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Written By Divya L , PharmaD
Reviewed By Veda Maddala , M Pharmacy
Non returnable*
COD available

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Composition :

CLINDAMYCIN-250MG

Manufacturer/Marketer :

Zee Laboratories Ltd

Consume Type :

ORAL

Return Policy :

Not Returnable

Expires on or after :

About Klariva 250 mg Tablet

Klariva 250 mg Tablet belongs to the class of ‘antibiotics’, primarily used to treat bacterial infections. Bacterial infection occurs when harmful bacteria grow in the body and causes illness. It can infect any part of the body and multiply very quickly. Klariva 250 mg Tablet will not work for viral infections, such as common cold and flu.

Klariva 250 mg Tablet contains 'Clindamycin' that works by preventing bacterial protein synthesis, leading to the inhibition of bacterial growth. It shows a bacteriostatic effect that stops bacterial reproduction. Klariva 250 mg Tablet effectively treats infections caused by gram-positive and anaerobic (living without air) bacteria, including susceptible strains of Staphylococcus aureus, Streptococcus pneumoniae, and Clostridium perfringens.

Take Klariva 250 mg Tablet as advised by a doctor. Klariva 250 mg Tablet may cause side effects, although not everybody gets them. Common side effects of Klariva 250 mg Tablet include stomach pain, nausea, vomiting, diarrhoea, heartburn, skin rash, and vaginal itching or discharge. Most of these side effects do not require medical attention and gradually resolve over time. If these side effects persist longer, please consult your doctor.

Inform the doctor if you are allergic to any of the components in Klariva 250 mg Tablet . Let your doctor know if you have any liver disease, kidney disease, gastrointestinal diseases (colitis, an inflammation of the colon), yellow food dye allergy, and allergic conditions (asthma, hay fever, eczema). Do not use Klariva 250 mg Tablet while getting vaccinated with live bacterial vaccines (typhoid vaccine) since Klariva 250 mg Tablet may affect vaccine activity. Klariva 250 mg Tablet should be used only with a doctor's advice during pregnancy and breastfeeding.

Uses of Klariva 250 mg Tablet

Bacterial infections.

Directions for Use

Tablet/capsule: Swallow the tablet/capsule as a whole with a glass of water. Do not chew, crush or break it.Oral liquid: Measure the liquid with a measuring cup and take it as advised by the doctor.

Medicinal Benefits

Klariva 250 mg Tablet is an antibiotic that treats bacterial infections. It works by inhibiting bacterial protein synthesis, which inhibits bacterial growth. It shows a bacteriostatic effect, which stops bacterial reproduction but doesn't kill them. Klariva 250 mg Tablet effectively treats infections caused by gram-positive and anaerobic (living without air) bacteria, including susceptible strains of Staphylococcus aureus, Streptococcus pneumoniae, and Clostridium perfringens.

Storage

Store in a cool and dry place away from sunlight

Drug Warnings

Do not use Klariva 250 mg Tablet if you are allergic to any of its components. Let your doctor know if you have any liver or kidney diseases, gastrointestinal diseases (colitis, Clostridium difficile-associated diarrhoea), yellow food dye allergy, and allergic conditions (asthma, hay fever, eczema). Do not use Klariva 250 mg Tablet while getting vaccinated with live bacterial vaccines (typhoid vaccine) since Klariva 250 mg Tablet may affect vaccine activity. Pregnant and breastfeeding women should consult their doctor before taking Klariva 250 mg Tablet . Klariva 250 mg Tablet should be used in children only when prescribed by a doctor.

Drug-Drug Interactions

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ClindamycinIndinavir
Severe
ClindamycinAtazanavir
Severe

Drug-Drug Interactions

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ClindamycinIndinavir
Severe
How does the drug interact with Klariva 250 mg Tablet:
Concomitant use of Klariva 250 mg Tablet with indinavir may increase the effects of Klariva 250 mg Tablet.

How to manage the interaction:
Although there is a possible interaction, Klariva 250 mg Tablet can be taken with indinavir if prescribed by the doctor. Consult the prescriber if you experience persistent vomiting, nausea, abdominal pain, or diarrhoea.
ClindamycinAtazanavir
Severe
How does the drug interact with Klariva 250 mg Tablet:
Co-administration of Klariva 250 mg Tablet with Atazanavir may increase the effects of Klariva 250 mg Tablet.

How to manage the interaction:
Although there is a possible interaction, Klariva 250 mg Tablet can be taken with atazanavir if prescribed by the doctor. Consult the prescriber if you experience persistent nausea, vomiting, diarrhea, or abdominal pain. Do not discontinue the medication without consulting a doctor.
ClindamycinEstradiol
Severe
How does the drug interact with Klariva 250 mg Tablet:
When taken in combination, Klariva 250 mg Tablet can lower the amount or action of estradiol.

How to manage the interaction:
Co-administration of Estradiol with Klariva 250 mg Tablet can result in an interaction, but it can be taken if a doctor has advised it. Do not stop using any medications without a doctor's advice.
ClindamycinItraconazole
Severe
How does the drug interact with Klariva 250 mg Tablet:
Concomitant use of Klariva 250 mg Tablet with itraconazole can reduce the metabolism and increase the levels of Klariva 250 mg Tablet in the body. This may increase the risk or severity of side effects.

How to manage the interaction:
Although there is a possible interaction, Klariva 250 mg Tablet can be taken with itraconazole if prescribed by the doctor. Consult a doctor immediately if you experience persistent vomiting, nausea, abdominal pain, or diarrhea. Do not stop using any medications without first talking to your doctor.
ClindamycinKetoconazole
Severe
How does the drug interact with Klariva 250 mg Tablet:
Coadministration of use of Klariva 250 mg Tablet with ketoconazole can increase the effects of Klariva 250 mg Tablet.

How to manage the interaction:
Although there is a possible interaction, Klariva 250 mg Tablet can be taken with ketoconazole if prescribed by the doctor. Consult the prescriber if you experience persistent vomiting, nausea, abdominal pain or diarrhea. Do not discontinue any medication without consulting a doctor. Do not discontinue any medication without consulting a doctor.
ClindamycinBotulinum toxin
Severe
How does the drug interact with Klariva 250 mg Tablet:
Taking Klariva 250 mg Tablet with Botulinum toxin can increase the risk or severity of side effects.

How to manage the interaction:
Taking Klariva 250 mg Tablet with Botulinum toxin together can result in an interaction, they can be taken together if prescribed by a doctor. However, if you experience any unusual symptoms contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
ClindamycinAtracurium
Severe
How does the drug interact with Klariva 250 mg Tablet:
Co-administration of Klariva 250 mg Tablet with Atracurium can increase the risk of muscle weakness.

How to manage the interaction:
Taking Klariva 250 mg Tablet with Atracurium together can possibly result in an interaction, but it can be taken if a doctor has advised it. "Klariva 250 mg Tablet can affect the muscles and nerves in your body. When used with other medications that also affect the muscles and nerves, it can cause a serious problem called neuromuscular blockade. If you have trouble breathing or can't breathe at all, please call your doctor right away." Do not stop using any medications without a doctor's advice.
ClindamycinCholera, live attenuated
Severe
How does the drug interact with Klariva 250 mg Tablet:
Co-administration of Klariva 250 mg Tablet may reduce the activity of the cholera vaccine.

How to manage the interaction:
Talk to your doctor before receiving the Cholera vaccine if you are currently being treated with Klariva 250 mg Tablet or have been treated within the last 14 days. To ensure adequate vaccine response, you should not receive cholera vaccine until at least 14 days after you complete antibiotic therapy. Do not discontinue the medication without consulting a doctor.
ClindamycinFosphenytoin
Severe
How does the drug interact with Klariva 250 mg Tablet:
When Klariva 250 mg Tablet is taken with Fosphenytoin, it can cause the body to process Klariva 250 mg Tablet faster.

How to manage the interaction:
Although there is a possible interaction between Klariva 250 mg Tablet and Fosphenytoin, you can take these medicines together if prescribed by your doctor. If you notice any symptoms like sudden drowsiness, fatigue, confusion, itching, burning, or tingling sensation, abnormal body movements, or loss of coordination, make sure to contact your doctor right away. Do not stop using any medications without first talking to your doctor.
ClindamycinBacitracin
Severe
How does the drug interact with Klariva 250 mg Tablet:
Co-administration of Klariva 250 mg Tablet with Bacitracin may increase the risk of kidney and/or nerve damage.

How to manage the interaction:
Although there is a possible interaction, Klariva 250 mg Tablet can be taken with bacitracin if prescribed by the doctor. Consult the prescriber if you experience signs and symptoms of kidney damage such as sudden weight gain or weight loss, nausea, vomiting, fluid retention, loss of appetite, increased or decreased urination, swelling, shortness of breath, muscle cramps, tiredness, weakness, dizziness, confusion, and irregular heart rhythm. Let your doctor know if you develop seizures; hearing problems; or numbness, burning or tingling in your hands and feet. If you develop diarrhoea or vomiting during treatment with these medications, drink plenty of fluids to prevent dehydration, as dehydration may harm the kidney.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

  • Include whole-grain foods like multigrain bread and brown rice in your diet. 
  • Taking probiotics after an antibiotic treatment reduces the risk of antibiotic-associated diarrhoea. 
  • Try taking yoghurt, cheese, sauerkraut, and kimchi that help restore the intestine's good bacteria.
  • Include more fibre-enriched food in your diet that is easily digested by your gut bacteria. Fibre foods may also help restore healthy gut bacteria after a course of antibiotics. 
  • Avoid intake of alcoholic beverages as it can make you dehydrated and affect your sleep. 
  • Manage stress, eat healthily, drink plenty of water, exercise regularly, and get plenty of sleep. 

Habit Forming

No

Therapeutic Class

ANTIBIOTICS

Author Details

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Drug-Diseases Interactions

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CLINDAMYCIN-250MGOther bacterial intestinal infections
Severe
CLINDAMYCIN-250MGDisorders related to short gestation and low birth weight, not elsewhere classified
Severe

Drug-Diseases Interactions

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CLINDAMYCIN-250MGOther bacterial intestinal infections
Severe
How does the disease interact with Klariva 250 mg Tablet:
Almost all antibacterial medications have been associated with reports of Clostridioides difficile-associated diarrhoea (CDAD), formerly known as pseudomembranous colitis. It can vary from mild diarrhoea to deadly colitis.

How to manage the interaction:
Clostridioides difficile-associated diarrhea (CDAD) ranging from mild diarrhoea to colitis has been reported during treatment with antibacterial agents. Therapy should be administered cautiously in patients with history of gastrointestinal disease, particularly colitis and pseudomembranous colitis. Appropriate fluid and electrolyte management, protein supplementation, and antibacterial treatment of C difficile is advised.
CLINDAMYCIN-250MGDisorders related to short gestation and low birth weight, not elsewhere classified
Severe
How does the disease interact with Klariva 250 mg Tablet:
Benzyl alcohol is frequently used as a preservative in the formulation of multidose vials for parenteral medicines. Manufacturers of pharmaceuticals believe that using them in neonates, especially preterm and underweight newborns, is contraindicated. In low birth weight preterm newborns, the use of benzyl alcohol in bacteriostatic saline intravascular flush and endotracheal tube lavage solutions has been linked to mortality and serious respiratory and metabolic problems.

How to manage the interaction:
Parenteral medications containing benzyl alcohol as a preservative are contraindicated in neonates, particularly premature infants and infants of low birth weight.
CLINDAMYCIN-250MGOther diseases of liver
Moderate
How does the disease interact with Klariva 250 mg Tablet:
The liver is the primary site of Klariva 250 mg Tablet metabolism. Patients with significantly impaired hepatic function may have a rise in the blood concentration of Klariva 250 mg Tablet and a prolongation of the half-life. Additionally, the drug's usage may result in abnormal liver enzyme levels and jaundice. Patients with liver problems should receive Klariva 250 mg Tablet therapy with caution. When given every 8 hours, dosage modifications might not be required. However, with high-dose therapy, serum concentrations should be observed, and during prolonged therapy, regular liver function tests should be carried out.

How to manage the interaction:
Klariva 250 mg Tablet is primarily metabolized by the liver. Therapy with Klariva 250 mg Tablet should be administered cautiously in patients with liver disease. Serum concentrations should be monitored during high-dose therapy, and periodic liver function tests should be performed during prolonged therapy.
CLINDAMYCIN-250MGOther disorders of kidney and ureter, not elsewhere classified
Moderate
How does the disease interact with Klariva 250 mg Tablet:
Klariva 250 mg Tablet is partially removed by the kidney. Klariva 250 mg Tablet should be used with caution in individuals with significantly impaired renal function. Dosage changes are probably to be required. Serum Klariva 250 mg Tablet concentrations should be monitored throughout high-dose therapy, and renal function tests should be conducted on a regular basis during extended medication.

How to manage the interaction:
Therapy with Klariva 250 mg Tablet should be administered cautiously in patients with severely impaired renal function. Serum Klariva 250 mg Tablet concentrations should be monitored during high-dose therapy, and periodic renal function tests should be performed during prolonged therapy.
CLINDAMYCIN-250MGOther disorders of kidney and ureter, not elsewhere classified
Moderate
How does the disease interact with Klariva 250 mg Tablet:
Klariva 250 mg Tablet is partially removed by the kidney. Klariva 250 mg Tablet should be used with caution in individuals with significantly impaired renal function. Dosage changes are probably to be required. Serum Klariva 250 mg Tablet concentrations should be monitored throughout high-dose therapy, and renal function tests should be conducted on a regular basis during extended medication.

How to manage the interaction:
Therapy with Klariva 250 mg Tablet should be administered cautiously in patients with severely impaired renal function. Serum Klariva 250 mg Tablet concentrations should be monitored during high-dose therapy, and periodic renal function tests should be performed during prolonged therapy.

FAQs

Klariva 250 mg Tablet is an antibiotic that treats bacterial infections. It works by inhibiting bacterial protein synthesis, which retards bacterial growth.

Klariva 250 mg Tablet should be used with proper caution and doctor consultation if you have any liver disease, kidney disease, gastrointestinal diseases (colitis, an inflammation of the colon), yellow food dye allergy, and allergic conditions (asthma, hay fever, eczema).

Klariva 250 mg Tablet can affect the live vaccines like typhoid vaccine and decrease its effectiveness. Please consult a doctor before you start Klariva 250 mg Tablet if you are due to undergo any vaccinations.

Klariva 250 mg Tablet may cause abnormal liver function tests as one of its side effects. Please consult your doctor before starting Klariva 250 mg Tablet if you have any history of liver problems.

It is recommended to complete the course of Klariva 250 mg Tablet even if you feel better as it is an antibiotic, and stopping it midway may lead to recurring infections.

Diarrhoea can be a side-effect of Klariva 250 mg Tablet . Drink enough fluids and eat non-spicy food if you experience diarrhoea. If you find blood in stools (tarry stools) or experience severe diarrhoea, consult your doctor. Do not take anti-diarrhoeal medicine on your own.

Drug-Drug Interactions Checker List

  • ERYTHROMYCIN
  • WARFARIN
  • CARBAMAZEPINE
  • RIFAMPICIN
  • PHENYTOIN

Special Advise

  • Liver function monitoring (Liver function tests) is recommended in patients with severe liver disease.
  • Clostridium difficile-associated diarrhoea (CDAD) is reported during the usage of antibiotics. Please consult your doctor if you experience prolonged diarrhoea.
  • Coagulation (blood clotting) tests are recommended when Klariva 250 mg Tablet is used along with anticoagulants.

Disease/Condition Glossary

Bacterial infection: It occurs when harmful bacteria grow in the body and causes illness. It can infect any part of the body and multiply very quickly. Bacteria may be gram-positive (have a thick cell wall) or gram-negative (do not have a cell wall). Some common symptoms of a bacterial infection include cough, fever, shortness of breath, chills, muscle pain, fatigue, and tiredness. Untreated bacterial infections may lead to serious life-threatening conditions like sepsis.

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