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Written By Santoshini Reddy G , M Pharmacy
Reviewed By Veda Maddala , M Pharmacy

About Folitrax-25 Tablet 4's

Folitrax-25 Tablet 4's belongs to the class of medicines called 'anti-metabolites and immunosuppressants' used to treat active rheumatoid arthritis, including polyarticular juvenile rheumatoid arthritis, severe psoriasis, and severe psoriatic arthritis. Folitrax-25 Tablet 4's is used alone or in combination with other medicines to treat breast cancer, lung cancer, head and neck cancer, mycosis fungoides (type of blood cancer), and advanced stage non-Hodgkin's lymphomas (cancer that starts in the lymphatic system).

Folitrax-25 Tablet 4's contains 'Methotrexate' that works by interrupting the processes of the immune system that cause inflammation in the joint tissues. It reduces pain and inflammation and delays joint damage and disease progression over time. Besides this, Folitrax-25 Tablet 4's prevents and stops the growth of cancer cells, thereby helps treat cancer. Folitrax-25 Tablet 4's treats psoriasis by suppressing the overactive immune system that is responsible for causing psoriasis.

In some cases, Folitrax-25 Tablet 4's may cause common side-effects such as nausea, vomiting, diarrhoea, unusual fatigue, dizziness, headache, loss of appetite, lowered resistance to infections, tingling sensation, leukopenia (decreased number of white blood cells), and soreness of mouth and lips. You are advised to talk to your doctor if you experience these side effects persistently.

Take Folitrax-25 Tablet 4's exactly as prescribed by the doctor; daily intake of Folitrax-25 Tablet 4's could lead to serious toxic effects. Do not take Folitrax-25 Tablet 4's if you are pregnant or breastfeeding. Folitrax-25 Tablet 4's may cause dizziness and fatigue, so drive only if you are alert. Avoid consuming alcohol whilst on treatment with Folitrax-25 Tablet 4's. Your doctor may advise you to undergo regular blood tests, kidney and liver tests to monitor your condition. Inform your doctor about your medications and health condition to rule out any unpleasant side effects/interactions.

rxMedicinePrescription drug

Whats That

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Non returnable*
COD available

Online payment accepted

Manufacturer/Marketer

Ipca Laboratories Ltd

Consume Type

ORAL

Return Policy

Not Returnable

Expires on or after

Apr-24

for this medicine

Uses of Folitrax-25 Tablet 4's

Rheumatoid arthritis, Psoriatic arthritis, Psoriasis, Cancer

Medicinal Benefits

Folitrax-25 Tablet 4's belongs to the class of medicines called 'anti-metabolites and immunosuppressants' used to treat active rheumatoid arthritis, including polyarticular juvenile rheumatoid arthritis (arthritis in children), severe psoriasis, and severe psoriatic arthritis. Folitrax-25 Tablet 4's helps treat rheumatoid arthritis and psoriatic arthritis by interrupting the processes of the immune system that cause inflammation in the joint tissues. It reduces pain and inflammation and delays joint damage and disease progression over time. Folitrax-25 Tablet 4's treats psoriasis by suppressing the overactive immune system that is responsible for causing psoriasis. Folitrax-25 Tablet 4's is used alone or in combination with other medicines to treat breast cancer, lung cancer, head and neck cancer, mycosis fungoides (type of blood cancer), and advanced stage non-Hodgkin's lymphomas (cancer that starts in the lymphatic system). Folitrax-25 Tablet 4's prevents and stops the growth of cancer cells by interfering with DNA production. Folitrax-25 Tablet 4's may also be used to treat inflammatory bowel disease.

Side Effects of Folitrax-25 Tablet 4's

  • Nausea
  • Vomiting
  • Diarrhoea
  • Unusual fatigue
  • Dizziness
  • Headache
  • Loss of appetite
  • Elevated liver enzymes
  • Lowered resistance to infections
  • Tingling sensation
  • Leukopenia (decreased number of white blood cells)
  • Soreness of mouth and lips

Directions for Use

Folitrax-25 Tablet 4's should be taken exactly as prescribed by the doctor. Tablet/capsule: Take it one hour after food in the evening or as advised by the doctor. Swallow the tablet/capsule as a whole with a glass of water whilst standing or sitting upright; do not break or chew it. Oral solution: Take the prescribed quantity by mouth using the dosing syringe.

Storage

Store in a cool and dry place away from sunlight

Drug Warnings

Do not take Folitrax-25 Tablet 4's if you are allergic to any of its contents; if you have immunodeficiency conditions, bone marrow problems, low white blood cell count, low platelet count, serious anaemia, liver problems due to alcohol abuse, chronic liver disease; if you are pregnant or breastfeeding. Talk to your doctor before taking Folitrax-25 Tablet 4's if you have/had liver or kidney problems, ulceration in the stomach or bowels, poor general condition, received any vaccinations or if you are due to have any vaccinations, diabetes, ascites (fluid in the stomach area), lung problems or fluid in the lungs. Folitrax-25 Tablet 4's may cause dizziness and fatigue, so drive only if you are alert. Take Folitrax-25 Tablet 4's exactly as directed by the doctor as it may cause serious problems if not taken in the dose and duration prescribed by the doctor. Stop taking Folitrax-25 Tablet 4's and consult your doctor immediately if you have mouth sores, diarrhoea, a fever, dehydration, cough, bleeding, shortness of breath, any signs of infection, or a skin rash.

Therapeutic Class

IMMUNOSUPPRESSANTS

Drug-Drug Interactions

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MethotrexateEtretinate
Critical
MethotrexateAcitretin
Severe

Drug-Drug Interactions

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MethotrexateEtretinate
Critical
How does the drug interact with Folitrax-25 Tablet 4's:
Co-administration of Etretinate with Folitrax-25 Tablet 4's may increase the risk or severity of liver problems.

How to manage the interaction:
Taking Etretinate with Folitrax-25 Tablet 4's is generally avoided as it can possibly result in an interaction, it can be taken if a doctor has advised it. Do not stop using any medications without talking to a doctor.
MethotrexateAcitretin
Severe
How does the drug interact with Folitrax-25 Tablet 4's:
Co-administration of Acitretin with Folitrax-25 Tablet 4's may increase the risk or severity of liver problems.

How to manage the interaction:
Although there is a possible interaction between Acitretin with Folitrax-25 Tablet 4's, you can take these medicines together if only when prescribed by a doctor. Do not discontinue any medications without talking to a doctor.
MethotrexateAmpicillin
Severe
How does the drug interact with Folitrax-25 Tablet 4's:
Co-administration of Folitrax-25 Tablet 4's with Ampicillin can increase the levels and side effects of Folitrax-25 Tablet 4's.

How to manage the interaction:
Although there is a possible interaction between Folitrax-25 Tablet 4's and ampicillin, you can take these medicines together if prescribed by your doctor. However, if you experience any symptoms such as tiredness, dizziness, fainting, unusual bleeding or bruising, chills, fever, sore throat, body pains. Consult a doctor immediately. Do not stop using medications without a doctor's advice.
MethotrexateEtodolac
Severe
How does the drug interact with Folitrax-25 Tablet 4's:
Co-administration of Folitrax-25 Tablet 4's with etodolac can increase the level and effects of Folitrax-25 Tablet 4's. This can increase the risk of side effects.

How to manage the interaction:
Although there is a possible interaction between Folitrax-25 Tablet 4's and etodolac, you can take these medicines together if prescribed by a doctor. However, if you experience any symptoms such as mouth sores or ulcers, nausea, vomiting, diarrhea, rash, appetite loss, joint pain or swelling, yellowing of the skin or eyes, dark urine, shortness of breath, a dry cough, pallor, dizziness or fainting, unusual bruising or bleeding, seizures, infection; as well as flu-like signs (fever, chills, body pains, sore throat, and weakening of the muscles), consult a doctor immediately. Do not stop using medications without a doctor's advice.
MethotrexatePiroxicam
Severe
How does the drug interact with Folitrax-25 Tablet 4's:
Coadministration of Folitrax-25 Tablet 4's with piroxicam can increase the levels and side effects.

How to manage the interaction:
Although there is a possible interaction between piroxicam and Folitrax-25 Tablet 4's, it can be taken if prescribed by a doctor. However, if you experience any symptoms such as mouth ulcers or sores, vomiting, fever, chills, body aches, sore throat, muscle weakness, diarrhea, rash, loss of appetite, joint pain or swelling, yellow discoloration of skin and eyes, dark urine, breathing difficulty, dry cough, paleness, dizziness or fainting, unusual bruising or bleeding, seizures(fits), Consult a doctor. Do not stop using any medications without consulting a doctor.
MethotrexateBaricitinib
Severe
How does the drug interact with Folitrax-25 Tablet 4's:
Co-administration of Baricitinib and Folitrax-25 Tablet 4's can increase the risk or severity of developing serious infections.

How to manage the interaction:
Although there is a possible interaction between Baricitinib and Folitrax-25 Tablet 4's, you can take these medicines together if prescribed by your doctor. However, if you experience any symptoms such as fever, chills, diarrhea, sore throat, muscle aches, shortness of breath, weight loss, red or inflamed skin, and pain or burning during urination. Consult a doctor. Do not stop using any medications without consulting a doctor.
MethotrexateTacrolimus
Severe
How does the drug interact with Folitrax-25 Tablet 4's:
Taking tacrolimus with Folitrax-25 Tablet 4's may increase the risk of kidney problems.

How to manage the interaction:
Although there is a possible interaction between tacrolimus and Folitrax-25 Tablet 4's, you can take these medicines together if prescribed by your doctor. However, if you experience any symptoms such as nausea, vomiting, loss of hunger, increased or decreased urination, sudden weight gain or weight loss, fluid retention, swelling, shortness of breath, tiredness, weakness, dizziness. Consult your doctor. Do not stop using any medications without consulting to a doctor.
MethotrexateMefenamic acid
Severe
How does the drug interact with Folitrax-25 Tablet 4's:
Coadministration of Mefenamic acid with Folitrax-25 Tablet 4's may increase the blood levels and side effects of Folitrax-25 Tablet 4's.

How to manage the interaction:
Although there is a possible interaction between mefenamic acid and Folitrax-25 Tablet 4's, you can take these medicines together if prescribed by your doctor. However, if you experience any symptoms such as nausea, vomiting, diarrhea, rash, appetite loss, joint pain or swelling, yellowing of the skin or eyes, dark urine, breathing difficulty, a dry cough, dizziness or fainting, unusual bruising or bleeding, seizures(fits), mouth sores or ulcers, infection, as well as flu-like symptoms(fever, chills, body pains, sore throat, and weakening of the muscles), consult a doctor immediately. Do not stop using medications without a doctor's advice.
MethotrexateCladribine
Severe
How does the drug interact with Folitrax-25 Tablet 4's:
Co-administration of Folitrax-25 Tablet 4's with cladribine can increase the risk or severity of developing serious infections.

How to manage the interaction:
Although there is a possible interaction between cladribine and Folitrax-25 Tablet 4's, you can take these medicines together if prescribed by your doctor. However, if you experience any symptoms such as fever, chills, diarrhea, sore throat, muscle aches, shortness of breath, weight loss, red or inflamed skin, and pain or burning during urination, Consult a doctor. Do not stop using any medications without consulting a doctor.
MethotrexateOxacillin
Severe
How does the drug interact with Folitrax-25 Tablet 4's:
Coadministration of Folitrax-25 Tablet 4's with oxacillin can increase the risk of developing serious infections.

How to manage the interaction:
Although there is a possible interaction between oxacillin and Folitrax-25 Tablet 4's, you can take these medicines together if prescribed by your doctor. However, if you experience any symptoms such as fever, chills, diarrhea, sore throat, muscle aches, shortness of breath, weight loss, red or inflamed skin and pain or burning during urination. Consult your doctor. Do not stop using any medications without first consulting to your doctor.

Drug-Food Interactions

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METHOTREXATE-25MGCaffeine containing foods/drinks
Moderate

Drug-Food Interactions

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METHOTREXATE-25MGCaffeine containing foods/drinks
Moderate
Common Foods to Avoid:
Cocoa, Coffee, Dark Chocolate, Energy Drinks With Caffeine, Green Tea, Kola Nut, Tea, Tiramisu

How to manage the interaction:
Caffeine may reduce the effectiveness of Folitrax-25 Tablet 4's. Avoid taking caffeine while taking Folitrax-25 Tablet 4's. This can increase the risk or severity of side effects.

Drug-Diseases Interactions

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No Drug - Disease interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Diseases Interactions

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Drug-Drug Interactions Checker List

  • CELECOXIB
  • ACETAMINOPHEN
  • HYDROCODONE
  • DULOXETINE
  • ETANERCEPT
  • ADALIMUMAB
  • ESOMEPRAZOLE
  • HYDROXYCHLOROQUINE

Diet & Lifestyle Advise

Arthritis:

  • Physical activity helps in strengthening muscles and relieves joint stiffness. Gentle exercises like 20-30minutes of walking or swimming would be helpful.
  • Performing yoga may also help in improving joint flexibility and pain management.
  • Maintain a healthy weight by performing regular low-strain exercises and eating healthy food.
  • Get adequate sleep as resting the muscles can help reduce inflammation and swelling.
  • De-stress yourself by meditating, reading books, taking a warm bubble bath or listening to soothing music.
  • Acupuncture, massage and physical therapy may also be helpful.
  • Eat food rich in antioxidants such as berries, spinach, kidney beans, dark chocolate, etc.
  • Foods containing flavonoids help in reducing inflammation. These include soy, berries, broccoli, grapes and green tea.
  • Avoid smoking and alcohol consumption.

Psoriasis:

  • Include foods such as cherries, berries, leafy vegetables, salmon, sardines, and fish rich in omega-3 fatty acids.
  • Consume antioxidant-rich spices and herbs like cumin, ginger, sage and thyme.
  • Avoid processed foods, refined sugars, and fatty foods.
  • Limit intake of food that might trigger allergies, such as dairy products, soy, eggs, and nuts.
  • Include fruits, vegetables, whole grains, healthy fats and fish in your diet.
  • Reducing stress and maintaining a good sleep cycle would be helpful.
  • Avoiding getting in contact with harsh soaps, detergents and rough fabrics.

Cancer:

  • Consume a healthy diet and exercise regularly to maintain proper weight.
  • Avoid smoking and alcohol consumption.
  • Include leafy vegetables, citrus fruits, fatty fish, berries, yoghurt, apples, peaches, cauliflower, cabbage, broccoli, beans, herbs, and spices in your diet.
  • Avoid fast food, fried food, processed meats, refined carbs, and added sugar.
  • Get optimal sleep; rest well.

Habit Forming

No

Special Advise

  • Women of child-bearing age must use effective contraception whilst on treatment with Folitrax-25 Tablet 4's and for at least 6 months after the last dose.
  • Male patients are advised to consult their doctor regarding the possibility of sperm preservation before starting the treatment as Folitrax-25 Tablet 4's may cause infertility.
  • Folitrax-25 Tablet 4's may make you more susceptible to infections; consult your doctor if you develop any signs of infections such as fever, sore throat, breathlessness, jaundice, unexplained bleeding or bruising.
  • Your doctor may advise regular blood tests, kidney and liver tests to monitor your condition.
  • If you miss a dose of Folitrax-25 Tablet 4's, call your doctor and ask if you should take the missed dose or not.

Author Details

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Disease/Condition Glossary

Rheumatoid arthritis: It is an autoimmune disease (the body's immune system attacks its tissue) that leads to joint pain and damage. Symptoms of rheumatoid arthritis include pain, inflammation of joints, difficulty moving, and swelling.

Psoriatic arthritis: It is a type of inflammatory arthritis which occurs in patients with psoriasis. It could also occur in patients without psoriasis, particularly in those who have relatives with psoriasis. It affects large joints in the lower extremities, distal joints of toes and fingers, back, and pelvis. Symptoms include inflammation of joints, difficulty moving, swelling, patches of red, scaly skin, and pain.

Psoriasis: It is a chronic autoimmune skin condition that causes the skin to multiply ten times faster than normal. This leads to a rapid build-up of skin cells, causing scaling on the skin surface. Symptoms include inflamed, red, raised patches of skin, soreness around the patches, itching, burning sensations, painful, swollen joints, and dry skin.

Cancer: It is a genetic change in which the cells divide uncontrollably and spread into surrounding tissues. There are two types of cancer, namely benign (localized) and metastatic (spread to the whole body). Cancer growth can be prevented by chemotherapy (by strong antibiotics), radiation, and stem cell therapy. 

Folitrax-25 Tablet 4's Substitute

Substitutes safety advice
  • Folitrax-25 Injection 1 ml

    by Others

    60.80per tablet
  • Meditrex-25 Tablet 4's

    by Others

    47.43per tablet
  • Methora 25 Tablet 10's

    by Others

    57.15per tablet
  • Merex 500 Injection 20 ml

    by Others

    50.11per tablet
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