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Written By Santoshini Reddy G , M Pharmacy
Reviewed By Hari Kumar , MBBS
Non returnable*
COD available

Online payment accepted

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Manufacturer/Marketer

Gufic Bioscience Ltd

Consume Type

PARENTERAL

Return Policy

Not Returnable

Expires on or after

Jan-27

for this medicine

About Imefic Plus 1 gm Injection

Imefic Plus 1 gm Injection is used to treat severe bacterial infections of the lungs, heart, bladder, skin, kidneys, bones, joints, blood, stomach and female reproductive organs. Imefic Plus 1 gm Injection may also be used in the management of patients with low white blood cell count who have a fever, which is suspected to be due to bacterial infection. Bacterial infections are caused due to the multiplication of harmful bacteria inside or on the body. Imefic Plus 1 gm Injection does not work against infections caused by the virus, including cold and flu. 
 
Imefic Plus 1 gm Injection is a combination of two drugs, namely: Cilastatin (dehydropeptidase inhibitor) and Imipenem (antibacterial). Cilastatin inhibits the dehydropeptidase enzyme, which causes the breakdown of Imipenem, thereby helps imipenem to stay active for a longer duration. Imipenem prevents the formation of the bacterial protective covering, which is necessary for the survival of the bacteria. Together, Imefic Plus 1 gm Injection helps to treat bacterial infections.
 
Imefic Plus 1 gm Injection will be administered by a healthcare professional; do not self-administer. In some cases, Imefic Plus 1 gm Injection may cause common side effects such as nausea, vomiting, diarrhoea, swelling, and redness at the site of injection. Most of these side effects do not require medical attention and will resolve gradually over time. However, you are advised to talk to your doctor if you experience these side effects persistently.
 
Consult your doctor if you are pregnant or breastfeeding. Imefic Plus 1 gm Injection may cause dizziness, so drive with caution. Avoid alcohol consumption as it might cause increased dizziness and sleepiness. Imefic Plus 1 gm Injection should not be given to children below one year or those who weigh below 30kg with kidney problems. Imefic Plus 1 gm Injection is not recommended in paediatric patients with CNS infections due to the risk of seizures. Keep your doctor informed about your health condition and medications to rule out any unpleasant side effects.

Uses of Imefic Plus 1 gm Injection

Severe bacterial infections

Directions for Use

Imefic Plus 1 gm Injection will be administered by a healthcare professional; do not self-administer.

Medicinal Benefits

Imefic Plus 1 gm Injection is a combination of two drugs, namely: Cilastatin (dehydropeptidase inhibitor) and Imipenem (antibacterial). Imefic Plus 1 gm Injection is used to treat severe bacterial infections of the lungs, heart, bladder, skin, kidneys, bones, joints, blood, stomach, and female reproductive organs. Imefic Plus 1 gm Injection may also be used in the management of patients with low white blood cell count who have a fever, which is suspected to be due to bacterial infection. Cilastatin inhibits the dehydropeptidase enzyme, which causes the breakdown of Imipenem, thereby helps imipenem to stay active for a longer duration. Imipenem prevents the formation of the bacterial protective covering, which is necessary for the survival of the bacteria. Together, Imefic Plus 1 gm Injection helps to treat bacterial infections. Imipenem is a broad-spectrum antibiotic that is effective against a wide range of aerobic and anaerobic bacteria.

Storage

Store in a cool and dry place away from sunlight

Side Effects of Imefic Plus 1 gm Injection

  • Nausea
  • Vomiting
  • Diarrhoea
  • Swelling
  • Redness at the site of injection

Drug Warnings

Do not take Imefic Plus 1 gm Injection if you are allergic to any of its components. Inform your doctor if you have an allergy to antibiotics, colitis, gastrointestinal disease, urinary/kidney problems, CNS disorders, seizures/fits, or liver problems. Consult your doctor if you are pregnant or breastfeeding. Avoid alcohol consumption as it might cause increased dizziness and sleepiness. Imefic Plus 1 gm Injection should not be given to children below one year or those who weigh below 30kg with kidney problems. Imefic Plus 1 gm Injection is not recommended in paediatric patients with CNS infections due to the risk of seizures. Imefic Plus 1 gm Injection may cause dizziness and sleepiness, so drive with caution.

Drug-Drug Interactions

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No Drug - Drug interactions found in our data. We may lack specific data on this medicine and are actively working to update our database. Consult your doctor for personalized advice

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Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

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Diet & Lifestyle Advise

  • Antibiotics can alter the useful bacteria in the stomach, which help in digestion. Therefore, you are advised to take foods rich in probiotics such as yoghurt/curd, kefir, buttermilk, natto and cheese.
  • Eat fibre-rich food like whole grains, beans, lentils, berries, broccoli, peas and bananas.
  • Avoid foods rich in calcium, grapefruit and grapefruit juice as they might hinder the absorption of antibiotics.
  • Avoid/limit the consumption of alcohol and usage of tobacco.

Habit Forming

No

Therapeutic Class

ANTIBIOTICS

Imefic Plus 1 gm Injection Substitute

Substitutes safety advice
  • Zicerot 1gm/1gm Injection

    by Others

    2802.76per tablet

Author Details

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Drug-Diseases Interactions

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No Drug - Disease interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

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FAQs

Imefic Plus 1 gm Injection is a combination of two drugs, namely: Cilastatin and Imipenem. Cilastatin inhibits the dehydropeptidase enzyme, which causes the breakdown of Imipenem, thereby helps imipenem to stay active for a longer duration. Imipenem prevents the formation of the bacterial protective covering, which is necessary for the survival of the bacteria. Together, Imefic Plus 1 gm Injection helps to treat bacterial infections.

Diarrhoea might be a side-effect of Imefic Plus 1 gm Injection. Drink lots of fluids and eat non-spicy food if you experience diarrhoea. If you find blood in stools (tarry stools) or if you experience prolonged diarrhoea with abdominal pain, consult your doctor. Do not take anti-diarrheal medicine on your own.

Concomitant administration of Probenecid (used to treat gout and hyperuricemia) along with Imefic Plus 1 gm Injection is not recommended as it might result in an increase of plasma levels and half-life of Imipenem.

Ganciclovir (anti-viral) should not be co-administered along with Imefic Plus 1 gm Injection unless benefits outweigh the risks as generalised seizures have been reported when taken together.

Imefic Plus 1 gm Injection may cause changes in urine colour and amount of urine. Do not worry and consult your doctor if you have any concerns regarding this.

Imefic Plus 1 gm Injection may rarely cause thrush or candidiasis, which is a fungal infection occurring due to the overgrowth of yeast-like fungus in the mouth or throat. Regularly rinse your mouth with water to prevent the growth of fungus.

Drug-Drug Interactions Checker List

  • GANCICLOVIR
  • PROBENECID
  • VALPROIC ACID
  • DIVALPROEX SODIUM
  • WARFARIN

Special Advise

  • Imefic Plus 1 gm Injection may cause abnormal Coombs, liver, blood, and kidney function tests. Inform the person doing the tests that you are on treatment with Imefic Plus 1 gm Injection. 

Disease/Condition Glossary

Bacterial infections: A bacterial infection is a condition in which harmful bacteria enter, multiply, and infect the body. Harmful bacteria produce chemicals known as toxins, which can damage tissue and cause sickness. Symptoms of bacterial infection include fever, chills, and fatigue. Anyone can become infected with a bacterial infection. But, people with a weak immune system or taking immunosuppressive medicines are more prone to bacterial infection.

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