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Written By Lakshmithulasi Yarragunta , Pharm-D (PB)
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
Non returnable*
COD available

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Whats That

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Composition :

CABOZANTINIB-40MG

Manufacturer/Marketer :

Adley Pharmaceuticals Ltd

Consume Type :

ORAL

Return Policy :

Not Returnable

Expires on or after :

About Kabonib 40 mg Tablet

Kabonib 40 mg Tablet is an anti-cancer medicine used in the treatment of renal cell carcinoma. It is a disease in which cancer cells grow uncontrollably in the kidney and form a tumor. Kabonib 40 mg Tablet is used in treating advanced renal cell carcinoma as first-line therapy for advanced renal cell carcinoma in combination with nivolumab and hepatocellular carcinoma in patients who have previously been treated with sorafenib.

Kabonib 40 mg Tablet contains Cabozantinib as an active ingredient, which belongs to the class of medicines known as kinase inhibitors. It works by inhibiting the action of an enzyme (tyrosine kinase) and thus stops the abnormal growth of cancer cells.

Kabonib 40 mg Tablet may cause certain side effects such as diarrhea, decreased appetite, nausea, vomiting, increased blood pressure, muscle cramps, decreased weight, dizziness, and constipation. Inform your doctor if any of these side effects bother you. Kabonib 40 mg Tablet should be taken as advised by your doctor.

Avoid taking Kabonib 40 mg Tablet if you are allergic to it or any other components of it. Before taking Kabonib 40 mg Tablet , inform your doctor if you have/had liver or kidney disease, gastrointestinal disorders, heart problems, blood or bleeding disorders, open or healing wounds, and a history of recent surgery. This medicine is known to cause embryo-fetal toxicity. Hence, it is not recommended for use in pregnancy and breastfeeding.

Uses of Kabonib 40 mg Tablet

Renal Cell Carcinoma, Hepatocellular carcinoma.

Directions for Use

Take Kabonib 40 mg Tablet as prescribed by the doctor. It should be taken at least one hour before food or 2 hours after food. Swallow it as a whole with a glass of water. Do not crush, break, or chew the medicine. Avoid taking more than the prescribed dose of medicine.

Medicinal Benefits

Kabonib 40 mg Tablet contains Cabozantinib, which is used in treating advanced renal cell carcinoma and liver cancer. It works by stopping the action of a tyrosine kinase enzyme that causes the multiplication of cancerous cells. This helps stop the abnormal growth of cancer cells and thus reduce the further spread to other parts of the body. It also decreases the blood supply to cancer tumors to slow down the growth of the tumor.  In this way, Kabonib 40 mg Tablet stops the body's production, spread and growth of cancerous cells.

Storage

Store in a cool and dry place away from sunlight

Drug Warnings

To treat your condition effectually, continue taking Kabonib 40 mg Tablet for the period that your doctor has prescribed. Caution should be exercised if you have/had liver or kidney disease, any planned surgery, heart disease, blood or bleeding disorders, open/healing of wound, or gastrointestinal disorders. Inform your doctor if you are pregnant or are planning to become pregnant before starting the treatment, as this medicine is known to cause embryo-fetal toxicity. Kabonib 40 mg Tablet may cause hypertension, thrombotic events, hemorrhagic events, gastrointestinal perforation and fistula, Reversible Posterior Leukoencephalopathy Syndrome (RPLS), hepatotoxicity, severe diarrhoea, Osteonecrosis of the jaw (ONJ), Palmar-Plantar Erythrodysesthesia (PPE), adrenal insufficiency, impaired wound healing, and proteinuria in some patients. Hence, inform your doctor about your complete medication and medical history before taking Kabonib 40 mg Tablet . Breastfeeding should be discontinued in nursing mothers during the treatment as it passes into breast milk and may cause a possible risk to the infant. Avoid driving and operating machines, as this medicine may cause dizziness. This medicine is not recommended for use in children below 18 years of age as the safety and efficacy are not established.

Drug-Drug Interactions

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Drug-Drug Interactions

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How does the drug interact with Kabonib 40 mg Tablet:
Coadministration of Nortriptyline with Kabonib 40 mg Tablet can increase the risk or severity of irregular heart rhythm.

How to manage the interaction:
Taking Nortriptyline with Kabonib 40 mg Tablet together can result in an interaction, it can be taken if your doctor has advised it. However, if you experience sudden dizziness, lightheadedness, fainting, shortness of breath, chest pain or tightness, rapid heartbeat, or memory loss, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
How does the drug interact with Kabonib 40 mg Tablet:
Coadministration of Kabonib 40 mg Tablet and Apixaban co-administration may raise the risk of bleeding.

How to manage the interaction:
Even though combining Kabonib 40 mg Tablet and Apixaban may cause an interaction, it is still possible to take it if your doctor advises you to. Consult a doctor if you experience symptoms like blood in your urine or stool (or a black stool), severe bruising, prolonged nosebleeds, feeling dizzy or lightheaded, weakness or severe headache, vomiting blood or coughing up blood, heavy menstrual bleeding (in women), difficulty breathing, or chest pain. Without consulting a doctor, never stop taking any medications.
How does the drug interact with Kabonib 40 mg Tablet:
Taking Atomoxetine with Kabonib 40 mg Tablet can increase the chance of a serious abnormal heart rhythm.

How to manage the interaction:
Co-administration of Atomoxetine with Kabonib 40 mg Tablet can result in an interaction, but it can be taken if a doctor has advised it. However, if you notice any irregular heart rhythm, heart problems, or other symptoms like diarrhea, dizziness, or shortness of breath, call a doctor right away. Do not stop using any medications without a doctor's advice.
How does the drug interact with Kabonib 40 mg Tablet:
Taking azithromycin with cabozantinb may increase the risk of an abnormal heart rhythm.

How to manage the interaction:
Although using azithromycin alongside cabozantinb can result in an interaction, it can be taken if a doctor has advised it. However, if you experience sudden dizziness, lightheadedness, fainting, breathing difficulty, or rapid heartbeat, consult the doctor immediately. Do not stop any medications without a doctor's advice.
How does the drug interact with Kabonib 40 mg Tablet:
Using Kabonib 40 mg Tablet together with mefenamic acid may increase the risk of bleeding.

How to manage the interaction:
Although there is a possible interaction between Mefenamic acid and Kabonib 40 mg Tablet, you can take these medicines together if prescribed by your doctor. If you notice any of these symptoms like blood clotting problems, excessive bleeding, or severe headaches, it's best to contact a doctor right away. They can help address any complications and provide the necessary support. Do not stop using any medications without talking to a doctor.
How does the drug interact with Kabonib 40 mg Tablet:
Taking Dabigatran etexilate with Kabonib 40 mg Tablet can increase the risk of bleeding leading to serious blood loss.

How to manage the interaction:
Taking Dabigatran etexilate with Kabonib 40 mg Tablet together can possibly result in an interaction, but it can be taken if your doctor has advised it. However, if you experience unusual bleeding or bruising, dizziness, lightheadedness, red or black, tarry stools, coughing up or vomiting fresh or dried blood that looks like coffee grounds, severe headache, and weakness, consult the doctor. Do not stop using any medications without a doctor's advice.
How does the drug interact with Kabonib 40 mg Tablet:
Taking Idarubicin and Kabonib 40 mg Tablet together can increase the chance of a serious abnormal heart rhythm. If you suffer from any cardiac conditions, or electrolyte disturbances (such as magnesium or potassium deficiency brought on by severe or prolonged diarrhea or vomiting), you may be at higher risk.

How to manage the interaction:
Taking Idarubicin and Kabonib 40 mg Tablet together can possibly result in an interaction, it can be taken if your doctor has advised it. However, if you experience sudden dizziness, lightheadedness, fainting, shortness of breath, or rapid heartbeat, consult a doctor immediately. Do not discontinue any medications without a doctor's advice.
How does the drug interact with Kabonib 40 mg Tablet:
The combined use of Kabonib 40 mg Tablet and Ibuprofen can increase the risk of bleeding.

How to manage the interaction:
using Kabonib 40 mg Tablet and Ibuprofen can lead to an interaction, it can be taken if advised by your doctor. However, if you experience any symptoms like unusual bleeding or bruising, dizziness, lightheadedness, red or black tarry stools, coughing or vomiting fresh or dried blood that looks like coffee grounds, severe headache, and weakness, consult the doctor immediately. Do not stop using any medications without a doctor's advice.
How does the drug interact with Kabonib 40 mg Tablet:
Co-administration of Kabonib 40 mg Tablet with mifepristone may significantly increase the effect of Kabonib 40 mg Tablet.

How to manage the interaction:
Taking Kabonib 40 mg Tablet with mifepristone together can result in an interaction, it can be taken if doctor has advised it. Contact a doctor immediately if you experience symptoms such as nausea, vomiting, diarrhea, loss of appetite, weight loss, mouth sores, abdominal pain, skin rash, unusual bruising or bleeding, delayed wound healing, high blood pressure, dizziness, lightheadedness, fainting, breathing difficulty, heart palpitations, paleness, fatigue, fever, chills, sore throat, muscle aches, blood in phlegm, red or inflamed skin, body sores, and pain or burning during urination. Do not discontinue any medications without consulting a doctor.
How does the drug interact with Kabonib 40 mg Tablet:
Taking ondansetron with Kabonib 40 mg Tablet increases the risk of an abnormal heart rhythm.

How to manage the interaction:
Co-administration of ondansetron along with Kabonib 40 mg Tablet can result in an interaction, it can be taken if a doctor has advised it. However, if you experience abrupt dizziness, lightheadedness, fainting, shortness of breath, or rapid heartbeat, get medical help immediately. Do not discontinue any medications without a doctor's advice.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

  • Physical activity helps strengthen muscles, reduces fatigue, helps in weight loss, and gives strength. Gentle activities like 20-30 minutes of walking or swimming would be helpful.
  • Maintain a healthy weight by performing regular low-strain exercises and eating healthy food.
  • Getting adequate sleep as resting helps improve your health and mental ability and improves attention.
  • De-stress yourself by meditating, reading books, taking a warm bubble bath, or listening to soothing music.
  • Eat food rich in antioxidants such as berries, spinach, etc.
  • Foods containing fibre help in better digestion. These include beans, peas, lentils, whole grains, nuts, and seeds.
  • Avoid smoking and alcohol consumption.
  • Maintain a healthy weight.

Habit Forming

No

Therapeutic Class

ANTINEOPLASTIC

Drug-Diseases Interactions

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No Drug - Disease interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Diseases Interactions

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FAQs

Kabonib 40 mg Tablet contains Cabozantinib, which works by stopping the action of a tyrosine kinase enzyme that causes the multiplication of cancerous cells.

Kabonib 40 mg Tablet may cause thyroid dysfunction, leading to decreased thyroid hormone levels. This effect causes hypothyroidism. So, notify your doctor if you feel extremely tired, colder than others, sudden weight gain/ weight loss, hair loss, or change in voice while using this medicine.

Drug-Drug Interactions Checker List

  • CLARITHROMYCIN
  • RITONAVIR
  • ITRACONAZOLE
  • KETOCONAZOLE
  • DILTIAZEM
  • ERYTHROMYCIN
  • CARBAMAZEPINE
  • PHENYTOIN
  • PHENOBARBITAL
  • RIFAMPICIN

Special Advise

  • Your doctor may suggest periodic liver function tests, kidney function tests, and urine tests to monitor the function of the liver kidney and the presence of protein in urine due to the use of Kabonib 40 mg Tablet .
  • Seek medical attention immediately if you have swelling in your lower legs, fast heartbeats, or trouble breathing, as it may be a sign of a heart problem.
  • It is advised to use effective contraceptive methods while using Kabonib 40 mg Tablet to prevent pregnancy.

Disease/Condition Glossary

Renal Cell Carcinoma: Also known as kidney cancer. It is the most common type of cancer seen in adults. This condition occurs when cancer/ malignant cells grow uncontrollably in the kidney and form a tumor. Advanced kidney cancer (metastatic renal cell carcinoma) occurs when the malignant cells spread to other parts of the body. Symptoms include red, orange, or pink-coloured urine due to the presence of blood in the urine.

Hepatocellular carcinoma: Also known as liver cancer. It occurs when the cancer/ malignant cells grow out of control. This infects the liver, destroys the liver cells and affects the ability of the liver to work properly. Symptoms may include abdominal pain, loss of appetite, weight loss, and pale bowel motions.

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