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Written By Divya L , PharmaD
Reviewed By Bayyarapu Mahesh Kumar , M Pharmacy
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About Gazodox M 400mg/10mg Tablet

Gazodox M 400mg/10mg Tablet is a respiratory medication, primarily used to treat and prevent asthma and chronic obstructive pulmonary diseases (COPD). Asthma is a breathing problem in which airways narrow, swell and produce extra mucus, leading to difficulty breathing. COPD is a group of lung diseases that mainly include emphysema (shortness of breath) and chronic bronchitis (inflammation of the lining of your bronchial tubes).

Gazodox M 400mg/10mg Tablet is a combination of two medicines: Doxofylline (bronchodilator) and Montelukast (leukotriene receptor antagonist). Doxofylline works by relaxing muscles and widening the airways of the lungs. It treats the airflow obstruction in the lungs, thereby relieving chest tightness, wheezing and cough to make breathing easier. Montelukast blocks the leukotrienes (chemicals released in response when a body comes in contact with an allergen), thereby reducing inflammation and swelling in the nose. It also inhibits bronchoconstriction (narrowing of airways in the lungs that lead to breathing difficulties).

Your doctor will advise the dose and duration of the course based on the severity of your disease. The common side effects of Gazodox M 400mg/10mg Tablet include fever, nausea, vomiting, stomach pain/epigastric pain, headache, insomnia (difficulty in sleeping), irritation, sore throat, increased heart rate and flu-like symptoms. Most of these side effects of Gazodox M 400mg/10mg Tablet do not require any medical attention and gradually resolve over time. However, if the side effects are persistent, please reach out to your doctor.

Gazodox M 400mg/10mg Tablet is not intended for use during an acute asthma attack. Your doctor may suggest other medications for your sudden asthma attack. Please inform your doctor in advance if you have heart, liver, kidney and lung diseases, seizures (fits) and depression, phenylketonuria (birth defect caused by the build-up of an amino acid called phenylalanine in the body), hyperthyroidism (overactive thyroid), high blood pressure, stomach ulcers and viral infections before taking Gazodox M 400mg/10mg Tablet. It is advisable to check with your doctor if you are pregnant, currently breastfeeding, or taking any other prescribed or non-prescribed medicines before starting Gazodox M 400mg/10mg Tablet.

Uses of Gazodox M 400mg/10mg Tablet

Chronic Obstructive Pulmonary Disease (COPD), Bronchitis, Asthma, Emphysema, Bronchospasm and Allergic rhinitis.

Directions for Use

Tablet: Swallow it as a whole with water; do not crush, break or chew it.

Medicinal Benefits

Gazodox M 400mg/10mg Tablet is a combination of Doxofylline and Montelukast. Doxofylline works by relaxing muscles and widening the airways of the lungs. It treats the airflow obstruction in the lungs, thereby relieving chest tightness, wheezing and cough to make breathing easier. Montelukast blocks leukotrienes (chemicals released in response when a body comes in contact with an allergen) and reduces inflammation and swelling in the nose. It also inhibits bronchoconstriction (narrowing of airways in the lungs that lead to breathing difficulties). Montelukast is also used to relieve exercise-induced bronchospasm (shortness of breath that occurs only during exercise).

Storage

Keep out of sight and reach of children.
Side effects of Gazodox M 400mg/10mg Tablet
Dealing with Medication-Induced Headache:
  • Hydrate your body: Drink enough water to prevent dehydration and headaches.
  • Calm Your Mind: Deep breathing and meditation can help you relax and relieve stress.
  • Rest and Recharge: Sleep for 7-8 hours to reduce headache triggers.
  • Take rest: lie down in a quiet, dark environment.
  • Cold or warm compresses can help reduce tension.
  • Stay Upright: Maintain good posture to keep symptoms from getting worse.
  • To treat headaches naturally, try acupuncture or massage therapy.
  • Over-the-counter pain relievers include acetaminophen and ibuprofen.
  • Prescription Assistance: Speak with your doctor about more substantial drug alternatives.
  • Severe Headaches: Seek emergency medical assistance for sudden, severe headaches.
  • Frequent Headaches: If you get reoccurring headaches, consult your doctor.
  • Headaches with Symptoms: Seek medical attention if your headaches include fever, disorientation, or weakness.
Here are the 7 steps to manage Dizziness caused by medication:
  • Inform your doctor about dizziness symptoms. They may adjust your medication regimen or prescribe additional medications to manage symptoms.
  • Follow your doctor's instructions for taking medication, and take it at the same time every day to minimize dizziness.
  • When standing up, do so slowly and carefully to avoid sudden dizziness.
  • Avoid making sudden movements, such as turning or bending quickly, which can exacerbate dizziness.
  • Drink plenty of water throughout the day to stay hydrated and help alleviate dizziness symptoms.
  • If you're feeling dizzy, sit or lie down and rest until the dizziness passes.
  • Track when dizziness occurs and any factors that may trigger it, and share this information with your doctor to help manage symptoms.
  • Drink water or other clear fluids.
  • To prevent worsening of pain, limit intake of tea, coffee, or alcohol.
  • Include bland foods like rice, toast, crackers, and rice in your diet.
  • Avoid lying down immediately after eating as it may cause indigestion or heartburn.
  • Avoid acidic and spicy food as it may cause indigestion.
Here are the step-by-step strategies to manage the side effects of "indigestion" caused by medication usage:
  • Take medications with food (if recommended): It can help prevent stomach distress and indigestion.
  • Eat smaller, more frequent meals: Divide daily food intake into smaller, more frequent meals to ease digestion.
  • Avoid trigger foods: Identify and avoid foods that trigger indigestion, such as spicy, fatty, or acidic foods.
  • Stay upright after eating: Sit or stand upright for at least 1-2 hours after eating to prevent stomach acid from flowing into the oesophagus.
  • Avoid carbonated drinks: Avoid drinking carbonated beverages, such as soda or beer, which can worsen indigestion.
  • Manage stress: To alleviate indigestion, engage in stress-reducing activities like deep breathing exercises or meditation.
  • Consult a doctor if needed: If indigestion worsens or persists, consult a healthcare professional to adjust the medication regimen or explore alternative treatments.
  • Maintain a gentle oral hygiene routine by brushing your teeth twice daily with a soft-bristled toothbrush and fluoride toothpaste, and flossing once a day to remove trapped food particles.
  • Modify your diet to limit sugary and acidic foods and beverages, and opt for soft, easy-to-chew foods to reduce discomfort and promote healing.
  • Manage pain and discomfort with over-the-counter medication, cold compresses, and warm salt water rinses as needed.
  • Adopt healthy lifestyle habits, including quitting smoking and tobacco use, staying hydrated, and stimulating saliva production with sugar-free gum to support overall health and well-being.
  • Avoid extreme temperatures and irritants, such as extremely hot or cold foods and drinks, to prevent further discomfort and promote a smooth recovery.
  • Get ample rest; this helps your stomach to settle.
  • Eat soft and easy-to-digest foods like white rice, bananas, crackers and apple sauce.
  • Include probiotics-rich food like yoghurt, kefir, or miso, as they help maintain gut functioning.
  • Wash your hands properly before preparing/eating food and after using the toilet.
  • Drink water, broth or diluted fruit juice to replace electrolytes and lost fluids.
  • Avoid caffeine, alcohol, high-fat, fried and fast foods, as well as sweetened beverages.

Drug Warnings

Do not stop taking this medicine of your own unless advised by your doctor. Before taking Gazodox M 400mg/10mg Tablet, let your doctor know if have heart, liver, kidney and lung diseases, neuropsychiatric disorders like seizures (fits) and depression, phenylketonuria (birth defect caused by the build-up of an amino acid called phenylalanine in the body), hyperthyroidism (overactive thyroid), high blood pressure, stomach ulcers and viral infections. Gazodox M 400mg/10mg Tablet is not intended for use during an acute asthma attack. Therapy with medicines like Montelukast should be cautiously administered in patients with neuropsychiatric disorders. Please seek medical advice if you are pregnant, currently breastfeeding, or taking any other prescribed or non-prescribed medicines before starting Gazodox M 400mg/10mg Tablet.

Drug-Drug Interactions

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Drug-Drug Interactions

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How does the drug interact with Gazodox M 400mg/10mg Tablet:
Coadministration of Miconazole with Gazodox M 400mg/10mg Tablet may increase the blood levels and effects of Gazodox M 400mg/10mg Tablet. This increases the risk or severity of side effects.

How to manage the interaction:
Although there is a possible interaction between miconazole and Gazodox M 400mg/10mg Tablet, you can take these medicines together if prescribed by your doctor. However, if you experience any symptoms such as fever, sore throat, cough, stomach pain, diarrhea, earache, runny nose, or uncommon, depression, confusion, difficulty concentrating, anxiety, hallucinations, irritability. memory impairment, restlessness, sleep walking, Consult a doctor immediately. Do not stop using medications without a doctor's advice.
How does the drug interact with Gazodox M 400mg/10mg Tablet:
Coadministration of Gazodox M 400mg/10mg Tablet and primidone can reduce the levels and effects of Gazodox M 400mg/10mg Tablet.

How to manage the interaction:
Taking Gazodox M 400mg/10mg Tablet and Primidone together can possibly result in an interaction, it can be taken if prescribed by a doctor. However, if you experience any unusual symptoms, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
How does the drug interact with Gazodox M 400mg/10mg Tablet:
Coadministration of Gazodox M 400mg/10mg Tablet and Phenytoin may reduce the blood levels and effects of Gazodox M 400mg/10mg Tablet. This can lead to low treatment outcomes.

How to manage the interaction:
Taking Gazodox M 400mg/10mg Tablet and Phenytoin may interact with one another, but they can be taken together if your doctor has prescribed them. However, if you experience signs such as headache, fever, sore throat, cough, abdominal pain, diarrhoea, earache, runny nose, or behaviour and mood changes, consult a doctor immediately. Do not discontinue any medications without consulting a doctor.
MontelukastRifapentine
Severe
How does the drug interact with Gazodox M 400mg/10mg Tablet:
Coadministration of Rifapentine with Gazodox M 400mg/10mg Tablet may reduce the blood levels and effects of Gazodox M 400mg/10mg Tablet. This can lead to low treatment outcomes.

How to manage the interaction:
Taking Rifapentine with Gazodox M 400mg/10mg Tablet together can possibly result in an interaction, it can be taken if your doctor has advised it. If you experience increased side effects such as headache, fever, sore throat, cough, abdominal pain, diarrhea, earaches, runny nose, or behavior and mood changes consult a doctor. Do not discontinue any medications without consulting a doctor.
How does the drug interact with Gazodox M 400mg/10mg Tablet:
Coadministration of Gazodox M 400mg/10mg Tablet and rifabutin can reduce the levels and effects of Rifabutin. This can lead to low treatment outcomes.

How to manage the interaction:
Taking Gazodox M 400mg/10mg Tablet and rifabutin together can possibly result in an interaction, it can be taken if your doctor has advised it. However, if you experience increased side effects such as headache, fever, sore throat, cough, abdominal pain, diarrhea, earache, runny nose, or behavior and mood changes consult a doctor. Do not discontinue any medications without consulting a doctor.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

  • Add ginger to foods or tea as it contains some anti-inflammatory compounds that can relax membranes in the airways and reduce cough, irritation, and swelling in nasal passages.
  • Eat foods rich in potassium, such as tomatoes, bananas, asparagus, oranges, potatoes, avocados, dark leafy greens, and beetroot, as potassium is important for lung function and potassium deficiency may cause breathing problems.
  • Staying hydrated is vital for those with a cough or cold. Drink liquids at room temperature to get relief from runny nose, cough, and sneezing.
  • Do meditation, deep breathing, regular exercise, and try progressive muscle relaxation techniques to get relief from stress.
  • Quit smoking as it may reduce the effectiveness of the Gazodox M 400mg/10mg Tablet and irritate the lungs worsening breathing problems.
  • It is advised to avoid contact with known allergens (allergy-causing agents), such as pollen, dust, etc. Also, certain food items are known to cause allergies to you.
  • Maintain personal hygiene and keep your surroundings clean. 

Side Effects of Gazodox M 400mg/10mg Tablet

  • Fever
  • Nausea
  • Vomiting
  • Stomach pain/epigastric pain
  • Headache
  • Insomnia (difficulty in sleeping)
  • Irritation
  • Sore throat
  • Increased heart rate
  • Flu-like symptoms

Habit Forming

No

Therapeutic Class

RESPIRATORY STIMULANTS

Author Details

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Drug-Diseases Interactions

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No Drug - Disease interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Diseases Interactions

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FAQs

Gazodox M 400mg/10mg Tablet consists of Doxofylline and Montelukast. Doxofylline is a bronchodilator that works by relaxing muscles and widening the airways of the lungs. Montelukast is a leukotriene receptor antagonist that blocks leukotrienes (chemicals released in response when a body comes in contact with an allergen) and reduces inflammation and swelling in the nose.

Please take the missed dose as soon as possible. However, if it is time for the next dose, skip the missed dose and go back to your regular dosing schedule.

Gazodox M 400mg/10mg Tablet is not recommended for use during a sudden asthma attack since it does not act right away. It is advised to please consult your doctor to prescribe a fast-acting inhaler for rescuing your sudden breathing problems.

Therapy with leukotriene receptor antagonists like Montelukast may worsen the symptoms of psychotic events in patients with a history of mental illness. Careful administration and monitoring are essential before taking Gazodox M 400mg/10mg Tablet in patients with neuropsychiatric disorders. Please consult your doctor before taking Gazodox M 400mg/10mg Tablet if you have been diagnosed or have a history of mental illness like depression, seizures (fits) etc.

It is essential to let your doctor know if you have any history of heart, liver, kidney, and lung diseases, neuropsychiatric disorders like seizures (fits) and depression, phenylketonuria (birth defect caused by the build-up of an amino acid called phenylalanine in the body), hyperthyroidism (overactive thyroid), high blood pressure, hypoxaemia (low levels of oxygen in the blood), stomach ulcers and viral infections before taking Gazodox M 400mg/10mg Tablet.

Drug-Drug Interactions Checker List

  • ALLOPURINOL
  • CIMETIDINE
  • ERYTHROMYCIN
  • PHENYTOIN
  • SALBUTAMOL
  • CLINDAMYCIN

Special Advise

 

Disease/Condition Glossary

Asthma: It is a chronic (long-term) respiratory condition in which airways narrow, swell, and produce extra mucus, leading to difficulty in breathing. The symptoms of asthma include wheezing (whistling sound while breathing), shortness of breath, chest tightness, and cough, especially at night. The symptoms of mild persistent asthma may occur more than 2 times in a week and up to 4 nights in a month whereas, in the case of severe persistent asthma, the symptoms occur several times every day and most nights. The treatment for asthma includes medication, breathing exercises, and self-care. 

Chronic obstructive pulmonary disease (COPD): It is a group of lung diseases with emphysema (shortness of breath) and chronic bronchitis (inflammation of the lining of bronchial tubes). The major cause of COPD is smoking tobacco. Also, long-term exposure to fumes and chemicals may lead to COPD. The symptoms include chronic cough, shortness of breath or wheezing (whistle sound while breathing).

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Alcohol

Caution

Avoid drinking alcohol while taking Gazodox M 400mg/10mg Tablet to avail the maximum benefits and prevent the worsening of side-effects.

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Pregnancy

Caution

There is limited data on how Gazodox M 400mg/10mg Tablet affects pregnancy. Please consult your doctor if you are planning to conceive or already pregnant before starting Gazodox M 400mg/10mg Tablet.

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Breast Feeding

Caution

There is limited data on how Gazodox M 400mg/10mg Tablet affects breastfeeding. Please consult your doctor before starting Gazodox M 400mg/10mg Tablet.

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Driving

Caution

Do not drive or operate machinery if you experience drowsiness or difficulty in concentrating while using Gazodox M 400mg/10mg Tablet. Gazodox M 400mg/10mg Tablet may affect your ability to drive. Seek medical attention if the symptoms persist longer.

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Liver

Caution

Gazodox M 400mg/10mg Tablet should be used with caution in patients with liver diseases. Let your doctor know if you have any history of hepatic impairment before taking Gazodox M 400mg/10mg Tablet.

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Kidney

Caution

Gazodox M 400mg/10mg Tablet should be used with caution in patients with kidney diseases. Let your doctor know if you have any history of kidney diseases. Your doctor will weigh the benefits and potential risks before prescribing Gazodox M 400mg/10mg Tablet.

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Children

Caution

No information is available for use in children. Hence, consult your paediatrician before giving Gazodox M 400mg/10mg Tablet to your child.

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