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Reviewed By Sunny S , MBBS
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Composition :

OFLOXACIN-200MG

Consume Type :

ORAL

Return Policy :

Not Returnable

Expires on or after :

About Kefex-O Tablet

Kefex-O Tablet contains a class of antibiotics known as fluoroquinolones, primarily used to treat infections caused by bacteria including pneumonia, gonorrhoea (a sexually transmitted disease), typhoid fever, infectious diarrhoea, and infections of the skin, eye/ear, bone, joint, abdomen, and prostate (male reproductive gland). A bacterial infection is a condition in which bacteria grow in the body and cause infection. It can target any body part and multiple very quickly. 

Kefex-O Tablet contains antibacterial Ofloxacin, which helps in treating and preventing a wide range of bacterial infections. It is bactericidal and works by killing bacteria that cause infections.  It inhibits the repairing of bacterial cells and kills the bacteria, thereby preventing the further spread of the infection. Kefex-O Tablet is a broad-spectrum antibiotic against most Gram-negative bacteria, many Gram-positive bacteria and some anaerobes bacteria (that live without oxygen).

Kefex-O Tablet should be taken in the dose and duration as advised by your doctor. It is advised to take with food and be taken at a fixed time to achieve maximum effect. Do not take Kefex-O Tablet with dairy products as it may lower its efficacy. You may experience sleep problems, headache, dizziness, nausea, vomiting, diarrhoea, itching, external genital itching in women, vaginal inflammation (vaginitis) and taste changes in some cases. Most of these side effects of Kefex-O Tablet do not require medical attention and gradually resolve over time. However, if the side effects are persistent, reach out to your doctor. If you experience any allergic reaction symptoms such as rashes, itching, swelling, or shortness of breath, immediately contact the doctor.

Inform your doctor if you have any lung disease, muscle weakness (myasthenia gravis), sleeping disorder or difficulty sleeping (sleep apnoea), severe liver disease, or problem with alcohol or other prescription recreational drugs. Inform your doctor if you are planning to get pregnant, are pregnant, or breastfeeding. Use of Kefex-O Tablet is associated with an increased risk of tendinitis and tendon (tough tissue that connects muscle to bone) rupture in all ages. People taking Kefex-O Tablet who are over 60 years are at high risk, especially those who are taking any anti-allergic medicines like corticosteroid drugs. Kefex-O Tablet is contraindicated in people with kidney/heart diseases, and for those who have had lung transplant should its use is not recommended.

Uses of Kefex-O Tablet

Bacterial Infections

Directions for Use

Tablet: Take it with or without food (excluding dairy products). Swallow the tablet with a glass of water. Do not break, crush or chew it.Syrup: Shake the bottle well before use. Take the prescribed dose by mouth using the measuring cup/dosing syringe/dropper provided by the pack.

Medicinal Benefits

Kefex-O Tablet contains the antibiotic Ofloxacin, which helps in treating and preventing a wide range of bacterial infections caused by most Gram-negative bacteria, many Gram-positive bacteria, and some anaerobes bacteria (that live without oxygen). It is bactericidal in nature and works by killing bacteria that cause infections by prevents the formation of the cell wall required for living. It also inhibits the repair of bacterial cells. Altogether it kills the bacteria. Kefex-O Tablet has the advantage of good penetration in most deep tissues and body fluid. Hence, it is also suitable for the treatment of deep tissue and bone bacterial infections.

Storage

Store in a cool and dry place away from sunlight

Side Effects of Kefex-O Tablet

  • Tendon rupture
  • Arthralgia (joint pain)
  • Sleep problems
  • Headache
  • Dizziness
  • Nausea
  • Vomiting
  • Diarrhoea
  • Itching
  • External genital itching in women
  • Vaginal inflammation (vaginitis)
  • Taste changes

Drug Warnings

Do not take Kefex-O Tablet if you are allergic or have had a severe reaction to ofloxacin or any other quinolone or fluoroquinolone antibiotics such as delafloxacin, gemifloxacin, levofloxacin, moxifloxacin, and ciprofloxacin. Taking Kefex-O Tablet may increase the chances of developing tendinitis (swelling of a fibrous tissue that connects a bone to a muscle) or have a tendon rupture (tearing of a fibrous tissue that connects a bone to a muscle). Inform your doctor if you have or have ever had a kidney, heart, or lung transplant, kidney disease, a joint or tendon disorder such as rheumatoid arthritis (an autoimmune disorder of joints causing pain, swelling, and loss of function), seizures (fits), epilepsy or if you participate in regular physical activity. Taking Kefex-O Tablet may worsen muscle weakness in people with myasthenia gravis (a nervous system disorder that causes muscle weakness) and cause severe difficulty breathing or death. Dairy products should be avoided along with Kefex-O Tablet. And also, exposure to sunlight should be avoided while taking Kefex-O Tablet as it may cause increased phototoxicity or photosensitivity. Patients with epilepsy and irregular heartbeat (QT prolongation) should tell their doctor before taking Kefex-O Tablet.

Drug-Drug Interactions

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CefiximeCholera, live attenuated
Severe

Drug-Drug Interactions

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CefiximeCholera, live attenuated
Severe
How does the drug interact with Kefex-O Tablet:
Co-administration of Kefex-O Tablet with Cholera vaccine may reduce the effectiveness of the vaccine.

How to manage the interaction:
Talk to your doctor before receiving the cholera vaccine if you are currently being treated with Kefex-O Tablet or have been treated within the last 14 days. To ensure adequate vaccine response, you should not receive cholera vaccine until at least 14 days after you complete your antibiotic therapy. Do not discontinue the medication without consulting a doctor.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

  • Do not drink or eat a lot of caffeine-containing products such as coffee, tea, energy drinks, cola, or chocolate. Kefex-O Tablet may increase nervousness, sleeplessness, and anxiety caused by caffeine.
  • Probiotics should be taken after taking the full course of Kefex-O Tablet to restore some healthy bacteria in the intestines that may have been killed. Taking probiotics after antibiotic treatment can reduce the risk of antibiotic-associated diarrhea. Certain fermented foods like yogurt, cheese, sauerkraut, kombucha, and kimchi can help restore the intestine's good bacteria. 
  • Include more fiber-enriched food in your diet, as it can be easily digested by your gut bacteria, which helps stimulate their growth. Thus, fiber-rich foods may help restore healthy gut bacteria after a course of antibiotics. Whole grains like whole-grain bread, brown rice should be included in your diet. Make sure you drink plenty of water or other fluids every day while you are taking Kefex-O Tablet.
  • Avoid alcoholic beverages with Kefex-O Tablet as it can make you dehydrated and may affect your sleep. This can make it harder for your body to aid the Kefex-O Tablet in fighting off infections.

Habit Forming

No

Therapeutic Class

ANTIBIOTICS

Kefex-O Tablet Substitute

Substitutes safety advice
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  • Zenflox-200 Tablet 10's

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    7.43per tablet

Drug-Diseases Interactions

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OFLOXACIN-200MGOther bacterial intestinal infections
Severe
OFLOXACIN-200MGDisorders resulting from impaired renal tubular function
Moderate

Drug-Diseases Interactions

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OFLOXACIN-200MGOther bacterial intestinal infections
Severe
How does the disease interact with Kefex-O Tablet:
Almost all antibacterial medications have been associated to reports of Clostridioides difficile-associated diarrhoea (CDAD), formerly known as pseudomembranous colitis. It can vary from mild diarrhoea to deadly colitis. Clindamycin and lincomycin are two of the most frequent offenders.

How to manage the interaction:
Antibiotics may cause Clostridioides difficile-associated diarrhoea (CDAD), which may range from mild diarrhoea to fatal colitis. Appropriate fluid and electrolyte management, protein supplementation, antibacterial treatment of C difficile, and surgical evaluation is advised.
OFLOXACIN-200MGDisorders resulting from impaired renal tubular function
Moderate
How does the disease interact with Kefex-O Tablet:
The kidneys remove the majority of beta-lactam antibiotics as unaltered drugs and, in certain situations, as metabolites as well. In individuals with poor renal function, the blood concentrations of beta-lactam antibiotics and their metabolites may rise and their half-lives may be prolonged. According to the particular product package labelling, dosage modifications may be required. These alterations should be based on the severity of the infection as well as the degree of renal impairment. Renal function tests should be carried out on a regular basis during extended and/or high-dose therapy since these medicines have occasionally been linked to nephrotoxicity and changes in renal function.

How to manage the interaction:
The serum concentration may be increased in patients with impaired kidney function as most beta-lactam antibiotics are eliminated by the kidney. Dose adjustment may be necessary for patients with kidney dysfunction. Regular renal function tests are advised.
OFLOXACIN-200MGAbnormal serum enzyme levels
Moderate
How does the disease interact with Kefex-O Tablet:
Hepatitis cases have been associated to the usage of several cephalosporins. Alkaline phosphatase, AST, and ALT levels have all shown a brief spike. When these medications are provided to people with hepatic problems, caution and close observation are advised.

How to manage the interaction:
Caution and monitoring is recommended in patients with liver disorders.
OFLOXACIN-200MGEpilepsy
Moderate
How does the disease interact with Kefex-O Tablet:
It has been suggested that cephalosporins can cause seizures. In particular in patients with a history of epilepsy and/or where prescribed doses of cephalosporins were exceeded because of renal impairment, cephalosporins have been associated with nonconvulsive status epilepticus (NCSE), encephalopathy, coma, asterixis, neuromuscular excitability, and myoclonia. Depending on the creatinine clearance, change the dosage. In individuals with known seizure disorders, anticonvulsant medication should be maintained. Patients should get a neurological exam to see if medication should be stopped if CNS side effects like seizures happen.

How to manage the interaction:
Cephalosporin antibiotics may trigger seizures. Dose adjustment may be needed.

FAQs

If you miss a dose of Kefex-O Tablet, take the missed dose as soon as you remember it. However, if it's almost time for the next dose, do not take a double dose to make up for a missed one.

No, Kefex-O Tablet should not be taken along with dairy products as it might affect the absorption and efficacy of Kefex-O Tablet. However, you can take it with a meal that includes these foods or drinks.

Kefex-O Tablet makes your skin sensitive to sunlight known as photosensitivity. So, prolonged exposure to sunlight or ultraviolet light should be avoided. In case of emergency, you should always wear sunscreen before going out.

Yes, after taking Kefex-O Tablet, you may have diarrhea. Kefex-O Tablet is an antibiotic that kills or prevents bacterial growth, so in case some good intestinal bacteria which aid in digestion might also get killed. So, drink plenty of fluids and take probiotics to prevent excessive loss of fluids from the body (dehydration).

No, Kefex-O Tablet should be taken in the dose and duration as advised by the doctor. If you take it in more than the recommended dose, it might cause unpleasant side effects. If you think your symptoms are not improving, please consult your doctor

You are recommended to take Kefex-O Tablet either 2 hours before or 2 hours after taking an antacid, multivitamin, or other product that has calcium/magnesium/aluminium/iron/zinc, antiulcer agent (sucralfate) or anti-HIV drug (didanosine).

Drug-Drug Interactions Checker List

  • ASPIRIN
  • WARFARIN
  • CLOZAPINE
  • OLANZAPINE
  • CHLORPROPAMIDE
  • GLIMEPIRIDE
  • GLIPIZIDE
  • GLYBURIDE
  • METFORMIN
  • TOLAZAMIDE
  • TOLBUTAMIDE
  • AMIODARONE
  • DISOPYRAMIDE
  • PROCAINAMIDE
  • QUINIDINE
  • IBUPROFEN
  • NAPROXEN
  • SUCRALFATE
  • DIDANOSINE

Special Advise

Tendon damage (especially to the Achilles tendon) can occur within 48 hours of starting Kefex-O Tablet treatment. The onset of symptoms and signs of the side effects may be delayed several months after stopping treatment. At the first sign of tendinitis (like painful swelling, inflammation), immediately stop taking Kefex-O Tablet. The affected limbs should be appropriately treated (e.g., immobilisation). Corticosteroids medicines (like anti-inflammatory drugs including cortisone, prednisone, prednisolone, methylprednisolone, dexamethasone, betamethasone, hydrocortisone should not be used if signs of tendon rupture occur.

Disease/Condition Glossary

A bacterial infection is a condition in which harmful bacteria enter, multiply, and infect our bodies. It can target any body part and multiple very quickly. When you get infected with bacteria, you can experience generalized symptoms, like fevers, chills, and fatigue. Bacteria are of various forms comprising commonly of spherical, rod, and spiral-shaped. Bacterial infections vary from minor illnesses like sore throat and ear infections to severe brain infections like meningitis and encephalitis. Few harmful bacteria that cause infections include Streptococcus, Staphylococcus, and E. coli. Anyone can become infected with a bacterial infection. People with weak immune systems or taking immunosuppressive medicine can make them more prone to bacterial infection.

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