Kynteles 300 mg Injection 1's

Written By Lakshmithulasi Yarragunta , Pharm-D (PB)

Reviewed By Dr Aneela Siddabathuni , MPharma., PhD

MRP ₹71310

(Inclusive of all Taxes)

₹7131.0 Cashback (10%)

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Non returnable*

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Prescription drug

Whats That

About Kynteles 300 mg Injection

Kynteles 300 mg Injection belongs to the class of monoclonal antibodies which is used in the treatment of moderately to severe Crohn’s disease (a chronic inflammatory bowel disease that affects any part of the gastrointestinal tract, mainly small and large intestine) and ulcerative colitis (an inflammatory bowel disease that causes swelling in the digestive tract).

Kynteles 300 mg Injection consists of Vedolizumab, which belongs to the class of integrin receptor antagonists. It works by binding to the chemical substance called α4β7 integrin (present on the surface of the WBC that enters the gut), which is responsible for inflammation.

Kynteles 300 mg Injection may cause side effects such as nausea, headache, fever, joint pain, tiredness, cough, back pain, itching, dizziness, and injection site reactions. Most of these side effects do not require medical attention or resolve over time. However, if these side effects persist for longer, please consult your doctor on priority. Kynteles 300 mg Injection is a parenteral medicine. It will be administered by a trained healthcare doctor. Hence, do not self-administer.

Kynteles 300 mg Injection should be avoided if you are allergic to any of its components. Inform your doctor if you have any history of serious infections, tuberculosis, gastrointestinal disorders, liver or kidney diseases, or a weak immune system, as it can worsen your health condition. Kynteles 300 mg Injection may cause dizziness, so drive only if you are alert and focused. Kynteles 300 mg Injection should not be given to children below 18 years of age as safety has not been established. Consult the doctor if you are pregnant or breastfeeding.

Uses of Kynteles 300 mg Injection

Crohn’s disease, Ulcerative colitis.

Directions for Use

Kynteles 300 mg Injection will be administered by a healthcare professional. Do not self-administer.

Medicinal Benefits

Kynteles 300 mg Injection consists of Vedolizumab as an active ingredient, which belongs to the class of integrin receptor antagonists. It works by binding to the chemical substance called α4β7 integrin (present on the surface of the WBC that enters the gut), which is responsible for inflammation. This alters the gene expression of blood monocytes and thus helps reduce inflammation and is used in the treatment of moderately to severe Crohn’s disease and Ulcerative colitis.

Storage

Keep Kynteles 300 mg Injection out of the sight and reach of children.

Side effects of Kynteles 300 mg Injection

Common Cold

Here are the steps to manage the medication-triggered Common Cold:

Inform your doctor about the common cold symptoms you're experiencing due to medication.
Your doctor may adjust your treatment plan, which could include changing your medication, adding new medications, or offering advice on managing your symptoms.
Practice good hygiene, including frequent handwashing, avoiding close contact with others, and avoiding sharing utensils or personal items.
Drink plenty of fluids, such as warm water or soup, to help thin out mucus.
Get plenty of rest and engage in stress-reducing activities to help your body recover. If your symptoms don't subside or worsen, consult your doctor for further guidance.

Common Cold

Here are the steps to manage the medication-triggered Upper respiratory tract infection:

Inform your doctor about the symptoms you're experiencing due to medication.
Your doctor may adjust your treatment plan, which could include changing your medication, adding new medications, or offering advice on managing your symptoms.
Practice good hygiene, including frequent handwashing, avoiding close contact with others, and avoiding sharing utensils or personal items.
Stay hydrated by drinking plenty of fluids to help loosen and clear mucus from your nose, throat, and airways.
Get plenty of rest and engage in stress-reducing activities to help your body recover. If your symptoms don't subside or worsen, consult your doctor for further guidance.

Collection Of Pus Near The Anus

Headache

Dealing with Medication-Induced Headache:

Hydrate your body: Drink enough water to prevent dehydration and headaches.
Calm Your Mind: Deep breathing and meditation can help you relax and relieve stress.
Rest and Recharge: Sleep for 7-8 hours to reduce headache triggers.
Take rest: lie down in a quiet, dark environment.
Cold or warm compresses can help reduce tension.
Stay Upright: Maintain good posture to keep symptoms from getting worse.
To treat headaches naturally, try acupuncture or massage therapy.
Over-the-counter pain relievers include acetaminophen and ibuprofen.
Prescription Assistance: Speak with your doctor about more substantial drug alternatives.
Severe Headaches: Seek emergency medical assistance for sudden, severe headaches.
Frequent Headaches: If you get reoccurring headaches, consult your doctor.
Headaches with Symptoms: Seek medical attention if your headaches include fever, disorientation, or weakness.

Shortness Of Breath

Here are the seven steps to manage medication-triggered Dyspnea (Difficulty Breathing or Shortness of Breath):

Tell your doctor immediately if you experience shortness of breath after taking medication.
Your doctor may adjust the medication regimen or dosage or give alternative medical procedures to minimize the symptoms of shortness of breath.
Monitor your oxygen levels and breathing rate regularly to track changes and potential side effects.
For controlling stress and anxiety, try relaxation techniques like deep breathing exercises, meditation, or yoga.
Make lifestyle changes, such as quitting smoking, exercising regularly, and maintaining a healthy weight.
Seek emergency medical attention if you experience severe shortness of breath, chest pain, or difficulty speaking.
Follow up regularly with your doctor to monitor progress, adjust treatment plans, and address any concerns or questions.

Hives Or Skin Rash

Avoid trigger foods that can cause allergic reactions, such as nuts, shellfish, or dairy products.
Keep a food diary to track potential food allergens.
Include omega-3 rich foods like salmon and walnuts to reduce inflammation.
Wear loose, comfortable clothing made from soft fabrics like cotton.
Apply cool compresses or take cool baths to reduce itching.
Use gentle soaps and avoid harsh skin products.
Reduce stress through relaxation techniques like meditation or deep breathing.

Reddening Of The Face

Managing Medication-Triggered Flushing (Reddening of the skin): A Step-by-Step Guide:

Consult your doctor if you experience skin redness, itching, or irritation after taking medication.
Your doctor may adjust your treatment plan by changing your medication or providing guidance on managing your erythema symptoms.
Your doctor may recommend or prescribe certain medications to help alleviate symptoms.
Apply cool compresses or calamine lotion to the affected skin area to reduce redness and itching.
Stay hydrated by drinking plenty of water to help alleviate symptoms and keep your skin hydrated.
Monitor your skin condition closely and promptly report any changes, worsening symptoms, or concerns to your healthcare provider.

Drug Warnings

Kynteles 300 mg Injection should be avoided if allergic to it or any other components present. Inform your doctor if you have any history of serious infections, tuberculosis, gastrointestinal disorders, liver or kidney diseases, or a weak immune system, as it can worsen your health condition. Do not take live vaccines while being treated with Kynteles 300 mg Injection to prevent any serious consequences. Kynteles 300 mg Injection may cause serious reactions, including infusion-related or allergic reactions. It may also increase the risk of hepatotoxicity, serious infections and hypersensitivity reactions in some patients. Hence, patients should be carefully monitored for changes during and after the treatment. Hence, patients should be carefully monitored for changes during and after the treatment. Kynteles 300 mg Injection is not recommended for use in children below 18 years of age as safety and efficacy are not established. Kynteles 300 mg Injection may cause dizziness, so drive only if you are alert and focused. This medicine can cause Progressive Multifocal Leukoencephalopathy (PML) in most patients with compromised immune systems. Hence, Kynteles 300 mg Injection is contraindicated in patients who have or had PML. Consult your doctor immediately if the patient develops confusion or problems thinking, loss of balance, change in the way you walk or talk, decreased strength or weakness on one side of the body, blurred vision, or loss of vision.

Drug-Drug Interactions

VedolizumabInfliximab

Severe

VedolizumabCladribine

Severe

Drug-Drug Interactions

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VedolizumabInfliximab

Severe

How does the drug interact with Kynteles 300 mg Injection:
Combining Infliximab with Vedolizumabcan lead to or increase the risk or severity of developing serious infections.

How to manage the interaction:
Co-administration of Kynteles 300 mg Injection with Infliximab can result in an interaction, but it can be taken if your doctor has advised it. However, if you experience symptoms of fever, chills, diarrhea, sore throat, muscle aches, shortness of breath, blood in sputum, weight loss, red or inflamed skin, body sores, and pain or burning during urination, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.

VedolizumabCladribine

Severe

How does the drug interact with Kynteles 300 mg Injection:
Taking Cladribine with Kynteles 300 mg Injection can increase the risk of developing serious infections.

How to manage the interaction:
Taking Cladribine with Kynteles 300 mg Injection together can possibly result in an interaction, but it can be taken if your doctor has advised it. However, if you experience fever, chills, diarrhea, sore throat, muscle pains, breathing difficulty, blood in your coughing fluid, weight loss, red or irritated skin, body sores, and discomfort or burning sensation when you urinate, consult a doctor. Do not stop using any medications without a doctor's advice.

VedolizumabEtanercept

Severe

How does the drug interact with Kynteles 300 mg Injection:
When Etanercept is used with Kynteles 300 mg Injection, the likelihood or severity of infection may increase.

How to manage the interaction:
Although taking Etanercept and Kynteles 300 mg Injection together can cause an interaction, it can be taken if a doctor has suggested it. However, if you develop fever, chills, diarrhea, sore throat, muscular pains, shortness of breath, blood in phlegm, weight loss, red or irritated skin, body sores, or discomfort or burning during urination, consult a doctor immediately. Do not discontinue any medications without a doctor's advice.

VedolizumabTofacitinib

Severe

How does the drug interact with Kynteles 300 mg Injection:
Taking Kynteles 300 mg Injection with Tofacitinib may increase the risk of infection.

How to manage the interaction:
Taking Tofacitinib with Kynteles 300 mg Injection together can possibly result in an interaction, but it can be taken if your doctor has advised it. However, consult the doctor immediately if you experience symptoms such as fever, chills, diarrhea, sore throat, muscle aches, shortness of breath, blood in phlegm, weight loss, red or inflamed skin, body sores, and pain or burning during urination.Do not stop using any medications without a doctor's advice.

VedolizumabLenalidomide

Severe

How does the drug interact with Kynteles 300 mg Injection:
Combining Lenalidomide with Kynteles 300 mg Injection can increase the chances of experiencing harmful side effects.

How to manage the interaction:
Taking Lenalidomide with Kynteles 300 mg Injection together can possibly result in an interaction, but it can be taken if your doctor has advised it. However, contact a doctor if you experience any symptoms of infection, such as chills, diarrhea, sore throat, muscle aches, shortness of breath, blood in phlegm, weight loss, red or irritated skin, body sores, discomfort, or burning during urination. Do not stop using any medications without first talking to your doctor.

VedolizumabBaricitinib

Severe

How does the drug interact with Kynteles 300 mg Injection:
Coadministration of Kynteles 300 mg Injection with Baricitinib can increase the risk of developing serious infections.

How to manage the interaction:
There may be a possibility of interaction between Baricitinib and Kynteles 300 mg Injection, but it can be taken if prescribed by a doctor. However, consult a doctor if you experience fever, chills, diarrhea, sore throat, muscle pains, breathing difficulty, blood in your coughing fluid, weight loss, red or irritated skin, body sores, and discomfort or burning when you urinate. Do not stop using any medications without a doctor's advice.

Drug-Food Interactions

No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

Maintain a low-fat diet and eat foods rich in vitamin C, such as bell peppers, spinach, parsley and berries, which help heal faster.
Eat more fibre-rich foods such as fruits and vegetables.
Eat smaller meals all day and drink small amounts of water throughout the day.
If you are intolerant to lactose, lower your intake of milk.
Avoid foods high in sugar, fat, and processed foods, as these may cause inflammation.
Try to avoid alcohol as it can affect your stomach and intestine and also limits the absorption of the important nutrients required by your body.

Side Effects of Kynteles 300 mg Injection

Shortness of breath
Injection site reactions
Headache
Nausea
Upper respiratory tract infections.
Chest pain
Fever
Joint pain
Tiredness
Cough
Back pain
Itching
blurred vision or loss of vision

Habit Forming

No

Therapeutic Class

MONOCLONAL ANTIBODIES

Author Details

Written By

Lakshmithulasi Yarragunta

Pharm-D (PB)

Reviewed By

Dr Aneela Siddabathuni

MPharma., PhD

Last Updated

Jul 8, 2025 | 9:49 AM IST

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Drug-Diseases Interactions

No Drug - Disease interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Diseases Interactions

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FAQs

How does Kynteles 300 mg Injection work?

Kynteles 300 mg Injection works by binding to the chemical substance called α4β7 integrin, which is responsible for inflammation. This alters the gene expression of blood monocytes and thus helps reduce inflammation.

Before receiving Kynteles 300 mg Injection, what should be informed to my healthcare provider?

Inform your doctor about your complete medical and medication history, especially if you have any history of serious infections, tuberculosis, gastrointestinal disorders, liver or kidney diseases, or a weak immune system, as it can worsen your health condition.

Drug-Drug Interactions Checker List

INFLIXIMAB
ADALIMUMAB
GOLIMUMAB
ETANERCEPT
NATALIZUMAB

Special Advise

It is advised to closely monitor the patient for infections like active tuberculosis during and after the treatment, though the patient gets a negative tuberculin test.
It is essential to inform your doctor if you have any active viral, bacterial, and fungal infections before starting Kynteles 300 mg Injection.

Disease/Condition Glossary

Ulcerative colitis: Ulcerative colitis is a serious inflammatory bowel disease causing inflammation in the digestive tract. It produces ulcers on the inner lining of the large intestine, which may cause bleeding and discharge of pus and mucus. The common symptoms include bloody stools, stomach pain, rectal pain, diarrhoea, fever, or weight loss. Additionally, it may cause other problems such as joint pain or swelling, mouth sores, skin problems, decreased appetite, or nausea.

Crohn’s disease: Crohn’s disease is a type of chronic inflammatory bowel disease that can affect any part of the gastrointestinal tract, from mouth to anus. But mostly occurs in the small intestine and large intestine. The symptoms include blood in stools, stomach cramps, tiredness, diarrhoea, fever, weight loss, or loss of appetite.