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  3. Lenshil 4mg Capsule 10's

Lenshil 4mg Capsule 10's, Pack of 10 CAPSULES
Written By Lakshmithulasi Yarragunta , Pharm-D (PB)
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
Non returnable*
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Whats That

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Composition :

LENVATINIB-4MG

Manufacturer/Marketer :

Shilpa Medicare Ltd

Consume Type :

ORAL

Return Policy :

Not Returnable

Expires on or after :

About Lenshil 4mg Capsule

Lenshil 4mg Capsule is an anti-cancer medicine used in the treatment of various types of cancers. Cancer is a disease caused by the abnormal growth of cells that divide uncontrollably. This medicine is used in treating hepatocellular carcinoma as a first-line therapy, differentiated thyroid cancer in patients with locally recurrent or metastatic, progressive, radioactive iodine-refractory, advanced renal cell carcinoma in combination with pembrolizumab, and advanced endometrial cancer in combination with pembrolizumab.

Lenshil 4mg Capsule contains Lenvatinib, which belongs to the class of medicines known as kinase inhibitors. It works by inhibiting the action of an enzyme (tyrosine kinase) and thus stops the abnormal growth of cancer cells.

Lenshil 4mg Capsule may cause certain side effects such as diarrhoea, decreased appetite, nausea, vomiting, tiredness, itching, rash, headache, cough, abdominal pain, hoarseness, and dizziness. Inform your doctor if any of these side effects bother you. Lenshil 4mg Capsule should be taken as prescribed by your doctor. Do not take more than the recommended dose of medicine.

If you are allergic to Lenshil 4mg Capsule or its components, inform your doctor. Before taking Lenshil 4mg Capsule , inform your doctor if you have/had liver or kidney disease, calcium deficiency, heart problems, increased blood pressure, seizures, bleeding disorders, vision problems, and a history of blood clots. This medicine is known to cause embryo-fetal toxicity. It is not recommended for use in pregnancy and breastfeeding. 

Uses of Lenshil 4mg Capsule

Renal Cell Carcinoma, Hepatocellular carcinoma, Differentiated thyroid cancer, Endometrial cancer.

Directions for Use

Take Lenshil 4mg Capsule as prescribed by the doctor. It can be taken with or without food. Swallow it as a whole with a glass of water. Do not crush, break, or chew it. It is advised not to take more than the recommended dose of medicine.

Medicinal Benefits

Lenshil 4mg Capsule contains Lenvatinib, which is used in treating different types of cancer. It works by stopping the action of a tyrosine kinase enzyme that causes the multiplication of cancerous cells. This helps stop the abnormal growth of cancer cells and thus reduce the further spread to other parts of the body. It also decreases the blood supply to cancer tumors to slow down the growth of the tumor.  In this way, Lenshil 4mg Capsule stops the body's production, spread and growth of cancerous cells.

Storage

Store in a cool and dry place away from sunlight
Side effects of Lenshil 4mg Capsule
  • Rest well; get enough sleep.
  • Eat a balanced diet and drink enough water.
  • Manage stress with yoga and meditation.
  • Limit alcohol and caffeine.
  • Physical activities like walking or jogging might help boost energy and make you feel less tired.
Here are the precise steps to cope with diarrhoea caused by medication usage:
  • Inform Your Doctor: Notify your doctor immediately about your diarrhoea symptoms. This allows them to adjust your medication or provide guidance on managing side effects.
  • Stay Hydrated: Drink plenty of fluids to replace lost water and electrolytes. Choose water, clear broth, and electrolyte-rich drinks. Avoid carbonated or caffeinated beverages to effectively rehydrate your body.
  • Follow a Bland Diet: Eat easy-to-digest foods to help firm up your stool and settle your stomach. Try incorporating bananas, rice, applesauce, toast, plain crackers, and boiled vegetables into your diet.
  • Avoid Trigger Foods: Steer clear of foods that can worsen diarrhoea, such as spicy, fatty, or greasy foods, high-fibre foods, and dairy products (especially if you're lactose intolerant).
  • Practice Good Hygiene: Maintain good hygiene to prevent the spread of infection. To stay healthy, wash your hands frequently, clean and disinfect surfaces regularly, and avoid exchanging personal belongings with others.
  • Take Anti-Diarrheal Medications: If your doctor advises, anti-diarrheal medications such as loperamide might help manage diarrhoea symptoms. Always follow your doctor's directions.
  • Keep track of your diarrhoea symptoms. If they don't get better or worse or are accompanied by severe stomach pain, blood, or dehydration signs (like extreme thirst or dark urine), seek medical help.
Here are the steps to manage Joint Pain caused by medication usage:
  • Please inform your doctor about joint pain symptoms, as they may adjust your medication regimen or prescribe additional medications to manage symptoms.
  • Your doctor may prescribe common pain relievers if necessary to treat joint discomfort.
  • Maintaining a healthy lifestyle is key to relieving joint discomfort. Regular exercise, such as low-impact sports like walking, cycling, or swimming, should be combined with a well-balanced diet. Aim for 7-8 hours of sleep per night to assist your body in repairing and rebuilding tissue.
  • Applying heat or cold packs to the affected joint can help reduce pain and inflammation.
  • Please track when joint pain occurs and any factors that may trigger it, and share this information with your doctor to help manage symptoms.
  • If your joint pain is severe or prolonged, consult a doctor to rule out any underlying disorders that may require treatment.
  • Consume more protein-rich foods and healthy fats like beans, avocados, cheese, nuts and lean meats to minimize appetite.
  • Prefer foods high in fiber to help feel full for a long time.
  • If you have decreased appetite, eat only when you are hungry.
  • Eat several small meals or snacks all day.
  • Try to take only small sips of fluids while eating.
  • Weight loss without physical activity needs immediate medical attention.
  • Get a physical examination and blood tests done to identify factors causing weight loss that could be related to metabolism and thyroid function.
  • Avoid smoking and alcohol intake as it can alter your liver condition and increase your weight loss.
  • Practice meditation and yoga to avoid anxiety, which can be one of the leading causes of weight loss.
  • Talk to your dietician and consume food which can maintain ideal weight.
Overcome Medication-Induced Nausea: A 9-Step Plan
  • Inform your doctor about the nausea and discuss possible alternatives to the medication or adjustments to the dosage.
  • Divide your daily food intake into smaller, more frequent meals to reduce nausea.
  • Opt for bland, easily digestible foods like crackers, toast, plain rice, bananas, and applesauce.
  • Avoid certain foods that can trigger nausea, such as fatty, greasy, spicy, and smelly foods.
  • Drink plenty of fluids, such as water, clear broth, or electrolyte-rich beverages like coconut water or sports drinks.
  • Use ginger (tea, ale, or candies) to help relieve nausea.
  • Get adequate rest and also avoid strenuous activities that can worsen nausea.
  • Talk to your doctor about taking anti-nausea medication if your nausea is severe.
  • Record when your nausea occurs, what triggers it, and what provides relief to help you identify patterns and manage your symptoms more effectively.
Dealing with Medication-Induced Headache:
  • Hydrate your body: Drink enough water to prevent dehydration and headaches.
  • Calm Your Mind: Deep breathing and meditation can help you relax and relieve stress.
  • Rest and Recharge: Sleep for 7-8 hours to reduce headache triggers.
  • Take rest: lie down in a quiet, dark environment.
  • Cold or warm compresses can help reduce tension.
  • Stay Upright: Maintain good posture to keep symptoms from getting worse.
  • To treat headaches naturally, try acupuncture or massage therapy.
  • Over-the-counter pain relievers include acetaminophen and ibuprofen.
  • Prescription Assistance: Speak with your doctor about more substantial drug alternatives.
  • Severe Headaches: Seek emergency medical assistance for sudden, severe headaches.
  • Frequent Headaches: If you get reoccurring headaches, consult your doctor.
  • Headaches with Symptoms: Seek medical attention if your headaches include fever, disorientation, or weakness.

Drug Warnings

To treat your condition effectually, continue taking Lenshil 4mg Capsule for the period that your doctor has prescribed. Avoid taking Lenshil 4mg Capsule if you are allergic to it or any other components present in it. Caution should be exercised if you have/had liver or kidney disease, any planned surgery, heart disease, stroke, blood or bleeding disorders, or gastrointestinal disorders. Inform your doctor if you are pregnant or are planning to become pregnant before starting the treatment, as this medicine is known to cause embryo-fetal toxicity. Breastfeeding should be discontinued in nursing mothers during the treatment as it passes into breast milk and may cause a possible risk to the infant. Avoid driving and operating machines, as this medicine may cause visual disturbances. This medicine is not recommended for use in children below 18 years of age as the safety and efficacy are not established. Lenshil 4mg Capsule may cause hypertension, thrombotic events, hemorrhagic events, hypothyroidism, gastrointestinal perforation and fistula, Reversible Posterior Leukoencephalopathy Syndrome (RPLS), elevated liver enzymes, kidney impairment, hypocalcemia, wound healing problems, and osteonecrosis in some patients. Hence, inform your doctor about your complete medication and medical history before taking Lenshil 4mg Capsule .

Drug-Drug Interactions

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LenvatinibThioridazine
Critical
LenvatinibSaquinavir
Critical

Drug-Drug Interactions

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LenvatinibThioridazine
Critical
How does the drug interact with Lenshil 4mg Capsule:
Taking Lenshil 4mg Capsule and Thioridazine together can raise the risk of an abnormal heart rhythm.

How to manage the interaction:
Using Lenshil 4mg Capsule and Thioridazine is not recommended, but they can be taken together if advised by your doctor. However, contact your doctor if you experience drowsiness, lightheadedness, fainting, shortness of breath, or irregular heartbeat. Do not stop taking any medications without consulting a doctor.
LenvatinibSaquinavir
Critical
How does the drug interact with Lenshil 4mg Capsule:
Taking Lenshil 4mg Capsule and Saquinavir together can raise the risk of an abnormal heart rhythm.

How to manage the interaction:
Although using Lenshil 4mg Capsule and Saquinavir together can possibly result in an interaction, they can be taken together if advised by your doctor. However, contact your doctor if you experience drowsiness, lightheadedness, fainting, shortness of breath, or irregular heartbeat. Do not stop taking any medications without consulting a doctor.
LenvatinibPimozide
Critical
How does the drug interact with Lenshil 4mg Capsule:
Coadministration of Lenshil 4mg Capsule with Pimozide can increase the risk of an irregular heart rhythm.

How to manage the interaction:
Although using Lenshil 4mg Capsule and Pimozide together can possibly result in an interaction, they can be taken together if advised by your doctor. However, contact your doctor if you experience drowsiness, lightheadedness, fainting, shortness of breath, or irregular heartbeat. Do not stop taking any medications without consulting a doctor.
LenvatinibMesoridazine
Critical
How does the drug interact with Lenshil 4mg Capsule:
Taking Lenshil 4mg Capsule with Mesoridazine can increase the risk of an irregular heart rhythm that may be serious.

How to manage the interaction:
Although there is an interaction between Lenshil 4mg Capsule and mesoridazine, they can be taken together if prescribed by a doctor. However, consult your doctor if you experience sudden dizziness, lightheadedness, fainting, shortness of breath. Do not discontinue any medications without consulting a doctor.
LenvatinibZiprasidone
Critical
How does the drug interact with Lenshil 4mg Capsule:
Taking Lenshil 4mg Capsule and Ziprasidone together can raise the risk of an abnormal heart rhythm.

How to manage the interaction:
Although using Lenshil 4mg Capsule and Ziprasidone together is not recomended as it can possibly result in an interaction, they can be taken together if advised by your doctor. However, contact your doctor if you experience drowsiness, lightheadedness, fainting, shortness of breath, or irregular heartbeat. Do not stop taking any medications without consulting a doctor.
LenvatinibHalofantrine
Critical
How does the drug interact with Lenshil 4mg Capsule:
Taking Lenshil 4mg Capsule and Halofantrine together can raise the risk of an abnormal heart rhythm.

How to manage the interaction:
Although using Lenshil 4mg Capsule and Halofantrine together can possibly result in an interaction, they can be taken together if advised by your doctor. However, contact your doctor if you experience drowsiness, lightheadedness, fainting, shortness of breath, or irregular heartbeat. Do not stop taking any medications without consulting a doctor.
LenvatinibGrepafloxacin
Critical
How does the drug interact with Lenshil 4mg Capsule:
Coadministration of grepafloxacin and Lenshil 4mg Capsule can increase the risk irregular heart rhythm.

How to manage the interaction:
Although using Lenshil 4mg Capsule and Grepafloxacin together is not recommended as it can possibly result in an interaction, they can be taken together if advised by your doctor. Do not stop taking any medications without consulting a doctor.
LenvatinibSparfloxacin
Critical
How does the drug interact with Lenshil 4mg Capsule:
Taking Lenshil 4mg Capsule and Sparfloxacin together can raise the risk of an abnormal heart rhythm.

How to manage the interaction:
Using Lenshil 4mg Capsule and Sparfloxacin is not recommended, but they can be taken together if advised by your doctor. However, contact your doctor if you experience drowsiness, lightheadedness, fainting, shortness of breath, or irregular heartbeat. Do not stop taking any medications without consulting a doctor.
LenvatinibDofetilide
Severe
How does the drug interact with Lenshil 4mg Capsule:
Taking Lenshil 4mg Capsule and Dofetilide together can raise the risk of an abnormal heart rhythm.

How to manage the interaction:
Although there is an interaction between Lenshil 4mg Capsule and Dofetilide, but it can be taken if prescribed by a doctor. However, if you experience symptoms like a fast or irregular heartbeat, prolonged diarrhea or vomiting, sudden dizziness or feeling lightheaded, fainting, shortness of breath, contact your doctor immediately. Do not stop using any medications without a doctor's advice.
LenvatinibFingolimod
Severe
How does the drug interact with Lenshil 4mg Capsule:
Taking Lenshil 4mg Capsule and Fingolimod together can raise the risk of an abnormal heart rhythm.

How to manage the interaction:
Taking Lenshil 4mg Capsule with Fingolimod together can possibly result in an interaction, but it can be taken if your doctor has advised it. However, if you experience sudden dizziness, lightheadedness, fainting, or shortness of breath, severe or long-lasting diarrhoea, or vomiting, contact your doctor immediately. Do not discontinue any medications without consulting a doctor.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

  • Eat food rich in antioxidants such as berries, spinach, etc.
  • Foods containing fibre help in better digestion. These include beans, peas, lentils, whole grains, nuts, and seeds.
  • Physical activity helps strengthen muscles, reduces fatigue, helps in weight loss, and gives strength. Gentle activities like 20-30 minutes of walking or swimming would be helpful.
  • Maintain a healthy weight by performing regular low-strain exercises and eating healthy food.
  • Getting adequate sleep as resting helps improve your health and mental ability and improves attention.
  • De-stress yourself by meditating, reading books, taking a warm bubble bath, or listening to soothing music.
  • Avoid smoking and alcohol consumption.
  • Maintain a healthy weight.

Habit Forming

No

Therapeutic Class

ANTINEOPLASTIC

Lenshil 4mg Capsule Substitute

Substitutes safety advice

Product Substitutes

Author Details

Lakshmithulasi YarraguntaDoctor badge

Written By

Lakshmithulasi Yarragunta

Pharm-D (PB)

Dr Aneela SiddabathuniDoctor badge

Reviewed By

Dr Aneela Siddabathuni

MPharma., PhD

Last Updated

Jul 8, 2025 | 9:50 AM IST

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Drug-Diseases Interactions

verifiedApollotooltip
No Drug - Disease interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Diseases Interactions

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FAQs

Lenshil 4mg Capsule contains Lenvatinib, which works by inhibiting the action of a tyrosine kinase enzyme that causes the multiplication of cancerous cells.

It is advised not to miss any dose of medicine. If you miss it, take the medicine as soon as you remember. However, if it is time for your next dose, avoid taking the missed dose and do not double the dose.

Drug-Drug Interactions Checker List

  • ESCITALOPRAM
  • CITALOPRAM
  • EFAVIRENZ
  • TERIFLUNOMIDE
  • SPARFLOXACIN
  • MOXIFLOXACIN

Special Advise

  • Your doctor may suggest periodic liver function tests, kidney function tests, lung function tests and urine tests to monitor the function of the liver, kidney, lungs and the presence of protein in urine due to the use of Lenshil 4mg Capsule .
  • Using contraceptive pills while using Lenshil 4mg Capsule to prevent pregnancy is advised.
  • Thyroid function and adrenocorticotropic hormone levels will be monitored during treatment to avoid any life-threatening side effects.
  • It is advised to use contraceptive pills while using Lenshil 4mg Capsule to prevent pregnancy.
  • Seek medical attention immediately if you have swelling in your lower legs, fast heartbeats, or trouble breathing, as it may be a sign of a heart problem.

Disease/Condition Glossary

Renal Cell Carcinoma: Also known as kidney cancer. It is the most common type of cancer seen in adults. This condition occurs when cancer/ malignant cells grow uncontrollably in the kidney and form a tumor. Advanced kidney cancer (metastatic renal cell carcinoma) occurs when the malignant cells spread to other parts of the body. Symptoms include red, orange, or pink-coloured urine due to the presence of blood in the urine.

Hepatocellular carcinoma: Also known as liver cancer. It occurs when the cancer/ malignant cells grow out of control. This infects the liver, destroys the liver cells and affects the ability of the liver to work properly. Symptoms may include abdominal pain, loss of appetite, weight loss, and pale bowel motions.

Differentiated Thyroid cancer: This condition occurs when the cancer cells grow abnormally in the thyroid gland. The thyroid gland is a butterfly-shaped organ present under the neck. This gland is useful in producing hormones responsible for the functioning of the body. Differentiated thyroid cancer is the most common type of thyroid carcinoma, which includes papillary thyroid cancer and follicular thyroid cancer.

Endometrial cancer: It is a cancer which affects the endometrium (lining of the womb or uterus). Symptoms may include bleeding between periods, pelvic pain, and pain during sexual intercourse. This cancer mostly occurs due to certain factors such as increasing age, obesity, never being pregnant, family history of cancer, and diabetes. It is usually seen in women above the age of 55 years. This condition is not life-threatening when it is diagnosed and treated in the early stages.

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