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LEOQUIN 500EC TABLET

LEOQUIN 500EC TABLET

Consult Doctor
Prescription drug
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Consume Type

ORAL

Return Policy

Not Returnable

Expires on or after

Apr-24

for this medicine

About LEOQUIN 500EC TABLET

LEOQUIN 500EC TABLET belongs to the class of medications called 'quinoline' primarily used to treat malaria. LEOQUIN 500EC TABLET gives a degree of protection (prophylaxis) against malaria when people travel to areas where malarial cases exist. It is effective against Plasmodium vivax, Plasmodium ovale, and Plasmodium malariae. LEOQUIN 500EC TABLET is not effective against Plasmodium falciparum. Besides this, it also treats amoebiasis (intestinal dysentery) and rheumatic disease (arthritis). 

LEOQUIN 500EC TABLET contains 'chloroquine' which acts by killing the malarial parasites, i.e. Plasmodium and stops the formation of the nontoxic heme metabolite hemozoin by the parasite. Heme part of the red blood cells is broken by the malarial, causing parasites. LEOQUIN 500EC TABLET prevents the breakdown of heme part and is actually toxic to the parasite. It kills the parasitic form living in red blood cells that resides in the liver.

LEOQUIN 500EC TABLET should be taken as prescribed by your doctor. The dose of LEOQUIN 500EC TABLET can vary depending upon your condition and the severity of the infection. The common side effects of LEOQUIN 500EC TABLET include vomiting, nausea, hair loss and itchy skin. Everyone need not experience the above side effects. In case of any discomfort, speak with a doctor.

Before starting LEOQUIN 500EC TABLET, please inform your doctor if you are allergic to chloroquine or have kidney or liver problems. Do not take LEOQUIN 500EC TABLET on your own. LEOQUIN 500EC TABLET is safe to use during pregnancy and breastfeeding. Prolonged use of LEOQUIN 500EC TABLET may have a severe risk on the heart and retina of the eyes leading to pounding heartbeats and permanent vision problems. 

Uses of LEOQUIN 500EC TABLET

Malaria, Intestinal amoebiasis, Rheumatoid arthritis

Medicinal Benefits

LEOQUIN 500EC TABLET falls into a group of medicines known as antimalarials, indicated for treating or preventing malaria. LEOQUIN 500EC TABLET contains chloroquine, which belongs to quinoline. It works by preventing the formation of the nontoxic heme metabolite hemozoin by the parasite. Due to this, the parasite dies from its own toxic by-products released due to haemoglobin's metabolism. LEOQUIN 500EC TABLET is also indicated for the treatment of rheumatoid arthritis and autoimmune diseases like lupus and intestinal infection caused by amoeba (amoebiasis).

Directions for Use

Tablet/Capsule: Swallow it as a whole with water; do not crush, break or chew it.Syrup/Suspension: Shake the bottle well before use. Take the prescribed dose by mouth using the measuring cup/dosing syringe/dropper provided by the pack.

Storage

Store in a cool and dry place away from sunlight

Side Effects of LEOQUIN 500EC TABLET

  • Abnormal heart rhythm
  • Stomach pain
  • Nausea (being sick)
  • Diarrhoea
  • Loss of appetite
  • Headache
  • Skin rash
  • Liver problems

Drug Warnings

LEOQUIN 500EC TABLET does not respond well against all malaria strains, so consult with your doctor if you do not respond well to LEOQUIN 500EC TABLET. This medicine can affect heart health, especially if a person is taking medications, including the antibiotic azithromycin and anticancer like tamoxifen. An individual must consult with the doctor if they are noticing fast or pounding heartbeats and sudden dizziness. This medicine cannot be used for a long duration as it may cause irreversible damage to the eye that could lead to vision problems. LEOQUIN 500EC TABLET cannot be used in persons who have heart disease, heart rhythm disorder, diabetes, a stomach disorder, an allergy to quinine, liver or kidney disease, psoriasis, alcoholism, porphyria (a genetic enzyme disorder that affects the skin or nervous system), a genetic enzyme deficiency called glucose-6-phosphate dehydrogenase (G6PD) deficiency. Consult with your doctor if you are pregnant or breastfeeding as this medicine could only be used if prescribed by the doctor. 

Drug Interactions

Drug-Drug Interaction: LEOQUIN 500EC TABLET can interact with pain killers (aspirin), anti-allergic (hydroxyzine), anticancer (tamoxifen), antibiotics (ciprofloxacin, amoxicillin/clavulanate, azithromycin, celecoxib), immunosuppressants (mycophenolate mofetil), antimalarials (proguanil, primaquine, mefloquine, hydroxychloroquine), antianxiety medicine (pregabalin), anti-epileptic (levetiracetam), antacids (esomeprazole), proguanil, and anti-anxiety drugs (alprazolam).

Drug-Food Interaction: Limit the consumption of grapefruit or grapefruit juice with LEOQUIN 500EC TABLET as it can significantly increase the level of this medicine in the blood. 

Drug-Disease Interaction: People affected with eye disorder (oculotoxicity), blood disease (porphyria), heart disease (arrhythmias), bone marrow suppression, ear disorder (cytotoxicity), seizures, enzyme deficiency (G-6-PD deficiency), liver disease (hepatotoxicity), muscle disorder (myasthenia gravis), skin disease (psoriasis) should not take LEOQUIN 500EC TABLET without doctors consultation.

Drug-Drug Interactions Checker List

  • PHENYLBUTAZONE
  • NEOSTIGMINE
  • PYRIDOSTIGMINE
  • AMPICILLIN
  • CIMETIDINE
  • TAMOXIFEN

Habit Forming

No

Diet & Lifestyle Advise

  • Always take LEOQUIN 500EC TABLET with meals for reduced gastric irritation.
  • Adequate nutrition is the key for improvement in malaria induced weakness.
  • It is important to allow the patient to eat regularly in small amounts to tolerate the food. 
  • Increase fluid and protein intake for malaria induced weight loss.
  • Proper rest and mosquito-free premises is important for the patient to recover.

Special Advise

Do not take LEOQUIN 500EC TABLET if you have had a previous reaction to LEOQUIN 500EC TABLET, or if you have certain eye problems involving your retina. Tell your healthcare provider about any problems you may have with your eyes.

Disease/Condition Glossary

Malaria: It is a severe & fatal parasitic infection caused by a protozoan called Plasmodium. 4 types of parasites can infect humans with malaria: Plasmodium falciparum, Plasmodium vivax, Plasmodium ovale, and Plasmodium malaria. Female anopheles mosquito bites cause it. If bitten by an infected mosquito (the Anopheles mosquito), malaria parasites are injected into the blood. These parasites then migrate to the liver where they multiply via the bloodstream. A patient doesn't feel sick at this period because the parasites are in the liver. Then the parasites leave the liver and enter the red blood cells where the parasites are developing, and then the red blood cells burst, allowing them to transfer to another blood cell. The parasites release harmful chemicals into the bloodstream at this point, and the patient begins to feel ill. Malaria leads to periodic fever-chills, anaemia, kidney failure, and jaundice due to excessive red blood cell death due to plasmodium growth inside them.

Country of origin

India

Manufacturer/Marketer address

LEO Pharma A/S, Industriparken 55, DK-2750 Ballerup, Danmark
Other Info - LEO0018

FAQs

LEOQUIN 500EC TABLET works by preventing the formation of the nontoxic heme metabolite hemozoin by the parasite. Due to this, the parasite dies from its own toxic by-products released due to haemoglobin's metabolism.
The use of LEOQUIN 500EC TABLET is not allowed in persons who are already taking any antibiotic (azithromycin) as it may cause dangerous effects on the heart.
No such effect has been reported yet. Always consult your doctor for the change of dose regimen or an alternative medicine if needed.
No such harmful interaction has been reported in patients who take this drug under strict doctors' surveillance. However, some patients might experience eye (retina) damage and cause pounding heart, so patient taking LEOQUIN 500EC TABLET is advised to consult a doctor and have regular check-ups cyclically.
There may be a risk of hemolysis in patients with G6PD deficiency while using LEOQUIN 500EC TABLET. Doctor's consultation is mandatory before you start this medication.

Disclaimer

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Alcohol

Caution

No serious interaction has been reported between alcohol and LEOQUIN 500EC TABLET yet alcohol should be avoided with LEOQUIN 500EC TABLET as it aggravates side effects.

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Pregnancy

Caution

LEOQUIN 500EC TABLET should be used with caution and can only be used in pregnancy if recommended by the doctor.

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Breast Feeding

Caution

It is not safe to breastfeed while taking LEOQUIN 500EC TABLET as this medicine can pass into breast milk. A patient is advised to take this drug only on doctor's consultation.

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Driving

Caution

LEOQUIN 500EC TABLET may cause blurred vision, so one should avoid driving or doing any activity that needs mental alertness. A patient is thus advised to take this drug only on doctor's consultation.

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Liver

Caution

LEOQUIN 500EC TABLET therapy is unlikely to cause liver injury in normal individuals but can trigger an acute worsening of porphyria in rare cases. Thus doctor's consultation is recommended before taking LEOQUIN 500EC TABLET.

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Kidney

Caution

LEOQUIN 500EC TABLET administration impairs kidney function in a few cases, so a patient is recommended to consult a doctor before taking LEOQUIN 500EC TABLET.

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Children

Safe if prescribed

LEOQUIN 500EC TABLET is safe to use in children, yet dose adjustment by a doctor will be done on the basis of age, weight, and severity of the infection.