I-Don Injection belongs to a class of drugs called antiemetics used to prevent nausea and vomiting during chemotherapy. Nausea is a feeling of uneasiness of the stomach that often comes before vomiting. On the other hand, vomiting is the forcible voluntary or involuntary emptying of stomach contents through the mouth.

I-Don Injection contains Ondansetron which works by blocking the action of serotonin, a chemical that stimulates the vomiting centre (chemoreceptor trigger zone – CTZ) located in the brain. Thus, it prevents nausea and vomiting. 

I-Don Injection will be administered by a healthcare professional. Do not self-administer. In some cases, I-Don Injection may cause headache, constipation, a feeling of warmth or flushing, redness, and irritation at the site of injection. Most of these side effects of I-Don Injection do not require medical attention and gradually resolve over time. However, if the side effects persist or worsen, please consult your doctor. 

If you are allergic to Ondansetron, Palanosetron, Granisetron, or any other medicines, please tell your doctor. I-Don Injection should be given to children only in doses advised by the doctor based on the child’s body weight or body surface area. If you are pregnant or breastfeeding, must inform your doctor before receiving I-Don Injection.

I-Don Injection contains Ondansetron that blocks the action of serotonin, a chemical that stimulates the vomiting centre (chemoreceptor trigger zone – CTZ) located in the brain. Thus, it prevents nausea and vomiting caused by chemotherapy in adults and children and also after surgery. Additionally, I-Don Injection can be used to prevent nausea and vomiting caused by radiotherapy for cancer in adults.

• Headache
• Constipation
• A feeling of warmth or flushing
• Redness and irritation at the site of injection

If you are allergic to Ondansetron, Palanosetron, Granisetron, or any other medicines, please tell your doctor. I-Don Injection should be given to children only in doses as advised by the doctor based on the child’s body weight or body surface area. I-Don Injection should be used during pregnancy or breastfeeding after consultation with a doctor. If you have problems with levels of sodium, magnesium, and potassium salts in your blood, inform your doctor before taking I-Don Injection. 

Drug-Drug Interaction: I-Don Injection may interact with anticonvulsants (phenytoin, carbamazepine), antituberculosis drug (rifampicin), antibiotics (erythromycin), antifungal (ketoconazole), narcotic analgesics (tramadol, methadone), beta-blockers, anti-arrhythmic medicines, antidepressants (citalopram, fluoxetine, fluvoxamine, paroxetine, sertraline, escitalopram, duloxetine, venlafaxine), chemotherapy drugs (anthracyclines, trastuzumab) and antipsychotic (haloperidol).

Drug-Food Interaction: No interactions found.

Drug-Disease Interaction: If you have a blockage in the gut, liver or heart problems, imbalance of potassium, sodium and magnesium in the blood, inform your doctor before taking I-Don Injection.

• PHENYTOIN
• CARBAMAZEPINE
• RIFAMPICIN
• ERYTHROMYCIN
• KETOCONAZOLE
• TRAMADOL
• CITALOPRAM
• FLUOXETINE
• FLUVOXAMINE
• PAROXETINE
• SERTRALINE
• ESCITALOPRAM
• DULOXETINE
• VENLAFAXINE
• HALOPERIDOL

• Eat a healthy and a low-fat diet, especially in small portions, as it will be easy for digestion. Avoid eating over-sweet food and include more salty food, especially if you have been vomiting.
• Drink any other liquid at least 30 minutes after eating food. 
• If the smell of food makes you feel sick (vomit), do not cook food as it may worsen your condition. Let someone else do the cooking or use prepared food from the freezer.

Nausea and vomiting: Nausea is a feeling of uneasiness of the stomach that often comes before vomiting. On the other hand, vomiting is the forcible voluntary or involuntary emptying of stomach contents through the mouth. In short, nausea and vomiting are not diseases but are symptoms of many conditions like infections, motion sickness, an early stage of pregnancy, and gastroparesis (slow stomach emptying). A receptor located in the brain known as the chemoreceptor trigger zone (CTZ) controls vomiting.