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Knilonat 150 Capsule 10's belongs to the class of anticancer drugs called tyrosine kinase inhibitors used in the treatment of Philadelphia chromosome-positive chronic myeloid leukemia (Ph+ CML). Ph+ CML is a type of blood cancer that causes white blood cells to behave differently.
Knilonat 150 Capsule 10's contains Nilotinib which works by blocking the action of an abnormal protein (Bcr-Abl tyrosine kinase) produced by an abnormal Philadelphia chromosome that signals abnormal white blood cells (cancerous cells) to multiply. Thereby, it stops the multiplication and inhibits the growth of cancerous cells and then causes the death of these cells.
Take Knilonat 150 Capsule 10's as prescribed. You are recommended to take Knilonat 150 Capsule 10's for as long as your doctor has advised it for you based on your medical condition. Sometimes, Knilonat 150 Capsule 10's may cause common side effects such as vomiting, nausea, diarrhoea, headache, constipation, tiredness, and muscle and joint pain. Most of these side effects of Knilonat 150 Capsule 10's do not require medical attention and gradually resolve over time. However, if the side effects persist or worsen, please consult your doctor.
If you are allergic to Nilotinib or any other medicines, please tell your doctor. Avoid taking Knilonat 150 Capsule 10's if you are pregnant or breastfeeding. You are recommended to use effective contraceptive methods while taking Knilonat 150 Capsule 10's and for two weeks after completing the course of Knilonat 150 Capsule 10's. Knilonat 150 Capsule 10's is not recommended for children below one year of age. Drive only if you are alert as Knilonat 150 Capsule 10's may cause dizziness or visual disorders as side effects in some people. If you have yellow skin and eyes, dark-coloured urine, or stomach pain while taking Knilonat 150 Capsule 10's, contact your doctor immediately, as these might be symptoms of liver problems.
Knilonat 150 Capsule 10's contains Nilotinib, an anticancer drug used to treat Philadelphia chromosome-positive chronic myeloid leukemia (Ph+ CML). In chronic myeloid leukemia (CML) patients, a change in genetic material (DNA) triggers a signal that tells the body to produce more abnormal white blood cells (cancerous cells). Nilotinib works by blocking this signal and thus stops the production of cancerous cells. Knilonat 150 Capsule 10's is used in adults and children with newly diagnosed Ph+ CML in the chronic phase and in adults with Ph+ CML in the accelerated and chronic phase who did not tolerate or no longer benefit from other treatments, including Imatinib.
If you are allergic to Nilotinib or any other medicines, please tell your doctor. Avoid taking Knilonat 150 Capsule 10's if you are pregnant or breastfeeding. You are recommended to use effective contraceptive methods while taking Knilonat 150 Capsule 10's and for two weeks after completing the course of Knilonat 150 Capsule 10's. Knilonat 150 Capsule 10's is not recommended for children below one year of age. Knilonat 150 Capsule 10's may affect the growth and development of children with chronic phase Ph+ CML. Some children and adolescents may have slower than normal growth while taking Knilonat 150 Capsule 10's. Therefore, your doctor will monitor the growth of your child at regular visits. Drive only if you are alert as Knilonat 150 Capsule 10's may cause dizziness or visual disorders as side effects in some people. Knilonat 150 Capsule 10's may increase the risk of liver problems, especially in people with a history of liver problems. Therefore, if you have yellow skin and eyes, dark-coloured urine, or stomach pain while taking Knilonat 150 Capsule 10's, contact your doctor immediately, as these might be symptoms of liver problems. Inform your doctor if you have a severe problem with lactose (milk sugar) or other sugars as Knilonat 150 Capsule 10's may contain lactose. Most people who have mild or moderate lactose intolerance can take Knilonat 150 Capsule 10's. Avoid taking Knilonat 150 Capsule 10's if you have low levels of magnesium or potassium in the blood or long QTc syndrome. If you have had a surgical procedure involving the removal of the entire stomach (total gastrectomy), inform your doctor before taking Knilonat 150 Capsule 10's.
Drug-Drug Interaction: Knilonat 150 Capsule 10's may interact with anti-arrhythmic drugs (disopyramide, quinidine, amiodarone, sotalol, procainamide), antibiotics (clarithromycin, moxifloxacin), antimalarial drugs (chloroquine), antipsychotics (haloperidol, pimozide), opioid analgesics (methadone, fentanyl, alfentanil), anticonvulsants (phenytoin, carbamazepine, phenobarbital), blood thinner (warfarin), anti-HIV drug (rifampicin), antifungals (itraconazole, ketoconazole, voriconazole) and immunosuppressants (cyclosporine, tacrolimus, sirolimus). Inform your doctor if you are using any medicines before taking Knilonat 150 Capsule 10's.
Drug-Food Interaction: Avoid grapefruit juice, grapefruit and any supplement containing grapefruit extract while taking Knilonat 150 Capsule 10's as it may increase the amount of Nilotinib in the body and cause serious side effects. Also, Knilonat 150 Capsule 10's may interact with St. John’s wort (a herbal product used to treat depression).
Drug-Disease Interaction: Avoid taking Knilonat 150 Capsule 10's if you have low levels of magnesium or potassium in the blood or long QTc syndrome. If you have had pancreatitis, stroke or other problems due to decreased blood flow to the brain, have QTc prolongation or a family history of it, bleeding problems, irregular heartbeat, have low problems with decreased blood flow to your legs, have low levels of magnesium or potassium in blood, heart or liver problems, inform your doctor before taking Knilonat 150 Capsule 10's.
Regular tests are recommended during treatment with Knilonat 150 Capsule 10's:
Philadelphia chromosome-positive chronic myeloid leukemia (Ph+ CML): It is a common form of chronic myeloid leukemia (CML) that occurs when specific chromosomes swap positions, causing an abnormality in the chromosomes, creating the Philadelphia chromosome. The abnormal chromosomes produce an abnormal protein called Bcr-Abl tyrosine kinase, which then triggers a signal to produce abnormal white blood cells in the bone marrow. CML is a type of blood cancer which makes the body produce too many abnormal white blood cells. Many people with Ph+ CML will not experience symptoms before their diagnosis. However, if symptoms do occur, they include weight loss, weakness, night sweats, extreme tiredness, feeling full after only small meals, bone pain, and easy bleeding.
About Knilonat 150 Capsule 10's
Knilonat 150 Capsule 10's belongs to the class of anticancer drugs called tyrosine kinase inhibitors used in the treatment of Philadelphia chromosome-positive chronic myeloid leukemia (Ph+ CML). Ph+ CML is a type of blood cancer that causes white blood cells to behave differently.
Knilonat 150 Capsule 10's contains Nilotinib which works by blocking the action of an abnormal protein (Bcr-Abl tyrosine kinase) produced by an abnormal Philadelphia chromosome that signals abnormal white blood cells (cancerous cells) to multiply. Thereby, it stops the multiplication and inhibits the growth of cancerous cells and then causes the death of these cells.
Take Knilonat 150 Capsule 10's as prescribed. You are recommended to take Knilonat 150 Capsule 10's for as long as your doctor has advised it for you based on your medical condition. Sometimes, Knilonat 150 Capsule 10's may cause common side effects such as vomiting, nausea, diarrhoea, headache, constipation, tiredness, and muscle and joint pain. Most of these side effects of Knilonat 150 Capsule 10's do not require medical attention and gradually resolve over time. However, if the side effects persist or worsen, please consult your doctor.
If you are allergic to Nilotinib or any other medicines, please tell your doctor. Avoid taking Knilonat 150 Capsule 10's if you are pregnant or breastfeeding. You are recommended to use effective contraceptive methods while taking Knilonat 150 Capsule 10's and for two weeks after completing the course of Knilonat 150 Capsule 10's. Knilonat 150 Capsule 10's is not recommended for children below one year of age. Drive only if you are alert as Knilonat 150 Capsule 10's may cause dizziness or visual disorders as side effects in some people. If you have yellow skin and eyes, dark-coloured urine, or stomach pain while taking Knilonat 150 Capsule 10's, contact your doctor immediately, as these might be symptoms of liver problems.
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Uses of Knilonat 150 Capsule 10's
Medicinal Benefits
Knilonat 150 Capsule 10's contains Nilotinib, an anticancer drug used to treat Philadelphia chromosome-positive chronic myeloid leukemia (Ph+ CML). In chronic myeloid leukemia (CML) patients, a change in genetic material (DNA) triggers a signal that tells the body to produce more abnormal white blood cells (cancerous cells). Nilotinib works by blocking this signal and thus stops the production of cancerous cells. Knilonat 150 Capsule 10's is used in adults and children with newly diagnosed Ph+ CML in the chronic phase and in adults with Ph+ CML in the accelerated and chronic phase who did not tolerate or no longer benefit from other treatments, including Imatinib.
Side Effects of Knilonat 150 Capsule 10's
Directions for Use
Storage
Drug Warnings
If you are allergic to Nilotinib or any other medicines, please tell your doctor. Avoid taking Knilonat 150 Capsule 10's if you are pregnant or breastfeeding. You are recommended to use effective contraceptive methods while taking Knilonat 150 Capsule 10's and for two weeks after completing the course of Knilonat 150 Capsule 10's. Knilonat 150 Capsule 10's is not recommended for children below one year of age. Knilonat 150 Capsule 10's may affect the growth and development of children with chronic phase Ph+ CML. Some children and adolescents may have slower than normal growth while taking Knilonat 150 Capsule 10's. Therefore, your doctor will monitor the growth of your child at regular visits. Drive only if you are alert as Knilonat 150 Capsule 10's may cause dizziness or visual disorders as side effects in some people. Knilonat 150 Capsule 10's may increase the risk of liver problems, especially in people with a history of liver problems. Therefore, if you have yellow skin and eyes, dark-coloured urine, or stomach pain while taking Knilonat 150 Capsule 10's, contact your doctor immediately, as these might be symptoms of liver problems. Inform your doctor if you have a severe problem with lactose (milk sugar) or other sugars as Knilonat 150 Capsule 10's may contain lactose. Most people who have mild or moderate lactose intolerance can take Knilonat 150 Capsule 10's. Avoid taking Knilonat 150 Capsule 10's if you have low levels of magnesium or potassium in the blood or long QTc syndrome. If you have had a surgical procedure involving the removal of the entire stomach (total gastrectomy), inform your doctor before taking Knilonat 150 Capsule 10's.
Therapeutic Class
Drug-Drug Interactions Checker List
Diet & Lifestyle Advise
Habit Forming
Special Advise
Regular tests are recommended during treatment with Knilonat 150 Capsule 10's:
Disease/Condition Glossary
Philadelphia chromosome-positive chronic myeloid leukemia (Ph+ CML): It is a common form of chronic myeloid leukemia (CML) that occurs when specific chromosomes swap positions, causing an abnormality in the chromosomes, creating the Philadelphia chromosome. The abnormal chromosomes produce an abnormal protein called Bcr-Abl tyrosine kinase, which then triggers a signal to produce abnormal white blood cells in the bone marrow. CML is a type of blood cancer which makes the body produce too many abnormal white blood cells. Many people with Ph+ CML will not experience symptoms before their diagnosis. However, if symptoms do occur, they include weight loss, weakness, night sweats, extreme tiredness, feeling full after only small meals, bone pain, and easy bleeding.