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  3. KLACID 500MG INJECTION

KLACID 500MG INJECTION, Pack of 1 INJECTION
KLACID 500MG INJECTION, Pack of 1 INJECTION
KLACID 500MG INJECTION, Pack of 1 INJECTION
KLACID 500MG INJECTION, Pack of 1 INJECTION
Written By Bayyarapu Mahesh Kumar , M Pharmacy
Reviewed By Veda Maddala , M Pharmacy
Non returnable*
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Whats That

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Composition :

CLARITHROMYCIN-500MG

Manufacturer/Marketer :

Abbott India Ltd

Consume Type :

PARENTERAL

Return Policy :

Not Returnable

Expires on or after :

NPPA :

Regulated

About KLACID 500MG INJECTION

KLACID 500MG INJECTION belongs to the group of medicines known as macrolide antibiotics used to treat infections caused by bacteria such as bronchitis, pneumonia, throat, sinus, skin and soft tissue infections. It is prescribed for treating severe infections or when oral therapy is ineffective. A bacterial infection is a condition in which bacteria grow in the body and cause infection. It can target any body part and multiply very quickly.

KLACID 500MG INJECTION contains 'Clarithromycin', which works by killing the bacteria that cause the infection by preventing the synthesis of essential proteins necessary for the survival of the bacteria. Thereby, it effectively treats bacterial infections.

KLACID 500MG INJECTION will be administered by a healthcare professional; do not self-administer. You may experience injection site phlebitis (redness, swelling, and pain), headache, nausea (feeling sick) or vomiting (being sick), stomach cramps or tummy pain, and diarrhoea. Most of these side effects of KLACID 500MG INJECTION do not require medical attention and gradually resolve over time. Please consult your doctor if these side effects become troublesome.

Inform your doctor if you are pregnant, suspect you are pregnant, plan to have a baby or if you are breastfeeding; your doctor will prescribe KLACID 500MG INJECTION only if the benefits outweigh the risk. Let your doctor know if you have/had liver problems; your doctor may need to monitor your liver function. KLACID 500MG INJECTION may cause dizziness, confusion, and loss of balance. If you experience these, you should not drive or operate machinery. Let your doctor know about your medical condition and the medications you are taking to avoid any interactions.

Uses of KLACID 500MG INJECTION

Bacterial infections

Directions for Use

KLACID 500MG INJECTION will be administered by a qualified healthcare professional. Kindly do not self-administer.

Medicinal Benefits

KLACID 500MG INJECTION belongs to the group of medicines known as macrolide antibiotics used to treat infections caused by bacteria such as lower respiratory tract infections (acute and chronic bronchitis and pneumonia), upper respiratory tract infections (sinusitis and pharyngitis), and skin & soft tissue infections [folliculitis (inflammation of hair follicles), erysipelas (large raised red patches on the skin), cellulitis (bacterial skin infection)]. KLACID 500MG INJECTION works by preventing the production of proteins required by the bacteria for its survival. Thereby killing the bacteria and treating infections. KLACID 500MG INJECTION is prescribed for treating severe infections or when oral therapy is ineffective. 

Storage

Store in a cool and dry place away from sunlight
Side effects of Klacid 500mg Injection
  • Use a warm compress on the affected area to help reduce discomfort.
  • Elevate the affected limb above heart level.
  • Remove the IV catheter (if applicable) and reinsert at a different site.
  • Consult your healthcare provider if symptoms are severe or persist.
  • Skin rash caused by allergies is due to irritants or allergens. Therefore, avoid contact with such irritants.
  • Consult your doctor for proper medication and apply an anti-itch medication. Follow the schedule and use the medication whenever needed.
  • Protect your skin from extreme heat and try to apply wet compresses.
  • Soak in the cool bath, which gives a soothing impact to the affected area.
  • Always wear loose-fitting clothes which are suitable for your activity.
  • Include the diet containing fruits like watermelon, grapes, bananas and green leafy vegetables.
  • Drink plenty of water stay hydrated.
  • Avoid moving more and staying in hot sun.
Here are the precise steps to cope with diarrhoea caused by medication usage:
  • Inform Your Doctor: Notify your doctor immediately about your diarrhoea symptoms. This allows them to adjust your medication or provide guidance on managing side effects.
  • Stay Hydrated: Drink plenty of fluids to replace lost water and electrolytes. Choose water, clear broth, and electrolyte-rich drinks. Avoid carbonated or caffeinated beverages to effectively rehydrate your body.
  • Follow a Bland Diet: Eat easy-to-digest foods to help firm up your stool and settle your stomach. Try incorporating bananas, rice, applesauce, toast, plain crackers, and boiled vegetables into your diet.
  • Avoid Trigger Foods: Steer clear of foods that can worsen diarrhoea, such as spicy, fatty, or greasy foods, high-fibre foods, and dairy products (especially if you're lactose intolerant).
  • Practice Good Hygiene: Maintain good hygiene to prevent the spread of infection. To stay healthy, wash your hands frequently, clean and disinfect surfaces regularly, and avoid exchanging personal belongings with others.
  • Take Anti-Diarrheal Medications: If your doctor advises, anti-diarrheal medications such as loperamide might help manage diarrhoea symptoms. Always follow your doctor's directions.
  • Keep track of your diarrhoea symptoms. If they don't get better or worse or are accompanied by severe stomach pain, blood, or dehydration signs (like extreme thirst or dark urine), seek medical help.
To prevent, manage, and treat Constipation caused by medication usage, follow these steps:
  • Preventing Vomiting (Before it Happens)
  • Take medication exactly as prescribed by your doctor. This can help minimize side effects, including vomiting.
  • Having a small meal before taking your medication can help reduce nausea and vomiting.
  • Talk to your doctor about taking anti-nausea medication along with your prescribed medication.
  • Managing Vomiting (If it Happens)
  • Try taking ginger in the form of tea, ale, or candy to help alleviate nausea and vomiting.
  • What to Do if Vomiting Persists
  • Consult your doctor if vomiting continues or worsens, consult the doctor for guidance on adjusting your medication or additional treatment.
Here are the step-by-step strategies to manage the side effects of "indigestion" caused by medication usage:
  • Take medications with food (if recommended): It can help prevent stomach distress and indigestion.
  • Eat smaller, more frequent meals: Divide daily food intake into smaller, more frequent meals to ease digestion.
  • Avoid trigger foods: Identify and avoid foods that trigger indigestion, such as spicy, fatty, or acidic foods.
  • Stay upright after eating: Sit or stand upright for at least 1-2 hours after eating to prevent stomach acid from flowing into the oesophagus.
  • Avoid carbonated drinks: Avoid drinking carbonated beverages, such as soda or beer, which can worsen indigestion.
  • Manage stress: To alleviate indigestion, engage in stress-reducing activities like deep breathing exercises or meditation.
  • Consult a doctor if needed: If indigestion worsens or persists, consult a healthcare professional to adjust the medication regimen or explore alternative treatments.
Overcome Medication-Induced Nausea: A 9-Step Plan
  • Inform your doctor about the nausea and discuss possible alternatives to the medication or adjustments to the dosage.
  • Divide your daily food intake into smaller, more frequent meals to reduce nausea.
  • Opt for bland, easily digestible foods like crackers, toast, plain rice, bananas, and applesauce.
  • Avoid certain foods that can trigger nausea, such as fatty, greasy, spicy, and smelly foods.
  • Drink plenty of fluids, such as water, clear broth, or electrolyte-rich beverages like coconut water or sports drinks.
  • Use ginger (tea, ale, or candies) to help relieve nausea.
  • Get adequate rest and also avoid strenuous activities that can worsen nausea.
  • Talk to your doctor about taking anti-nausea medication if your nausea is severe.
  • Record when your nausea occurs, what triggers it, and what provides relief to help you identify patterns and manage your symptoms more effectively.

Drug Warnings

Do not take KLACID 500MG INJECTION if you are allergic or hypersensitive to clarithromycin, any of the ingredients in KLACID 500MG INJECTION, any other macrolide antibiotic, or ketolide (macrolide derivatives). Consult your doctor if you are pregnant or breastfeeding. Inform your doctor if you have/had hypokalemia (abnormally low levels of potassium in the blood), hypomagnesemia (abnormally low levels of magnesium in the blood), severe kidney or liver problems, heart rhythm disorders, heart problems, or are prone to fungal infections (e.g. thrush).

Drug-Drug Interactions

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ClarithromycinSimvastatin
Critical
ClarithromycinIsavuconazole
Critical

Drug-Drug Interactions

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ClarithromycinSimvastatin
Critical
How does the drug interact with Klacid 500mg Injection:
Co-administration of Klacid 500mg Injection and Simvastatin can increase the blood levels and effects of Simvastatin. This can increase the risk of side effects such as liver damage and rhabdomyolysis(which involves the breakdown of skeletal muscle tissue).

How to manage the interaction:
Taking Klacid 500mg Injection and Simvastatin together is not recommended as it can lead to an interaction, it can be taken if advised by your doctor. However, if you experience any symptoms like muscle pain, tenderness, or weakness, fever or dark colored urine, chills, joint pain or swelling, unusual bleeding or bruising, skin rash, itching, loss of appetite, fatigue, nausea, vomiting, and yellowing of the skin or eyes, contact your doctor immediately. Do not discontinue any medications without first consulting your doctor.
ClarithromycinIsavuconazole
Critical
How does the drug interact with Klacid 500mg Injection:
When Isavuconazole is taken with Klacid 500mg Injection, it can increase the risk of side effects.

How to manage the interaction:
Co-administration of Klacid 500mg Injection and Isavuconazole can lead to an interaction, it can be taken if advised by a doctor. However, if you experience any symptoms like nausea, vomiting, or diarrhoea, consult a doctor immediately. Do not stop using any medications without a doctor's advice.
ClarithromycinDroperidol
Critical
How does the drug interact with Klacid 500mg Injection:
Co-administration of Droperidol with Klacid 500mg Injection can increase the risk of an irregular heart rhythm.

How to manage the interaction:
Taking Klacid 500mg Injection with Droperidol can result in an interaction, it should be taken only if a doctor has advised it. However, if you experience dizziness, lightheadedness, fainting, shortness of breath, or heart palpitation, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
ClarithromycinTerfenadine
Critical
How does the drug interact with Klacid 500mg Injection:
When Terfenadine is taken with Klacid 500mg Injection, the amount of Terfenadine in the blood can go up.

How to manage the interaction:
Co-administration of Klacid 500mg Injection and Terfenadine can lead to an interaction, it can be taken if advised by a doctor. However, if you experience any symptoms like dizziness, lightheadedness, fainting, shortness of breath, or heart palpitations, consult a doctor immediately. Do not stop using any medications without a doctor's advice.
ClarithromycinColchicine
Critical
How does the drug interact with Klacid 500mg Injection:
Coadministration of colchicine with Klacid 500mg Injection may increase the blood levels of colchicine, increasing the risk of serious side effects.

How to manage the interaction:
Taking Colchicine with Klacid 500mg Injection is not recommended, they can be taken together if advised by your doctor. However, contact your doctor if you experience abdominal pain, nausea, vomiting, diarrhea, fever, muscle pain, weakness, fatigue, and/or numbness or tingling in your hands and feet. Do not stop taking any medications without consulting a doctor.
ClarithromycinLomitapide
Critical
How does the drug interact with Klacid 500mg Injection:
When Lomitapide is taken with Klacid 500mg Injection, it can lower the metabolism of Lomitapide.

How to manage the interaction:
Co-administration of Klacid 500mg Injection and Lomitapide can lead to an interaction, it can be taken if advised by a doctor. However, if you experience any symptoms like diarrhea, nausea, vomiting, stomach pain or discomfort, indigestion, gas, constipation, and liver damage, consult a doctor immediately. Do not stop using any medications without a doctor's advice.
ClarithromycinNimodipine
Critical
How does the drug interact with Klacid 500mg Injection:
When Nimodipine is taken with Klacid 500mg Injection, it can increase the risk of side effects.

How to manage the interaction:
Co-administration of Klacid 500mg Injection and Nimodipine is not recommended as it can lead to an interaction, it can be taken if advised by a doctor. However, if you experience any symptoms like irregular heart rhythm, swelling, and low blood pressure, consult a doctor immediately. Do not stop using any medications without a doctor's advice.
ClarithromycinConivaptan
Critical
How does the drug interact with Klacid 500mg Injection:
When Klacid 500mg Injection is taken with Conivaptan, it can lower the rate at which Conivaptan is broken down in the body.

How to manage the interaction:
Taking Klacid 500mg Injection with Convivaptan can result in an interaction, it should be taken only if a doctor has advised it. However, if you experience swallowing, trouble speaking, muscle weakness, trouble controlling body movements, confusion, mood changes, or seizures, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
ClarithromycinSaquinavir
Critical
How does the drug interact with Klacid 500mg Injection:
When Klacid 500mg Injection is taken with Saquinavir, increases the risk of an irregular heart rhythm.

How to manage the interaction:
Co-administration of Klacid 500mg Injection and Saquinavir can lead to an interaction, it can be taken if advised by a doctor. However, if you experience any symptoms like dizziness, lightheadedness, fainting, shortness of breath, or heart palpitations, consult a doctor immediately. Do not stop using any medications without a doctor's advice.
ClarithromycinAstemizole
Critical
How does the drug interact with Klacid 500mg Injection:
When Astemizole is taken with Klacid 500mg Injection, it can cause a decrease in the metabolism of Astemizole.

How to manage the interaction:
Taking Klacid 500mg Injection with Astemizole is not recommended, please consult your doctor before taking it.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

  • Take probiotics after completing the full course of KLACID 500MG INJECTION to restore healthy bacteria in the intestine that may have been killed due to the use of antibiotics. Taking probiotics after antibiotic treatment can reduce the risk of antibiotic-associated diarrhoea. Certain fermented foods like yoghurt, cheese, sauerkraut and kimchi can help restore the intestine's good bacteria.
  • Include more fibre-enriched food in your diet, as it can be easily digested by gut bacteria which helps stimulate their growth. Whole grains like whole-grain bread, and brown rice, should be included in the diet.
  • Avoid intake of alcoholic beverages with KLACID 500MG INJECTION as it can make you dehydrated and affect your sleep. This can make it harder for your body to aid KLACID 500MG INJECTION in fighting off infections.

Habit Forming

No

Therapeutic Class

ANTI- BACTERIALS

KLACID 500MG INJECTION Substitute

Substitutes safety advice

Product Substitutes

Author Details

Bayyarapu Mahesh KumarDoctor badge

Written By

Bayyarapu Mahesh Kumar

M Pharmacy

Veda MaddalaDoctor badge

Reviewed By

Veda Maddala

M Pharmacy

Last Updated

Jul 8, 2025 | 9:46 AM IST

Doctor imageWe provide you with authentic, trustworthy and relevant information

Drug-Diseases Interactions

verifiedApollotooltip
CLARITHROMYCIN-500MGOther bacterial intestinal infections
Severe
CLARITHROMYCIN-500MGToxic liver disease
Moderate

Drug-Diseases Interactions

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CLARITHROMYCIN-500MGOther bacterial intestinal infections
Severe
How does the disease interact with Klacid 500mg Injection:
Almost all antibacterial medications have been associated with cases of Clostridioides difficile-associated diarrhoea (CDAD), formerly known as pseudomembranous colitis. It can vary from mild diarrhoea to deadly colitis. Clindamycin and lincomycin are two of the most frequent those involved.

How to manage the interaction:
Anti-bacterial medicines may cause Clostridioides difficile-associated diarrhea (CDAD) ranging from mild diarrhoea to colitis. Therapy should be administered with caution in patients with history of gastrointestinal disease, particularly colitis and pseudomembranous colitis. Appropriate fluid and electrolyte management, protein supplementation, antibacterial treatment of C difficile is advised.
CLARITHROMYCIN-500MGToxic liver disease
Moderate
How does the disease interact with Klacid 500mg Injection:
Patients on Klacid 500mg Injection have been reported to experience hepatic dysfunction, including elevated liver enzymes, cholestatic and/or hepatocellular hepatitis, with or without jaundice. Using this medication to patients with hepatic impairment requires caution and close monitoring. If hepatitis signs and symptoms appear, treatment must be stopped.

How to manage the interaction:
Caution and monitoring is advised if Klacid 500mg Injection is used in patients with liver impairment. Treatment must be discontinued immediately if signs and symptoms of hepatitis such as anorexia, jaundice, dark urine, pruritus, or tender abdomen occur. The use of Klacid 500mg Injection is contraindicated in patients with a history of cholestatic jaundice or liver impairment associated with the prior use of Klacid 500mg Injection.
CLARITHROMYCIN-500MGOther disorders of kidney and ureter, not elsewhere classified
Moderate
How does the disease interact with Klacid 500mg Injection:
The kidney and liver are the organs that eliminate of Klacid 500mg Injection the most. In individuals with severe renal impairment (CrCl 30 mL/min), a lower dose or longer dosing intervals are advised. Patients with mild to moderate renal impairment often do not require dosage modifications, while medication accumulation may happen if there is concurrent liver illness. It is suggested to monitor.

How to manage the interaction:
Dose adjustment may be needed in patients with severe kidney impairment. Monitoring is advised in patients with mild to moderate kidney impairment.
CLARITHROMYCIN-500MGMyasthenia gravis and other myoneural disorders
Moderate
How does the disease interact with Klacid 500mg Injection:
Myasthenia gravis symptoms have been observed to worsen and new myasthenic syndrome symptoms appear when macrolide antibiotics are used, according to reports. In patients who have a history of myasthenia gravis, therapy with these medicines should be used with caution.

How to manage the interaction:
Therapy should be administered cautiously in patients with a history of myasthenia gravis as the use of macrolide antibiotics has been reported to exacerbate symptoms of myasthenia gravis.
CLARITHROMYCIN-500MGAbnormal results of function studies
Moderate
How does the disease interact with Klacid 500mg Injection:
Macrolides have been associated with an increase in the QT interval and occasional cases of arrhythmia. Patients with known QT interval prolongation, ventricular cardiac arrhythmia, including torsades de pointes, patients with proarrhythmic conditions like untreated hypokalemia or hypomagnesemia, clinically significant bradycardia, or patients taking other drugs that prolong the QT interval should avoid taking Klacid 500mg Injection and erythromycin.

How to manage the interaction:
Klacid 500mg Injection should be avoided in patients with known prolongation of the QT interval, abnormal heart rhythm, uncorrected low potassium or low magnesium, clinically significant slow heart rate, or receiving other drugs that prolong the QT interval.

FAQs

KLACID 500MG INJECTION kills the harmful bacteria by preventing the production of proteins required by the bacteria for its survival.

Using KLACID 500MG INJECTION together with statins (medicines used to lower cholesterol levels) is not advisable. Please notify your doctor if you must take these medications. Your doctor may advise you to maintain a time gap between these two medications.

KLACID 500MG INJECTION can cause Clostridium difficile-associated diarrhoea (CDAD). If you have diarrhoea that is watery or bloody, inform your doctor. Do not use anti-diarrhoea medicine unless your doctor tells you to.

You should avoid taking KLACID 500MG INJECTION if you have liver or kidney dysfunction, heart rhythm disorder (arrhythmia) or QT prolongation, electrolyte imbalance (low potassium or magnesium level), or muscle problems (myasthenia gravis). Inform your doctor if you have these conditions before taking KLACID 500MG INJECTION.

KLACID 500MG INJECTION should not be taken with any ergot derivates such as ergotamine or dihydroergotamine used to treat migraine. Consult your doctor if you have any concerns.

Prolonged use of KLACID 500MG INJECTION can result in a yeast infection or oral thrush. Look out for symptoms like white patches in the mouth or changes in vaginal discharge.

Drug-Drug Interactions Checker List

  • ERGOTAMINE
  • DIHYDROERGOTAMINE
  • TERFENADINE
  • ASTEMIZOLE
  • CISAPRIDE
  • DOMPERIDONE
  • PIMOZIDE
  • LOVASTATIN
  • SIMVASTATIN
  • LOMITAPIDE
  • ATORVASTATIN
  • MIDAZOLAM
  • COLCHICINE
  • TICAGRELOR
  • RANOLAZINE
  • ALPRAZOLAM
  • BUDESONIDE/FORMOTEROL

Special Advise

  • KLACID 500MG INJECTION might affect blood and liver tests. Inform the person doing the tests that you are taking KLACID 500MG INJECTION.

Disease/Condition Glossary

Bacterial infection: A bacterial infection is a condition in which harmful bacteria enter, multiply, and infect the body. It can target any body part and multiply very quickly. When you get infected with bacteria, you can experience generalized symptoms like fever, chills, and fatigue. Anyone can become infected with a bacterial infection. But, people with a weak immune system or taking immunosuppressive medicines are more prone to bacterial infection.

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