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Knilonat 150 Capsule 10's

Knilonat 150 Capsule 10's

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Prescription drug
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Composition

NILOTINIB-150MG

Consume Type

ORAL

Return Policy

Not Returnable

for this medicine

About Knilonat 150 Capsule 10's

Knilonat 150 Capsule 10's belongs to the class of anticancer drugs called tyrosine kinase inhibitors used in the treatment of Philadelphia chromosome-positive chronic myeloid leukemia (Ph+ CML). Ph+ CML is a type of blood cancer that causes white blood cells to behave differently.

Knilonat 150 Capsule 10's contains Nilotinib which works by blocking the action of an abnormal protein (Bcr-Abl tyrosine kinase) produced by an abnormal Philadelphia chromosome that signals abnormal white blood cells (cancerous cells) to multiply. Thereby, it stops the multiplication and inhibits the growth of cancerous cells and then causes the death of these cells.

Take Knilonat 150 Capsule 10's as prescribed. You are recommended to take Knilonat 150 Capsule 10's for as long as your doctor has advised it for you based on your medical condition. Sometimes, Knilonat 150 Capsule 10's may cause common side effects such as vomiting, nausea, diarrhoea, headache, constipation, tiredness, and muscle and joint pain. Most of these side effects of Knilonat 150 Capsule 10's do not require medical attention and gradually resolve over time. However, if the side effects persist or worsen, please consult your doctor.

If you are allergic to Nilotinib or any other medicines, please tell your doctor. Avoid taking Knilonat 150 Capsule 10's if you are pregnant or breastfeeding. You are recommended to use effective contraceptive methods while taking Knilonat 150 Capsule 10's and for two weeks after completing the course of Knilonat 150 Capsule 10's. Knilonat 150 Capsule 10's is not recommended for children below one year of age. Drive only if you are alert as Knilonat 150 Capsule 10's may cause dizziness or visual disorders as side effects in some people. If you have yellow skin and eyes, dark-coloured urine, or stomach pain while taking Knilonat 150 Capsule 10's, contact your doctor immediately, as these might be symptoms of liver problems. 

Uses of Knilonat 150 Capsule 10's

Philadelphia chromosome-positive chronic myeloid leukemia (Ph+ CML)

Medicinal Benefits

Knilonat 150 Capsule 10's contains Nilotinib, an anticancer drug used to treat Philadelphia chromosome-positive chronic myeloid leukemia (Ph+ CML). In chronic myeloid leukemia (CML) patients, a change in genetic material (DNA) triggers a signal that tells the body to produce more abnormal white blood cells (cancerous cells). Nilotinib works by blocking this signal and thus stops the production of cancerous cells. Knilonat 150 Capsule 10's is used in adults and children with newly diagnosed Ph+ CML in the chronic phase and in adults with Ph+ CML in the accelerated and chronic phase who did not tolerate or no longer benefit from other treatments, including Imatinib. 

Directions for Use

Take this medicine on an empty stomach or as advised by the doctor. Avoid eating food for at least 2 hours before taking Knilonat 150 Capsule 10's and avoid eating for at least 1 hour after taking Knilonat 150 Capsule 10's. Swallow it as a whole with a glass of water. If you are unable to swallow it, open the capsule and sprinkle the contents in 1 teaspoon of applesauce and take it right away (within 15 minutes). Do not use more than one teaspoon of apple sauce for each capsule, and do not use any food other than apple sauce.

Storage

Store in a cool and dry place away from sunlight

Side Effects of Knilonat 150 Capsule 10's

  • Vomiting
  • Nausea
  • Diarrhoea
  • Headache
  • Constipation
  • Tiredness
  • Muscle and joint pain

Drug Warnings

If you are allergic to Nilotinib or any other medicines, please tell your doctor. Avoid taking Knilonat 150 Capsule 10's if you are pregnant or breastfeeding. You are recommended to use effective contraceptive methods while taking Knilonat 150 Capsule 10's and for two weeks after completing the course of Knilonat 150 Capsule 10's. Knilonat 150 Capsule 10's is not recommended for children below one year of age. Knilonat 150 Capsule 10's may affect the growth and development of children with chronic phase Ph+ CML. Some children and adolescents may have slower than normal growth while taking Knilonat 150 Capsule 10's. Therefore, your doctor will monitor the growth of your child at regular visits. Drive only if you are alert as Knilonat 150 Capsule 10's may cause dizziness or visual disorders as side effects in some people. Knilonat 150 Capsule 10's may increase the risk of liver problems, especially in people with a history of liver problems. Therefore, if you have yellow skin and eyes, dark-coloured urine, or stomach pain while taking Knilonat 150 Capsule 10's, contact your doctor immediately, as these might be symptoms of liver problems. Inform your doctor if you have a severe problem with lactose (milk sugar) or other sugars as Knilonat 150 Capsule 10's may contain lactose. Most people who have mild or moderate lactose intolerance can take Knilonat 150 Capsule 10's. Avoid taking Knilonat 150 Capsule 10's if you have low levels of magnesium or potassium in the blood or long QTc syndrome. If you have had a surgical procedure involving the removal of the entire stomach (total gastrectomy), inform your doctor before taking Knilonat 150 Capsule 10's.

Drug Interactions

Drug-Drug Interaction: Knilonat 150 Capsule 10's may interact with anti-arrhythmic drugs (disopyramide, quinidine, amiodarone, sotalol, procainamide), antibiotics (clarithromycin, moxifloxacin), antimalarial drugs (chloroquine), antipsychotics (haloperidol, pimozide), opioid analgesics (methadone, fentanyl, alfentanil), anticonvulsants (phenytoin, carbamazepine, phenobarbital), blood thinner (warfarin), anti-HIV drug (rifampicin), antifungals (itraconazole, ketoconazole, voriconazole) and immunosuppressants (cyclosporine, tacrolimus, sirolimus). Inform your doctor if you are using any medicines before taking Knilonat 150 Capsule 10's.

Drug-Food Interaction: Avoid grapefruit juice, grapefruit and any supplement containing grapefruit extract while taking Knilonat 150 Capsule 10's as it may increase the amount of Nilotinib in the body and cause serious side effects. Also, Knilonat 150 Capsule 10's may interact with St. John’s wort (a herbal product used to treat depression). 

Drug-Disease Interaction: Avoid taking Knilonat 150 Capsule 10's if you have low levels of magnesium or potassium in the blood or long QTc syndrome. If you have had pancreatitis, stroke or other problems due to decreased blood flow to the brain, have QTc prolongation or a family history of it, bleeding problems, irregular heartbeat, have low problems with decreased blood flow to your legs, have low levels of magnesium or potassium in blood, heart or liver problems, inform your doctor before taking Knilonat 150 Capsule 10's.

Drug-Drug Interactions Checker List

  • DISOPYRAMIDE
  • QUINIDINE
  • AMIODARONE
  • SOTALOL
  • PROCAINAMIDE
  • CLARITHROMYCIN
  • MOXIFLOXACIN
  • CHLOROQUINE
  • HALOPERIDOL
  • PIMOZIDE
  • METHADONE
  • FENTANYL
  • ALFENTANIL
  • PHENYTOIN
  • CARBAMAZEPINE
  • PHENOBARBITAL
  • WARFARIN
  • RIFAMPICIN
  • ITRACONAZOLE
  • KETOCONAZOLE
  • VORICONAZOLE
  • CYCLOSPORINE
  • TACROLIMUS
  • SIROLIMUS

Habit Forming

No

Diet & Lifestyle Advise

  • Drink nutrient-rich liquids such as juices, shakes and soups if you have trouble swallowing solid food.
  • Eat frequently by opting for 4 to 6 smaller meals a day instead of 2 to 3 big meals.
  • Consume a variety of vegetables, including legumes.
  • Eat whole grains, whole fruits, and fat-free or low-fat dairy products.
  • Include a variety of proteins in the diet, such as lean meats, poultry, seafood, soy, beans, and eggs.
  • Use healthy oils such as olive oil.
  • Drink plenty of water to keep yourself hydrated.

Special Advise

  • Knilonat 150 Capsule 10's can cause a possibly life-threatening heart problem called QTc prolongation (causes irregular heartbeat, which may lead to sudden death). Therefore, if you faint, feel lightheaded or have an irregular heartbeat while taking Knilonat 150 Capsule 10's, please contact your doctor immediately, as these might be symptoms of QTc prolongation.

Regular tests are recommended during treatment with Knilonat 150 Capsule 10's:

  • To monitor the number of blood cells (red blood cells, white blood cells and platelets), liver and pancreas function in the body to see how Knilonat 150 Capsule 10's is tolerated.
  • To monitor electrolytes (magnesium, potassium) in the body that are essential in the functioning of the heart.
  • To check the level of fats and sugar in the blood.
  • Also, ECG is recommended to check the heart rate.

Disease/Condition Glossary

Philadelphia chromosome-positive chronic myeloid leukemia (Ph+ CML): It is a common form of chronic myeloid leukemia (CML) that occurs when specific chromosomes swap positions, causing an abnormality in the chromosomes, creating the Philadelphia chromosome. The abnormal chromosomes produce an abnormal protein called Bcr-Abl tyrosine kinase, which then triggers a signal to produce abnormal white blood cells in the bone marrow. CML is a type of blood cancer which makes the body produce too many abnormal white blood cells. Many people with Ph+ CML will not experience symptoms before their diagnosis. However, if symptoms do occur, they include weight loss, weakness, night sweats, extreme tiredness, feeling full after only small meals, bone pain, and easy bleeding.  

Country of origin

India
Other Info - KNI0011

FAQs

Knilonat 150 Capsule 10's contains Nilotinib, an anticancer drug. In chronic myeloid leukemia (CML) patients, a change in genetic material (DNA) triggers a signal that tells the body to produce more abnormal white blood cells (cancerous cells). Nilotinib works by blocking this signal and thus stops the production of cancerous cells.
You are not recommended to take antacids and Knilonat 150 Capsule 10's at the same time. You are advised to take antacids containing magnesium hydroxide, aluminium hydroxide, and simethicone about two hours before or two hours after taking Knilonat 150 Capsule 10's. However, please consult a doctor before taking other medicines with Knilonat 150 Capsule 10's.
You are recommended to avoid grapefruit juice, grapefruit and any supplement containing grapefruit extract while taking Knilonat 150 Capsule 10's as it may increase the amount of Nilotinib in the body and cause serious side effects.

Disclaimer

While we strive to provide complete, accurate, and expert-reviewed content on our 'Platform', we make no warranties or representations and disclaim all responsibility and liability for the completeness, accuracy, or reliability of the aforementioned content. The content on our platform is for informative purposes only, and may not cover all clinical/non-clinical aspects. Reliance on any information and subsequent action or inaction is solely at the user's risk, and we do not assume any responsibility for the same. The content on the Platform should not be considered or used as a substitute for professional and qualified medical advice. Please consult your doctor for any query pertaining to medicines, tests and/or diseases, as we support, and do not replace the doctor-patient relationship.
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Alcohol

Consult your doctor

The interaction of Knilonat 150 Capsule 10's with alcohol is unknown. Please discuss with your doctor if you have any concerns regarding this.

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Pregnancy

Unsafe

Knilonat 150 Capsule 10's is not recommended for use during pregnancy as it may harm the unborn baby. Therefore, inform your doctor if you are pregnant or planning for pregnancy before taking Knilonat 150 Capsule 10's. Also, you are advised to use effective birth control measures during treatment with Knilonat 150 Capsule 10's and for up to 2 weeks after the last dose of Knilonat 150 Capsule 10's.

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Breast Feeding

Unsafe

You are recommended to avoid breastfeeding during treatment with Knilonat 150 Capsule 10's and for two weeks after the final dose. Inform your doctor if you are breastfeeding.

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Driving

Caution

If you experience side effects such as dizziness or visual disorders, avoid driving or operating machinery until you are alert.

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Liver

Caution

Inform your doctor if you have liver problems before taking Knilonat 150 Capsule 10's. Your doctor may adjust the dose if necessary based on your condition.

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Kidney

Consult your doctor

Limited information is available on the use of Knilonat 150 Capsule 10's in patients with impaired kidney function. Therefore, if you have kidney problems, inform your doctor before taking Knilonat 150 Capsule 10's.

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Children

Caution

Knilonat 150 Capsule 10's is not recommended for children below 1 year of age as the safety and effectiveness were not established.

Author Details

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