apollo
0

Welcome User

Login/Sign Up

Home
Buy Medicines
Lab Tests
Doctor Consult
Circle Membership
Insurance
Blogs
Contact Us
Privacy Policy
Return & Refunds
Need Help
Terms and Conditions
  1. Home
  2. Medicine

  3. LEOQUIN 500EC TABLET

LEOQUIN 500EC TABLET, Pack of 10 TabletS
Written By aquibnaseer ,
Reviewed By Sunny S , MBBS
Non returnable*
Know More
COD available

Online payment accepted

rxMedicinePrescription drug

Whats That

tooltip

Composition :

CHLOROQUINE-500MG

Manufacturer/Marketer :

Leo Pharmaceuticals Ltd

Consume Type :

ORAL

Return Policy :

Not Returnable

Expires on or after :

About Leoquin EC 500 mg Tablet

Leoquin EC 500 mg Tablet belongs to the class of medications called 'quinoline' primarily used to treat malaria. Leoquin EC 500 mg Tablet gives a degree of protection (prophylaxis) against malaria when people travel to areas where malarial cases exist. It is effective against Plasmodium vivax, Plasmodium ovale, and Plasmodium malariae. Leoquin EC 500 mg Tablet is not effective against Plasmodium falciparum. Besides this, it also treats amoebiasis (intestinal dysentery) and rheumatic disease (arthritis). 

Leoquin EC 500 mg Tablet contains 'chloroquine' which acts by killing the malarial parasites, i.e. Plasmodium and stops the formation of the nontoxic heme metabolite hemozoin by the parasite. Heme part of the red blood cells is broken by the malarial, causing parasites. Leoquin EC 500 mg Tablet  prevents the breakdown of heme part and is actually toxic to the parasite. It kills the parasitic form living in red blood cells that resides in the liver.

Leoquin EC 500 mg Tablet should be taken as prescribed by your doctor. The dose of Leoquin EC 500 mg Tablet can vary depending upon your condition and the severity of the infection. The common side effects of Leoquin EC 500 mg Tablet include vomiting, nausea, hair loss and itchy skin. Everyone need not experience the above side effects. In case of any discomfort, speak with a doctor.

Before starting Leoquin EC 500 mg Tablet , please inform your doctor if you are allergic to chloroquine or have kidney or liver problems. Do not take Leoquin EC 500 mg Tablet on your own. Leoquin EC 500 mg Tablet is safe to use during pregnancy and breastfeeding. Prolonged use of Leoquin EC 500 mg Tablet may have a severe risk on the heart and retina of the eyes leading to pounding heartbeats and permanent vision problems. 

Uses of Leoquin EC 500 mg Tablet

Malaria, Intestinal amoebiasis, Rheumatoid arthritis

Directions for Use

Tablet/Capsule: Swallow it as a whole with water; do not crush, break or chew it.Syrup/Suspension: Shake the bottle well before use. Take the prescribed dose by mouth using the measuring cup/dosing syringe/dropper provided by the pack.

Medicinal Benefits

Leoquin EC 500 mg Tablet falls into a group of medicines known as antimalarials, indicated for treating or preventing malaria. Leoquin EC 500 mg Tablet contains chloroquine, which belongs to quinoline. It works by preventing the formation of the nontoxic heme metabolite hemozoin by the parasite. Due to this, the parasite dies from its own toxic by-products released due to haemoglobin's metabolism. Leoquin EC 500 mg Tablet is also indicated for the treatment of rheumatoid arthritis and autoimmune diseases like lupus and intestinal infection caused by amoeba (amoebiasis).

Storage

Store in a cool and dry place away from sunlight

Drug Warnings

Leoquin EC 500 mg Tablet does not respond well against all malaria strains, so consult with your doctor if you do not respond well to Leoquin EC 500 mg Tablet . This medicine can affect heart health, especially if a person is taking medications, including the antibiotic azithromycin and anticancer like tamoxifen. An individual must consult with the doctor if they are noticing fast or pounding heartbeats and sudden dizziness. This medicine cannot be used for a long duration as it may cause irreversible damage to the eye that could lead to vision problems. Leoquin EC 500 mg Tablet cannot be used in persons who have heart disease, heart rhythm disorder, diabetes, a stomach disorder, an allergy to quinine, liver or kidney disease, psoriasis, alcoholism, porphyria (a genetic enzyme disorder that affects the skin or nervous system), a genetic enzyme deficiency called glucose-6-phosphate dehydrogenase (G6PD) deficiency. Consult with your doctor if you are pregnant or breastfeeding as this medicine could only be used if prescribed by the doctor. 

Drug-Drug Interactions

verifiedApollotooltip
ChloroquineSparfloxacin
Critical
ChloroquineLevacetylmethadol
Critical

Drug-Drug Interactions

Login/Sign Up

ChloroquineSparfloxacin
Critical
How does the drug interact with Leoquin 500ec Tablet:
Using Leoquin 500ec Tablet together with sparfloxacin can increase the risk of an irregular heart rhythm

How to manage the interaction:
Taking Leoquin 500ec Tablet with Sparfloxacin is not recommended, but it can be taken together if prescribed by a doctor. However, consult your doctor if you experience unusual symptoms. Do not discontinue any medications without consulting a doctor.
ChloroquineLevacetylmethadol
Critical
How does the drug interact with Leoquin 500ec Tablet:
Using Levacetylmethadol together with Leoquin 500ec Tablet can increase the risk of an irregular heart rhythm

How to manage the interaction:
Taking Leoquin 500ec Tablet with Levacetylmethadol is not recommended, as it can possibly result in an interaction, it can be taken if your doctor has advised it. However, if you experience sudden dizziness, lightheadedness, fainting, breathing difficulty, or rapid heartbeat, consult the doctor immediately. Do not discontinue any medications without consulting a doctor.
ChloroquineAgalsidase alfa
Critical
How does the drug interact with Leoquin 500ec Tablet:
When Agalsidase alfa is used with Leoquin 500ec Tablet, it may decrease the effectiveness of the Agalsidase alfa.

How to manage the interaction:
Taking Agalsidase alfa with Leoquin 500ec Tablet is not recommended, it can be taken together if prescribed by a doctor. However, if you experience any unusual symptoms, contact a doctor immediately. Do not stop using any medications without talking to a doctor.
ChloroquineAurothioglucose
Critical
How does the drug interact with Leoquin 500ec Tablet:
Taking Aurothioglucose with Leoquin 500ec Tablet can cause blood disorders and other severe side effects

How to manage the interaction:
Taking Aurothioglucose with Leoquin 500ec Tablet is not recommended, as it can cause an interaction, but it can be taken together if prescribed by a doctor. However, consult your doctor if you experience unusual symptoms. Do not discontinue any medications without consulting a doctor.
ChloroquineDronedarone
Critical
How does the drug interact with Leoquin 500ec Tablet:
When Leoquin 500ec Tablet is taken with Dronedarone, it may increase the risk of abnormal heart rhythm.

How to manage the interaction:
Taking Leoquin 500ec Tablet with Dronedarone is not recommended, as it can possibly result in an interaction, it can be taken if your doctor has advised it. However, if you experience sudden dizziness, lightheadedness, fainting, breathing difficulty, or rapid heartbeat, consult the doctor immediately. Do not discontinue any medications without consulting a doctor.
ChloroquinePazopanib
Critical
How does the drug interact with Leoquin 500ec Tablet:
Taking pazopanib with Leoquin 500ec Tablet can increase the risk of irregular heart rhythm.

How to manage the interaction:
Taking Pazopanib with Leoquin 500ec Tablet is not recommended, but it can be taken together if prescribed by a doctor. However, consult your doctor if you experience sudden dizziness, lightheadedness, fainting, shortness of breath. Do not discontinue any medications without consulting a doctor.
ChloroquineCisapride
Critical
How does the drug interact with Leoquin 500ec Tablet:
Taking Leoquin 500ec Tablet with Cisapride can increase the risk of a serious abnormal heart rhythm.

How to manage the interaction:
Taking Leoquin 500ec Tablet with Cisapride is not recommended as it can possibly result in an interaction, it can be taken if your doctor has advised it. However, if you experience sudden dizziness, lightheadedness, fainting, breathing difficulty, or rapid heartbeat, consult the doctor immediately.
ChloroquineBepridil
Critical
How does the drug interact with Leoquin 500ec Tablet:
Using Leoquin 500ec Tablet together with bepridil can increase the risk of an irregular heart rhythm

How to manage the interaction:
Taking Leoquin 500ec Tablet with Bepridil is not recommended, as it can possibly result in an interaction, it can be taken if your doctor has advised it. However, if you experience sudden dizziness, lightheadedness, fainting, breathing difficulty, or rapid heartbeat, consult the doctor immediately.
ChloroquineSaquinavir
Critical
How does the drug interact with Leoquin 500ec Tablet:
Using saquinavir together with Leoquin 500ec Tablet can increase the risk of an irregular heart rhythm.

How to manage the interaction:
Taking Leoquin 500ec Tablet with Saquinavir is not recommended, as it can possibly result in an interaction, it can be taken if your doctor has advised it. However, if you experience sudden dizziness, lightheadedness, fainting, breathing difficulty, or rapid heartbeat, consult the doctor immediately. Do not discontinue any medications without consulting a doctor.
ChloroquineAgalsidase beta
Critical
How does the drug interact with Leoquin 500ec Tablet:
Using Leoquin 500ec Tablet with Agalsidase beta can reduce the effectiveness of agalsidase beta.

How to manage the interaction:
Taking Agalsidase beta with Leoquin 500ec Tablet is not recommended, but can be taken together if prescribed by a doctor. However, if you experience any unusual symptoms contact a doctor immediately. Do not stop using any medications without talking to a doctor.

Drug-Food Interactions

verifiedApollotooltip
No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

Login/Sign Up

Diet & Lifestyle Advise

  • Always take Leoquin EC 500 mg Tablet with meals for reduced gastric irritation.
  • Adequate nutrition is the key for improvement in malaria induced weakness.
  • It is important to allow the patient to eat regularly in small amounts to tolerate the food. 
  • Increase fluid and protein intake for malaria induced weight loss.
  • Proper rest and mosquito-free premises is important for the patient to recover.

Habit Forming

No

Therapeutic Class

ANTI- MALARIALS

Leoquin EC 500 mg Tablet Substitute

Substitutes safety advice

Product Substitutes

Author Details

Sunny S

Reviewed By

Sunny S

MBBS

Last Updated

Jul 8, 2025 | 9:31 AM IST

Doctor imageWe provide you with authentic, trustworthy and relevant information

Drug-Diseases Interactions

verifiedApollotooltip
CHLOROQUINE-500MGDisorders of porphyrin and bilirubin metabolism
Severe
CHLOROQUINE-500MGOther cardiac arrhythmias
Moderate

Drug-Diseases Interactions

Login/Sign Up

CHLOROQUINE-500MGDisorders of porphyrin and bilirubin metabolism
Severe
How does the disease interact with Leoquin 500ec Tablet:
Porphyria: In porphyria the use of Leoquin 500ec Tablet may aggravate this condition. Avoid Leoquin 500ec Tablet use until it is required.

How to manage the interaction:
If the risks aren't expected to outweigh the possible advantages, Leoquin 500ec Tablet shouldn't be utilized on these patients.
CHLOROQUINE-500MGOther cardiac arrhythmias
Moderate
How does the disease interact with Leoquin 500ec Tablet:
Arrhythmias:Leoquin 500ec Tablet has adverse effect like prolongation of QT interval, ventricular arrhythmias and torsades de pointes. Monitor ECG before initiation and during the therapy.

How to manage the interaction:
If you have sudden dizziness, lightheadedness, fainting, shortness of breath, or rapid heartbeat while taking these medications, whether they are taken together or separately, you should seek immediate assistance from a doctor. A close monitoring of ECG is required.
CHLOROQUINE-500MGEpilepsy
Moderate
How does the disease interact with Leoquin 500ec Tablet:
Seizures: Leoquin 500ec Tablet may cause epileptic seizures in susceptible patients. Administer Leoquin 500ec Tablet in patients with history of epilepsy.

How to manage the interaction:
In those who are vulnerable, Leoquin 500ec Tablet may result in epileptic fits. Patients who already have epileptic fits or have a low tolerance for seizures may be at greater risk.
CHLOROQUINE-500MGOther diseases of blood and blood-forming organs
Moderate
How does the disease interact with Leoquin 500ec Tablet:
Bone marrow suppression: With the use of Leoquin 500ec Tablet adverse effects such as neutropenia, agranulocytosis, aplastic anemia, and thrombocytopenia. In patients with preexisting bone marrow suppression use cautiously and monitor for complete blood count. Discontinue the Leoquin 500ec Tablet if any serious blood disorder is suspected.

How to manage the interaction:
It is important to inform your doctor if you have prior conditions like bone marrow suppression, a complete blood picture is advised to be taken if you are on a long term therapy with Leoquin 500ec Tablet. If you suspect any blood disorders, please inform it to your doctor immediately.
CHLOROQUINE-500MGOther hearing loss
Moderate
How does the disease interact with Leoquin 500ec Tablet:
Ototoxicity: Rarely, Leoquin 500ec Tablet was been associated with ototoxicity.The use of Leoquin 500ec Tablet has been associated rarely with ototoxicity. With long-term, high-dose Leoquin 500ec Tablet therapy which is irreversible nerve-type deafness may occur. In some patients with preexisting auditory damage, tinnitus, decrease in hearing may occur. Use with caution and discontinue therapy if new auditory defects occur or if hearing loss becomes worse.

How to manage the interaction:
If you any existing hearing damage, do not forget to inform it your doctor, so that a close monitoring can be done during the treatment with Leoquin 500ec Tablet.
CHLOROQUINE-500MGPsoriasis
Moderate
How does the disease interact with Leoquin 500ec Tablet:
In psoriasis patients, the Leoquin 500ec Tablet use may exacerbate severe attack of psoriasis. Do not use Leoquin 500ec Tablet unless the potential benefits vs risks outweighs.

How to manage the interaction:
It is important to tell your doctor if you have any existing skin conditions like psoriasis. Your doctor may prescribe the medication, if the benefits are more than the risks.
CHLOROQUINE-500MGMyasthenia gravis and other myoneural disorders
Moderate
How does the disease interact with Leoquin 500ec Tablet:
myasthenia gravis Use of Leoquin 500ec Tablet may exacerbate new onset of symptoms in patients with previously diagnosed myasthenia gravis. Use cautiously.

How to manage the interaction:
If you are suffering from myasthenia gravis, do not forget to tell it to your doctor. If you are taking Leoquin 500ec Tablet and experiencing symptoms like muscle weakness or weakness of the arms and legs, drooping of upper eyelid, difficulty speaking, difficulty swallowing, double vision, tiredness, or shortness of breath please inform your doctor.

FAQs

Leoquin EC 500 mg Tablet works by preventing the formation of the nontoxic heme metabolite hemozoin by the parasite. Due to this, the parasite dies from its own toxic by-products released due to haemoglobin's metabolism.

The use of Leoquin EC 500 mg Tablet is not allowed in persons who are already taking any antibiotic (azithromycin) as it may cause dangerous effects on the heart.

No such effect has been reported yet. Always consult your doctor for the change of dose regimen or an alternative medicine if needed.

No such harmful interaction has been reported in patients who take this drug under strict doctors' surveillance. However, some patients might experience eye (retina) damage and cause pounding heart, so patient taking Leoquin EC 500 mg Tablet is advised to consult a doctor and have regular check-ups cyclically.

There may be a risk of hemolysis in patients with G6PD deficiency while using Leoquin EC 500 mg Tablet . Doctor's consultation is mandatory before you start this medication.

Drug-Drug Interactions Checker List

  • PHENYLBUTAZONE
  • NEOSTIGMINE
  • PYRIDOSTIGMINE
  • AMPICILLIN
  • CIMETIDINE
  • TAMOXIFEN

Special Advise

Do not take Leoquin EC 500 mg Tablet if you have had a previous reaction to Leoquin EC 500 mg Tablet , or if you have certain eye problems involving your retina. Tell your healthcare provider about any problems you may have with your eyes.

Disease/Condition Glossary

Malaria: It is a severe & fatal parasitic infection caused by a protozoan called Plasmodium. 4 types of parasites can infect humans with malaria: Plasmodium falciparum, Plasmodium vivax, Plasmodium ovale, and Plasmodium malaria. Female anopheles mosquito bites cause it. If bitten by an infected mosquito (the Anopheles mosquito), malaria parasites are injected into the blood. These parasites then migrate to the liver where they multiply via the bloodstream. A patient doesn't feel sick at this period because the parasites are in the liver. Then the parasites leave the liver and enter the red blood cells where the parasites are developing, and then the red blood cells burst, allowing them to transfer to another blood cell. The parasites release harmful chemicals into the bloodstream at this point, and the patient begins to feel ill. Malaria leads to periodic fever-chills, anaemia, kidney failure, and jaundice due to excessive red blood cell death due to plasmodium growth inside them.

Have a query?

Buy best Infections & Infestation products by

whatsapp Floating Button