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  3. Globucel VF Injection 100 ml

Globucel VF Injection 100 ml, Pack of 1 Injection
Written By ,
Reviewed By Bayyarapu Mahesh Kumar , M Pharmacy
Non returnable*
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Composition :

HUMAN NORMAL IMMUNOGLOBULIN-5GM

Manufacturer/Marketer :

Intas Pharmaceuticals Ltd

Consume Type :

PARENTERAL

Return Policy :

Not Returnable

Expires on or after :

About Globucel VF Injection

Globucel VF Injection belongs to the class of medications called ‘immunising agents’ used to treat immunoglobulin (antibody) deficiency and certain inflammatory disorders. It is used to treat immunoglobulin deficiency in people with primary immunodeficiency or PID (present from birth) and secondary immunodeficiency or SID (developed in the later stages of life). Globucel VF Injection is also used to treat inflammatory disorders such as primary immune thrombocytopenia (reduced number of platelets), Guillain-Barre syndrome (short-term inflammation of the peripheral nerves causing weakness of legs and upper limbs), Kawasaki disease (inflammation of blood vessels in children), chronic inflammatory demyelinating polyneuropathy or CIDP (long-term inflammation of peripheral nerves), and multifocal motor neuropathy (progressive disease leading to weakness of arms and legs).

Globucel VF Injection contains ‘Human normal immunoglobulin’, which replaces the deficient antibodies necessary to act against infections and inflammation. It works exactly as the immunoglobulins present in the body. Immunoglobulins are an essential part of the immune system, which recognises the antigens or foreign elements in the body and aids in their destruction. It also helps to reduce inflammation by improving immunity.

Globucel VF Injection will be administered by a trained healthcare professional; hence do not self-administer. This may cause side effects such as swelling or hardening at the injection site and headache, pain in the face, back, arms, legs, joints, or neck, fever, flu-like illness (runny nose and sore throat), blisters in the mouth, and throat, and throat tightness. These side effects are usually mild and temporary. However, if any of the side effects persist or get worse, inform your doctor immediately.

It is not recommended to take Globucel VF Injection if you are allergic to any of its contents or have blood clotting disorders. Before taking Globucel VF Injection , inform your doctor if you have had any vaccinations recently or have already had this product recently. Globucel VF Injection should be used with caution in people with immunoglobulin A (IgA) deficiency (IgA is a type of antibody that protects against infections). Globucel VF Injection is probably safe when given to children, pregnant women, and breastfeeding mothers. Globucel VF Injection should be used with caution in elderly people. Globucel VF Injection may not interact with alcohol. Globucel VF Injection may cause dizziness, so do not drive or operate heavy machinery if you feel dizzy.

Uses of Globucel VF Injection

Immunoglobulin deficiency and inflammatory disorders such as primary immune thrombocytopenia, Guillain-Barre syndrome, Kawasaki disease, chronic inflammatory demyelinating polyneuropathy, and multifocal motor neuropathy.

Directions for Use

A trained healthcare professional will administer Globucel VF Injection , so do not self-administer. The injection is given subcutaneously (under the skin), whereas infusion is given via intravenous (into the vein) route.

Medicinal Benefits

Globucel VF Injection acts by replacing the deficient antibodies that are necessary to act against infections and inflammation. It works exactly as the immunoglobulins present in the body. Immunoglobulins are an important part of the immune system, which recognizes the antigens or foreign elements in the body and causes their destruction. It is used to treat immunoglobulin deficiency in people with primary immunodeficiency or PID (present from birth) and secondary immunodeficiency or SID (developed in the later stages of life). Globucel VF Injection is also used to treat inflammatory disorders such as primary immune thrombocytopenia (reduced number of platelets), Guillain-Barre syndrome (short-term inflammation of the peripheral nerves causing weakness of legs and upper limbs), Kawasaki disease (inflammation of blood vessels in children), chronic inflammatory demyelinating polyneuropathy or CIDP (long-term inflammation of peripheral nerves), and multifocal motor neuropathy (progressive disease leading to weakness of arms and legs).

Storage

Store in a cool and dry place away from sunlight
Side effects of Globucel VF Injection 100 ml
Dealing with Medication-Induced Headache:
  • Hydrate your body: Drink enough water to prevent dehydration and headaches.
  • Calm Your Mind: Deep breathing and meditation can help you relax and relieve stress.
  • Rest and Recharge: Sleep for 7-8 hours to reduce headache triggers.
  • Take rest: lie down in a quiet, dark environment.
  • Cold or warm compresses can help reduce tension.
  • Stay Upright: Maintain good posture to keep symptoms from getting worse.
  • To treat headaches naturally, try acupuncture or massage therapy.
  • Over-the-counter pain relievers include acetaminophen and ibuprofen.
  • Prescription Assistance: Speak with your doctor about more substantial drug alternatives.
  • Severe Headaches: Seek emergency medical assistance for sudden, severe headaches.
  • Frequent Headaches: If you get reoccurring headaches, consult your doctor.
  • Headaches with Symptoms: Seek medical attention if your headaches include fever, disorientation, or weakness.
  • Drink water or other clear fluids.
  • To prevent worsening of pain, limit intake of tea, coffee, or alcohol.
  • Include bland foods like rice, toast, crackers, and rice in your diet.
  • Avoid lying down immediately after eating as it may cause indigestion or heartburn.
  • Avoid acidic and spicy food as it may cause indigestion.
  • Chest pain may last for a while and needs immediate medical attention as it is a significant health issue to be attended to.
  • Take rest and refrain from doing physical activity for a while, and restart after a few days.
  • Try applying an ice pack to the strained area for at least 20 minutes thrice a day. Ice pack thus helps reduce inflammation.
  • Sit upright and maintain proper posture if there is persistent chest pain. • Use extra pillows to elevate your position and prop your chest up while sleeping.
  • Get plenty of rest and sleep.
  • Keep your body warm.
  • Drink plenty of fluids to stay hydrated.
  • Avoid strenuous activities.
  • Maintain good hygiene to prevent flu from spreading.
  • Drink warm fluids such as warm water with honey, broth or herbal tea to soothe sore throat.
  • Gargle with warm salt water to decrease inflammation.
  • Suck on hard candies or lozenges to increase the production of saliva and soothe your throat.
  • Avoid smoking, spicy foods, and extremely hot fluids.
  • Rest your voice and get enough sleep.
  • Avoid trigger foods that can cause allergic reactions, such as nuts, shellfish, or dairy products.
  • Keep a food diary to track potential food allergens.
  • Include omega-3 rich foods like salmon and walnuts to reduce inflammation.
  • Wear loose, comfortable clothing made from soft fabrics like cotton.
  • Apply cool compresses or take cool baths to reduce itching.
  • Use gentle soaps and avoid harsh skin products.
  • Reduce stress through relaxation techniques like meditation or deep breathing.

Drug Warnings

Globucel VF Injection should be used with caution in people with immunoglobulin A (IgA) deficiency (IgA is a type of antibody that protects against infections) as there is an increased risk of allergic reactions. Globucel VF Injection may cause a sudden fall in blood pressure with an allergic reaction, including shock, even in patients who have tolerated previous treatment with this medicine. So, it is advised to monitor patients during infusion and at least 20 min after the infusion. If you develop a severe headache, drowsiness, fever, neck stiffness, sensitivity to light, nausea, and vomiting after Globucel VF Injection , inform your doctor immediately. It may signify aseptic meningitis syndrome (severe inflammation of the brain's linings). Globucel VF Injection should be used with caution in people with obesity or overweight, diabetes, high blood pressure (hypertension), hypovolemia (low blood volume), and blood clotting disorders, as there is a risk of developing a blood clot (very rare effect of Globucel VF Injection ). So, inform your doctor if you notice any sign of a blood clot, such as pain, swelling and unusual warmth of a limb, weakness on one side of the body, confusion, sudden shortness of breath, chest pain worsening on deep breathing, and difficulty speaking. Globucel VF Injection should be used with caution in patients with kidney problems or who have taken medicines that may harm kidneys (nephrotoxic drugs) as Globucel VF Injection may cause problems with kidney function in these people. In rare cases, Globucel VF Injection may cause non-cardiogenic pulmonary oedema (accumulation of fluid in the lungs' air spaces, which is a non-heart related condition). In such cases, patients may experience breathing difficulty, bluish skin, and very low oxygen levels in the blood.

Drug-Drug Interactions

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Human immunoglobulinSulfasalazine
Severe
Human immunoglobulinDiclofenac
Severe

Drug-Drug Interactions

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Human immunoglobulinSulfasalazine
Severe
How does the drug interact with Globucel VF Injection 100 ml:
Coadministration of Globucel VF Injection 100 ml with sulfasalazine may increase the risk or severity of kidney problems.

How to manage the interaction:
Co-administration of Globucel VF Injection 100 ml with Sulfasalazine can result in an interaction, but it can be taken if a doctor has advised it. However, if you experience nausea, vomiting, loss of appetite, increased or decreased urination, sudden weight gain or loss, fluid retention, swelling, shortness of breath, muscle cramps, tiredness, weakness, dizziness, confusion, or an irregular heart rhythm, consult a doctor. Do not discontinue any medications without consulting a doctor.
Human immunoglobulinDiclofenac
Severe
How does the drug interact with Globucel VF Injection 100 ml:
Taking diclofenac with Globucel VF Injection 100 ml may increase the risk of kidney problems.

How to manage the interaction:
Although there is an interaction between Globucel VF Injection 100 ml and Diclofenac, you can take these medicines together if prescribed by a doctor. However, consult the doctor immediately if you experience symptoms such as nausea, vomiting, loss of appetite, increased or decreased urination, sudden weight gain or weight loss, fluid retention, swelling, shortness of breath, muscle cramps, tiredness, weakness, dizziness, confusion, and irregular heart rhythm. Do not discontinue any medications without consulting a doctor.
Human immunoglobulinPiroxicam
Severe
How does the drug interact with Globucel VF Injection 100 ml:
Taking Globucel VF Injection 100 ml with piroxicam, may raise the risk of kidney problems.

How to manage the interaction:
Co-administration of Globucel VF Injection 100 ml with Piroxicam can result in an interaction, but it can be taken if a doctor has advised it. However, if you experience nausea, vomiting, loss of appetite, increased or decreased urination, sudden weight gain or loss, fluid retention, swelling, breathing difficulty, muscle cramps, dizziness, confusion, or an irregular heart rhythm, consult a doctor. Do not discontinue any medications without consulting a doctor.
Human immunoglobulinPolymyxin b
Severe
How does the drug interact with Globucel VF Injection 100 ml:
Taking Globucel VF Injection 100 ml with Polymyxin- b, may raise the risk of kidney problems.

How to manage the interaction:
Although taking Globucel VF Injection 100 ml and Polymyxin b together can cause an interaction, it can be taken if a doctor has suggested it. However, if you experience nausea, vomiting, loss of appetite, increased or decreased urination, sudden weight gain or loss, swelling, shortness of breath, muscle cramps, tiredness, weakness, dizziness, confusion, or an irregular heart rhythm, consult a doctor. Do not discontinue any medications without consulting a doctor.
Human immunoglobulinGentamicin
Severe
How does the drug interact with Globucel VF Injection 100 ml:
Co-administration of Globucel VF Injection 100 ml with Gentamicin may raise the risk of kidney problems.

How to manage the interaction:
Although taking Globucel VF Injection 100 ml and Gentamicin together can cause an interaction, it can be taken if a doctor has suggested it. However, if you experience nausea, vomiting, loss of appetite, increased or decreased urination, sudden weight gain or loss, fluid retention, swelling, shortness of breath, muscle cramps, tiredness, weakness, dizziness, confusion, or an irregular heart rhythm, consult a doctor. Do not discontinue any medications without consulting a doctor.
Human immunoglobulinCapreomycin
Severe
How does the drug interact with Globucel VF Injection 100 ml:
Taking Globucel VF Injection 100 ml with capreomycin, may raise the risk of kidney problems.

How to manage the interaction:
Taking Globucel VF Injection 100 ml with Capreomycin together can result in an interaction, but it can be taken if a doctor has advised it. However, if you experience nausea, vomiting, loss of appetite, increased or decreased urination, sudden weight gain or loss, fluid retention, swelling, shortness of breath, muscle cramps, tiredness, weakness, dizziness, confusion, or an irregular heart rhythm, consult a doctor. Do not discontinue any medications without consulting a doctor.
Human immunoglobulinIndometacin
Severe
How does the drug interact with Globucel VF Injection 100 ml:
Co-administration of Globucel VF Injection 100 ml with Indometacin may increase the risk of kidney problems.

How to manage the interaction:
Co-administration of Globucel VF Injection 100 ml with Indomethacin can result in an interaction, but it can be taken if a doctor has advised it. However, if you experience nausea, vomiting, loss of appetite, increased or decreased urination, sudden weight gain or loss, swelling, breathing difficulty, muscle cramps, tiredness, dizziness, confusion, or an irregular heart rhythm, consult a doctor. Do not discontinue any medications without consulting a doctor.
Human immunoglobulinPamidronic acid
Severe
How does the drug interact with Globucel VF Injection 100 ml:
Taking Globucel VF Injection 100 ml with pamidronic acid, may raise the risk of kidney problems.

How to manage the interaction:
Co-administration of Globucel VF Injection 100 ml with Pamidronic acid can result in an interaction, but it can be taken if a doctor has advised it. However, if you experience nausea, vomiting, loss of appetite, increased or decreased urination, sudden weight gain or loss, fluid retention, swelling, shortness of breath, muscle cramps, tiredness, weakness, dizziness, confusion, or an irregular heart rhythm, consult a doctor. Do not discontinue any medications without consulting a doctor.
Human immunoglobulinValdecoxib
Severe
How does the drug interact with Globucel VF Injection 100 ml:
Taking Globucel VF Injection 100 ml with valdecoxib, may raise the risk of kidney problems.

How to manage the interaction:
Taking Globucel VF Injection 100 ml with Valdecoxib together can result in an interaction, but it can be taken if a doctor has advised it. However, if you experience nausea, vomiting, loss of appetite, increased or decreased urination, sudden weight gain or loss, fluid retention, swelling, shortness of breath, muscle cramps, tiredness, weakness, dizziness, confusion, or an irregular heart rhythm, consult a doctor. Do not discontinue any medications without consulting a doctor.
Human immunoglobulinAdefovir dipivoxil
Severe
How does the drug interact with Globucel VF Injection 100 ml:
Taking Globucel VF Injection 100 ml with adefovir, may raise the risk of kidney problems.

How to manage the interaction:
Although there is a possible interaction between Globucel VF Injection 100 ml and Adefovir dipivoxil, you can take these medicines together if prescribed by a doctor. However, if you have nausea, vomiting, loss of appetite, increased or decreased urination, sudden weight gain or loss, fluid retention, swelling, shortness of breath, muscle cramps, tiredness, weakness, dizziness, confusion, or an irregular heart rhythm, consult a doctor. Do not discontinue any medications without consulting a doctor.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

  • Eat a healthy diet that includes grains,  fresh fruits, vegetables, lean meats, and dairy products. 
  • Stay active and do moderate exercises every day. Maintain a normal weight.
  • Get enough sleep, as sleep and immunity are closely related.
  • Limit intake of sugar-rich foods or drinks.
  • Stay hydrated. 
  • Practice good hygiene.
  • Manage stress levels. 

Habit Forming

No

Therapeutic Class

IMMUNIZING AGENTS

Globucel VF Injection Substitute

Substitutes safety advice

Product Substitutes

Drug-Diseases Interactions

verifiedApollotooltip
No Drug - Disease interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Diseases Interactions

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FAQs

Drug-Drug Interactions Checker List

  • FUROSEMIDE
  • ETHACRYNIC ACID
  • MMR VACCINE
  • VARICELLA (LIVE ATTENUATED)

Special Advise

  • Globucel VF Injection  should not be given intravenously.
  • The side effects can be reduced or sometimes avoided by giving the Globucel VF Injection  at a slow rate.
  • The patient should be observed during the whole infusion and for at least 20 min after giving the Globucel VF Injection to exclude any development of the allergic reaction.
  • It is strongly recommended that each time a dose of Globucel VF Injection is given, the name and batch number of the medicine should be recorded to maintain a record of the batches used.
  • Globucel VF Injection may alter some blood test results for a certain time, so inform your doctor that you have Globucel VF Injection before undergoing blood tests.
  • Globucel VF Injection should be used with caution in patients with diabetes as it may alter blood sugar levels. Globucel VF Injection doesn’t contain sugar; however, it can be diluted in a special sugar solution before giving the infusion.
  • Do not take any vaccines (especially live vaccines) at least three months after taking Globucel VF Injection as this medicine may make the vaccine less effective. 

Disease/Condition Glossary

Immunoglobulin deficiency: Immunoglobulin deficiency indicates low levels of antibodies in the body due to decreased ability or inability to produce enough antibodies. It can be primary immunodeficiency (PID) and acquired or secondary immunodeficiency (SID). PID is congenital and a disorder present from birth. In PID, there is. On the other hand, SID is an acquired disorder that you get later in life.  Immunoglobulin deficiency can lead to recurrent infections and ineffective antimicrobial treatment.

Primary immune thrombocytopenia: In this condition, platelet levels are decreased in the blood. This condition causes easy bruising or bleeding. Children may also experience purplish spots on the lower legs. In children, this condition usually resolves without any treatment. However, adults may require treatment to control bleeding.  

Guillain-Barre syndrome: It is a rare condition in which the immune system attacks the nerves due to an acute bacterial or viral infection. Symptoms include weakness and tingling in the legs and feet that can spread to the upper body. Some patients may also develop paralysis.

Kawasaki disease: It is the inflammation of the blood vessels that is characterized by rashes and fever. It can also affect lymph nodes and cause symptoms in your nose, mouth, and throat. This condition is seen in young infants and children.

Chronic inflammatory demyelinating neuropathy (CIDP): It is a condition in which nerves in the body are affected. Symptoms include slow reflexes and weakness of the arms and legs.

Multifocal motor neuropathy: It is a condition in which motor nerves (nerves that control movements and actions) are affected due to abnormal responses of the immune system. Symptoms include weakness in the upper and lower arms, cramps, involuntary twitching, and atrophy (wasting) of affected muscles.

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