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Written By Santoshini Reddy G , M Pharmacy
Reviewed By Veda Maddala , M Pharmacy

About Klotrim 5Ml Inj

Klotrim 5Ml Inj belongs to the group of medicines called ‘antibiotics’ used to treat bacterial infections of the urinary tract, respiratory tract (bronchitis), ear (otitis media), lungs (pneumonia), skin, brain and toxoplasmosis (infection caused by a bacteria called toxoplasma). Bacterial infections are caused due to the multiplication of harmful bacteria inside or on the body. Klotrim 5Ml Inj does not work against infections caused by the virus, including cold and flu. 

Klotrim 5Ml Inj is a combination of two antibiotics, namely: Trimethoprim and Sulfamethoxazole. Trimethoprim prevents the formation of tetrahydrofolic acid, and sulfamethoxazole stops the bacteria from making dihydrofolic acid. Tetrahydrofolic acid and dihydrofolic acid are essential for the formation of proteins and nucleic acids in the bacterial cell, which is necessary for the survival of the bacteria. By inhibiting these, Klotrim 5Ml Inj stops the growth of bacteria and kills them. Thereby, it helps to treat bacterial infections.

Klotrim 5Ml Inj will be administered by a healthcare professional; do not self-administer. In some cases, you may experience certain common side effects such as high levels of potassium in the blood, palpitations (abnormal heartbeats), thrush or candidiasis (fungal infection), headache, nausea, diarrhoea, and skin rashes. Most of these side effects do not require medical attention and resolve gradually over time. However, you are advised to talk to your doctor if you experience these side effects persistently.

Before starting Klotrim 5Ml Inj, please inform your doctor if you have any allergy (against any antibiotic), severe kidney or liver problems, porphyria (blood disorder), or blood problems which may cause bleeding or bruising. Inform your doctor if you are pregnant or breastfeeding before receiving this injection. Klotrim 5Ml Inj is not recommended for infants below 6 weeks. Keep your doctor informed about your medical history and your ongoing medications to rule out any side effects/interactions.

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Non returnable*
COD available

Online payment accepted

Consume Type

PARENTERAL

Return Policy

3 Days Returnable

Expires on or after

Apr-24

for this medicine

Uses of Klotrim 5Ml Inj

Bacterial infections

Medicinal Benefits

Klotrim 5Ml Inj belongs to the group of medicines called ‘antibiotics’ used to treat various bacterial infections of the urinary tract, respiratory tract (bronchitis), ear (otitis media), lungs (pneumonia), skin, brain and toxoplasmosis (infection caused by a bacteria called toxoplasma). Klotrim 5Ml Inj is a combination of two antibiotics, namely: Trimethoprim (folic acid inhibitors) and Sulfamethoxazole (sulfonamides). Trimethoprim prevents the formation of tetrahydrofolic acid, and sulfamethoxazole stops the bacteria from making dihydrofolic acid. Tetrahydrofolic acid and dihydrofolic acid are essential for the formation of proteins and nucleic acids in the bacterial cell, which is necessary for the survival of the bacteria. By inhibiting these, Klotrim 5Ml Inj kills the bacteria and stops their growth. Thereby, it helps to treat bacterial infections. Klotrim 5Ml Inj is a broad-spectrum antibiotic which is active against a wide range of gram-positive and gram-negative bacteria.

Side Effects of Klotrim 5Ml Inj

  • High levels of potassium in the blood
  • Palpitations (abnormal heartbeats)
  • Thrush or candidiasis (fungal infection)
  • Headache
  • Nausea
  • Diarrhoea
  • Skin rashes

 

Directions for Use

Klotrim 5Ml Inj is administered by a healthcare professional; do not self-administer.

Storage

Store in a cool and dry place away from sunlight

Drug Warnings

Do not take Klotrim 5Ml Inj if you are allergic to any of its contents; if you have severe liver or kidney problems, thrombocytopenia (low levels of platelets in the blood), or porphyria (a rare blood problem). Consult your doctor immediately if you experience skin rash or prolonged, significant diarrhoea with abdominal pain. Talk to your doctor before taking Klotrim 5Ml Inj if you have severe allergies, asthma, ulcers, blood disorders, thyroid dysfunction, diabetes, are elderly, underweight or malnourished; if you have a folic acid deficiency, glucose-6-phosphate dehydrogenase deficiency, or high levels of potassium in the blood. Consult your doctor if you are pregnant or breastfeeding. 

Therapeutic Class

ANTIBIOTIC COMBINATION

Drug-Drug Interactions

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TrimethoprimBCG vaccine
Critical
sulfamethoxazoleClozapine
Severe

Drug-Drug Interactions

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TrimethoprimBCG vaccine
Critical
How does the drug interact with Klotrim 5Ml Inj:
Taking Klotrim 5Ml Inj with BCG vaccine can reduce the effectiveness of the BCG vaccine

How to manage the interaction:
Although there is an interaction between Klotrim 5Ml Inj and BCG vaccine is not recommended, they can be taken together if prescribed by a doctor. Do not discontinue any medications without consulting a doctor.
sulfamethoxazoleClozapine
Severe
How does the drug interact with Klotrim 5Ml Inj:
The combined use of Klotrim 5Ml Inj and clozapine may increase the risk or severity of toxicity.

How to manage the interaction:
There may be a possibility of interaction between Clozapine and Klotrim 5Ml Inj, but it can be taken if prescribed by a doctor. If you're having any of these symptoms like fever, chills, sore throat, or muscle aches, it's important to contact your doctor right away. They may be able to recommend other options for you that won't cause any problems. Don't worry, there are solutions available to help you feel better. Do not discontinue any medications without first consulting your doctor.
TrimethoprimCaptopril
Severe
How does the drug interact with Klotrim 5Ml Inj:
Taking captopril with Klotrim 5Ml Inj may increase the risk of hyperkalemia (high level of potassium in the blood) and kidney problems.

How to manage the interaction:
Although there is a interaction between Klotrim 5Ml Inj and captopril, they can be taken together if prescribed by a doctor. Do not discontinue any medications without consulting a doctor.
TrimethoprimProcaine
Severe
How does the drug interact with Klotrim 5Ml Inj:
Co-administration of Klotrim 5Ml Inj with procaine may increase the risk of blood disorders.

How to manage the interaction:
Taking Klotrim 5Ml Inj with Procaine together can possibly result in an interaction, but it can be taken if your doctor has advised it. If you notice any of these symptoms like gray skin, feeling sick, headache, dizziness, tiredness, trouble breathing, fast heartbeat, or feeling anxious or confused, contact your doctor right away. Do not stop using any medications without talking to your doctor.
TrimethoprimPotassium gluconate
Severe
How does the drug interact with Klotrim 5Ml Inj:
Taking potassium gluconate with Klotrim 5Ml Inj can increase the risk of high potassium levels in the blood.

How to manage the interaction:
Although there is a possible interaction between Klotrim 5Ml Inj and Potassium gluconate, you can take these medicines together if prescribed by your doctor. However, if you are feeling sick, feeling weak, confused, or having a weak or irregular heartbeat contact your doctor immediately. Do not stop using any medications without talking to your doctor.
TrimethoprimRopivacaine
Severe
How does the drug interact with Klotrim 5Ml Inj:
Using ropivacaine with Klotrim 5Ml Inj can cause higher levels of Klotrim 5Ml Inj in the blood.

How to manage the interaction:
Although taking Ropivacaine and Klotrim 5Ml Inj together can evidently cause an interaction, it can be taken if your doctor has suggested it. However, if you experience gray discoloration of the skin, abnormal blood coloration, nausea, headache, dizziness, lightheadedness, fatigue, shortness of breath, rapid or shallow breathing, a rapid heartbeat, palpitation, anxiety, or confusion contact your doctor immediately. Do not stop using any medications without a doctor's advice.
TrimethoprimPotassium acetate
Severe
How does the drug interact with Klotrim 5Ml Inj:
Taking potassium acetate with Klotrim 5Ml Inj may increase potassium levels in the blood which can increase the risk of kidney problems.

How to manage the interaction:
Although there is a possible interaction between Klotrim 5Ml Inj and Potassium acetate, you can take these medicines together if prescribed by your doctor. However, if you have unusual symptoms contact your doctor right away. Do not discontinue any medications without consulting your doctor.
TrimethoprimFosphenytoin
Severe
How does the drug interact with Klotrim 5Ml Inj:
Taking fosphenytoin with Klotrim 5Ml Inj may increase the risk of side effects.

How to manage the interaction:
Although there is an interaction between fosphenytoin and Klotrim 5Ml Inj, they can be taken together if prescribed by a doctor. However, consult a doctor if you experience, weakness, vomiting, blurry vision, or trouble speaking. Do not discontinue any medications without consulting a doctor.
TrimethoprimCandesartan
Severe
How does the drug interact with Klotrim 5Ml Inj:
Taking Klotrim 5Ml Inj with candesartan can increase the risk of hyperkalemia (high potassium levels in the blood) and kidney problems.

How to manage the interaction:
Although there is an interaction between candesartan and Klotrim 5Ml Inj, they can be taken together if prescribed by a doctor. Do not discontinue any medications without consulting a doctor.
TrimethoprimMethotrexate
Severe
How does the drug interact with Klotrim 5Ml Inj:
Coadministration of Klotrim 5Ml Inj with methotrexate can increase the risk or severity of blood disorders.

How to manage the interaction:
Although there is a possible interaction between Klotrim 5Ml Inj and methotrexate, you can take these medicines together if prescribed by your doctor. However, if you experience any symptoms such as pale skin, fatigue, dizziness, fainting, unusual bruising or bleeding, fever, chills, diarrhea, sore throat, muscle pains, breathing difficulty, blood in phlegm, weight loss, red or inflamed skin, body sores, and pain or burning during urination, contact a doctor immediately. Do not stop using any medications without consulting to a doctor.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Drug-Diseases Interactions

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No Drug - Disease interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Diseases Interactions

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Drug-Drug Interactions Checker List

  • WARFARIN
  • PHENYTOIN
  • DIGOXIN
  • ZIDOVUDINE
  • PROCAINAMIDE

Diet & Lifestyle Advise

  • Antibiotics can alter the useful bacteria in the stomach, which help in digestion. Therefore, you are advised to take foods rich in probiotics such as yoghurt/curd, kefir, sauerkraut, tempeh, kimchi, miso, kombucha, buttermilk, natto and cheese.
  • Eat fibre-rich food like whole grains, beans, lentils, berries, broccoli, peas and bananas.
  • Avoid foods rich in calcium, grapefruit and grapefruit juice as they might hinder the absorption of antibiotics.
  • Avoid consumption of alcohol and usage of tobacco.

 

Habit Forming

No

Special Advise

  • Klotrim 5Ml Inj may affect certain laboratory test results such as blood tests. Inform the lab technician that you are taking Klotrim 5Ml Inj. 
  • Your doctor may advise you to get regular tests if you have kidney problems or if you have been prescribed Klotrim 5Ml Inj for a longer duration, to know if the medicine is working properly.

 

Author Details

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Disease/Condition Glossary

Bacterial infections: A bacterial infection is a condition in which harmful bacteria enter, multiply, and infect the body cells. Infectious or harmful bacteria can make you sick and reproduce quickly in the body. These harmful bacteria produce chemicals known as toxins, which can damage tissue and make you sick. Symptoms include fever, chills, and fatigue. Anyone can become infected with a bacterial infection. But, people with a weak immune system or taking immunosuppressive medicine are more prone to bacterial infection.

Klotrim 5Ml Inj Substitute

Substitutes safety advice
  • Cotrimoxazole 400 mg Tablet 10's

    1.62per tablet
  • Septran Adult Tablet 10's

    0.86per tablet
  • Cotrimoxazole SS Tablet 10's

    1.08per tablet
  • Septran 100mg Tablet 10's

    0.86per tablet
  • Ivtrim Inj 5Ml

    210.60per tablet
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