Janumet 50 mg/500 mg Tablet is a combination drug of Sitagliptin (DPP4 inhibitors) and Metformin (Biguanides) belongs to the class of anti-diabetic. Type 2 diabetes is a condition in which either the body stops producing enough insulin (the hormone which helps to decrease sugar levels in the blood) or there is resistance to the action of insulin. As a result, insulin is produced in large amounts but it is not able to act on the organs of the body.

Sitagliptin belongs to the class of dipeptidyl peptidase-4 (DPP-4) inhibitors which works by increasing the amounts of certain natural substances that lower blood sugar when it is high. Another medicine Metformin belongs to the class of biguanides which lowers glucose production in the liver, delays glucose absorption from intestines and increases the body's sensitivity to insulin. Together, it prevents blood glucose levels from rising to very high levels after meals.

Janumet 50 mg/500 mg Tablet should be taken with food to avoid an upset stomach. Janumet 50 mg/500 mg Tablet should be taken at the same time of the day each time for best results. For better advice, your doctor will decide, what dose should be taken and it can change timely depending upon your condition. The most common side effect of Janumet 50 mg/500 mg Tablet is hypoglycemia (low blood glucose levels) characterised by dizziness, sweating, palpitations, hunger pangs, dry mouth and skin etc. So, to avoid hypoglycemia, you should not miss meals and also should carry some form of sugar along with you. Other side effects include taste change, nausea, diarrhoea, stomach pain, headache, upper respiratory symptoms.

Janumet 50 mg/500 mg Tablet should not be stopped even if you feel better, without consulting your doctor as sugar level keeps changing. If you stop taking Janumet 50 mg/500 mg Tablet abruptly, it may increase your sugar levels which could further increase the risk of eyesight loss (retinopathy), kidney (nephropathy) and nerve damage (neuropathy). Janumet 50 mg/500 mg Tablet should not be taken if you have type 1 diabetes mellitus, severe kidney or liver disease. Please inform your doctor if you have any type of heart disease, is or planning to get pregnant or breastfeeding.

 Janumet 50 mg/500 mg Tablet helps your pancreas to produce more insulin, make effective utilization of insulin, and decreases excess of sugar that your liver makes. It helps in controlling rise of blood sugar level in your body after meal. Besides this, it does not cause weight gain in the prolonged use. Janumet 50 mg/500 mg Tablet plays a vital role in controlling blood sugar levels and prevents serious complications of diabetes like eyesight loss (retinopathy), kidney (nephropathy), nerve damage (neuropathy), diabetic foot ulcer and delayed wound healing.

Swallow it as a whole with water; do not crush, break or chew it.

• Low blood sugar

• Runny nose

• Sore throat

• Upper lung infection

• Diarrhoea

• Nausea

• Vomiting

• Gas

• Stomach upset

• Indigestion

• General weakness

• Headache

Janumet 50 mg/500 mg Tablet should not be used in patients with type 1 diabetes or with diabetic ketoacidosis. Some diabetic patients, while taking Janumet 50 mg/500 mg Tablet, might develop a rare but serious condition called lactic acidosis. In this condition, too much lactic acid is accumulated in the blood, which can damage the working of your liver and kidney required to eliminate excess lactic acid from the blood. Before you start taking Janumet 50 mg/500 mg Tablet, tell your doctor if you’ve ever had pancreatitis (inflammation of the pancreas), kidney disease, and low vitamin B12 levels. Janumet 50 mg/500 mg Tablet, when used with insulin, Janumet 50 mg/500 mg Tablet may lower the blood sugar level, leading to hypoglycaemia, which can be fatal. In this case, your doctor may adjust the dose by lowering the insulin dose or Janumet 50 mg/500 mg Tablet. Prolonged intake of Janumet 50 mg/500 mg Tablet may lower your thyroid-stimulating hormone (TSH); hence, an annual check-up of TSH is recommended. In rare cases, you may also develop a serious skin reaction known as bullous pemphigoid that requires immediate medical attention. Tell your doctor if you are going to have a diagnostic test with an injection of dye or X-ray contrast agent. You should stop using Janumet 50 mg/500 mg Tablet for a short time before an X-ray procedure.

Drug-Drug Interactions: Janumet 50 mg/500 mg Tablet interacts with an anti-depressant (bupropion), drugs used to treat glaucoma, antibiotics (cephalexin, ciprofloxacin), anti-acidity drugs (cimetidine), heart condition drugs (digoxin), anti-HIV drugs (dolutegravir), ethanol, saliva reducing drugs (glycopyrrolate), iodinated X-ray contrast agents, anti-epileptic drugs (topiramate, lamotrigine), heart-related chest medicine (ranolazine). Other drug interactions can contribute to increased low blood sugar, including sex hormones (androgens), anti-oxidant (alpha-lipoic acid), pain killers (aspirin), anti-TB drugs (prothionamide), growth hormones (pegvisomant), and other antidiabetic medicines.

Drug-Food Interactions: Intake of excessive alcoholic beverages may increase the chance of a life-threatening condition known as Lactic Acidosis. So, avoid intake of alcoholic beverages with Janumet 50 mg/500 mg Tablet.

Drug-Disease Interactions: People affected with heart diseases (like congestive heart failure and myocardial infarction), Vitamin B12 deficiency, and alcoholism should avoid intake of Janumet 50 mg/500 mg Tablet.

• BUPROPION
• CEPHALEXIN
• CIPROFLOXACIN
• CIMETIDINE
• DIGOXIN
• DOLUTEGRAVIR
• GLYCOPYRROLATE
• TOPIRAMATE
• LAMOTRIGINE
• RANOLAZINE
• ALPHA LIPOIC ACID
• ASPIRIN
• PROTHIONAMIDE
• PEGVISOMANT

• Fill your half plate with starchy veggies, a quarter with proteins, and a quarter with whole grain.
• Eat at regular intervals. Do not take a long gap between a meal or snack.
• Monitor your blood sugar level regularly especially when there are lots of fluctuations.
• Invest at least 150 min of moderate-intensity physical activity or one hour and 15 minutes of high-intensity exercise every week.
• Lose weight gradually to achieve a healthy body mass index (18.5 to 24.9).
• Replace refined carbohydrates-containing foods with whole grain foods and increase the intake of fruits and veggies and other fibre-enriched foods.
• Reduce intake of saturated fat (or hidden fats) in food like chips, crisps, pastries, biscuits, and samosas. Choose omega-3 fatty acid-containing oils for daily cooking. For frying, you can use palm oil, mustard oil, groundnut oil, rice bran oil, and safflower oil.
• Do not take stress as it may elevate your blood sugar level. You can adopt stress management techniques like mindfulness to control stress-related blood sugar changes.
• Opt for low-fat dairy products (low-fat yoghurt, fat-free milk, cheese, etc.).
• Keep your blood pressure as normal (140/90) as possible. As it reduces the risk of cardiovascular diseases in diabetes patients.

Type 2 diabetes is a condition where the body is unable to make sufficient insulin, or the insulin that it makes doesn't work properly or utilized by our body. This can cause high blood sugar levels (hyperglycaemia). Symptoms of type 2 diabetes include increased thirst, frequent urination at night, slow wound healing, increased hunger, fatigue, and blurred vision. In some cases, there may be weight gain while in rare cases weight loss may be observed. The complication of type 2 diabetes also includes neuropathy (nerve problems), nephropathy (kidney problems), and retinopathy (damaged retina of eyes or blindness), loss of limbs, sexual dysfunction, and an increase the chance of heart attack or stroke.