apollo
0
Written By Divya L , PharmaD
Reviewed By Sureshvarma D , MPharma
Non returnable*
COD available

Online payment accepted

rxMedicinePrescription drug

Whats That

tooltip

Composition :

GRANISETRON-1MG

Manufacturer/Marketer :

Aristo Pharmaceuticals Pvt Ltd

Consume Type :

ORAL

Return Policy :

Not Returnable

Expires on or after :

About Grandem-1 Tablet

Grandem-1 Tablet belongs to the class of ‘anti-emetic’ drugs, primarily used to treat nausea and vomiting caused by medical treatments, such as chemotherapy or radiation treatment for cancer, etc. Nausea is defined as stomach discomfort and the sensation of an urge to vomit. Vomiting is the forcible voluntary or involuntary emptying of contents of the stomach through the mouth.

Grandem-1 Tablet contains an anti-emetic (eases vomiting symptoms) medicine, 'Granisetron' that belongs to the class of serotonin receptor antagonists or serotonin blockers. It works by blocking the activity of serotonin (chemical messenger) in the brain that triggers nausea and vomiting during cancer treatment (chemotherapy or radiation therapy) or after surgery.

Your doctor will decide the dose and duration based on the severity of your medical condition. Common side effects of Grandem-1 Tablet include diarrhoea, constipation, stomach pain, weakness, headache, fever, dizziness, drowsiness, trouble sleeping , and anxiety. These side effects are not familiar to everyone and vary individually. If you notice any side effects that are not manageable, please consult your doctor.

If you use other prescription or non-prescription medicines, inform your doctor before using Grandem-1 Tablet . Let your doctor know if you have any liver, kidney, or heart diseases, stomach/intestinal problems, allergic reactions , and low levels of potassium and magnesium in the blood before starting Grandem-1 Tablet . Grandem-1 Tablet may make you dizzy or drowsy, hence avoid driving if you are not mentally alert. Consult your doctor before taking Grandem-1 Tablet if you are pregnant, planning for pregnancy, or breastfeeding. Avoid consuming alcohol along with Grandem-1 Tablet as it could lead to increased drowsiness. 

Uses of Grandem-1 Tablet

Nausea and vomiting.

Directions for Use

Tablet/Capsule: Swallow it as a whole with a glass of water, do not chew, crush or break it.Syrup/Liquid: Shake the bottle well before use. Take the prescribed dose by mouth using the measuring cup/dosing syringe/dropper provided by the pack.

Medicinal Benefits

Grandem-1 Tablet contains an anti-emetic drug, 'Granisetron' that treats nausea and vomiting caused due to cancer treatment (chemotherapy or radiation therapy) or after surgery, etc. Granisetron belongs to the class of 5-HT3 receptor antagonists (also called serotonin receptor antagonists or serotonin blockers). When the cells lining the gastrointestinal tract are damaged by chemotherapy or radiation therapy, they release a natural substance called serotonin (5HT3, 5-hydroxytryptamine). This serotonin binds to serotonin receptors on nerves that induces nausea and vomiting. Grandem-1 Tablet works by blocking the activity of serotonin in the brain and preventing post-operative nausea and vomiting.

Storage

Store in a cool and dry place away from sunlight
Side effects of Grandem-1 Tablet
Dealing with Medication-Induced Headache:
  • Hydrate your body: Drink enough water to prevent dehydration and headaches.
  • Calm Your Mind: Deep breathing and meditation can help you relax and relieve stress.
  • Rest and Recharge: Sleep for 7-8 hours to reduce headache triggers.
  • Take rest: lie down in a quiet, dark environment.
  • Cold or warm compresses can help reduce tension.
  • Stay Upright: Maintain good posture to keep symptoms from getting worse.
  • To treat headaches naturally, try acupuncture or massage therapy.
  • Over-the-counter pain relievers include acetaminophen and ibuprofen.
  • Prescription Assistance: Speak with your doctor about more substantial drug alternatives.
  • Severe Headaches: Seek emergency medical assistance for sudden, severe headaches.
  • Frequent Headaches: If you get reoccurring headaches, consult your doctor.
  • Headaches with Symptoms: Seek medical attention if your headaches include fever, disorientation, or weakness.
Here are the 7 steps to manage Dizziness caused by medication:
  • Inform your doctor about dizziness symptoms. They may adjust your medication regimen or prescribe additional medications to manage symptoms.
  • Follow your doctor's instructions for taking medication, and take it at the same time every day to minimize dizziness.
  • When standing up, do so slowly and carefully to avoid sudden dizziness.
  • Avoid making sudden movements, such as turning or bending quickly, which can exacerbate dizziness.
  • Drink plenty of water throughout the day to stay hydrated and help alleviate dizziness symptoms.
  • If you're feeling dizzy, sit or lie down and rest until the dizziness passes.
  • Track when dizziness occurs and any factors that may trigger it, and share this information with your doctor to help manage symptoms.
Overcome Medication-Induced Nausea: A 9-Step Plan
  • Inform your doctor about the nausea and discuss possible alternatives to the medication or adjustments to the dosage.
  • Divide your daily food intake into smaller, more frequent meals to reduce nausea.
  • Opt for bland, easily digestible foods like crackers, toast, plain rice, bananas, and applesauce.
  • Avoid certain foods that can trigger nausea, such as fatty, greasy, spicy, and smelly foods.
  • Drink plenty of fluids, such as water, clear broth, or electrolyte-rich beverages like coconut water or sports drinks.
  • Use ginger (tea, ale, or candies) to help relieve nausea.
  • Get adequate rest and also avoid strenuous activities that can worsen nausea.
  • Talk to your doctor about taking anti-nausea medication if your nausea is severe.
  • Record when your nausea occurs, what triggers it, and what provides relief to help you identify patterns and manage your symptoms more effectively.
Here are the steps to cope with constipation as a side effect of medication:
  • Inform your doctor about your constipation symptoms. They may adjust your medication or advise alternative treatments.
  • Stay hydrated by drinking sufficient of water (at least 8-10 glasses a day) to help soften stool and promote bowel movements.
  • Increase fibre intake by eating foods high in fibre, such as fruits, whole grains, vegetables and legumes, to help bulk up the stool.
  • Establish a bowel routine by trying to go to the bathroom at the same time each day to train your bowels.
  • Engaging in regular exercise, like walking or yoga, can support in bowel movement stimulation.
  • Consult your doctor if constipation persists, and discuss alternative treatments or adjustments to your medication.
To prevent, manage, and treat Constipation caused by medication usage, follow these steps:
  • Preventing Vomiting (Before it Happens)
  • Take medication exactly as prescribed by your doctor. This can help minimize side effects, including vomiting.
  • Having a small meal before taking your medication can help reduce nausea and vomiting.
  • Talk to your doctor about taking anti-nausea medication along with your prescribed medication.
  • Managing Vomiting (If it Happens)
  • Try taking ginger in the form of tea, ale, or candy to help alleviate nausea and vomiting.
  • What to Do if Vomiting Persists
  • Consult your doctor if vomiting continues or worsens, consult the doctor for guidance on adjusting your medication or additional treatment.
  • Rest well; get enough sleep.
  • Eat a balanced diet and drink enough water.
  • Manage stress with yoga and meditation.
  • Limit alcohol and caffeine.
  • Physical activities like walking or jogging might help boost energy and make you feel less tired.
  • Drink water or other clear fluids.
  • To prevent worsening of pain, limit intake of tea, coffee, or alcohol.
  • Include bland foods like rice, toast, crackers, and rice in your diet.
  • Avoid lying down immediately after eating as it may cause indigestion or heartburn.
  • Avoid acidic and spicy food as it may cause indigestion.

Drug Warnings

Grandem-1 Tablet may cause serotonin syndrome/toxicity when used with other drugs like ecstasy (MDMA) and antidepressants. Hence it is suggested to seek medical advice if you are using any prescription or non-prescription medicines. Inform your doctor if you have a history of stomach/intestinal problems like stomach ache, wind, feeling or being sick, and difficulty passing stools, heart problems, electrolyte imbalance (potassium, sodium or calcium), and liver or kidney diseases before starting Grandem-1 Tablet . Please consult your doctor if you are pregnant or breastfeeding if the doctor has advised you Grandem-1 Tablet . Grandem-1 Tablet may make you feel dizzy, so drive only if you are alert. Avoid consuming alcohol as it could lead to increased dizziness. Grandem-1 Tablet is not recommended in children below two years of age.

Drug-Drug Interactions

verifiedApollotooltip
GranisetronThioridazine
Critical
GranisetronPimozide
Critical

Drug-Drug Interactions

Login/Sign Up

GranisetronThioridazine
Critical
How does the drug interact with Grandem-1 Tablet:
Taking Grandem-1 Tablet with Thioridazine can increase the risk of an irregular heart rhythm.

How to manage the interaction:
Taking Grandem-1 Tablet with Thioridazine is not recommended as it can result in an interaction, it can be taken if a doctor has advised it. However, if you experience abrupt dizziness, lightheadedness, fainting, shortness of breath, or heart palpitations while taking any of these drugs, consult a doctor immediately. Do not discontinue any medications without a doctor's advice.
GranisetronPimozide
Critical
How does the drug interact with Grandem-1 Tablet:
Taking Grandem-1 Tablet with Pimozide can increase the risk of an irregular heart rhythm.

How to manage the interaction:
Taking Grandem-1 Tablet with Pimozide is not recommended as it can result in an interaction, it can be taken if a doctor has advised it. However, if you experience abrupt dizziness, lightheadedness, fainting, shortness of breath, or heart palpitations while taking any of these drugs, consult a doctor immediately. Do not stop using any medications without talking to a doctor.
GranisetronZiprasidone
Critical
How does the drug interact with Grandem-1 Tablet:
Taking Grandem-1 Tablet with Ziprasidone can increase the risk of abnormal heart rhythm.

How to manage the interaction:
Taking Grandem-1 Tablet with Ziprasidone is not recommended, as it can result in an interaction, it can be taken if a doctor has advised it. However, if you experience sudden dizziness, lightheadedness, fainting, breathing difficulty, or rapid heartbeat, consult the doctor immediately. Do not stop using any medications without talking to a doctor.
GranisetronSaquinavir
Critical
How does the drug interact with Grandem-1 Tablet:
When Grandem-1 Tablet is taken with Saquinavir, can increase the risk of an irregular heart rhythm.

How to manage the interaction:
Taking Grandem-1 Tablet with Saquinavir is not recommended as it can result in an interaction, it can be taken if a doctor has advised it. However, if you experience abrupt dizziness, lightheadedness, fainting, shortness of breath, or heart palpitations while taking any of these drugs, consult a doctor immediately. Do not discontinue any medications without a doctor's advice.
GranisetronSparfloxacin
Critical
How does the drug interact with Grandem-1 Tablet:
Taking Grandem-1 Tablet with Sparfloxacin can increase the chance of a serious abnormal heart rhythm.

How to manage the interaction:
Taking Grandem-1 Tablet with Sparfloxacin is not recommended as it can result in an interaction, it can be taken if a doctor has advised it. However, if you experience sudden dizziness, lightheadedness, fainting, breathing difficulty, or rapid heartbeat, consult the doctor immediately. Do not stop using any medications without talking to a doctor.
GranisetronDronedarone
Critical
How does the drug interact with Grandem-1 Tablet:
Taking Grandem-1 Tablet with Dronedarone can increase the risk of irregular heart rhythm.

How to manage the interaction:
Taking Grandem-1 Tablet with Dronedarone is not recommended as it can result in an interaction, it can be taken if a doctor has advised it. However, if you experience abrupt dizziness, lightheadedness, fainting, shortness of breath, or heart palpitations while taking any of these drugs, consult a doctor immediately. Do not discontinue any medications without a doctor's advice.
GranisetronMesoridazine
Critical
How does the drug interact with Grandem-1 Tablet:
Taking Grandem-1 Tablet with mesoridazine can increase the risk of an irregular heart rhythm. I

How to manage the interaction:
Taking Mesoridazine with Grandem-1 Tablet is not recommended as it can result in an interaction, it can be taken if a doctor has advised it. However, if you experience abrupt dizziness, lightheadedness, fainting, shortness of breath, or heart palpitations while taking any of these drugs, consult a doctor immediately. Do not discontinue any medications without a doctor's advice.
GranisetronCisapride
Critical
How does the drug interact with Grandem-1 Tablet:
Taking Grandem-1 Tablet with Cisapride can increase the risk of an irregular heart rhythm.

How to manage the interaction:
Taking Grandem-1 Tablet with Cisapride is not recommended as it can result in an interaction, it can be taken if a doctor has advised it. However, if you experience abrupt dizziness, lightheadedness, fainting, shortness of breath, or heart palpitations while taking any of these drugs, consult a doctor immediately. Do not discontinue any medications without a doctor's advice.
GranisetronGatifloxacin
Severe
How does the drug interact with Grandem-1 Tablet:
Taking Grandem-1 Tablet and Gatifloxacin can increase the chance of a serious abnormal heart rhythm.

How to manage the interaction:
Taking Grandem-1 Tablet and Gatifloxacin together can result in an interaction, it can be taken if a doctor has advised it. However, contact a doctor immediately if you experience sudden dizziness, lightheadedness, fainting, shortness of breath, chest pain or tightness, rapid heartbeat, or memory loss. Do not discontinue any medications without consulting a doctor.
GranisetronTryptophan
Severe
How does the drug interact with Grandem-1 Tablet:
When Grandem-1 Tablet is taken with tryptophan, can increase the risk of serotonin syndrome (condition in which a chemical called serotonin increase in body).

How to manage the interaction:
There may be a possibility of interaction between Grandem-1 Tablet and Tryptophan, but it can be taken if prescribed by a doctor. However, if you experience any of the following symptoms: confusion, hallucination, seizure, extreme changes in blood pressure, increased heart rate, fever, excessive sweating, shivering or shaking, blurred vision, muscle spasm or stiffness, tremor, incoordination, stomach cramp, nausea, vomiting, and diarrhoea, consult a doctor. Do not discontinue any medications without consulting a doctor

Drug-Food Interactions

verifiedApollotooltip
No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

Login/Sign Up

Diet & Lifestyle Advise

  • Avoid chocolates, junk food, cheese, processed food, alcohol and smoking.
  • You can try increasing your mindfulness by doing yoga, meditation, mindfulness-based cognitive therapy and stress reduction techniques.
  • Drink enough water to stay hydrated and limit or avoid alcohol and caffeine.
  • Include a diet rich in whole grains, vegetables and fruits. This is a healthier option than eating a lot of simple carbohydrates found in processed foods.
  • You can include antioxidants in your daily diet like ashwagandha, omega-3 fatty acids, green tea and lemon balm.
  • Try to spend time with your friends and family. Having a strong social network may help you lower your risk of anxiety.

Habit Forming

No

Therapeutic Class

ANTIEMETICS

Grandem-1 Tablet Substitute

Substitutes safety advice
  • Grandem MD Tablet 10's

    by AYUR

    10.35per tablet
  • Graniforce -MD Tablet 10's

    by Others

    9.23per tablet
  • Granicip 1 DT Tablet 4's

    by Others

    24.42per tablet
  • Avogran 1mg Tablet DT

    by Others

    17.31per tablet
  • Cadigran 1mg Tablet

    by Others

    19.47per tablet

Author Details

Doctor imageWe provide you with authentic, trustworthy and relevant information

Drug-Diseases Interactions

verifiedApollotooltip
No Drug - Disease interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Diseases Interactions

Login/Sign Up

FAQs

Grandem-1 Tablet contains Granisetron, an anti-emetic drug. It is a serotonin blocker that blocks the activity of serotonin, a chemical messenger that induces nausea and vomiting after treatments like chemotherapy and radiation therapy. Thus, Grandem-1 Tablet relieves from post-operative nausea and vomiting symptoms.

Grandem-1 Tablet may cause constipation as one of its side effects. You can avoid it by including high fibre food in your diet that improves your digestion. Limit the intake of alcohol to manage your constipation.

Grandem-1 Tablet should be used with caution if you have recent stomach/intestinal problems like stomach ache, wind, feeling or being sick or difficulty passing stools, heart problems, electrolyte imbalance (potassium, sodium or calcium), and liver or kidney diseases.

You are advised to complete the course prescribed by your doctor. Please do not stop taking this medicine unless advised by your doctor since it may lead to recurrent episodes of nausea and vomiting.

Take Grandem-1 Tablet as soon as possible. However, if it is time for the next dose, skip the missed dose and go back to your regular dosing schedule. Do not double the dose.

Drug-Drug Interactions Checker List

  • LITHIUM
  • DULOXETINE
  • AMIODARONE
  • QUINIDINE
  • RITONAVIR
  • ERYTHROMYCIN

Special Advise

Let your doctor know that you are taking Grandem-1 Tablet if you are undergoing any medical tests.

Disease/Condition Glossary

Nausea is defined as stomach discomfort and the sensation of an urge to vomit. It is a precursor to vomiting. It is not a painful symptom but can cause discomfort in the chest, upper abdomen or back of the throat. Nausea can be triggered by various factors like motion from a car and plane, taking pills on an empty stomach, eating too much or too little and drinking excessive amounts of alcohol.

Vomiting or throwing up is the forcible voluntary or involuntary emptying of the stomach contents through the mouth. Vomiting can also occur without having any underlying diseases in conditions like pregnancy, hangover, overeating and motion sickness. Nausea or vomiting may be triggered by many factors, including food poisoning, gastritis (inflammation of the stomach lining), an ulcer or bulimia (eating disorder).

Have a query?

whatsapp Floating Button
Buy Now
Add to Cart