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Unison Pharmaceuticals Pvt Ltd

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ORAL

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About Glyson-MF Tablet

Glyson-MF Tablet belongs to the class of anti-diabetic drugs. It is used in the treatment of type 2 diabetes mellitus. Diabetes mellitus is a metabolic disease that causes high blood sugar levels. It occurs when the insulin (a hormone produced by the beta cells of the pancreas) is resistant in breaking the glucose to produce energy (insulin resistance) or the pancreas (an organ behind the stomach) produces little or no insulin at all.

Glyson-MF Tablet is composed of two medicines, namely Glipizide and Metformin. Glipizide belongs to the class of sulfonylureas. It promotes insulin secretion from the beta cells of the pancreas and reduces the glucose output from the liver.  It has the fastest absorption and onset of action compared to other sulfonylureas. Metformin belongs to the class of biguanides and is used to manage blood sugar levels, particularly in obese patients. It exhibits a non-pancreatic effect to reduce serum glucose levels without increasing insulin secretion. It is also known as an insulin sensitizer as it increases the effects of insulin.

Take Glyson-MF Tablet with food at regular intervals as prescribed by your doctor to avoid stomach upset. Your doctor will decide the dosage form, and this may change timely depending on your blood sugar levels. The common side effects of Glyson-MF Tablet include hypoglycemia (low blood sugar levels), nausea, diarrhoea, indigestion, headache, dizziness, blurred vision, weakness, cold sweats, stomach pain, weight gain, and oedema (swelling). Although not everyone experiences these side effects, if they occur, seek medical attention. Lactic acidosis, is a rare, but serious metabolic complication of excess lactic acid in the blood that is caused by metformin accumulation is reported. The risk of lactic acidosis is high in people with kidney, liver, and heart diseases.

Before starting Glyson-MF Tablet , let your doctor know if you have any medical history of anaemia (low haemoglobin levels), seizures (fits), heart, kidney, and liver diseases. Also, speak to your doctor if you are on restricted food or fluid intake since Glyson-MF Tablet causes dehydration, low blood sugar, and kidney damage. Do not take or stop this medicine, if the doctor did not advise you to do so.

Uses of Glyson-MF Tablet

Type 2 Diabetes mellitus.

Directions for Use

Tablet: Swallow it as a whole with water; do not crush, break or chew it.Take Glyson-MF Tablet preferably with a meal, since it lowers the blood sugar levels and causes gastrointestinal side effects. Your doctor may start the course with a low dose and gradually maintain an effective dose to achieve the required blood glucose control.

Medicinal Benefits

Glyson-MF Tablet is used to treat type 2 diabetes mellitus. It is a combination of Glipizide and Metformin. Glipizide is effective in treating low blood sugar levels when used as an adjunct to diet and exercise. It promotes insulin secretion from the beta cells of the pancreas and reduces the glucose output from the liver. It also exhibits an extrapancreatic effect by improving insulin sensitivity at peripheral sites like muscle, fat, or liver cells. Metformin shows a non-pancreatic effect to reduce serum glucose levels without increasing insulin secretion. It is also known as an insulin sensitizer as it increases the effects of insulin. It is considered to be a unique anti-diabetic drug since it does not lower blood sugar levels.

Storage

Store in a cool and dry place away from sunlight
Side effects of Glyson-MF Tablet
  • Always wear loose-fitting clothes which are suitable for your activity.
  • Include the diet containing fruits like watermelon, grapes, bananas and green leafy vegetables.
  • Drink plenty of water stay hydrated.
  • Avoid moving more and staying in hot sun.
Overcome Medication-Induced Nausea: A 9-Step Plan
  • Inform your doctor about the nausea and discuss possible alternatives to the medication or adjustments to the dosage.
  • Divide your daily food intake into smaller, more frequent meals to reduce nausea.
  • Opt for bland, easily digestible foods like crackers, toast, plain rice, bananas, and applesauce.
  • Avoid certain foods that can trigger nausea, such as fatty, greasy, spicy, and smelly foods.
  • Drink plenty of fluids, such as water, clear broth, or electrolyte-rich beverages like coconut water or sports drinks.
  • Use ginger (tea, ale, or candies) to help relieve nausea.
  • Get adequate rest and also avoid strenuous activities that can worsen nausea.
  • Talk to your doctor about taking anti-nausea medication if your nausea is severe.
  • Record when your nausea occurs, what triggers it, and what provides relief to help you identify patterns and manage your symptoms more effectively.
  • Reduce fluid intake 2-3 hours prior to bedtime.
  • Limit alcohol and caffeine as they can increase urination and affect bladder health.
  • Maintain sleep hygiene.
  • Eat a low-salt and healthy diet.
  • If you experience low blood sugar levels, inform your doctor. They will assess the severity and make recommendations for the next actions.
  • Your doctor will assess your symptoms, blood sugar levels, and overall health before recommending the best course of action, which may include treatment, lifestyle modifications, or prescription adjustments.
  • Follow your doctor's instructions carefully to manage the episode and adjust your treatment plan.
  • Make medication adjustments as recommended by your doctor to prevent future episodes.
  • Implement diet and lifestyle modifications as your doctor advises to manage low blood sugar levels.
  • Monitor your blood sugar levels closely for patterns and changes.
  • Track your progress by recording your blood sugar levels, food intake, and physical activity.
  • Seek further guidance from your doctor if symptoms persist or worsen so that your treatment plan can be revised.
Here are the steps to manage Joint Pain caused by medication usage:
  • Please inform your doctor about joint pain symptoms, as they may adjust your medication regimen or prescribe additional medications to manage symptoms.
  • Your doctor may prescribe common pain relievers if necessary to treat joint discomfort.
  • Maintaining a healthy lifestyle is key to relieving joint discomfort. Regular exercise, such as low-impact sports like walking, cycling, or swimming, should be combined with a well-balanced diet. Aim for 7-8 hours of sleep per night to assist your body in repairing and rebuilding tissue.
  • Applying heat or cold packs to the affected joint can help reduce pain and inflammation.
  • Please track when joint pain occurs and any factors that may trigger it, and share this information with your doctor to help manage symptoms.
  • If your joint pain is severe or prolonged, consult a doctor to rule out any underlying disorders that may require treatment.
Dealing with Medication-Induced Headache:
  • Hydrate your body: Drink enough water to prevent dehydration and headaches.
  • Calm Your Mind: Deep breathing and meditation can help you relax and relieve stress.
  • Rest and Recharge: Sleep for 7-8 hours to reduce headache triggers.
  • Take rest: lie down in a quiet, dark environment.
  • Cold or warm compresses can help reduce tension.
  • Stay Upright: Maintain good posture to keep symptoms from getting worse.
  • To treat headaches naturally, try acupuncture or massage therapy.
  • Over-the-counter pain relievers include acetaminophen and ibuprofen.
  • Prescription Assistance: Speak with your doctor about more substantial drug alternatives.
  • Severe Headaches: Seek emergency medical assistance for sudden, severe headaches.
  • Frequent Headaches: If you get reoccurring headaches, consult your doctor.
  • Headaches with Symptoms: Seek medical attention if your headaches include fever, disorientation, or weakness.
  • Rest well; get enough sleep.
  • Eat a balanced diet and drink enough water.
  • Manage stress with yoga and meditation.
  • Limit alcohol and caffeine.
  • Physical activities like walking or jogging might help boost energy and make you feel less tired.

Drug Warnings

Glyson-MF Tablet can cause weight gain hence possible measures like eating healthy food and exercising are advised. It may also increase the risk of cardiovascular diseases and hypoglycemic conditions in renal and liver disease patients. Glyson-MF Tablet sometimes causes impairment of vitamin b12 absorption and results in anaemia (low haemoglobin levels). Glyson-MF Tablet has an increased risk of lactic acidosis. The risk of lactic acidosis is high in older people with kidney, liver and heart diseases. Hence, brief your medical history and take advice from your doctor before starting Glyson-MF Tablet . Avoid consuming excessive alcohol as it can potentiate lactic acidosis.

Drug-Drug Interactions

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Drug-Drug Interactions

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How does the drug interact with Glyson-MF Tablet:
Co-administration of Glyson-MF Tablet with Gatifloxacin may affect blood glucose levels. Both low blood glucose and, less frequently, high blood glucose have been reported.

How to manage the interaction:
Although there is a possible interaction, Glyson-MF Tablet can be taken with Gatifloxacin if prescribed by the doctor. Consult the prescriber if you experience symptoms such as nervousness, confusion, headache, dizziness, drowsiness, tremors, nausea, hunger, weakness, perspiration, palpitation, rapid heartbeat, increased urination, increased thirst, and increased hunger. Maintaining blood glucose levels is advised. Do not discontinue the medications without consulting a doctor.
How does the drug interact with Glyson-MF Tablet:
Co-administration of Miconazole may increase the blood levels and effects of Glyson-MF Tablet leading to hypoglycemia (low blood glucose levels).

How to manage the interaction:
Although there is a possible interaction, Glyson-MF Tablet can be taken with miconazole if prescribed by the doctor. Consult the prescriber if you experience symptoms of low blood sugar such as dizziness, drowsiness, nervousness, headache, confusion, tremor, nausea, palpitation, hunger, weakness, perspiration, and rapid heartbeat. Monitoring of blood glucose levels is advised. Do not discontinue the medications without consulting a doctor.
GlipizideEnoxacin
Severe
How does the drug interact with Glyson-MF Tablet:
Taking Enoxacin with Glyson-MF Tablet may affect blood glucose levels. Both high blood sugar levels or and, less frequently, low blood glucose have been reported.

How to manage the interaction:
Although there is a possible interaction Glyson-MF Tablet can be taken with Enoxacin if prescribed by the doctor. Consult the prescriber if you experience symptoms of low blood sugar such as dizziness, drowsiness, headache, nervousness, confusion, tremors, nausea, hunger, weakness, perspiration, palpitation, and rapid heartbeat or symptoms of high blood sugar like increased urination, increased thirst, or increased hunger. Monitoring of blood glucose levels is advised. Do not discontinue the medications without consulting a doctor.
How does the drug interact with Glyson-MF Tablet:
Taking Levofloxacin with Glyson-MF Tablet may affect blood glucose levels. Both high blood sugar levels or and, less frequently, low blood glucose have been reported.

How to manage the interaction:
Although there is a possible interaction Glyson-MF Tablet can be taken with Levofloxacin if prescribed by the doctor. Consult the prescriber if you experience dizziness, drowsiness, headache, nervousness, confusion, tremors, nausea, hunger, weakness, perspiration, palpitation, and rapid heartbeat, increased urination, increased thirst, or increased hunger. Monitoring of blood glucose levels is advised. Do not discontinue the medications without consulting a doctor.
How does the drug interact with Glyson-MF Tablet:
Taking Voriconazole may increase the blood levels and effects of Glyson-MF Tablet leading to hypoglycemia (low blood sugar levels).

How to manage the interaction:
Although there is a possible interaction Glyson-MF Tablet can be taken with Voriconazole if prescribed by the doctor. Consult a prescriber if you experience dizziness, headache, and rapid heartbeat. Do not discontinue the medications without consulting a doctor.
How does the drug interact with Glyson-MF Tablet:
Taking Moxifloxacin with Glyson-MF Tablet may affect blood glucose levels. Both high blood sugar levels or and low blood glucose.

How to manage the interaction:
Although there is a possible interaction Glyson-MF Tablet can be taken with Moxifloxacin if prescribed by the doctor. Consult the doctor if you experience dizziness, headache, rapid heartbeat, increased urination, increased thirst. Do not discontinue the medications without consulting a doctor.
GlipizideGrepafloxacin
Severe
How does the drug interact with Glyson-MF Tablet:
Taking Grepafloxacin with Glyson-MF Tablet may affect blood glucose levels. Both high blood sugar levels or and, less frequently, low blood glucose have been reported.

How to manage the interaction:
Although there is a possible interaction Glyson-MF Tablet can be taken with Grepafloxacin if prescribed by the doctor. Consult the prescriber if you experience symptoms of low blood sugar such as dizziness, drowsiness, headache, nervousness, confusion, tremors, nausea, hunger, weakness, perspiration, palpitation, and rapid heartbeat or symptoms of high blood sugar like increased urination, increased thirst, or increased hunger. Monitoring of blood glucose levels is advised. Do not discontinue the medications without consulting a doctor.
How does the drug interact with Glyson-MF Tablet:
Taking Ciprofloxacin with Glyson-MF Tablet may affect both high blood sugar levels or/and, less frequently, low blood glucose.

How to manage the interaction:
Although there is a possible interaction Glyson-MF Tablet can be taken with Ciprofloxacin if prescribed by the doctor. However, consult the doctor if you experience symptoms such as headache, dizziness, drowsiness, nervousness, confusion, tremor, nausea, hunger, weakness, excessive sweating, and rapid heartbeat, increased thirst, increased hunger, and increased urination. Do not discontinue the medications without consulting a doctor.
How does the drug interact with Glyson-MF Tablet:
Co-administration of Norfloxacin with Glyson-MF Tablet may occasionally affect blood glucose levels. Both Hyperglycemia (high blood sugar levels) and Hypoglycemia (low blood glucose) have been reported.

How to manage the interaction:
Although there is a possible interaction Glyson-MF Tablet can be taken with Norfloxacin if prescribed by the doctor. Consult the prescriber if you experience symptoms of low blood sugar such as dizziness, drowsiness, headache, nervousness, confusion, tremors, nausea, hunger, weakness, perspiration, palpitation, and rapid heartbeat or symptoms of high blood sugar like increased urination, increased thirst, or increased hunger. Maintaining blood glucose levels is advised. Do not discontinue any medications without consulting a doctor.
GlipizideCinoxacin
Severe
How does the drug interact with Glyson-MF Tablet:
Taking Cinoxacin with Glyson-MF Tablet may affect blood glucose levels. Both high blood sugar levels or and, less frequently, low blood glucose have been reported.

How to manage the interaction:
Although there is a possible interaction Glyson-MF Tablet can be taken with Cinoxacin if prescribed by the doctor. Consult the prescriber if you experience symptoms of low blood sugar such as dizziness, drowsiness, headache, nervousness, confusion, tremors, nausea, hunger, weakness, perspiration, palpitation, and rapid heartbeat or symptoms of high blood sugar like increased urination, increased thirst, or increased hunger. Monitoring of blood glucose levels is advised. Do not discontinue the medications without consulting a doctor.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

  • Maintain a fiber-rich diet and include healthy carbohydrates from fruits, vegetables and whole grains to maintain your blood glucose levels.
  • Eat at regular intervals
  • Keep a check on your weight and exercise regularly to keep your heart healthy.
  • Your doctor also guides you on how to notice and manage the early symptoms of high/low blood sugar levels.
  • Gastrointestinal side effects can be managed with simple modifications in your lifestyle. These include cutting down on sugars and fatty foods, and avoiding carbonated drinks and foods that cause gas.

Habit Forming

No

Therapeutic Class

ANTIDIABETICS

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Author Details

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Drug-Diseases Interactions

verifiedApollotooltip
GLIPIZIDE-5MG+METFORMIN-500MGType 2 diabetes mellitus
Severe
GLIPIZIDE-5MG+METFORMIN-500MGOther disorders of kidney and ureter, not elsewhere classified
Severe

Drug-Diseases Interactions

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GLIPIZIDE-5MG+METFORMIN-500MGType 2 diabetes mellitus
Severe
How does the disease interact with Glyson-MF Tablet:
Some sulfonylurea medications should not be used to treat diabetic ketoacidosis in individuals who are in or out of the coma. Additionally, these medications shouldn't be the only form of treatment for those with type I diabetes

How to manage the interaction:
Sulfonylureas are contraindicated for the treatment of patients with diabetic ketoacidosis, with or without coma.
GLIPIZIDE-5MG+METFORMIN-500MGOther disorders of kidney and ureter, not elsewhere classified
Severe
How does the disease interact with Glyson-MF Tablet:
Sulfonylureas are broken down in the liver, and their metabolites—some of which have therapeutic potential are eliminated through the urine and feces. Sulfonylureas may cause increased blood drug concentrations in patients with impaired liver and/or renal function, increasing the risk of severe hypoglycemia episodes brought on by these medications. Hepatic impairment may also result in a reduction in gluconeogenic ability, raising the risk even higher. Patients with hepatic and/or renal illness should receive sulfonylurea therapy with caution. It could be necessary to use lower doses and space out dosage adjustments more often. Due to decreased metabolism and/or medication excretion, these patients may experience extended hypoglycemia if it develops while they are receiving therapy

How to manage the interaction:
In patients with impaired kidney function, sulfonylureas may be exposed to higher serum drug concentrations leading to low blood sugar episodes. Therapy with sulfonylureas should be administered cautiously in patients with kidney disease.
GLIPIZIDE-5MG+METFORMIN-500MGSpecial screening examination for other diseases and disorders
Severe
How does the disease interact with Glyson-MF Tablet:
Compared to diet alone or diet plus insulin, the use of oral hypoglycemic medicines may be linked to a higher risk of cardiovascular mortality

How to manage the interaction:
The use of oral hypoglycemic agents may be associated with an increased risk of cardiovascular mortality.

FAQs

Glyson-MF Tablet contains two antidiabetic drugs, namely: Glipizide and Metformin. Glipizide promotes insulin secretion from the beta cells of the pancreas and reduces the glucose output from the liver. Metformin works by reducing the sugar production by cells in the liver and delays sugar absorption from the intestines.

Glyson-MF Tablet may increase the risk of low blood sugar levels, especially with alcohol intake, exercise more than usual, delay or missing snacks or meals. However, if you experience any signs of low blood pressure such as dizziness, nausea, light-headedness, dehydration or fainting, please consult a doctor.

You are not recommended to stop taking Glyson-MF Tablet on your own as discontinuing Glyson-MF Tablet suddenly may cause recurring symptoms or worsen the condition. However, if you experience any difficulty while taking Glyson-MF Tablet , please consult your doctor so that alternative medicine may be prescribed.

In type 1 diabetes, the body doesn’t produce insulin as the islet cells (insulin-producing cells) in the pancreas are destroyed completed. In type 2 diabetes, though islet cells are working, the body doesn’t respond to insulin as the body becomes resistant to insulin.

Drug-Drug Interactions Checker List

  • ASPIRIN
  • GLIPIZIDE
  • SITAGLIPTIN
  • INSULIN GLARGINE
  • FUROSEMIDE
  • METOPROLOL
  • LEVOTHYROXINE SODIUM

Special Advise

Regular blood tests are recommended while taking Glyson-MF Tablet to monitor blood sugar levels.

Disease/Condition Glossary

Diabetes mellitus, also known as adult-onset diabetes, is a metabolic disease that causes high blood sugar levels. It is a type 2 diabetes and occurs when the insulin (a hormone produced by the beta cells of the pancreas) is resistant in breaking the glucose to produce energy (insulin resistance) or the pancreas (an organ behind the stomach) produces little or no insulin at all. This disease mostly occurs in people aged above 40 years, but can also occur in childhood based on the risk factors. The treatment includes oral glucose-lowering medicines and insulin shots.

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