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  3. Instgra Tablet 30's

Instgra Tablet 30's, Pack of 1 TABLET
Instgra Tablet 30's, Pack of 1 TABLET
Instgra Tablet 30's, Pack of 1 TABLET
Not for online sale
Written By Santoshini Reddy G , M Pharmacy
Reviewed By Bayyarapu Mahesh Kumar , M Pharmacy
Non returnable*
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COD available

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Whats That

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Composition :

DOLUTEGRAVIR-50MG

Manufacturer/Marketer :

Emcure Pharmaceuticals Ltd

Consume Type :

ORAL

Return Policy :

Not Returnable

Expires on or after :

NPPA :

Regulated

About Instgra Tablet

Instgra Tablet belongs to a group of antiretroviral medicines called HIV integrase inhibitors indicated for the treatment of HIV infection. Instgra Tablet does not cure HIV infection. It reduces the viral load in the body and keeps it at a low level. Taking Instgra Tablet decreases the chance of developing AIDS (acquired immunodeficiency syndrome) and HIV-related illnesses such as cancer or serious infections.
 
Instgra Tablet contains Dolutegravir, which works by decreasing the amount of HIV in the blood. It also increases the count of CD4 cells, a type of white blood cells that help the body fight infection.
 
In some cases, Instgra Tablet may cause side effects such as nausea, vomiting, headache, and diarrhoea. Most of these side effects do not require medical attention and will resolve gradually. However, you are advised to talk to the doctor if the side effects persist or worsen.

Pregnancy testing should be performed in adolescents and adults of reproductive potential prior to starting Dolutegravir to rule out the use of Dolutegravir during the first trimester of pregnancy. Advise adolescents and adults with reproductive potential to take effective contraception on a regular basis. Avoid breastfeeding whilst on treatment with Instgra Tablet . Instgra Tablet may cause dizziness, so drive only if you are alert. Keep your doctor informed about your health condition and medications to prevent side effects/interactions.

Uses of Instgra Tablet

HIV infection

Directions for Use

Take Instgra Tablet with or without food. Swallow it as a whole with water; do not chew or crush it.

Medicinal Benefits

Instgra Tablet contains Dolutegravir, which belongs to a group of antiretroviral medicines indicated for the treatment of HIV infection. Instgra Tablet reduces the viral load in the body and keeps it at a low level. It also increases the count of CD4 cells, a type of white blood cells that help the body fight infection.

Storage

Store in a cool and dry place away from sunlight
Side effects of Instgra Tablet
Dealing with Medication-Induced Headache:
  • Hydrate your body: Drink enough water to prevent dehydration and headaches.
  • Calm Your Mind: Deep breathing and meditation can help you relax and relieve stress.
  • Rest and Recharge: Sleep for 7-8 hours to reduce headache triggers.
  • Take rest: lie down in a quiet, dark environment.
  • Cold or warm compresses can help reduce tension.
  • Stay Upright: Maintain good posture to keep symptoms from getting worse.
  • To treat headaches naturally, try acupuncture or massage therapy.
  • Over-the-counter pain relievers include acetaminophen and ibuprofen.
  • Prescription Assistance: Speak with your doctor about more substantial drug alternatives.
  • Severe Headaches: Seek emergency medical assistance for sudden, severe headaches.
  • Frequent Headaches: If you get reoccurring headaches, consult your doctor.
  • Headaches with Symptoms: Seek medical attention if your headaches include fever, disorientation, or weakness.
Here are the precise steps to cope with diarrhoea caused by medication usage:
  • Inform Your Doctor: Notify your doctor immediately about your diarrhoea symptoms. This allows them to adjust your medication or provide guidance on managing side effects.
  • Stay Hydrated: Drink plenty of fluids to replace lost water and electrolytes. Choose water, clear broth, and electrolyte-rich drinks. Avoid carbonated or caffeinated beverages to effectively rehydrate your body.
  • Follow a Bland Diet: Eat easy-to-digest foods to help firm up your stool and settle your stomach. Try incorporating bananas, rice, applesauce, toast, plain crackers, and boiled vegetables into your diet.
  • Avoid Trigger Foods: Steer clear of foods that can worsen diarrhoea, such as spicy, fatty, or greasy foods, high-fibre foods, and dairy products (especially if you're lactose intolerant).
  • Practice Good Hygiene: Maintain good hygiene to prevent the spread of infection. To stay healthy, wash your hands frequently, clean and disinfect surfaces regularly, and avoid exchanging personal belongings with others.
  • Take Anti-Diarrheal Medications: If your doctor advises, anti-diarrheal medications such as loperamide might help manage diarrhoea symptoms. Always follow your doctor's directions.
  • Keep track of your diarrhoea symptoms. If they don't get better or worse or are accompanied by severe stomach pain, blood, or dehydration signs (like extreme thirst or dark urine), seek medical help.
Overcome Medication-Induced Nausea: A 9-Step Plan
  • Inform your doctor about the nausea and discuss possible alternatives to the medication or adjustments to the dosage.
  • Divide your daily food intake into smaller, more frequent meals to reduce nausea.
  • Opt for bland, easily digestible foods like crackers, toast, plain rice, bananas, and applesauce.
  • Avoid certain foods that can trigger nausea, such as fatty, greasy, spicy, and smelly foods.
  • Drink plenty of fluids, such as water, clear broth, or electrolyte-rich beverages like coconut water or sports drinks.
  • Use ginger (tea, ale, or candies) to help relieve nausea.
  • Get adequate rest and also avoid strenuous activities that can worsen nausea.
  • Talk to your doctor about taking anti-nausea medication if your nausea is severe.
  • Record when your nausea occurs, what triggers it, and what provides relief to help you identify patterns and manage your symptoms more effectively.
  • Drink water or other clear fluids.
  • To prevent worsening of pain, limit intake of tea, coffee, or alcohol.
  • Include bland foods like rice, toast, crackers, and rice in your diet.
  • Avoid lying down immediately after eating as it may cause indigestion or heartburn.
  • Avoid acidic and spicy food as it may cause indigestion.
  • Rest well; get enough sleep.
  • Eat a balanced diet and drink enough water.
  • Manage stress with yoga and meditation.
  • Limit alcohol and caffeine.
  • Physical activities like walking or jogging might help boost energy and make you feel less tired.
Here are the few steps for dealing with itching caused by drug use:
  • Report the itching to your doctor immediately; they may need to change your medication or dosage.
  • Use a cool, damp cloth on the itchy area to help soothe and calm the skin, reducing itching and inflammation.
  • Keep your skin hydrated and healthy with gentle, fragrance-free moisturizers.
  • Try not to scratch, as this can worsen the itching and irritate your skin.
  • If your doctor prescribes, you can take oral medications or apply topical creams or ointments to help relieve itching.
  • Track your itching symptoms and follow your doctor's guidance to adjust your treatment plan if needed. If the itching persists, consult your doctor for further advice.

Drug Warnings

Do not take Instgra Tablet if you are allergic to any of its components or if you are taking fampridine (used in multiple sclerosis) or dofetilide (used to treat heart conditions). Inform your doctor if you notice joint pain, bone problems, and stiffness or symptoms of infection/inflammation, such as fever, headache, stomach ache, and difficulty breathing. Let the doctor know if you are taking prescription/non-prescription medicines, including herbal products or supplements.

Drug-Drug Interactions

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DolutegravirDofetilide
Critical
DolutegravirZinc gluconate
Severe

Drug-Drug Interactions

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DolutegravirDofetilide
Critical
How does the drug interact with Instgra Tablet:
Taking Instgra Tablet with dofetilide may possibly reduce the blood levels and effects of Instgra Tablet. This can increase the risk of an irregular heart rhythm that may be serious.

How to manage the interaction:
Although taking Instgra Tablet with Dofetilide is not recommended, they can be taken together if prescribed by a doctor. However, contact your doctor if you experience drowsiness, lightheadedness, fainting, or irregular heartbeat. Do not stop taking any medications without consulting a doctor.
DolutegravirZinc gluconate
Severe
How does the drug interact with Instgra Tablet:
Zinc gluconate reduces the absorption of Instgra Tablet, resulting in reduced efficacy of Instgra Tablet in treating HIV.

How to manage the interaction:
Although taking Instgra Tablet and Zinc gluconate together can possibly result in an interaction, they can be taken together if prescribed by your doctor. It is advised to take Instgra Tablet either two hours before or six hours after taking a dose of Zinc gluconate. If your condition worsens or develops new infections while taking these medications, it is important to contact a doctor immediately. Do not discontinue using any medications without consulting a doctor.
DolutegravirFerrous sulfate
Severe
How does the drug interact with Instgra Tablet:
Taking Instgra Tablet with ferrous sulfate can reduce the effectiveness of Instgra Tablet.

How to manage the interaction:
Although there is a possible interaction between Ferrous sulfate and Instgra Tablet, you can use these medicines together if prescribed by a doctor. It is advised to take Instgra Tablet either two hours before or six hours after taking a dose of Ferrous sulfate. Do not discontinue using any medications without consulting a doctor.
DolutegravirMagnesium sulfate
Severe
How does the drug interact with Instgra Tablet:
Taking Instgra Tablet with magnesium sulfate can reduce the effects of Instgra Tablet.

How to manage the interaction:
Although taking Instgra Tablet and Magnesium sulfate together can possibly result in an interaction, they can be taken together if prescribed by your doctor. However, if your condition gets worse or if you develop new infections while taking these medications, it is important to contact a doctor immediately. Do not discontinue using any medications without consulting a doctor.
DolutegravirAttapulgite
Severe
How does the drug interact with Instgra Tablet:
Taking Instgra Tablet with Attapulgite can reduce the effectiveness of Instgra Tablet.

How to manage the interaction:
Taking Instgra Tablet with Attapulgite together can possibly result in an interaction, they can be taken together if prescribed by your doctor. It is recommended to take Instgra Tablet at least two hours before or six hours after the attapulgite dose. Do not discontinue using any medications without consulting a doctor.
DolutegravirMagaldrate
Severe
How does the drug interact with Instgra Tablet:
Taking Instgra Tablet with magaldrate can reduce the effectiveness of Instgra Tablet.

How to manage the interaction:
Although taking Instgra Tablet and Magaldrate together can possibly result in an interaction, they can be taken together if prescribed by your doctor. It is advised to take Instgra Tablet either two hours before or six hours after taking a dose of Magaldrate. Do not discontinue using any medications without consulting a doctor.
DolutegravirAluminium hydroxide
Severe
How does the drug interact with Instgra Tablet:
Taking Instgra Tablet with aluminium hydroxide can reduce the effectiveness of Instgra Tablet.

How to manage the interaction:
Although taking Instgra Tablet and Aluminum hydroxide together can possibly result in an interaction, they can be taken together if prescribed by your doctor. It is recommended to take Instgra Tablet at least two hours before or six hours after the aluminium hydroxide dose. Do not discontinue using any medications without consulting a doctor.
DolutegravirEfavirenz
Severe
How does the drug interact with Instgra Tablet:
Taking Instgra Tablet with efavirenz can reduce the blood levels and effectiveness of Instgra Tablet.

How to manage the interaction:
Although taking Instgra Tablet and Efavirenz together can result in an interaction, they can be taken together if prescribed by your doctor. Do not discontinue any medications without consulting a doctor.
DolutegravirFerrous fumarate
Severe
How does the drug interact with Instgra Tablet:
Taking Instgra Tablet with ferric fumarate can reduce the effectiveness of Instgra Tablet.

How to manage the interaction:
Taking Ferrous Fumarate and Instgra Tablet together may result in an interaction, but they can be taken together as directed by your doctor. It is advised to take Instgra Tablet 2 hours before or 6 hours after taking Ferrous fumarate. Do not discontinue using any medications without consulting a doctor.
DolutegravirMagnesium gluconate
Severe
How does the drug interact with Instgra Tablet:
Taking Instgra Tablet with magnesium aspartate can reduce the effectiveness of Instgra Tablet.

How to manage the interaction:
Although taking Instgra Tablet and Magnesium gluconate together can possibly result in an interaction, they can be taken together if prescribed by your doctor. It is advised to take Instgra Tablet either two hours before or six hours after taking a dose of Magnesium gluconate. Do not discontinue using any medications without consulting a doctor.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

  • Practise safe sex by using condoms; it helps in reducing contact with semen and vaginal fluids.
  • Never share personal items that can have body fluids or blood on them, such as razor blades or toothbrushes.
  • Avoid sharing used needles, other injections or drug equipment.
  • Eat a healthy and balanced diet. Eat vitamin and nutrient-rich food, vegetables and fruits as it helps to boost your immune system. Opt for lean protein and whole grains.
  • Avoid eating raw meat and eggs. Consume properly boiled and cooked meat, poultry or seafood.
  • Eat bland and low-fat foods. Avoid spicy or oily foods if you experience nausea or vomiting.
  • Try to reduce emotional and physical stress by spending time with family or doing whatever makes you happy.

Habit Forming

No

Therapeutic Class

ANTIRETROVIRAL AGENTS

Instgra Tablet Substitute

Substitutes safety advice

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Author Details

Santoshini Reddy GDoctor badge

Written By

Santoshini Reddy G

M Pharmacy

Bayyarapu Mahesh KumarDoctor badge

Reviewed By

Bayyarapu Mahesh Kumar

M Pharmacy

Last Updated

Jul 8, 2025 | 9:49 AM IST

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Drug-Diseases Interactions

verifiedApollotooltip
No Drug - Disease interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Diseases Interactions

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FAQs

Instgra Tablet works by decreasing the amount of HIV in the blood. It also increases the count of CD4 cells, a type of white blood cells that help the body to fight infection.

Antacids used to treat heartburn or indigestion, multivitamins, calcium or iron supplements may stop the absorption of Instgra Tablet and make it less effective. Therefore, do not take antacid, multivitamins, calcium or iron supplements 6 hours before and 2 hours after taking Instgra Tablet . However, consult the doctor before taking other medicines while on treatment with Instgra Tablet .

Few people taking combination therapy for HIV may develop osteonecrosis. Consult the doctor if you experience symptoms of osteonecrosis, such as stiffness in the joints, joint pain or aches, and difficulty moving.

Drug-Drug Interactions Checker List

  • METFORMIN
  • RIFAMPICIN
  • PHENYTOIN
  • PHENOBARBITAL
  • OXCARBAZEPINE
  • CARBAMAZEPINE
  • St John's wort

Special Advise

  • During HIV therapy, there may be weight gain, and increase in blood lipids and blood glucose levels. Regular monitoring is advised.
  • Discuss with your doctor about effective birth control methods that you can use during your treatment. 

Disease/Condition Glossary

HIV infection: HIV (Human Immunodeficiency Virus) is a virus that attacks the immune system and destroys the white blood cells that help fight infection, making the individual susceptible to other infections or illnesses. People with HIV experience flu-like symptoms such as fever, chills, rash, night sweats, muscle aches, tiredness, and sore throat. These symptoms usually last for days to several weeks. It spreads through body fluids such as semen, vaginal fluid, and blood. If left untreated, this condition can lead to AIDS (Acquired Immunodeficiency Syndrome). It is a life-long condition, and there is no definite cure for it. However, it can be controlled by treating with antiretroviral drugs. 

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