apollo
logo
0Login
Introducing Our Latest Arrival!
Kombiglyze XR 5mg/500mg Tablet 7's

Kombiglyze XR 5mg/500mg Tablet 7's

Consult Doctor
Prescription drug
 Trailing icon

Consume Type

ORAL

Return Policy

Not Returnable

Expires on or after

Apr-24

for this medicine

About Kombiglyze XR 5mg/500mg Tablet 7's

Kombiglyze XR 5mg/500mg Tablet 7's belongs to a group of medicines known as antidiabetics, used in the treatment of type 2 diabetes in adults. Kombiglyze XR 5mg/500mg Tablet 7's is prescribed for the condition of type 2 diabetes when diet and exercise alone cannot control blood sugar levels. People with type 2 diabetes either do not produce enough insulin, or the insulin produced is unable to perform its function in the body (insulin resistance). Middle-aged or older individuals are most likely to suffer from type 2 diabetes, so it is also known as adult-onset diabetes.

Kombiglyze XR 5mg/500mg Tablet 7's contains two medications, namely: Saxagliptin and Metformin. Saxagliptin work by blocking the action of DPP-4/dipeptidyl peptidase-4  (an enzyme which destroys the hormone ‘Incretin’). The enzyme ‘Incretins’ help produce more insulin only when required and reduce blood sugar produced by the liver when not needed. On the other hand, Metformin, a 'biguanide', lowers the liver's glucose production, delays glucose absorption from the intestines, and increases the body's response to insulin. Together, they prevent the blood glucose levels from rising to very high levels, thus keeping your diabetes under control.

You are suggested to take Kombiglyze XR 5mg/500mg Tablet 7's for as long as your doctor has prescribed it. The most common side effect of Kombiglyze XR 5mg/500mg Tablet 7's is hypoglycemia (low blood glucose levels), upper respiratory tract infection, nasopharyngitis (nose and throat infection with common cold), and headache. Most of these side effects do not require medical attention and gradually resolve over time. If the side effects persist or worsen, consult a doctor.

Kombiglyze XR 5mg/500mg Tablet 7's should not be stopped even if you feel better. If you stop taking Kombiglyze XR 5mg/500mg Tablet 7's abruptly, it may increase your sugar levels which could further increase the risk of eyesight loss (retinopathy), kidney (nephropathy), and nerve damage (neuropathy). Kombiglyze XR 5mg/500mg Tablet 7's should not be taken if you have severe kidney or liver disease. Please inform your doctor if you have any heart disease, are planning to get pregnant or are breastfeeding. Safety and efficacy of Kombiglyze XR 5mg/500mg Tablet 7's in children under 18 years have not been established, so it should not be given to them. Patients taking digoxin (a heart medicine) with Kombiglyze XR 5mg/500mg Tablet 7's should be closely monitored as severe drug interaction has been observed.

Uses of Kombiglyze XR 5mg/500mg Tablet 7's

Type 2 diabetes (non-insulin-dependent diabetes).

Medicinal Benefits

Kombiglyze XR 5mg/500mg Tablet 7's contains two medications, namely: Saxagliptin and Metformin. Kombiglyze XR 5mg/500mg Tablet 7's helps keep your blood sugar levels under check. Kombiglyze XR 5mg/500mg Tablet 7's shows optimum effects when taken along with healthy lifestyle changes like weight loss, regular exercise, healthy diet, etc. Kombiglyze XR 5mg/500mg Tablet 7's plays a vital role in controlling blood sugar levels and prevents serious complications of diabetes like eyesight loss (retinopathy), kidney (nephropathy), nerve damage (neuropathy), diabetic foot ulcer, and delayed wound healing.

Directions for Use

Swallow Kombiglyze XR 5mg/500mg Tablet 7's as a whole with water; do not crush or chew it.

Storage

Store in a cool and dry place away from sunlight

Side Effects of Kombiglyze XR 5mg/500mg Tablet 7's

  • Dizziness
  • Sweating
  • Palpitations
  • Dry mouth and skin
  • Hypoglycaemia (low blood glucose level)

Drug Warnings

A prolonged intake of Kombiglyze XR 5mg/500mg Tablet 7's may cause acute pancreatitis (swollen pancreas) and critical kidney problem. Increased risk of hypoglycemia (low blood sugar level) can occur when Kombiglyze XR 5mg/500mg Tablet 7's is added to other anti-diabetic agents or insulin therapy. In this case, your doctor may adjust the dose of Kombiglyze XR 5mg/500mg Tablet 7's. Severe allergic reactions might occur in some patients taking Kombiglyze XR 5mg/500mg Tablet 7's, like anaphylaxis, angioedema (swelling under the skin), and exfoliative skin conditions, including Stevens-Johnson syndrome. 

Drug Interactions

Drug-Drug Interaction: Kombiglyze XR 5mg/500mg Tablet 7's interacts with an anti-depressant (bupropion), drugs used to treat glaucoma, antibiotics (cephalexin, ciprofloxacin), anti-acidity drugs (cimetidine), heart condition drugs (digoxin), anti-HIV drugs (dolutegravir), ethanol, saliva reducing drugs (glycopyrrolate), iodinated X-ray contrast agents, anti-epileptic drugs (topiramate, lamotrigine), heart-related chest medicine (ranolazine). Other drug interactions can contribute to an increased low blood sugar, including sex hormones (androgens), anti-oxidant (alpha-lipoic acid), painkillers (aspirin), anti-TB drugs (prothionamide), growth hormones (pegvisomant), and other antidiabetic medicines.

Drug-Food Interaction: Intake of excessive alcoholic beverages may increase the chance of a life-threatening condition known as Lactic Acidosis. So, avoid intake of alcoholic beverages with Kombiglyze XR 5mg/500mg Tablet 7's.

Drug-Disease Interaction: Kombiglyze XR 5mg/500mg Tablet 7's should be used with caution in patients with a history of pancreatitis/pancreatic disease and renal dysfunction.

Drug-Drug Interactions Checker List

  • DOLUTEGRAVIR
  • RANOLAZINE
  • TOPIRAMATE
  • ASPIRIN
  • DIGOXIN
  • CIMETIDINE
  • CIPROFLOXACIN
  • BUPROPION

Habit Forming

No

Diet & Lifestyle Advise

  • Invest at least 150 min of your week in moderate-intensity physical activity or one hour and 15 minutes of high-intensity exercise every week.
  • Replace refined carbohydrate-containing foods with whole grain foods and increase intake of fruits and vegetables and other fibre-enriched foods.
  • Reduce saturated fat (or hidden fats) intake in food like chips, crisps, pastries, biscuits, and samosas. Choose omega-3 fatty acid-containing oils for daily cooking. For frying, you can use palm oil, mustard oil, groundnut oil, rice bran oil, and safflower oil.
  • Avoid taking too much stress as it may elevate your blood sugar level. You can adopt stress management techniques like mindfulness to control stress-related blood sugar changes or meditation or yoga.
  • Opt for low-fat dairy products (low-fat yoghurt, fat-free milk, cheese, etc.).

Special Advise

Continue to take Kombiglyze XR 5mg/500mg Tablet 7's unless you are advised otherwise by your doctor, as a treatment for diabetes is usually lifelong.

Disease/Condition Glossary

Type 2 diabetes: It is a condition where the body is unable to make sufficient insulin, or the insulin that it makes doesn't work properly or is utilized by our body. This can cause high blood sugar levels (hyperglycemia). Symptoms of type 2 diabetes include increased thirst, frequent urination,  increased hunger, fatigue, and blurred vision. In some cases, there may be weight gain, while in rare cases, weight loss may be observed. The complication of type 2 diabetes includes neuropathy (nerve problems), nephropathy (kidney problems), retinopathy (damaged retina of eyes or blindness), loss of limbs, sexual dysfunction, and increased chance of heart attack or stroke.

Country of origin

United States

Manufacturer/Marketer address

Corporate & Registered Office, Block N1, 12th Floor, Manyata Embassy Business Park, Rachenahalli, Outer Ring Road, 560045, Bangalore
Other Info - KOM0013

FAQs

Yes, Kombiglyze XR 5mg/500mg Tablet 7's is known to cause stomach upset, indigestion, nausea, and diarrhoea. To avoid these side effects, please take Kombiglyze XR 5mg/500mg Tablet 7's with a meal. Also, Kombiglyze XR 5mg/500mg Tablet 7's should be taken at evenly spaced intervals to avoid any unpleasant side effects and for best results.
Kombiglyze XR 5mg/500mg Tablet 7's has been reported to increase blood cholesterol levels in a normal patient and thus not recommended in patients with hyperlipidemia.
The patient is advised to take the missed dose as soon as possible; otherwise, jump to the next dose. A patient should never take a double dose to compensate for the missed dose. It may aggravate harmful side effects.
According to American Diabetes Association, most of the studies carried out on Kombiglyze XR 5mg/500mg Tablet 7's and its ability to cause cancer resulted in a conclusion that Kombiglyze XR 5mg/500mg Tablet 7's is not associated with any form of cancer & hence is safe to use.
A patient who accidentally takes an overdose of Kombiglyze XR 5mg/500mg Tablet 7's may experience collapse, seizure attack, and troubled breathing. In such a case, without any delay, emergency health services must be contacted, and medical help should be sought.

Disclaimer

While we strive to provide complete, accurate, and expert-reviewed content on our 'Platform', we make no warranties or representations and disclaim all responsibility and liability for the completeness, accuracy, or reliability of the aforementioned content. The content on our platform is for informative purposes only, and may not cover all clinical/non-clinical aspects. Reliance on any information and subsequent action or inaction is solely at the user's risk, and we do not assume any responsibility for the same. The content on the Platform should not be considered or used as a substitute for professional and qualified medical advice. Please consult your doctor for any query pertaining to medicines, tests and/or diseases, as we support, and do not replace the doctor-patient relationship.
bannner image

Alcohol

Unsafe

Kombiglyze XR 5mg/500mg Tablet 7's is not advised to be taken with alcohol as it causes bizarre interactions. Both hypoglycemia (low blood sugar) and hyperglycemia (high blood sugar) may occur, depending on how much and how often you drink.

bannner image

Pregnancy

Caution

No harmful interaction has been reported in pregnant mothers, yet the patient is advised to consult a doctor before taking this drug during pregnancy.

bannner image

Breast Feeding

Caution

No harmful interaction has been reported in breastfeeding mothers, yet the patient is advised to consult a doctor before taking this drug.

bannner image

Driving

Caution

Caution is to be taken. If a patient feels dizzy while taking Kombiglyze XR 5mg/500mg Tablet 7's, do not drive or use any tools or machines. Hypoglycaemia may affect your ability to drive and use machines or work with a safe foothold, and there is a risk of hypoglycaemia after taking this medicine in combination with other medicines known to cause hypoglycaemia, such as insulin and sulphonylureas.

bannner image

Liver

Caution

It should be used with caution if you have liver conditions. Patients with severe liver problems are advised to take this drug with a doctor's consultation.

bannner image

Kidney

Caution

It should be used with caution if you have kidney problems. Patients with reduced kidney function are advised to consult with a doctor before taking Kombiglyze XR 5mg/500mg Tablet 7's as the doctor may decrease the dose as per his own judgment.

bannner image

Children

Caution

Kombiglyze XR 5mg/500mg Tablet 7's is not recommended for children and adolescents under 18 years. It is not known if this medicine is safe and effective when used in children and adolescents under 18 years of age. Consult your doctor for more information.

Add to Cart