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Prescription drugWhats That
Synonym :
GLIMEPIRIDE+METFORMIN HYDROCHLORIDE
Composition :
GLIMEPIRIDE-2MG + METFORMIN-500MG
Manufacturer/Marketer :
Hicxica Formulations Pvt Ltd
Consume Type :
ORAL
Return Policy :
Not Returnable
Expires on or after :
Drug-Drug Interactions
GlimepirideGrepafloxacin
Severe
GlimepirideOfloxacin
Severe
Drug-Drug Interactions
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GlimepirideGrepafloxacin
Severe
How does the drug interact with Hexaglim-M2 Tablet:
Co-administration of Hexaglim-M2 Tablet with Grepafloxacin can sometimes affect blood glucose levels. Both hyperglycemia (high blood glucose) and, less frequently, hypoglycemia (low blood glucose) have been reported.
How to manage the interaction:
Although there is a possible interaction between Hexaglim-M2 Tablet and Grepafloxacin, you can take these medicines together if prescribed by a doctor. If you experience any of these symptoms - low blood sugar, headache, dizziness, sleepiness, confusion, shaking, feeling hungry, weak, heart racing, high blood sugar, low blood sugar, serious infections, bleeding, feeling anxious, feeling sick or very thirsty - make sure to call a doctor right away. Do not stop using any medications without talking to a doctor.
Co-administration of Hexaglim-M2 Tablet with Grepafloxacin can sometimes affect blood glucose levels. Both hyperglycemia (high blood glucose) and, less frequently, hypoglycemia (low blood glucose) have been reported.
How to manage the interaction:
Although there is a possible interaction between Hexaglim-M2 Tablet and Grepafloxacin, you can take these medicines together if prescribed by a doctor. If you experience any of these symptoms - low blood sugar, headache, dizziness, sleepiness, confusion, shaking, feeling hungry, weak, heart racing, high blood sugar, low blood sugar, serious infections, bleeding, feeling anxious, feeling sick or very thirsty - make sure to call a doctor right away. Do not stop using any medications without talking to a doctor.
GlimepirideOfloxacin
Severe
How does the drug interact with Hexaglim-M2 Tablet:
Co-administration of Ofloxacin and Hexaglim-M2 Tablet can sometimes have an effect on blood glucose levels.
How to manage the interaction:
Although combining Ofloxacin and Hexaglim-M2 Tablet can lead to an interaction, they can be taken on a doctor's advice. If you experience any symptoms of hypoglycemia (headache, dizziness, sleepiness, nervousness, confusion, shaking, nausea, hunger, weakness, sweat, palpitation, and rapid heartbeat) or hyperglycemia (increased thirst, hunger, and urination), consult a doctor. Keep an eye on your blood glucose level. Do not discontinue any medications without consulting a doctor.
Co-administration of Ofloxacin and Hexaglim-M2 Tablet can sometimes have an effect on blood glucose levels.
How to manage the interaction:
Although combining Ofloxacin and Hexaglim-M2 Tablet can lead to an interaction, they can be taken on a doctor's advice. If you experience any symptoms of hypoglycemia (headache, dizziness, sleepiness, nervousness, confusion, shaking, nausea, hunger, weakness, sweat, palpitation, and rapid heartbeat) or hyperglycemia (increased thirst, hunger, and urination), consult a doctor. Keep an eye on your blood glucose level. Do not discontinue any medications without consulting a doctor.
GlimepirideVoriconazole
Severe
How does the drug interact with Hexaglim-M2 Tablet:
Co-administration of Hexaglim-M2 Tablet with Voriconazole may increase the blood levels and effects of Hexaglim-M2 Tablet.
How to manage the interaction:
Although there is a possible interaction, Hexaglim-M2 Tablet can be taken with voriconazole if prescribed by the doctor. Consult the prescriber if you experience headache, dizziness, and rapid heartbeat. Do not discontinue the medications without consulting a doctor.
Co-administration of Hexaglim-M2 Tablet with Voriconazole may increase the blood levels and effects of Hexaglim-M2 Tablet.
How to manage the interaction:
Although there is a possible interaction, Hexaglim-M2 Tablet can be taken with voriconazole if prescribed by the doctor. Consult the prescriber if you experience headache, dizziness, and rapid heartbeat. Do not discontinue the medications without consulting a doctor.
GlimepirideMoxifloxacin
Severe
How does the drug interact with Hexaglim-M2 Tablet:
Co-administration of Moxifloxacin can affect blood glucose levels. Both high blood glucose and low blood glucose.
How to manage the interaction:
Although there is a possible interaction, Hexaglim-M2 Tablet can be taken with Moxifloxacin if prescribed by the doctor. Consult the doctor if you experience headache, dizziness, rapid heartbeat, increased thirst, and increased urination. Do not discontinue the medications without consulting a doctor.
Co-administration of Moxifloxacin can affect blood glucose levels. Both high blood glucose and low blood glucose.
How to manage the interaction:
Although there is a possible interaction, Hexaglim-M2 Tablet can be taken with Moxifloxacin if prescribed by the doctor. Consult the doctor if you experience headache, dizziness, rapid heartbeat, increased thirst, and increased urination. Do not discontinue the medications without consulting a doctor.
GlimepirideNorfloxacin
Severe
How does the drug interact with Hexaglim-M2 Tablet:
Co-administration of Norfloxacin with Hexaglim-M2 Tablet may sometimes affect blood glucose levels. Both high blood glucose and, less frequently, low blood glucose have been reported.
How to manage the interaction:
Although there is a possible interaction, Hexaglim-M2 Tablet can be taken with norfloxacin if prescribed by the doctor. Consult the prescriber if you experience symptoms such as nervousness, confusion, headache, dizziness, drowsiness, tremors, nausea, hunger, weakness, perspiration, palpitation, rapid heartbeat, increased urination, increased thirst, and increased hunger. Maintaining blood glucose levels is advised. Do not discontinue any medications without consulting a doctor.
Co-administration of Norfloxacin with Hexaglim-M2 Tablet may sometimes affect blood glucose levels. Both high blood glucose and, less frequently, low blood glucose have been reported.
How to manage the interaction:
Although there is a possible interaction, Hexaglim-M2 Tablet can be taken with norfloxacin if prescribed by the doctor. Consult the prescriber if you experience symptoms such as nervousness, confusion, headache, dizziness, drowsiness, tremors, nausea, hunger, weakness, perspiration, palpitation, rapid heartbeat, increased urination, increased thirst, and increased hunger. Maintaining blood glucose levels is advised. Do not discontinue any medications without consulting a doctor.
GlimepirideCiprofloxacin
Severe
How does the drug interact with Hexaglim-M2 Tablet:
Taking ciprofloxacin with Hexaglim-M2 Tablet can cause both hyperglycemia (high blood sugar) and, less frequently, hypoglycemia (low blood sugar).
How to manage the interaction:
Although taking ciprofloxacin and Hexaglim-M2 Tablet together can possibly result in an interaction, it can be taken if your doctor has prescribed it. However, consult the doctor if you experience such as headache, dizziness, drowsiness, nervousness, confusion, tremor, nausea, hunger, weakness, excessive sweating, and rapid heartbeat or increased thirst, increased hunger, and increased urination. Do not discontinue the medications without consulting a doctor.
Taking ciprofloxacin with Hexaglim-M2 Tablet can cause both hyperglycemia (high blood sugar) and, less frequently, hypoglycemia (low blood sugar).
How to manage the interaction:
Although taking ciprofloxacin and Hexaglim-M2 Tablet together can possibly result in an interaction, it can be taken if your doctor has prescribed it. However, consult the doctor if you experience such as headache, dizziness, drowsiness, nervousness, confusion, tremor, nausea, hunger, weakness, excessive sweating, and rapid heartbeat or increased thirst, increased hunger, and increased urination. Do not discontinue the medications without consulting a doctor.
GlimepirideFluconazole
Severe
How does the drug interact with Hexaglim-M2 Tablet:
Co-administration of Fluconazole may increase the blood levels and effects of Hexaglim-M2 Tablet may cause low blood glucose.
How to manage the interaction:
Although there is a possible interaction, Hexaglim-M2 Tablet can be taken with fluconazole if prescribed by the doctor. Consult the prescriber if you experience symptoms of low blood sugar like headache, dizziness, drowsiness, nervousness, confusion, tremor, nausea, hunger, weakness, perspiration, palpitation, and rapid heartbeat. Monitoring of blood glucose levels is advised. Do not discontinue the medications without consulting a doctor.
Co-administration of Fluconazole may increase the blood levels and effects of Hexaglim-M2 Tablet may cause low blood glucose.
How to manage the interaction:
Although there is a possible interaction, Hexaglim-M2 Tablet can be taken with fluconazole if prescribed by the doctor. Consult the prescriber if you experience symptoms of low blood sugar like headache, dizziness, drowsiness, nervousness, confusion, tremor, nausea, hunger, weakness, perspiration, palpitation, and rapid heartbeat. Monitoring of blood glucose levels is advised. Do not discontinue the medications without consulting a doctor.
GlimepirideBumetanide
Severe
How does the drug interact with Hexaglim-M2 Tablet:
Bumetanide may interfere with blood glucose control and reduce the effectiveness of Hexaglim-M2 Tablet.
How to manage the interaction:
Although there is a possible interaction, Hexaglim-M2 Tablet can be taken with bumetanide if prescribed by the doctor. Monitoring of blood glucose levels is advised.
Bumetanide may interfere with blood glucose control and reduce the effectiveness of Hexaglim-M2 Tablet.
How to manage the interaction:
Although there is a possible interaction, Hexaglim-M2 Tablet can be taken with bumetanide if prescribed by the doctor. Monitoring of blood glucose levels is advised.
GlimepirideLevofloxacin
Severe
How does the drug interact with Hexaglim-M2 Tablet:
Co-administration of Hexaglim-M2 Tablet with Levofloxacin can affect blood glucose levels. Both hyperglycemia (high blood glucose) and, less frequently, hypoglycemia (low blood glucose) have been reported.
How to manage the interaction:
Co-administration of Levofloxacin with Hexaglim-M2 Tablet can result in an interaction, it can be taken if a doctor has advised it. Consult the prescriber if you experience dizziness, drowsiness, headache, nervousness, confusion, tremors, nausea, hunger, weakness, perspiration, palpitation, and rapid heartbeat, increased urination, increased thirst, or increased hunger. Monitoring of blood glucose levels is advised. Do not discontinue the medications without consulting a doctor.
Co-administration of Hexaglim-M2 Tablet with Levofloxacin can affect blood glucose levels. Both hyperglycemia (high blood glucose) and, less frequently, hypoglycemia (low blood glucose) have been reported.
How to manage the interaction:
Co-administration of Levofloxacin with Hexaglim-M2 Tablet can result in an interaction, it can be taken if a doctor has advised it. Consult the prescriber if you experience dizziness, drowsiness, headache, nervousness, confusion, tremors, nausea, hunger, weakness, perspiration, palpitation, and rapid heartbeat, increased urination, increased thirst, or increased hunger. Monitoring of blood glucose levels is advised. Do not discontinue the medications without consulting a doctor.
GlimepirideSunitinib
Severe
How does the drug interact with Hexaglim-M2 Tablet:
Taking Hexaglim-M2 Tablet with sunitinib may increase the risk of low blood sugar.
How to manage the interaction:
Although there is a possible interaction, Hexaglim-M2 Tablet can be taken with sunitinib if prescribed by the doctor. Consult the prescriber if you experience symptoms if low blood sugar such as headache, dizziness, drowsiness, nervousness, confusion, tremor, nausea, hunger, weakness, perspiration, palpitation, and rapid heartbeat. Do not discontinue the medications without consulting a doctor.
Taking Hexaglim-M2 Tablet with sunitinib may increase the risk of low blood sugar.
How to manage the interaction:
Although there is a possible interaction, Hexaglim-M2 Tablet can be taken with sunitinib if prescribed by the doctor. Consult the prescriber if you experience symptoms if low blood sugar such as headache, dizziness, drowsiness, nervousness, confusion, tremor, nausea, hunger, weakness, perspiration, palpitation, and rapid heartbeat. Do not discontinue the medications without consulting a doctor.
Drug-Food Interactions
No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.
Drug-Food Interactions
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Hexaglim-M2 Tablet Substitute
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Product Substitutes
Author Details
Drug-Diseases Interactions
GLIMEPIRIDE-2MG+METFORMIN-500MGHypertensive heart and renal disease
Severe
GLIMEPIRIDE-2MG+METFORMIN-500MGUnspecified kidney failure
Severe
Drug-Diseases Interactions
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GLIMEPIRIDE-2MG+METFORMIN-500MGHypertensive heart and renal disease
Severe
How does the disease interact with Hexaglim-M2 Tablet:
When compared to diet alone or diet plus insulin, the use of oral hypoglycemic medications may be associated with an increased risk of cardiovascular mortality. This alert is based on the University Group Diabetes Programme (UGDP) project, a long-term prospective clinical investigation aimed to assess the efficacy of glucose-lowering medications in preventing or delaying vascular problems in non-insulin-dependent diabetes patients. Patients treated for 5 to 8 years with diet with a fixed dose of either tolbutamide (a sulfonylurea) or phenformin (a biguanide) had a cardiovascular death risk nearly 2.5 times that of patients treated with diet alone, resulting in the cessation of both therapies in the research. Regardless of how these findings are interpreted, doctors and patients should be aware of the possibility.
How to manage the interaction:
The use of oral hypoglycemic agents may be associated with an increased risk of heart problems. Let the doctor know if you have heart problems.
When compared to diet alone or diet plus insulin, the use of oral hypoglycemic medications may be associated with an increased risk of cardiovascular mortality. This alert is based on the University Group Diabetes Programme (UGDP) project, a long-term prospective clinical investigation aimed to assess the efficacy of glucose-lowering medications in preventing or delaying vascular problems in non-insulin-dependent diabetes patients. Patients treated for 5 to 8 years with diet with a fixed dose of either tolbutamide (a sulfonylurea) or phenformin (a biguanide) had a cardiovascular death risk nearly 2.5 times that of patients treated with diet alone, resulting in the cessation of both therapies in the research. Regardless of how these findings are interpreted, doctors and patients should be aware of the possibility.
How to manage the interaction:
The use of oral hypoglycemic agents may be associated with an increased risk of heart problems. Let the doctor know if you have heart problems.
GLIMEPIRIDE-2MG+METFORMIN-500MGUnspecified kidney failure
Severe
How does the disease interact with Hexaglim-M2 Tablet:
Sulfonylureas are metabolised in the liver and eliminated in the urine and faeces as metabolites (some of which have pharmacologic activity). Patients with poor liver and/or renal function who are treated with sulfonylureas may be exposed to increased serum drug concentrations, increasing the risk of severe hypoglycemia episodes. In the context of hepatic impairment, gluconeogenic ability may be reduced, adding to the risk. Sulfonylurea therapy should be used with caution in people who have liver or kidney illness. It is possible that lower dosages and longer intervals between dosage adjustments will be required. If hypoglycemia occurs during treatment, it may be prolonged in these patients due to slower medication metabolism and/or excretion.
How to manage the interaction:
In patients with kidney problems, severe hypoglycemic episodes may occur. Therapy should be administered cautiously in patients with renal disease.
Sulfonylureas are metabolised in the liver and eliminated in the urine and faeces as metabolites (some of which have pharmacologic activity). Patients with poor liver and/or renal function who are treated with sulfonylureas may be exposed to increased serum drug concentrations, increasing the risk of severe hypoglycemia episodes. In the context of hepatic impairment, gluconeogenic ability may be reduced, adding to the risk. Sulfonylurea therapy should be used with caution in people who have liver or kidney illness. It is possible that lower dosages and longer intervals between dosage adjustments will be required. If hypoglycemia occurs during treatment, it may be prolonged in these patients due to slower medication metabolism and/or excretion.
How to manage the interaction:
In patients with kidney problems, severe hypoglycemic episodes may occur. Therapy should be administered cautiously in patients with renal disease.
GLIMEPIRIDE-2MG+METFORMIN-500MGOther disorders of adrenal gland
Moderate
How does the disease interact with Hexaglim-M2 Tablet:
Hypoglycemia is a common side effect of insulin and/or oral hypoglycemic medications. Patients who are debilitated or malnourished, those with defective counterregulatory mechanisms (e.g., autonomic neuropathy and adrenal or pituitary insufficiency), and those receiving beta-adrenergic blocking agents should exercise caution when using these drugs.
How to manage the interaction:
Care should be taken in patients who may be particularly susceptible to the development of hypoglycemic episodes during treatment.
Hypoglycemia is a common side effect of insulin and/or oral hypoglycemic medications. Patients who are debilitated or malnourished, those with defective counterregulatory mechanisms (e.g., autonomic neuropathy and adrenal or pituitary insufficiency), and those receiving beta-adrenergic blocking agents should exercise caution when using these drugs.
How to manage the interaction:
Care should be taken in patients who may be particularly susceptible to the development of hypoglycemic episodes during treatment.
GLIMEPIRIDE-2MG+METFORMIN-500MGAnaemia due to enzyme disorders
Moderate
How does the disease interact with Hexaglim-M2 Tablet:
In patients with glucose 6-phosphate dehydrogenase (G6PD) impairment, sulfonylureas can cause hemolytic anaemia. In individuals with G6PD deficiency, these medicines should be administered with caution, and a non-sulfonylurea option should be considered. Postmarketing reports of hemolytic anaemia in patients receiving these medications who did not have known G6PD deficiency have been received.
How to manage the interaction:
Therapy should be used with caution in patients with glucose 6-phosphate dehydrogenase (G6PD) deficiency. The use of a non-sulfonylurea alternative should be considered.
In patients with glucose 6-phosphate dehydrogenase (G6PD) impairment, sulfonylureas can cause hemolytic anaemia. In individuals with G6PD deficiency, these medicines should be administered with caution, and a non-sulfonylurea option should be considered. Postmarketing reports of hemolytic anaemia in patients receiving these medications who did not have known G6PD deficiency have been received.
How to manage the interaction:
Therapy should be used with caution in patients with glucose 6-phosphate dehydrogenase (G6PD) deficiency. The use of a non-sulfonylurea alternative should be considered.
GLIMEPIRIDE-2MG+METFORMIN-500MGOther disorders of fluid, electrolyte and acid-base balance
Moderate
How does the disease interact with Hexaglim-M2 Tablet:
Treatment with sulfonylureas may cause hyponatremia in individuals who are taking other drugs or have medical disorders that cause hyponatremia, or it may stimulate the secretion of antidiuretic hormone. Certain sulfonylureas have been linked to the syndrome of inappropriate antidiuretic hormone (SIADH) secretion, and these medications may enhance the peripheral (antidiuretic) action of ADH and/or increase ADH release. Caution should be exercised when treating individuals who have hyponatremia or are at increased risk of developing hyponatremia, such as the elderly, those using diuretics, or those who are volume-depleted.
How to manage the interaction:
Caution should be used when treating patients with low sodium or at greater risk of developing low sodium such as elderly patients, patients taking diuretics or those who are volume-depleted.
Treatment with sulfonylureas may cause hyponatremia in individuals who are taking other drugs or have medical disorders that cause hyponatremia, or it may stimulate the secretion of antidiuretic hormone. Certain sulfonylureas have been linked to the syndrome of inappropriate antidiuretic hormone (SIADH) secretion, and these medications may enhance the peripheral (antidiuretic) action of ADH and/or increase ADH release. Caution should be exercised when treating individuals who have hyponatremia or are at increased risk of developing hyponatremia, such as the elderly, those using diuretics, or those who are volume-depleted.
How to manage the interaction:
Caution should be used when treating patients with low sodium or at greater risk of developing low sodium such as elderly patients, patients taking diuretics or those who are volume-depleted.
