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Written By Sureshvarma D , MPharma
Reviewed By Hari Kumar , MBBS

About Grafotas-50 Capsule 5's

Grafotas-50 Capsule 5's belongs to the class of medicine called 'immunosuppressant' that helps to reduce the pain/inflammation in rheumatoid arthritis conditions and is also used to treat severe psoriasis. Besides this, it also prevents organ rejection after a kidney, heart, or liver transplant. Rheumatoid arthritis is an autoimmune disease (the body's immune system attacks its tissue) that leads to joint pain and damage. Psoriasis is a long-lasting, inflammatory skin illness. 

Grafotas-50 Capsule 5's contains 'cyclosporine' that works by reducing the function of the cells, causing inflammation, especially in the joint tissues, thereby decreasing pain and inflammation and slowing down the joint damage and disease progression over time. Besides this, after an organ transplant, your body will try to attack the new organ as it sees it as foreign. Grafotas-50 Capsule 5's helps stop your body from rejecting a new organ by suppressing your immune system. 

You are advised to take Grafotas-50 Capsule 5's for as long as your doctor has prescribed it for you, depending on your medical conditions. You may experience headaches, vomiting, nausea, high blood pressure, increased growth of hair, loss of appetite (feeling unwell and upset stomach), kidney disease, and diarrhoea. Most of these side effects do not require medical attention and will resolve gradually over time. However, you are advised to talk to your doctor if you experience these side effects persistently.

To treat your condition effectually, continue taking Grafotas-50 Capsule 5's for as long as your doctor has prescribed. To avoid recurring symptoms, do not stop it midway. Before taking Grafotas-50 Capsule 5's inform your doctor if you have any allergies, kidney disease, uncontrolled high blood pressure, and any type of cancer. Grafotas-50 Capsule 5's should not be taken by breastfeeding mothers as it passes into breast milk. Inform your doctor about your health condition and medicines to rule out any unpleasant side effects.

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Whats That

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Non returnable*
COD available

Online payment accepted

Synonym

CYCLOSPORIN

Composition

CICLOSPORIN-50MG

Consume Type

ORAL

Return Policy

Not Returnable

Expires on or after

Apr-24

for this medicine

Uses of Grafotas-50 Capsule 5's

Rheumatoid arthritis, Immunosuppressant therapy after organ (liver, kidney, and heart) transplant, and psoriasis (a skin disease that causes itchy and dry patches).

Medicinal Benefits

Grafotas-50 Capsule 5's belongs to the class of medicine called 'immunosuppressant' that helps to reduce the pain/inflammation in rheumatoid arthritis conditions and is also used to treat severe psoriasis. Besides this, it also prevents organ rejection after a kidney, heart, or liver transplant. Grafotas-50 Capsule 5's contains 'cyclosporine' that works by reducing the function of the cells, causing inflammation, especially in the joint tissues, thereby decreasing pain and inflammation and slowing down the joint damage and disease progression over time. Besides this, after an organ transplant, your body will try to attack the new organ as it sees it as foreign. Grafotas-50 Capsule 5's helps stop your body from rejecting a new organ by suppressing your immune system. 

Side Effects of Grafotas-50 Capsule 5's

  • Headache
  • Vomiting
  • Nausea
  • High blood pressure
  • Increased growth of hair
  • Loss of appetite (feeling unwell and having an upset stomach)
  • Kidney disease
  • Diarrhoea

Directions for Use

Tablet/Capsule: Swallow it as a whole with water; do not crush, break or chew it.Solution/Syrup/Suspension/Drops: Shake the bottle well before use. Take the prescribed dose by mouth using the measuring cup/dosing syringe/dropper provided by the pack.

Storage

Store in a cool and dry place away from sunlight

Drug Warnings

Do not take Grafotas-50 Capsule 5's if you are allergic to any immunosuppressant medicines or Cyclosporine. Let your doctor know if you have liver or kidney problems, high blood pressure, low levels of magnesium, and high levels of potassium. Grafotas-50 Capsule 5's may make you more susceptible to infections; consult your doctor if you develop any signs of severe conditions such as fever, sore throat, breathlessness, jaundice, unexplained bleeding, or bruising. Before taking Grafotas-50 Capsule 5's inform your doctor if you have any type of cancer. Grafotas-50 Capsule 5's should not be taken by breastfeeding mothers as it passes into breast milk. Inform your doctor about your health condition and medicines to rule out any unpleasant side effects.

Therapeutic Class

IMMUNOSUPPRESSANTS

Drug-Drug Interactions

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CiclosporinCidofovir
Critical
CiclosporinBaricitinib
Critical

Drug-Drug Interactions

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CiclosporinCidofovir
Critical
How does the drug interact with Grafotas-50 Capsule 5's:
Taking cyclosporine with cidofovir can increase the risk of kidney problems.

How to manage the interaction:
Taking Grafotas-50 Capsule 5's with Cidofovir is not recommended, but can be taken be together if prescribed by a doctor. However, if you experience nausea, vomiting, loss of hunger, increased or decreased urination, sudden weight gain or weight loss, swelling, shortness of breath, bone pain, muscle cramps, tiredness, weakness, dizziness, confusion, and irregular heart rhythm, contact the doctor immediately. Do not discontinue any medications without consulting a doctor
CiclosporinBaricitinib
Critical
How does the drug interact with Grafotas-50 Capsule 5's:
Co-administration of Baricitinib with Cyclosporine can increase the risk of infections as well as some cancers.

How to manage the interaction:
Taking Grafotas-50 Capsule 5's with Baricitinib is not recommended as it can cause an interaction, but it can be taken together if prescribed by a doctor. However, if you experience fever, chills, diarrhea, sore throat, muscle pains, breathing difficulty, blood in your coughing fluid, weight loss, red or irritated skin, body sores, and discomfort or burning sensation when you urinate, consult a doctor. Do not stop using any medications without a doctor's advice.
CiclosporinBosentan
Critical
How does the drug interact with Grafotas-50 Capsule 5's:
When Bosentan is taken with Cyclosporine, it may increase the risk of side effects.

How to manage the interaction:
Taking Grafotas-50 Capsule 5's with Bosentan is not recommended, but it can be taken if prescribed by the doctor. However, if you experience any symptoms like severe headache, nausea, or an increased heart rate, consult the doctor immediately. Do not stop using any medications without talking to a doctor.
CiclosporinPitavastatin
Critical
How does the drug interact with Grafotas-50 Capsule 5's:
Coadministration of pitavastatin with Grafotas-50 Capsule 5's may significantly increase the blood levels of pitavastatin which can increase the risk of side effects such as liver problems and rhabdomyolysis(involves the breakdown of skeletal muscle tissue).

How to manage the interaction:
Taking Pitavastatin with Grafotas-50 Capsule 5's is not recommended, as it can possibly result in an interaction, it can be taken if your doctor has advised it. However, if you experience symptoms like unexpected bruising or bleeding, skin rash, itching, tiredness, nausea, vomiting, yellowing of the skin or eyes, unexplained muscular pain, tenderness, or weakness, fever, dark urine, chills, joint pain, or swelling, consult a doctor. Do not discontinue any medications without a doctor's advice.
CiclosporinSimvastatin
Critical
How does the drug interact with Grafotas-50 Capsule 5's:
Combining Grafotas-50 Capsule 5's and Simvastatin can increase the blood levels and effects of Simvastatin. This can increase the risk of side effects such as liver damage and rhabdomyolysis(involves the breakdown of skeletal muscle tissue).

How to manage the interaction:
Taking Grafotas-50 Capsule 5's and Simvastatin together is not recommended as it can lead to an interaction, but it can be taken if advised by your doctor. However, if you experience any symptoms like muscle pain, tenderness, or weakness, fever or dark colored urine, chills, joint pain or swelling, unusual bleeding or bruising, skin rash, itching, loss of hunger, weakness, nausea, vomiting, and yellowing of the skin or eyes, contact the doctor immediately. Do not discontinue any medications without consulting your doctor.
CiclosporinAdefovir dipivoxil
Severe
How does the drug interact with Grafotas-50 Capsule 5's:
Coadministration of adefovir dipivoxil with Grafotas-50 Capsule 5's may significantly increase the negative effect of kidneys.

How to manage the interaction:
Although there is a possible interaction between adefovir dipivoxil and Grafotas-50 Capsule 5's, they can be taken together if your doctor has prescribed them. However, contact your doctor if experience any symptoms such as nausea, vomiting, loss of hunger, increased or decreased urination, sudden weight gain or weight loss, swelling, shortness of breath, muscle cramps, tiredness, weakness, dizziness, confusion, or irregular heart rhythm, contact a doctor immediately. Do not stop using any medications without talking to a doctor.
CiclosporinLeflunomide
Severe
How does the drug interact with Grafotas-50 Capsule 5's:
Using leflunomide together with Grafotas-50 Capsule 5's can increase the risk of side effects

How to manage the interaction:
Co-administration of Grafotas-50 Capsule 5's with leflunomide can possibly result in an interaction, but it can be taken if your doctor has advised it. However, if you experience contact a doctor immediately if you experience symptoms such as serious infection, anemia, bleeding problems, paleness, fatigue, dizziness, bruising, fever, chills, diarrhea, sore throat, muscle aches, or pain during urination. Do not stop using any medications without talking to a doctor.
CiclosporinColchicine
Severe
How does the drug interact with Grafotas-50 Capsule 5's:
Co-administration of colchicine with Grafotas-50 Capsule 5's may increases the blood levels and effects of both medications.

How to manage the interaction:
Although there is a possible interaction between colchicine and Grafotas-50 Capsule 5's, you can take these medicines together if prescribed by your doctor. However, contact a doctor immediately if you experience any symptoms such as abdominal pain, diarrhoea, fever, muscle pain, weakness, and numbness or tingling in your hands and feet. Do not discontinue any medications without consulting a doctor.
CiclosporinVenetoclax
Severe
How does the drug interact with Grafotas-50 Capsule 5's:
Co-administration of venetoclax with Grafotas-50 Capsule 5's may significantly increase the blood levels and effects of venetoclax.

How to manage the interaction:
Although there is a possible interaction between venetoclax and Grafotas-50 Capsule 5's, they can be taken together if your doctor has prescribed them. However, contact your doctor immediately if experience any symptoms such as nausea, paleness, vomiting, diarrhea and weakness. Do not stop using any medications without talking to a doctor.
CiclosporinDocetaxel
Severe
How does the drug interact with Grafotas-50 Capsule 5's:
Coadministration of docetaxel with Grafotas-50 Capsule 5's may significantly increase the blood levels of docetaxel.

How to manage the interaction:
Although there is a possible interaction between deferasirox and Grafotas-50 Capsule 5's, they can be taken together if your doctor has prescribed them. Contact your doctor immediately if experience fatigue, dizziness, fainting, unusual bruising or bleeding, fever, chills, diarrhea, sore throat, muscle aches, shortness of breath, blood in phlegm, red or inflamed skin, body sores, and pain or burning during urination. Do not stop using any medications without talking to a doctor.

Drug-Food Interactions

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CICLOSPORIN-50MGGrapefruit and Grapefruit Juice
Moderate

Drug-Food Interactions

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CICLOSPORIN-50MGGrapefruit and Grapefruit Juice
Moderate
Common Foods to Avoid:
Grapefruit Juice, Grapefruit

How to manage the interaction:
Consuming grapefruit and grapefruit juice while taking Grafotas-50 Capsule 5's can increase the effects of Grafotas-50 Capsule 5's. Avoid consuming grapefruit and grapefruit juice while taking Grafotas-50 Capsule 5's.

Drug-Diseases Interactions

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No Drug - Disease interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Diseases Interactions

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Drug-Drug Interactions Checker List

  • TACROLIMUS
  • AMILORIDE
  • SPIRONOLACTONE
  • ALISKIREN
  • ATORVASTATIN
  • PITAVASTATIN
  • SIMVASTATIN
  • ERYTHROMYCIN
  • AZITHROMYCIN
  • VORICONAZOLE
  • ITRACONAZOLE
  • DILTIAZEM
  • VERAPAMIL
  • DANAZOL
  • ALLOPURINOL
  • COLCHICINE
  • TELAPREVIR

Diet & Lifestyle Advise

  • Physical activity helps strengthen muscles and relieves joint stiffness. Gentle activities like 20-30 minutes of walking or swimming would be helpful.
  • Performing yoga may also help in improving joint flexibility and pain management.
  • Maintain a healthy weight by performing regular low-strain exercises and eating healthy food.
  • Get adequate sleep, as resting the muscles can help reduce inflammation and swelling.
  • Follow heat or cold therapy, and apply a cold or hot compress on the joints for 15-20 minutes regularly.
  • De-stress yourself by meditating, reading books, taking a warm bubble bath, or listening to soothing music.
  • Acupuncture, massage, and physical therapy may also be helpful.
  • Eat food rich in antioxidants such as berries, spinach, kidney beans, dark chocolate, etc.
  • Foods containing flavonoids help in reducing inflammation. These include soy, berries, broccoli, grapes, and green tea.
  • Avoid smoking and alcohol consumption.

Habit Forming

No

Special Advise

  • Use sunscreen while taking Grafotas-50 Capsule 5's, as it can make your skin more sensitive to sunlight and may cause skin cancer.
  • Long-term use of Grafotas-50 Capsule 5's may increase your risk of developing cancers like blood cancer, skin cancer, and immune system cancer (lymphoma). 

Author Details

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Disease/Condition Glossary

Rheumatoid arthritis: It is an autoimmune disease (the body's immune system attacks its tissue) that leads to joint pain and damage. Symptoms of rheumatoid arthritis include pain, inflammation of joints, difficulty moving, and swelling.

Organ (kidney, heart, or liver) transplant rejection: When you get a new organ transplanted into your body, your body recognizes it as a foreign element and tries to attack and reject it because it is not originally part of your body. So, immunosuppressant drugs like cyclosporine are given to such patients to suppress their immune system to prevent an attack on a newly transplanted organ. The goal is to adjust immunosuppressants to prevent rejection and minimize any side effects of the drugs.

Psoriasis: It is a long-lasting, inflammatory skin illness. It is not infectious but has a tendency to run in families. It causes itchy and red patches on the skin.

Grafotas-50 Capsule 5's Substitute

Substitutes safety advice
  • Sprintas-50Mg Softgel Capsule 5'S

    by AYUR

    52.02per tablet
  • Zymmune 50 Capsule 6's

    by Others

    52.05per tablet
  • Psoranext 50mg Capsule 6's

    by Others

    37.35per tablet
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