Leucovorin Calcium 15 mg Injection 2 ml belongs to the class of medicines known as folic acid analogues (a form of vitamin B). It is primarily used to treat harmful effects caused by an overdose of methotrexate (cancer medicine). Methotrexate is used to treat cancer, severe rheumatoid arthritis, and severe psoriasis. It can cause fatal side effects sometimes. Harmful effects of methotrexate include vision loss, seizures/ fits, loss of consciousness etc. Leucovorin Calcium 15 mg Injection 2 ml is also used to treat Anemia (low amount of red blood cells) brought on by low folic acid levels in the body. Leucovorin Calcium 15 mg Injection 2 ml is also used to treat colorectal cancer with the chemotherapeutic drug 5-fluorouracil (cancer that begins in the large intestine).

Leucovorin Calcium 15 mg Injection 2 ml contains leucovorin, which is a form of vitamin B. It is folic acid in its active form. Leucovorin Calcium 15 mg Injection 2 ml works by preventing healthy cells from the toxic effects of methotrexate (cancer medicines) while accepting it to enter and kill the cancer cells. It should be administered as soon as possible after taking methotrexate.

Leucovorin Calcium 15 mg Injection 2 ml is given by a health care professional in a hospital or clinic setting. You may experience infections, nausea, vomiting, diarrhoea, and constipation. Most of these side effects of Leucovorin Calcium 15 mg Injection 2 ml do not require medical attention and gradually resolve over time. However, if the side effects are persistent, reach out to your doctor.

Before taking the Leucovorin Calcium 15 mg Injection 2 ml, let your doctor know about all your allergic or hypersensitivity reactions to medicines or food. Inform your doctor about your medical history and other medications you are currently taking to rule out any potential negative effects. Inform your doctor if you are pregnant, planning to become pregnant, or breastfeeding or if you have anaemia, GI toxicity, renal impairment and seizures.

Leucovorin Calcium 15 mg Injection 2 ml is used to prevent the harmful effects of methotrexate (cancer medicine) when methotrexate is used to treat some types of cancer. Leucovorin Calcium 15 mg Injection 2 ml is also used to treat patients who accidentally overdose on methotrexate or similar medicines. Leucovorin Calcium 15 mg Injection 2 ml works by preventing healthy cells from the toxic effects of methotrexate (cancer medicines) while accepting it to enter and kill the cancer cells. Leucovorin injection is also used to treat anaemia (low red blood cell count) caused by low folic acid levels in the body. Leucovorin Calcium 15 mg Injection 2 ml is also used to treat colorectal cancer with the chemotherapeutic drug 5-fluorouracil (cancer that begins in the large intestine).

• Infections
• Nausea
• Vomiting
• Diarrhoea
• Constipation

Inform your doctor about any allergic or hypersensitive reactions to medications or food before taking the Leucovorin Calcium 15 mg Injection 2 ml. Inform your doctor about your medical history and any other medications you are currently taking so that any potential side effects can be ruled out. Also, let your doctor know if you are pregnant, intend to become pregnant, or are breastfeeding. Do not use Leucovorin Calcium 15 mg Injection 2 ml in more than prescribed doses or longer duration as it may cause adverse effects.

Drug-Drug Interactions: Leucovorin Calcium 15 mg Injection 2 ml may interact with anticancer medicines (e..g fluorouracil, capecitabine, pafolacianine) and antibiotics (e.g. trimethoprim, ceftriaxone).

Drug-Food Interactions: No interactions found.

Drug-Disease Interactions: Leucovorin Calcium 15 mg Injection 2 ml may interact with disease conditions, including anaemia, GI toxicity, renal impairment and seizures.

• FLUOROURACIL
• CAPECITABINE
• PAFOLACIANINE
• CEFTRIAXONE

• Create a well-balanced and healthy diet that includes vegetables, fruits, whole grains, legumes, omega-3-rich foods, and lean protein sources.
• Keep your weight under control with a BMI of 19.5-24.9.
• Avoid chronic stress.
• Limit or avoid alcohol consumption.
• Quitting smoking and alcohol consumption is the best strategy to lower the risk of many health complications.

• Inform your doctor if you are also taking certain medicines like phenytoin for your fits disorder, as Leucovorin Calcium 15 mg Injection 2 ml may reduce the antiepileptic effects.

Harmful effects of methotrexate: Methotrexate is used to treat cancer, severe rheumatoid arthritis, and severe psoriasis. It can cause side effects like swollen gums, headaches, hair loss, dizziness, etc. Infrequently, it can cause fatal side effects. Harmful effects of methotrexate include vision loss, seizures/ fits, loss of consciousness, etc. It can damage the blood, liver, bone marrow, lungs, etc. The drug can lead to birth defects and death in unborn babies.