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Imefic Plus 500 Injection

Imefic Plus 500 Injection

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Prescription drug
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Consume Type

PARENTERAL

Return Policy

Not Returnable

Expires on or after

Apr-24

for this medicine

About Imefic Plus 500 Injection

Imefic Plus 500 Injection is used to treat severe bacterial infections of the lungs, heart, bladder, skin, kidneys, bones, joints, blood, stomach and female reproductive organs. Imefic Plus 500 Injection may also be used in the management of patients with low white blood cell count who have a fever, which is suspected to be due to bacterial infection. Bacterial infections are caused due to the multiplication of harmful bacteria inside or on the body. Imefic Plus 500 Injection does not work against infections caused by the virus, including cold and flu. 
 
Imefic Plus 500 Injection is a combination of two drugs, namely: Cilastatin (dehydropeptidase inhibitor) and Imipenem (antibacterial). Cilastatin inhibits the dehydropeptidase enzyme, which causes the breakdown of Imipenem, thereby helps imipenem to stay active for a longer duration. Imipenem prevents the formation of the bacterial protective covering, which is necessary for the survival of the bacteria. Together, Imefic Plus 500 Injection helps to treat bacterial infections.
 
Imefic Plus 500 Injection will be administered by a healthcare professional; do not self-administer. In some cases, Imefic Plus 500 Injection may cause common side effects such as nausea, vomiting, diarrhoea, swelling, and redness at the site of injection. Most of these side effects do not require medical attention and will resolve gradually over time. However, you are advised to talk to your doctor if you experience these side effects persistently.
 
Consult your doctor if you are pregnant or breastfeeding. Imefic Plus 500 Injection may cause dizziness, so drive with caution. Avoid alcohol consumption as it might cause increased dizziness and sleepiness. Imefic Plus 500 Injection should not be given to children below one year or those who weigh below 30kg with kidney problems. Imefic Plus 500 Injection is not recommended in paediatric patients with CNS infections due to the risk of seizures. Keep your doctor informed about your health condition and medications to rule out any unpleasant side effects.

Uses of Imefic Plus 500 Injection

Severe bacterial infections

Medicinal Benefits

Imefic Plus 500 Injection is a combination of two drugs, namely: Cilastatin (dehydropeptidase inhibitor) and Imipenem (antibacterial). Imefic Plus 500 Injection is used to treat severe bacterial infections of the lungs, heart, bladder, skin, kidneys, bones, joints, blood, stomach, and female reproductive organs. Imefic Plus 500 Injection may also be used in the management of patients with low white blood cell count who have a fever, which is suspected to be due to bacterial infection. Cilastatin inhibits the dehydropeptidase enzyme, which causes the breakdown of Imipenem, thereby helps imipenem to stay active for a longer duration. Imipenem prevents the formation of the bacterial protective covering, which is necessary for the survival of the bacteria. Together, Imefic Plus 500 Injection helps to treat bacterial infections. Imipenem is a broad-spectrum antibiotic that is effective against a wide range of aerobic and anaerobic bacteria.

Directions for Use

Imefic Plus 500 Injection will be administered by a healthcare professional; do not self-administer.

Storage

Store in a cool and dry place away from sunlight

Side Effects of Imefic Plus 500 Injection

  • Nausea
  • Vomiting
  • Diarrhoea
  • Swelling
  • Redness at the site of injection

Drug Warnings

Do not take Imefic Plus 500 Injection if you are allergic to any of its components. Inform your doctor if you have an allergy to antibiotics, colitis, gastrointestinal disease, urinary/kidney problems, CNS disorders, seizures/fits, or liver problems. Consult your doctor if you are pregnant or breastfeeding. Avoid alcohol consumption as it might cause increased dizziness and sleepiness. Imefic Plus 500 Injection should not be given to children below one year or those who weigh below 30kg with kidney problems. Imefic Plus 500 Injection is not recommended in paediatric patients with CNS infections due to the risk of seizures. Imefic Plus 500 Injection may cause dizziness and sleepiness, so drive with caution.

Drug Interactions

Drug-Drug Interactions: Imefic Plus 500 Injection may interact with anti-viral (Ganciclovir), uricosurics (Probenecid), anti-epileptic (Valproic acid, Divalproex sodium), blood thinner (warfarin).

Drug-Food Interactions: No interactions found/established.

Drug-Disease Interactions: Inform your doctor if you have colitis (inflammation in the lining of the colon), CNS disorders, hemodialysis, kidney or liver dysfunction.

Drug-Drug Interactions Checker List

  • GANCICLOVIR
  • PROBENECID
  • VALPROIC ACID
  • DIVALPROEX SODIUM
  • WARFARIN

Habit Forming

No

Diet & Lifestyle Advise

  • Antibiotics can alter the useful bacteria in the stomach, which help in digestion. Therefore, you are advised to take foods rich in probiotics such as yoghurt/curd, kefir, buttermilk, natto and cheese.
  • Eat fibre-rich food like whole grains, beans, lentils, berries, broccoli, peas and bananas.
  • Avoid foods rich in calcium, grapefruit and grapefruit juice as they might hinder the absorption of antibiotics.
  • Avoid/limit the consumption of alcohol and usage of tobacco.

Special Advise

  • Imefic Plus 500 Injection may cause abnormal Coombs, liver, blood, and kidney function tests. Inform the person doing the tests that you are on treatment with Imefic Plus 500 Injection. 

Disease/Condition Glossary

Bacterial infections: A bacterial infection is a condition in which harmful bacteria enter, multiply, and infect the body. Harmful bacteria produce chemicals known as toxins, which can damage tissue and cause sickness. Symptoms of bacterial infection include fever, chills, and fatigue. Anyone can become infected with a bacterial infection. But, people with a weak immune system or taking immunosuppressive medicines are more prone to bacterial infection.

Country of origin

India

Manufacturer/Marketer address

37,1st Floor, Kamala Bhavan II, Swami Nityanand Road, Andheri (East), Mumbai - 400 069. (INDIA)
Other Info - IME0027

FAQs

Imefic Plus 500 Injection is a combination of two drugs, namely: Cilastatin and Imipenem. Cilastatin inhibits the dehydropeptidase enzyme, which causes the breakdown of Imipenem, thereby helps imipenem to stay active for a longer duration. Imipenem prevents the formation of the bacterial protective covering, which is necessary for the survival of the bacteria. Together, Imefic Plus 500 Injection helps to treat bacterial infections.
Diarrhoea might be a side-effect of Imefic Plus 500 Injection. Drink lots of fluids and eat non-spicy food if you experience diarrhoea. If you find blood in stools (tarry stools) or if you experience prolonged diarrhoea with abdominal pain, consult your doctor. Do not take anti-diarrheal medicine on your own.
Concomitant administration of Probenecid (used to treat gout and hyperuricemia) along with Imefic Plus 500 Injection is not recommended as it might result in an increase of plasma levels and half-life of Imipenem.
Ganciclovir (anti-viral) should not be co-administered along with Imefic Plus 500 Injection unless benefits outweigh the risks as generalised seizures have been reported when taken together.
Imefic Plus 500 Injection may cause changes in urine colour and amount of urine. Do not worry and consult your doctor if you have any concerns regarding this.
Imefic Plus 500 Injection may rarely cause thrush or candidiasis, which is a fungal infection occurring due to the overgrowth of yeast-like fungus in the mouth or throat. Regularly rinse your mouth with water to prevent the growth of fungus.

Disclaimer

While we strive to provide complete, accurate, and expert-reviewed content on our 'Platform', we make no warranties or representations and disclaim all responsibility and liability for the completeness, accuracy, or reliability of the aforementioned content. The content on our platform is for informative purposes only, and may not cover all clinical/non-clinical aspects. Reliance on any information and subsequent action or inaction is solely at the user's risk, and we do not assume any responsibility for the same. The content on the Platform should not be considered or used as a substitute for professional and qualified medical advice. Please consult your doctor for any query pertaining to medicines, tests and/or diseases, as we support, and do not replace the doctor-patient relationship.
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Alcohol

Caution

Avoid alcohol consumption as it might cause increased dizziness and sleepiness.

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Pregnancy

Caution

Please consult your doctor if you are pregnant or planning for pregnancy. Your doctor will prescribe Imefic Plus 500 Injection only if the benefits outweigh the risks.

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Breast Feeding

Caution

Imefic Plus 500 Injection may pass into breast milk. Please consult your doctor if you are breastfeeding; your doctor will decide if Imefic Plus 500 Injection can be given to breastfeeding mothers or not.

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Driving

Caution

Imefic Plus 500 Injection may cause dizziness and sleepiness. Avoid driving or operating machinery unless you are alert.

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Liver

Caution

Dose adjustment may be needed. Please consult your doctor if you have liver impairment/liver disease.

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Kidney

Caution

Dose adjustment may be needed. Please consult your doctor if you have any concerns regarding this or if you have kidney impairment/kidney disease.

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Children

Caution

Imefic Plus 500 Injection should not be given to children below one year or those who weigh below 30kg with kidney problems. Imefic Plus 500 Injection is not recommended in paediatric patients with CNS infections due to the risk of seizures.