interactions

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Drug-Drug Interactions Checker List

  • CELECOXIB
  • ACETAMINOPHEN
  • HYDROCODONE
  • DULOXETINE
  • ETANERCEPT
  • ADALIMUMAB
  • ESOMEPRAZOLE
  • HYDROXYCHLOROQUINE

Special Advise

  • Women of child-bearing age must use effective contraception whilst on treatment with Folitrax-2.5 Tablet 10's and for at least 6 months after the last dose.
  • Male patients are advised to consult their doctor regarding the possibility of sperm preservation before starting the treatment as Folitrax-2.5 Tablet 10's may cause infertility.
  • Folitrax-2.5 Tablet 10's may make you more susceptible to infections; consult your doctor if you develop any signs of infections such as fever, sore throat, breathlessness, jaundice, unexplained bleeding or bruising.
  • Your doctor may advise regular blood tests, kidney and liver tests to monitor your condition.
  • If you miss a dose of Folitrax-2.5 Tablet 10's, call your doctor and ask if you should take the missed dose or not.

Disease/Condition Glossary

Rheumatoid arthritis: It is an autoimmune disease (the body's immune system attacks its tissue) that leads to joint pain and damage. Symptoms of rheumatoid arthritis include pain, inflammation of joints, difficulty moving, and swelling.

Psoriatic arthritis: It is a type of inflammatory arthritis which occurs in patients with psoriasis. It could also occur in patients without psoriasis, particularly in those who have relatives with psoriasis. It affects large joints in the lower extremities, distal joints of toes and fingers, back, and pelvis. Symptoms include inflammation of joints, difficulty moving, swelling, patches of red, scaly skin, and pain.

Psoriasis: It is a chronic autoimmune skin condition that causes the skin to multiply ten times faster than normal. This leads to a rapid build-up of skin cells, causing scaling on the skin surface. Symptoms include inflamed, red, raised patches of skin, soreness around the patches, itching, burning sensations, painful, swollen joints, and dry skin.

Cancer: It is a genetic change in which the cells divide uncontrollably and spread into surrounding tissues. There are two types of cancer, namely benign (localized) and metastatic (spread to the whole body). Cancer growth can be prevented by chemotherapy (by strong antibiotics), radiation, and stem cell therapy. 

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