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  3. Kyfil 60 mg Injection 1's

Kyfil 60 mg Injection 1's, Pack of 1 INJECTION
Written By Bayyarapu Mahesh Kumar , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
Non returnable*
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Whats That

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Composition :

CARFILZOMIB-60MG

Manufacturer/Marketer :

Msn Laboratories Pvt Ltd

Consume Type :

PARENTERAL

Return Policy :

Not Returnable

About Kyfil 60 mg Injection 1's

Kyfil 60 mg Injection 1's belongs to the group of proteasome inhibitors (anti-cancer medicines). It is used alone and in combination with other medications to treat people with multiple myeloma (a type of cancer of the bone marrow) who have already been treated with other medicines. Multiple myeloma, also known as myeloma, is a type of bone marrow cancer that affects several areas of the body, such as the spine, skull, pelvis, and ribs.

Kyfil 60 mg Injection 1's contains Carfilzomib, which suppresses proteasomes that prevent protein breakdown in MM (multiple myeloma) cells. When proteasome function is stopped within the MM cell, a protein build-up occurs within the MM cell, which destroys the malignant cells.

Kyfil 60 mg Injection 1's is administered in a hospital setting by a physician qualified by training and experience to administer cancer chemotherapeutic agents. Sometimes, you may experience common side effects, such as fatigue (feeling overtired), anaemia, nausea, thrombocytopenia (low platelet level), dyspnea (feeling short of breath), diarrhoea, and pyrexia (fever). Most of these side effects do not require medical attention and will resolve gradually over time. However, you are advised to talk to your doctor if any of these side effects persist or worsen.

Before taking the Kyfil 60 mg Injection 1's, inform your doctor about all your allergic or hypersensitivity reactions to medicines or food. Kyfil 60 mg Injection 1's can cause fetal harm when administered to a pregnant woman. It is critical not to become pregnant while undergoing therapy and for several months afterwards. Before beginning treatment, discuss effective contraception with your healthcare professional. Inform them immediately if you or your partner becomes pregnant while undergoing therapy. Breastfeeding is usually not advised during this treatment since it is unknown whether this medication passes into breast milk. Do not skip any laboratory checks because Thrombocytopenia, Hepatic Toxicity and Hepatic Failure may occur. If it happens, reduce or interrupt dosing as clinically indicated.

Uses of Kyfil 60 mg Injection 1's

Multiple Myeloma

Directions for Use

Kyfil 60 mg Injection 1's will be administered in a hospital setting under the supervision of a physician qualified by training and experience to administer cancer chemotherapeutic agents.

Medicinal Benefits

Carfilzomib, a proteasome inhibitor, is present in Kyfil 60 mg Injection 1's. It suppresses proteasomes, preventing protein breakdown in MM (multiple myeloma) cells. When proteasome function is stopped within the MM cell, a protein build-up occurs within the MM cell, which destroys the malignant cells.

Storage

Store in a cool and dry place away from sunlight
Side effects of Kyfil 60 mg Injection
  • Rest well; get enough sleep.
  • Eat a balanced diet and drink enough water.
  • Manage stress with yoga and meditation.
  • Limit alcohol and caffeine.
  • Physical activities like walking or jogging might help boost energy and make you feel less tired.
Here's a comprehensive approach to managing medication-triggered fever:
  • Inform your doctor immediately if you experience a fever after starting a new medication.
  • Your doctor may adjust your medication regimen or dosage as needed to minimize fever symptoms.
  • Monitor your body temperature to monitor fever progression.
  • Drink plenty of fluids, such as water or electrolyte-rich beverages, to help your body regulate temperature.
  • Get plenty of rest and engage in relaxation techniques, such as deep breathing or meditation, to help manage fever symptoms.
  • Under the guidance of your doctor, consider taking medication, such as acetaminophen or ibuprofen, to help reduce fever.
  • If your fever is extremely high (over 103°F), or if you experience severe symptoms such as confusion, seizures, or difficulty breathing, seek immediate medical attention.
Here are the precise steps to cope with diarrhoea caused by medication usage:
  • Inform Your Doctor: Notify your doctor immediately about your diarrhoea symptoms. This allows them to adjust your medication or provide guidance on managing side effects.
  • Stay Hydrated: Drink plenty of fluids to replace lost water and electrolytes. Choose water, clear broth, and electrolyte-rich drinks. Avoid carbonated or caffeinated beverages to effectively rehydrate your body.
  • Follow a Bland Diet: Eat easy-to-digest foods to help firm up your stool and settle your stomach. Try incorporating bananas, rice, applesauce, toast, plain crackers, and boiled vegetables into your diet.
  • Avoid Trigger Foods: Steer clear of foods that can worsen diarrhoea, such as spicy, fatty, or greasy foods, high-fibre foods, and dairy products (especially if you're lactose intolerant).
  • Practice Good Hygiene: Maintain good hygiene to prevent the spread of infection. To stay healthy, wash your hands frequently, clean and disinfect surfaces regularly, and avoid exchanging personal belongings with others.
  • Take Anti-Diarrheal Medications: If your doctor advises, anti-diarrheal medications such as loperamide might help manage diarrhoea symptoms. Always follow your doctor's directions.
  • Keep track of your diarrhoea symptoms. If they don't get better or worse or are accompanied by severe stomach pain, blood, or dehydration signs (like extreme thirst or dark urine), seek medical help.
Here are the seven steps to manage medication-triggered Dyspnea (Difficulty Breathing or Shortness of Breath):
  • Tell your doctor immediately if you experience shortness of breath after taking medication.
  • Your doctor may adjust the medication regimen or dosage or give alternative medical procedures to minimize the symptoms of shortness of breath.
  • Monitor your oxygen levels and breathing rate regularly to track changes and potential side effects.
  • For controlling stress and anxiety, try relaxation techniques like deep breathing exercises, meditation, or yoga.
  • Make lifestyle changes, such as quitting smoking, exercising regularly, and maintaining a healthy weight.
  • Seek emergency medical attention if you experience severe shortness of breath, chest pain, or difficulty speaking.
  • Follow up regularly with your doctor to monitor progress, adjust treatment plans, and address any concerns or questions.
  • Managing a low platelet count (thrombocytopenia) caused by medication usage requires a multi-step approach. Here are some steps to help manage the condition:
  • Inform your doctor about your low platelet count and medication usage. They will assess the situation and guide the best course of action.
  • Your doctor may recommend adjusting or stopping the medication that is causing a low platelet count. This could involve switching to alternative medication or reducing the dosage.
  • Monitor your platelet count regularly through blood tests to track any changes. This will help the doctor determine the effectiveness of the treatment plan.
  • If an underlying condition, such as infection or inflammation, contributes to the low platelet count, your doctor will treat it.
  • In some cases, alternative treatments like platelet transfusions or medications that stimulate platelet production may be necessary.
  • Avoid risky activities and certain medications; eat a balanced diet with plenty of water to reduce bleeding risk and boost overall health.
  • If you experience severe bleeding or bruising, seek emergency medical attention immediately.
Overcome Medication-Induced Nausea: A 9-Step Plan
  • Inform your doctor about the nausea and discuss possible alternatives to the medication or adjustments to the dosage.
  • Divide your daily food intake into smaller, more frequent meals to reduce nausea.
  • Opt for bland, easily digestible foods like crackers, toast, plain rice, bananas, and applesauce.
  • Avoid certain foods that can trigger nausea, such as fatty, greasy, spicy, and smelly foods.
  • Drink plenty of fluids, such as water, clear broth, or electrolyte-rich beverages like coconut water or sports drinks.
  • Use ginger (tea, ale, or candies) to help relieve nausea.
  • Get adequate rest and also avoid strenuous activities that can worsen nausea.
  • Talk to your doctor about taking anti-nausea medication if your nausea is severe.
  • Record when your nausea occurs, what triggers it, and what provides relief to help you identify patterns and manage your symptoms more effectively.
  • Include iron-rich foods like dark leafy vegetables, lean red meat, legumes and fish in your diet.
  • Consume vitamin C-rich foods as they aid iron absorption.
  • Limit tea, cocoa, and coffee as these can slow iron absorption.
  • Exercise regularly; however, do not overdo it.

Drug Warnings

Before taking Kyfil 60 mg Injection 1's, inform your doctor about your medical history and other medications you are currently taking to rule out any potential negative effects. Avoid taking Kyfil 60 mg Injection 1's if you are pregnant or breastfeeding or allergic to any component present in Kyfil 60 mg Injection 1's. Both women and men using this Kyfil 60 mg Injection 1's should use birth control to avoid pregnancy. Inform your doctor right away if you or your partner become pregnant during treatment with Kyfil 60 mg Injection 1's. Inform your doctor if you have a history of heart failure and ischemia, Pulmonary Hypertension, Thrombocytopenia, low blood pressure or hepatic toxicity; your doctor will closely monitor and manage it. Carfilzomib injection may induce serious or life-threatening responses for up to 24 hours following administration. Before each dose of carfilzomib, you will be given specific drugs to assist in preventing a reaction. If you develop any of the following symptoms after your treatment, contact your doctor right away: fever, chills, joint or muscle pain, flushing or swelling of the face, swelling or tightening of the throat, vomiting, weakness, shortness of breath, disorientation or fainting, or chest tightness or pain.

Drug-Drug Interactions

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CarfilzomibAminocaproic acid
Severe
CarfilzomibDesogestrel
Severe

Drug-Drug Interactions

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CarfilzomibAminocaproic acid
Severe
How does the drug interact with Kyfil 60 mg Injection:
Coadministration of Aminocaproic acid and Kyfil 60 mg Injection can increase the risk of developing blood clots.

How to manage the interaction:
Co-administration of Kyfil 60 mg Injection with Aminocaproic acid can result in an interaction, but it can be taken if a doctor has advised it. However, if you experience any symptoms, such as chest pain, shortness of breath, redness or swelling in an arm or leg, or weakness, contact a doctor right away. Do not discontinue any medications without consulting a doctor.
CarfilzomibDesogestrel
Severe
How does the drug interact with Kyfil 60 mg Injection:
Kyfil 60 mg Injection can occasionally cause dangerous blood clots and using it together with ethinyl estradiol may increase the risk.

How to manage the interaction:
Co-administration of Desogestrel with Kyfil 60 mg Injection can possibly result in an interaction, but it can be taken if your doctor has advised it. If you notice any symptoms like rapid loss of eyesight, chest pain, shortness of breath, breathing difficulties, coughing up blood, pain, redness, or swelling in an arm or leg, and numbness or weakness on one side of the body, contact a doctor. Do not stop using any medications without a doctor's advice.
CarfilzomibLeflunomide
Severe
How does the drug interact with Kyfil 60 mg Injection:
Combining Kyfil 60 mg Injection with Leflunomide can increase the risk of negative side effects.

How to manage the interaction:
Taking Kyfil 60 mg Injection with Leflunomide together can possibly result in an interaction, but it can be taken if your doctor has advised it. If you have any of these symptoms, it's important to contact your doctor right away. These symptoms include liver damage, infection, fever, chills, diarrhea, sore throat, muscle aches, difficulty breathing, weight loss, pain, joint pain, swelling, bruising, skin rash, itching, loss of appetite, fatigue, nausea, vomiting, dark coloured urine, or bleeding. Do not discontinue any medications without consulting your doctor.
CarfilzomibStanozolol
Severe
How does the drug interact with Kyfil 60 mg Injection:
Coadministration of Kyfil 60 mg Injection and sulfasalazine can increase the risk or severity of developing blood clots.

How to manage the interaction:
Although taking Kyfil 60 mg Injection and sulfasalazine together can result in an interaction, it can be taken if your doctor has advised it. However, if you experience chest pain, shortness of breath, difficulty breathing, coughing up blood, sudden loss of vision, pain, redness, or swelling in an arm or leg, and numbness or weakness on one side of the body, consult a doctor immediately. Do not discontinue any medications without consulting a doctor.
CarfilzomibPrasterone
Severe
How does the drug interact with Kyfil 60 mg Injection:
Taking Prasterone with Kyfil 60 mg Injection can increase the risk of clotting.

How to manage the interaction:
Co-administration of Prasterone with Kyfil 60 mg Injection can result in an interaction, but it can be taken if a doctor has advised it. However, if you experience sudden loss of eyesight, chest pain, breathing difficulties, coughing up blood, pain, redness, or swelling in an arm or leg, and numbness or weakness on one side of the body, consult a doctor, immediately. Do not stop using any medications without a doctor's advice.
CarfilzomibTofacitinib
Severe
How does the drug interact with Kyfil 60 mg Injection:
Taking Kyfil 60 mg Injection with Tofacitinib may increase the risk of serious infections.

How to manage the interaction:
Co-administration of Tofacitinib with Kyfil 60 mg Injection can possibly result in an interaction, but it can be taken if your doctor has advised it. However, consult the doctor immediately if you experience symptoms such as fever, chills, diarrhea, sore throat, muscle aches, shortness of breath, blood in phlegm, weight loss, red or inflamed skin, body sores, and pain or burning during urination. Do not discontinue any medications without first consulting your doctor.
CarfilzomibTranexamic acid
Severe
How does the drug interact with Kyfil 60 mg Injection:
Co-administration of Kyfil 60 mg Injection with Tranexamic acid can increase the risk of blood clots.

How to manage the interaction:
Taking Kyfil 60 mg Injection with tranexamic acid is not recommended due to its increased effects, however, it can be taken only if a doctor has advised it. If you experience symptoms such as chest pain, shortness of breath, difficulty breathing, coughing up blood, sudden loss of vision, pain, and numbness or weakness on one side of the body contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
CarfilzomibAdalimumab
Severe
How does the drug interact with Kyfil 60 mg Injection:
Combining Adalimumab with Kyfil 60 mg Injection can increase the risk of infections.

How to manage the interaction:
Co-administration of Kyfil 60 mg Injection with Adalimumab can possibly result in an interaction, but it can be taken if your doctor has advised it. If you have any of these symptoms, it's important to contact your doctor right away infection, fever, chills, diarrhea, sore throat, muscle aches, shortness of breath, weight loss, pain or burning during urination. Do not stop using any medications without first talking to your doctor.
CarfilzomibEthinylestradiol
Severe
How does the drug interact with Kyfil 60 mg Injection:
Kyfil 60 mg Injection can cause serious blood clots and taking it with ethinyl estradiol may enhance the risk.

How to manage the interaction:
There may be a possibility of interaction between Kyfil 60 mg Injection and Ethinylestradiol, but it can be taken if prescribed by a doctor. However, if you experience chest pain, shortness of breath, difficulty breathing, coughing up blood, sudden loss of vision, pain, redness, or swelling in an arm or leg, or numbness or weakness on one side of the body, you should consult a doctor. Do not stop using any medications without a doctor's advice.
CarfilzomibLevonorgestrel
Severe
How does the drug interact with Kyfil 60 mg Injection:
Kyfil 60 mg Injection can occasionally cause dangerous blood clots and using it together with levonorgestrel may increase the risk.

How to manage the interaction:
Co-administration of Kyfil 60 mg Injection with Levonorgestrel can result in an interaction, but it can be taken if a doctor has advised it. If you notice any of these signs, it's important to contact a doctor right away: blood clots that can be harmful, high blood pressure or cholesterol, heart problems like heart attack or blockage in the lung, stroke, complications, chest pain, difficulty breathing, coughing up blood, sudden vision loss, pain, redness, or swelling in an arm or leg, and numbness or weakness on one side of your body. Do not discontinue any medications without consulting a doctor.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

  • De-stress yourself by meditating, reading books, taking a warm bubble bath or listening to soothing music.
  • Performing yoga may also help in improving both physical and mental health.
  • Maintain a healthy weight by performing regular low-strain exercises and eating healthy food.
  • Eat a healthy diet and exercise regularly to maintain proper weight.
  • Include leafy vegetables, citrus fruits, fatty fish, berries, yoghurt, apples, peaches, cauliflower, cabbage, broccoli, beans, and herbs.
  • Get optimal sleep; rest well.
  • Avoid smoking and alcohol consumption.
  • Avoid fast food, fried food, processed meats, refined carbs and added sugars.

Habit Forming

No

Therapeutic Class

CHEMOTHERAPY

Kyfil 60 mg Injection 1's Substitute

Substitutes safety advice

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Author Details

Bayyarapu Mahesh KumarDoctor badge

Written By

Bayyarapu Mahesh Kumar

M Pharmacy

Dr Aneela SiddabathuniDoctor badge

Reviewed By

Dr Aneela Siddabathuni

MPharma., PhD

Last Updated

Jul 8, 2025 | 9:50 AM IST

Doctor imageWe provide you with authentic, trustworthy and relevant information

Drug-Diseases Interactions

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No Drug - Disease interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Diseases Interactions

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FAQs

Kyfil 60 mg Injection 1's contains Carfilzomib, which inhibits proteasomes and thereby prevents protein breakdown in MM (multiple myeloma) cells. When the proteasome action within the MM cell is disturbed, a protein accumulation occurs, destroying the cancerous cells.

No, it is unsafe to father a child while taking Kyfil 60 mg Injection 1's. It is recommended for sexually active men to use condoms while on treatment and for at least several months after their last dose of Kyfil 60 mg Injection 1's.

Based on the medical condition, Kyfil 60 mg Injection 1's may be given alone or together with other medicines used to treat multiple myeloma.

Tell your healthcare professional immediately if you get any signs of an infusion-related reaction during or after the infusion. Your doctor may give other medicines, or the infusion may need to be slowed down or stopped.

Kyfil 60 mg Injection 1's can cause a significant decrease in the number of blood cells and platelets. Your doctor may suggest laboratory tests before and during the treatment. Tell your healthcare provider if you develop a fever or have signs of bruising or bleeding.

Drug-Drug Interactions Checker List

  • ADALIMUMAB
  • BARICITINIB
  • FINGOLIMOD
  • BCG VACCINE
  • DENGUE VACCINE
  • CLOZAPINE
  • METHYLTESTOSTERONE

Special Advise

  • Pregnancy testing is recommended for females of reproductive potential prior to initiating treatment with Kyfil 60 mg Injection 1's.
  • Keep all appointments with your doctor and the laboratory. Your doctor will order laboratory tests before, during and after your treatment to check your body's response to Kyfil 60 mg Injection 1's to see if your blood cells are affected by this drug.
  • Do not donate sperm during treatment with Kyfil 60 mg Injection 1's and for three months after your last dose.

Disease/Condition Glossary

Myeloma, also called multiple myeloma, is a cancer of the plasma cells. Plasma cells are white blood cells that make antibodies that protect us from infection. In myeloma, the cells grow too much, crowding out normal cells in the bone marrow that make red blood cells, platelets, and other white blood cells. Multiple myeloma, the most common type of plasma cell tumour, develops in the bone marrow and can spread throughout the body.

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