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Written By Divya L , PharmaD
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
Non returnable*
COD available

Online payment accepted

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Whats That

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Composition :

GRANISETRON-1MG

Manufacturer/Marketer :

Aristo Pharmaceuticals Pvt Ltd

Consume Type :

PARENTERAL

Return Policy :

Not Returnable

Expires on or after :

About GRANDEM 1MG INJECTION 1ML

GRANDEM 1MG INJECTION 1ML belongs to the class of 'anti-emetic' drugs, primarily used to treat nausea and vomiting caused by medical treatments after surgery or chemotherapy or radiation treatment for cancer. Nausea is defined as stomach discomfort and the sensation of an urge to vomit. Vomiting is the forcible voluntary or involuntary emptying of contents of the stomach through the mouth.

GRANDEM 1MG INJECTION 1ML contains an anti-emetic (eases vomiting symptoms) medicine, 'Granisetron', that belongs to the class of 5-HT3 receptor antagonists (also called serotonin receptor antagonists or serotonin blockers). It works by blocking the brain's serotonin (chemical messenger) activity that triggers nausea and vomiting during cancer treatment (chemotherapy or radiation therapy) or after surgery.

GRANDEM 1MG INJECTION 1ML will be administered by a healthcare professional; do not self-administer. Your doctor will decide the dose and duration based on the severity of your medical condition. Common side effects of GRANDEM 1MG INJECTION 1ML include diarrhoea, constipation, stomach pain, weakness, headache, fever, drowsiness, trouble sleeping, pain, redness, and swelling at the injection site. These side effects are not familiar to everyone and vary individually. If you notice any side effects that are not manageable, please consult your doctor.

If you use other prescription or non-prescription medicines, inform your doctor before using GRANDEM 1MG INJECTION 1ML. Let your doctor know if you have any liver, kidney or heart diseases, stomach/intestinal problems, allergic reactions, and low levels of potassium and magnesium in the blood before starting GRANDEM 1MG INJECTION 1ML. This medicine may make you dizzy or drowsy; hence avoid driving or operating machinery if you are not mentally alert. Consult your doctor before using GRANDEM 1MG INJECTION 1ML if you are pregnant, planning for pregnancy or breastfeeding. Avoid consuming alcohol while being treated with GRANDEM 1MG INJECTION 1ML as it could lead to unwanted side effects. 

Uses of GRANDEM 1MG INJECTION 1ML

Nausea and vomiting.

Directions for Use

It will be administered by a healthcare professional; do not self-administer.

Medicinal Benefits

GRANDEM 1MG INJECTION 1ML contains an anti-emetic medicine, 'Granisetron', that treats nausea and vomiting caused due to cancer treatment (chemotherapy or radiation therapy) or after surgery. Granisetron belongs to the class of 5-HT3 receptor antagonists (also called serotonin receptor antagonists or serotonin blockers). When the cells lining the gastrointestinal tract are damaged by chemotherapy or radiation therapy, they release a natural substance called serotonin (5HT3, 5-hydroxytryptamine). This serotonin binds to serotonin receptors on nerves that induces nausea and vomiting. GRANDEM 1MG INJECTION 1ML works by blocking the brain's serotonin activity and preventing postoperative nausea and vomiting. 

Storage

Store in a cool and dry place away from sunlight

Side Effects of GRANDEM 1MG INJECTION 1ML

  • Diarrhoea
  • Constipation
  • Stomach pain
  • Weakness
  • Headache
  • Fever
  • Dizziness
  • Drowsiness
  • Trouble sleeping
  • Pain, redness, and swelling at the injection site

Drug Warnings

Seeking medical advice if you use prescription or non-prescription medicines while being treated with GRANDEM 1MG INJECTION 1ML is suggested. Inform your doctor about a history of stomach/intestinal problems, heart diseases, electrolyte imbalance (potassium, sodium or calcium), and liver or kidney diseases before starting GRANDEM 1MG INJECTION 1ML. Please consult your doctor if you are pregnant or breastfeeding if the doctor advised you GRANDEM 1MG INJECTION 1ML. This medicine may make you feel dizzy, so drive or operate machinery only if you are alert. Avoid consuming alcohol during the course, as it could lead to increased dizziness. GRANDEM 1MG INJECTION 1ML is not recommended in children below two years of age.

Drug-Drug Interactions

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GranisetronMesoridazine
Critical
GranisetronSaquinavir
Critical

Drug-Drug Interactions

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GranisetronMesoridazine
Critical
How does the drug interact with Grandem 1mg Injection 1ml:
Taking Grandem 1mg Injection 1ml with mesoridazine can increase the risk of an irregular heart rhythm. I

How to manage the interaction:
Taking Mesoridazine with Grandem 1mg Injection 1ml is not recommended as it can result in an interaction, it can be taken if a doctor has advised it. However, if you experience abrupt dizziness, lightheadedness, fainting, shortness of breath, or heart palpitations while taking any of these drugs, consult a doctor immediately. Do not discontinue any medications without a doctor's advice.
GranisetronSaquinavir
Critical
How does the drug interact with Grandem 1mg Injection 1ml:
When Grandem 1mg Injection 1ml is taken with Saquinavir, can increase the risk of an irregular heart rhythm.

How to manage the interaction:
Taking Grandem 1mg Injection 1ml with Saquinavir is not recommended as it can result in an interaction, it can be taken if a doctor has advised it. However, if you experience abrupt dizziness, lightheadedness, fainting, shortness of breath, or heart palpitations while taking any of these drugs, consult a doctor immediately. Do not discontinue any medications without a doctor's advice.
GranisetronDronedarone
Critical
How does the drug interact with Grandem 1mg Injection 1ml:
Taking Grandem 1mg Injection 1ml with Dronedarone can increase the risk of irregular heart rhythm.

How to manage the interaction:
Taking Grandem 1mg Injection 1ml with Dronedarone is not recommended as it can result in an interaction, it can be taken if a doctor has advised it. However, if you experience abrupt dizziness, lightheadedness, fainting, shortness of breath, or heart palpitations while taking any of these drugs, consult a doctor immediately. Do not discontinue any medications without a doctor's advice.
GranisetronThioridazine
Critical
How does the drug interact with Grandem 1mg Injection 1ml:
Taking Grandem 1mg Injection 1ml with Thioridazine can increase the risk of an irregular heart rhythm.

How to manage the interaction:
Taking Grandem 1mg Injection 1ml with Thioridazine is not recommended as it can result in an interaction, it can be taken if a doctor has advised it. However, if you experience abrupt dizziness, lightheadedness, fainting, shortness of breath, or heart palpitations while taking any of these drugs, consult a doctor immediately. Do not discontinue any medications without a doctor's advice.
GranisetronZiprasidone
Critical
How does the drug interact with Grandem 1mg Injection 1ml:
Taking Grandem 1mg Injection 1ml with Ziprasidone can increase the risk of abnormal heart rhythm.

How to manage the interaction:
Taking Grandem 1mg Injection 1ml with Ziprasidone is not recommended, as it can result in an interaction, it can be taken if a doctor has advised it. However, if you experience sudden dizziness, lightheadedness, fainting, breathing difficulty, or rapid heartbeat, consult the doctor immediately. Do not stop using any medications without talking to a doctor.
GranisetronCisapride
Critical
How does the drug interact with Grandem 1mg Injection 1ml:
Taking Grandem 1mg Injection 1ml with Cisapride can increase the risk of an irregular heart rhythm.

How to manage the interaction:
Taking Grandem 1mg Injection 1ml with Cisapride is not recommended as it can result in an interaction, it can be taken if a doctor has advised it. However, if you experience abrupt dizziness, lightheadedness, fainting, shortness of breath, or heart palpitations while taking any of these drugs, consult a doctor immediately. Do not discontinue any medications without a doctor's advice.
GranisetronSparfloxacin
Critical
How does the drug interact with Grandem 1mg Injection 1ml:
Taking Grandem 1mg Injection 1ml with Sparfloxacin can increase the chance of a serious abnormal heart rhythm.

How to manage the interaction:
Taking Grandem 1mg Injection 1ml with Sparfloxacin is not recommended as it can result in an interaction, it can be taken if a doctor has advised it. However, if you experience sudden dizziness, lightheadedness, fainting, breathing difficulty, or rapid heartbeat, consult the doctor immediately. Do not stop using any medications without talking to a doctor.
GranisetronPimozide
Critical
How does the drug interact with Grandem 1mg Injection 1ml:
Taking Grandem 1mg Injection 1ml with Pimozide can increase the risk of an irregular heart rhythm.

How to manage the interaction:
Taking Grandem 1mg Injection 1ml with Pimozide is not recommended as it can result in an interaction, it can be taken if a doctor has advised it. However, if you experience abrupt dizziness, lightheadedness, fainting, shortness of breath, or heart palpitations while taking any of these drugs, consult a doctor immediately. Do not stop using any medications without talking to a doctor.
GranisetronDofetilide
Severe
How does the drug interact with Grandem 1mg Injection 1ml:
Taking Grandem 1mg Injection 1ml with dofetilide increases the risk of an abnormal heart rhythm.

How to manage the interaction:
Taking Grandem 1mg Injection 1ml with Dofetilide together can result in an interaction, but it can be taken if a doctor has advised it. However, if you experience abrupt dizziness, lightheadedness, fainting, shortness of breath, or rapid heartbeat, get medical help immediately. Do not discontinue any medications without consulting a doctor.
GranisetronSotalol
Severe
How does the drug interact with Grandem 1mg Injection 1ml:
Taking Sotalol and Grandem 1mg Injection 1ml can increase the risk or severity of irregular heart rhythms.

How to manage the interaction:
Although there is a possible interaction between Sotalol and Grandem 1mg Injection 1ml, you can take these medicines together if prescribed by a doctor. However, consult a doctor immediately if you experience abrupt dizziness, lightheadedness, fainting, shortness of breath, or rapid heartbeat. Do not discontinue any medications without consulting a doctor.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

  • Avoid chocolates, junk food, cheese, processed food, alcohol, and smoking. 
  • You can try increasing your mindfulness by doing yoga, meditation, mindfulness-based cognitive therapy, and stress reduction techniques.
  • Drink enough water to stay hydrated and limit or avoid alcohol and caffeine.
  • Include a diet rich in whole grains, vegetables, and fruits.
  • You can include antioxidants in your daily diet, like ashwagandha, omega-3 fatty acids, green tea, and lemon.
  • Try to spend time with your friends and family. Having a strong social network may help you lower your risk of anxiety.

Habit Forming

No

Therapeutic Class

ANTIEMETICS

GRANDEM 1MG INJECTION 1ML Substitute

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Author Details

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Drug-Diseases Interactions

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No Drug - Disease interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Diseases Interactions

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FAQs

GRANDEM 1MG INJECTION 1ML contains Granisetron, an anti-emetic drug. It is a serotonin blocker that blocks the activity of serotonin, a chemical messenger that induces nausea and vomiting after treatments like chemotherapy and radiation therapy. Thus, GRANDEM 1MG INJECTION 1ML relieves post-operative nausea and vomiting symptoms.

GRANDEM 1MG INJECTION 1ML may cause constipation as one of its side effects. You can avoid it by including high-fibre food in your diet that improves your digestion. Limit the intake of alcohol to manage your constipation.

GRANDEM 1MG INJECTION 1ML should be used with caution if you have recent stomach/intestinal problems like stomach ache, wind, feeling or being sick, difficulty passing stools, heart rhythm disorder, a recent stomach or intestinal surgery, electrolyte imbalance (potassium, sodium or calcium), and liver or kidney diseases.

You are advised to complete the course prescribed by your doctor. Please do not stop taking this medicine unless advised by your doctor since it may lead to recurrent episodes of nausea and vomiting.

Drug-Drug Interactions Checker List

  • FLUOXETINE
  • DULOXETINE
  • AMIODARONE
  • SOTALOL
  • PIMOZIDE
  • ERYTHROMYCIN

Special Advise

  • Let your doctor know you are taking GRANDEM 1MG INJECTION 1ML if you undergo medical tests.
  • Heart function monitoring with an ECG or EKG (electrocardiogram) is recommended in heart patients since GRANDEM 1MG INJECTION 1ML may cause irregular heartbeat and QT prolongation (heart muscle takes longer than normal to recharge between beats).

Disease/Condition Glossary

Nausea is defined as stomach discomfort and the sensation of an urge to vomit. It is a precursor to vomiting. It is not a painful symptom but can cause discomfort in the chest, upper abdomen, or back of the throat. Nausea can be triggered by various factors like motion from a car and plane, taking pills on an empty stomach, eating too much or too little, and drinking excessive amounts of alcohol. 

Vomiting or throwing up is the forcible voluntary or involuntary emptying of contents of the stomach through the mouth. Vomiting can also occur without any underlying diseases like pregnancy, hangovers, overeating, and motion sickness. Nausea or vomiting may be triggered by many factors, including food poisoning, gastritis (inflammation of the stomach lining), an ulcer, or bulimia (eating disorder).

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