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Manufacturer/Marketer :

Astra Zeneca Pharma India Ltd

Consume Type :

ORAL

Return Policy :

Not Returnable

Expires on or after :

About Kombiglyze XR 5mg/500mg Tablet

Kombiglyze XR 5mg/500mg Tablet belongs to a group of medicines known as antidiabetics, used in the treatment of type 2 diabetes in adults. Kombiglyze XR 5mg/500mg Tablet is prescribed for the condition of type 2 diabetes when diet and exercise alone cannot control blood sugar levels. People with type 2 diabetes either do not produce enough insulin, or the insulin produced is unable to perform its function in the body (insulin resistance). Middle-aged or older individuals are most likely to suffer from type 2 diabetes, so it is also known as adult-onset diabetes.

Kombiglyze XR 5mg/500mg Tablet contains two medications, namely: Saxagliptin and Metformin. Saxagliptin work by blocking the action of DPP-4/dipeptidyl peptidase-4  (an enzyme which destroys the hormone ‘Incretin’). The enzyme ‘Incretins’ help produce more insulin only when required and reduce blood sugar produced by the liver when not needed. On the other hand, Metformin, a 'biguanide', lowers the liver's glucose production, delays glucose absorption from the intestines, and increases the body's response to insulin. Together, they prevent the blood glucose levels from rising to very high levels, thus keeping your diabetes under control.

You are suggested to take Kombiglyze XR 5mg/500mg Tablet for as long as your doctor has prescribed it. The most common side effect of Kombiglyze XR 5mg/500mg Tablet is hypoglycemia (low blood glucose levels), upper respiratory tract infection, nasopharyngitis (nose and throat infection with common cold), and headache. Most of these side effects do not require medical attention and gradually resolve over time. If the side effects persist or worsen, consult a doctor.

Kombiglyze XR 5mg/500mg Tablet should not be stopped even if you feel better. If you stop taking Kombiglyze XR 5mg/500mg Tablet abruptly, it may increase your sugar levels which could further increase the risk of eyesight loss (retinopathy), kidney (nephropathy), and nerve damage (neuropathy). Kombiglyze XR 5mg/500mg Tablet should not be taken if you have severe kidney or liver disease. Please inform your doctor if you have any heart disease, are planning to get pregnant or are breastfeeding. Safety and efficacy of Kombiglyze XR 5mg/500mg Tablet in children under 18 years have not been established, so it should not be given to them. Patients taking digoxin (a heart medicine) with Kombiglyze XR 5mg/500mg Tablet should be closely monitored as severe drug interaction has been observed.

Uses of Kombiglyze XR 5mg/500mg Tablet

Type 2 diabetes (non-insulin-dependent diabetes).

Directions for Use

Swallow Kombiglyze XR 5mg/500mg Tablet as a whole with water; do not crush or chew it.

Medicinal Benefits

Kombiglyze XR 5mg/500mg Tablet contains two medications, namely: Saxagliptin and Metformin. Kombiglyze XR 5mg/500mg Tablet helps keep your blood sugar levels under check. Kombiglyze XR 5mg/500mg Tablet shows optimum effects when taken along with healthy lifestyle changes like weight loss, regular exercise, healthy diet, etc. Kombiglyze XR 5mg/500mg Tablet plays a vital role in controlling blood sugar levels and prevents serious complications of diabetes like eyesight loss (retinopathy), kidney (nephropathy), nerve damage (neuropathy), diabetic foot ulcer, and delayed wound healing.

Storage

keep Kombiglyze XR 5mg/500mg Tablet out of sight and reach of children.
Side effects of Kombiglyze XR 5mg/500mg Tablet
  • If you experience low blood sugar levels, inform your doctor. They will assess the severity and make recommendations for the next actions.
  • Your doctor will assess your symptoms, blood sugar levels, and overall health before recommending the best course of action, which may include treatment, lifestyle modifications, or prescription adjustments.
  • Follow your doctor's instructions carefully to manage the episode and adjust your treatment plan.
  • Make medication adjustments as recommended by your doctor to prevent future episodes.
  • Implement diet and lifestyle modifications as your doctor advises to manage low blood sugar levels.
  • Monitor your blood sugar levels closely for patterns and changes.
  • Track your progress by recording your blood sugar levels, food intake, and physical activity.
  • Seek further guidance from your doctor if symptoms persist or worsen so that your treatment plan can be revised.
  • Frequent flossing and brushing can help remove bacteria and debris that can give your teeth a metallic taste.
  • The metallic flavor may be caused by a zinc deficiency. Eat foods like meat, chicken, and oysters that are high in zinc.
  • Reducing the intake of foods with strong aromas, like onions and garlic, as they may intensify the taste of metallic substances.
  • Avoid smoking and tobacco products as they may intensify the metallic flavor.
Here are the steps to manage the medication-triggered Upper respiratory tract infection:
  • Inform your doctor about the symptoms you're experiencing due to medication.
  • Your doctor may adjust your treatment plan, which could include changing your medication, adding new medications, or offering advice on managing your symptoms.
  • Practice good hygiene, including frequent handwashing, avoiding close contact with others, and avoiding sharing utensils or personal items.
  • Stay hydrated by drinking plenty of fluids to help loosen and clear mucus from your nose, throat, and airways.
  • Get plenty of rest and engage in stress-reducing activities to help your body recover. If your symptoms don't subside or worsen, consult your doctor for further guidance.
Here are the steps to manage the medication-triggered Sinusitis (Sinus infection or Inflammation Of Sinuses):
  • Consult your doctor if you experience symptoms of sinusitis, such as nasal congestion, facial pain, or headaches, which may be triggered by your medication.
  • Your doctor may adjust your treatment plan by changing your medication, adding new medications, or providing guidance on managing your sinusitis symptoms.
  • Practice good hygiene, including frequent handwashing, avoiding close contact with others, and avoiding sharing utensils or personal items.
  • If your doctor advises, you can use nasal decongestants or saline nasal sprays to help relieve nasal congestion and sinus pressure.
  • To help your body recover, get plenty of rest, stay hydrated, and engage in stress-reducing activities. If your symptoms persist or worsen, consult your doctor for further guidance.
Here are the steps to manage the medication-triggered Common Cold:
  • Inform your doctor about the common cold symptoms you're experiencing due to medication.
  • Your doctor may adjust your treatment plan, which could include changing your medication, adding new medications, or offering advice on managing your symptoms.
  • Practice good hygiene, including frequent handwashing, avoiding close contact with others, and avoiding sharing utensils or personal items.
  • Drink plenty of fluids, such as warm water or soup, to help thin out mucus.
  • Get plenty of rest and engage in stress-reducing activities to help your body recover. If your symptoms don't subside or worsen, consult your doctor for further guidance.
  • Rest well; get enough sleep.
  • Eat a balanced diet and drink enough water.
  • Manage stress with yoga and meditation.
  • Limit alcohol and caffeine.
  • Physical activities like walking or jogging might help boost energy and make you feel less tired.
Here are the 7 steps to manage Dizziness caused by medication:
  • Inform your doctor about dizziness symptoms. They may adjust your medication regimen or prescribe additional medications to manage symptoms.
  • Follow your doctor's instructions for taking medication, and take it at the same time every day to minimize dizziness.
  • When standing up, do so slowly and carefully to avoid sudden dizziness.
  • Avoid making sudden movements, such as turning or bending quickly, which can exacerbate dizziness.
  • Drink plenty of water throughout the day to stay hydrated and help alleviate dizziness symptoms.
  • If you're feeling dizzy, sit or lie down and rest until the dizziness passes.
  • Track when dizziness occurs and any factors that may trigger it, and share this information with your doctor to help manage symptoms.

Drug Warnings

A prolonged intake of Kombiglyze XR 5mg/500mg Tablet may cause acute pancreatitis (swollen pancreas) and critical kidney problem. Increased risk of hypoglycemia (low blood sugar level) can occur when Kombiglyze XR 5mg/500mg Tablet is added to other anti-diabetic agents or insulin therapy. In this case, your doctor may adjust the dose of Kombiglyze XR 5mg/500mg Tablet. Severe allergic reactions might occur in some patients taking Kombiglyze XR 5mg/500mg Tablet, like anaphylaxis, angioedema (swelling under the skin), and exfoliative skin conditions, including Stevens-Johnson syndrome. 

Drug-Drug Interactions

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MetforminIopromide
Critical

Drug-Drug Interactions

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How does the drug interact with Kombiglyze XR 5mg/500mg Tablet:
Coadministration of Kombiglyze XR 5mg/500mg Tablet with Gatifloxacin may sometimes affect blood glucose levels. Both high blood glucose and, less frequently, low blood glucose have been reported.

How to manage the interaction:
Although there is a possible interaction, Kombiglyze XR 5mg/500mg Tablet can be taken with Gatifloxacin if prescribed by the doctor. Consult the doctor if you experience nervousness, confusion, headache, dizziness, drowsiness, tremors, nausea, hunger, weakness, perspiration, palpitation, rapid heartbeat, urination, thirst, and hunger. Monitoring blood glucose levels is advised. Do not discontinue any medications without first consulting your doctor.
MetforminIopromide
Critical
How does the drug interact with Kombiglyze XR 5mg/500mg Tablet:
Co-administration of Iopromide with Kombiglyze XR 5mg/500mg Tablet can increase the risk of lactic acidosis.

How to manage the interaction:
Taking Iopromide with Kombiglyze XR 5mg/500mg Tablet is not recommended, please consult a doctor before taking it. Do not discontinue the medication without consulting a doctor.
MetforminIocetamic acid
Critical
How does the drug interact with Kombiglyze XR 5mg/500mg Tablet:
Co-administration of Kombiglyze XR 5mg/500mg Tablet and Iocetamic acid can increase the risk of lactic acidosis (when the body produces too much lactic acid).

How to manage the interaction:
Taking Kombiglyze XR 5mg/500mg Tablet with Iocetamic acid is generally avoided as it can result in an interaction, please consult your doctor before taking it.
MetforminIopentol
Critical
How does the drug interact with Kombiglyze XR 5mg/500mg Tablet:
Co-administration of Iopentol with Kombiglyze XR 5mg/500mg Tablet can increase the risk of side effects.

How to manage the interaction:
Taking Kombiglyze XR 5mg/500mg Tablet with Iopentol is not recommended, please consult your doctor before taking it.
MetforminIomeprol
Critical
How does the drug interact with Kombiglyze XR 5mg/500mg Tablet:
Co-administration of Iomeprol with Kombiglyze XR 5mg/500mg Tablet can increase the risk of side effects.

How to manage the interaction:
Taking Kombiglyze XR 5mg/500mg Tablet with Iomeprol is not recommended, please consult a doctor before taking it. Do not discontinue the medications without consulting a doctor.
MetforminIoglicic acid
Critical
How does the drug interact with Kombiglyze XR 5mg/500mg Tablet:
Co-administration of Ioglicic acid with Kombiglyze XR 5mg/500mg Tablet can increase the risk of side effects.

How to manage the interaction:
Taking Kombiglyze XR 5mg/500mg Tablet with Ioglicic acid is generally avoided as it can result in an interaction, please consult your doctor before taking it.
MetforminIodixanol
Critical
How does the drug interact with Kombiglyze XR 5mg/500mg Tablet:
Co-administration of Iodixanol with Kombiglyze XR 5mg/500mg Tablet can increase the risk of side effects.

How to manage the interaction:
Taking Kombiglyze XR 5mg/500mg Tablet with Iodixanol is not recommended, please consult a doctor before taking it. Do not discontinue the medications without consulting a doctor.
MetforminIotroxic acid
Critical
How does the drug interact with Kombiglyze XR 5mg/500mg Tablet:
Co-administration of Iotroxic acid with Kombiglyze XR 5mg/500mg Tablet can increase the risk of side effects.

How to manage the interaction:
Taking Kombiglyze XR 5mg/500mg Tablet with Iotroxic acid is not recommended, please consult your doctor before taking it.
MetforminIobenzamic acid
Critical
How does the drug interact with Kombiglyze XR 5mg/500mg Tablet:
Co-administration of Kombiglyze XR 5mg/500mg Tablet and Iobenzamic acid can increase the risk of lactic acidosis (when the body produces too much lactic acid).

How to manage the interaction:
Taking Kombiglyze XR 5mg/500mg Tablet with Iobenzamic acid is generally avoided as it can result in an interaction, please consult your doctor before taking it.
MetforminIocarmic acid
Critical
How does the drug interact with Kombiglyze XR 5mg/500mg Tablet:
Co-administration of Kombiglyze XR 5mg/500mg Tablet and Iocarmic acid can increase the risk of lactic acidosis (when the body produces too much lactic acid).

How to manage the interaction:
Taking Kombiglyze XR 5mg/500mg Tablet with Iocarmic acid is generally avoided as it can result in an interaction. please consult your doctor before taking it.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

  • Invest at least 150 min of your week in moderate-intensity physical activity or one hour and 15 minutes of high-intensity exercise every week.
  • Replace refined carbohydrate-containing foods with whole grain foods and increase intake of fruits and vegetables and other fibre-enriched foods.
  • Reduce saturated fat (or hidden fats) intake in food like chips, crisps, pastries, biscuits, and samosas. Choose omega-3 fatty acid-containing oils for daily cooking. For frying, you can use palm oil, mustard oil, groundnut oil, rice bran oil, and safflower oil.
  • Avoid taking too much stress as it may elevate your blood sugar level. You can adopt stress management techniques like mindfulness to control stress-related blood sugar changes or meditation or yoga.
  • Opt for low-fat dairy products (low-fat yoghurt, fat-free milk, cheese, etc.).

Side Effects of Kombiglyze XR 5mg/500mg Tablet

  • Dizziness
  • Sweating
  • Palpitations
  • Dry mouth and skin
  • Hypoglycaemia (low blood glucose level)

Habit Forming

No

Therapeutic Class

ANTIDIABETICS

Drug-Diseases Interactions

verifiedApollotooltip
No Drug - Disease interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Diseases Interactions

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FAQs

Yes, Kombiglyze XR 5mg/500mg Tablet is known to cause stomach upset, indigestion, nausea, and diarrhoea. To avoid these side effects, please take Kombiglyze XR 5mg/500mg Tablet with a meal. Also, Kombiglyze XR 5mg/500mg Tablet should be taken at evenly spaced intervals to avoid any unpleasant side effects and for best results.

Kombiglyze XR 5mg/500mg Tablet has been reported to increase blood cholesterol levels in a normal patient and thus not recommended in patients with hyperlipidemia.

The patient is advised to take the missed dose as soon as possible; otherwise, jump to the next dose. A patient should never take a double dose to compensate for the missed dose. It may aggravate harmful side effects.

According to American Diabetes Association, most of the studies carried out on Kombiglyze XR 5mg/500mg Tablet and its ability to cause cancer resulted in a conclusion that Kombiglyze XR 5mg/500mg Tablet is not associated with any form of cancer & hence is safe to use.

A patient who accidentally takes an overdose of Kombiglyze XR 5mg/500mg Tablet may experience collapse, seizure attack, and troubled breathing. In such a case, without any delay, emergency health services must be contacted, and medical help should be sought.

Drug-Drug Interactions Checker List

  • DOLUTEGRAVIR
  • RANOLAZINE
  • TOPIRAMATE
  • ASPIRIN
  • DIGOXIN
  • CIMETIDINE
  • CIPROFLOXACIN
  • BUPROPION

Special Advise

Continue to take Kombiglyze XR 5mg/500mg Tablet unless you are advised otherwise by your doctor, as a treatment for diabetes is usually lifelong.

Disease/Condition Glossary

Type 2 diabetes: It is a condition where the body is unable to make sufficient insulin, or the insulin that it makes doesn't work properly or is utilized by our body. This can cause high blood sugar levels (hyperglycemia). Symptoms of type 2 diabetes include increased thirst, frequent urination,  increased hunger, fatigue, and blurred vision. In some cases, there may be weight gain, while in rare cases, weight loss may be observed. The complication of type 2 diabetes includes neuropathy (nerve problems), nephropathy (kidney problems), retinopathy (damaged retina of eyes or blindness), loss of limbs, sexual dysfunction, and increased chance of heart attack or stroke.

Have a query?

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Alcohol

Unsafe

Kombiglyze XR 5mg/500mg Tablet is not advised to be taken with alcohol as it causes bizarre interactions. Both hypoglycemia (low blood sugar) and hyperglycemia (high blood sugar) may occur, depending on how much and how often you drink.

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Pregnancy

Caution

No harmful interaction has been reported in pregnant mothers, yet the patient is advised to consult a doctor before taking this drug during pregnancy.

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Breast Feeding

Caution

No harmful interaction has been reported in breastfeeding mothers, yet the patient is advised to consult a doctor before taking this drug.

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Driving

Caution

Caution is to be taken. If a patient feels dizzy while taking Kombiglyze XR 5mg/500mg Tablet, do not drive or use any tools or machines. Hypoglycaemia may affect your ability to drive and use machines or work with a safe foothold, and there is a risk of hypoglycaemia after taking this medicine in combination with other medicines known to cause hypoglycaemia, such as insulin and sulphonylureas.

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Liver

Caution

It should be used with caution if you have liver conditions. Patients with severe liver problems are advised to take this drug with a doctor's consultation.

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Kidney

Caution

It should be used with caution if you have kidney problems. Patients with reduced kidney function are advised to consult with a doctor before taking Kombiglyze XR 5mg/500mg Tablet as the doctor may decrease the dose as per his own judgment.

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Children

Caution

Kombiglyze XR 5mg/500mg Tablet is not recommended for children and adolescents under 18 years. It is not known if this medicine is safe and effective when used in children and adolescents under 18 years of age. Consult your doctor for more information.

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