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Written By Lakshmithulasi Yarragunta , Pharm-D (PB)
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD

About Levo-Anawin 0.5% Injection 20 ml

Levo-Anawin 0.5% Injection 20 ml is a local anaesthetic medicine used to reduce pain and discomfort during medical procedures. It produces local numbness and relieves pain. Pain is a symptom triggered by the nervous system, which causes uncomfortable sensations in the body. The tolerance level of pain might vary from person to person.

Levo-Anawin 0.5% Injection 20 ml contains Levobupivacaine as an active ingredient, which belongs to the group of medicines called 'amide-type anaesthetics'. It works by acting on the nervous system and nerves to block the transmission of pain signals in the pain area, which results in the loss of pain.

Levo-Anawin 0.5% Injection 20 ml may cause certain side effects such as weakness, tingling, restlessness, drowsiness, headache, blurred vision, difficulty speaking, irregular heartbeat, chills or shivering, back pain, nausea and vomiting. These side effects may not be similar to everyone and vary individually. If any of these side effects bother you, inform your doctor. Levo-Anawin 0.5% Injection 20 ml will be administered by the doctor or the nurse before the surgery.

Inform your doctor if you have liver, kidney or heart diseases, high or low blood pressure, excess fat in the body and breathing problems before administering Levo-Anawin 0.5% Injection 20 ml. This medicine is contraindicated in patients with severe hypotension, cardiogenic or hypovolaemic shock, the paracervical block in obstetrics and intravenous regional anaesthesia. Levo-Anawin 0.5% Injection 20 ml is recommended for infiltration analgesia (ilioinguinal/iliohypogastric blocks) in children older than six months.

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Non returnable*
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Consume Type

PARENTERAL

Return Policy

3 Days Returnable

Expires on or after

Apr-24

for this medicine

Uses of Levo-Anawin 0.5% Injection 20 ml

Surgical Anaesthesia, Pain Management

Medicinal Benefits

Levo-Anawin 0.5% Injection 20 ml contains Levobupivacaine, used to relieve pain and discomfort during labour, surgery, dental treatment and other medical procedures. It works by blocking the transmission of pain signals in the pain area by acting on the nervous system and nerves. This blockage causes the loss of pain sensation helps in numbing the localized area, and provides relief from pain. Levo-Anawin 0.5% Injection 20 ml is injected as an epidural injection at the spinal cord during labour and Caesarean section to prevent labour pain.

Side Effects of Levo-Anawin 0.5% Injection 20 ml

  • Weakness
  • Restlessness
  • Drowsiness
  • Headache
  • Blurred vision
  • Irregular heartbeat
  • Hypotension
  • Chills
  • Back pain
  • Nausea
  • Vomiting 
  • Difficulty speaking

Directions for Use

Levo-Anawin 0.5% Injection 20 ml will be administered by a healthcare professional; do not self-administer.

Storage

Store in a cool and dry place away from sunlight

Drug Warnings

Inform your doctor if you have liver, kidney or heart diseases, high or low blood pressure, excess fat in the body and breathing problems before starting Levo-Anawin 0.5% Injection 20 ml. This medicine is contraindicated in patients with severe hypotension, such as cardiogenic or hypovolemic shock, for use in the paracervical block in obstetrics and for intravenous regional anaesthesia. Levo-Anawin 0.5% Injection 20 ml is not recommended for children 12 years of age. Let your doctor know about your complete medical and medication history, including prescription and non-prescription medications, vitamins and herbal supplements, before starting Levo-Anawin 0.5% Injection 20 ml. Levo-Anawin 0.5% Injection 20 ml released into breast milk during breastfeeding. Please inform your doctor if you are pregnant, planning to conceive or a breastfeeding mother. Avoid alcohol to prevent the worsening of side effects further.

Therapeutic Class

LOCAL ANESTHETICS

Drug-Drug Interactions

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LevobupivacaineCyclophosphamide
Severe
LevobupivacainePhenobarbital
Severe

Drug-Drug Interactions

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LevobupivacaineCyclophosphamide
Severe
How does the drug interact with Levo-Anawin 0.5% Injection 20 ml:
Co-administration of Cyclophosphamide with Levo-Anawin 0.5% Injection 20 ml can increase the risk of methemoglobinemia (low level of oxygen in the blood).

How to manage the interaction:
Co-administration of Levo-Anawin 0.5% Injection 20 ml with Cyclophosphamide can possibly result in an interaction, but it can be taken if a doctor has advised it. Keep a close eye on any signs or symptoms of Methemoglobinemia. If you notice any of these symptoms like gray skin, feeling sick, headaches, dizziness, tiredness, or trouble breathing, make sure to call a doctor right away. Do not stop using any medications without talking to a doctor.
LevobupivacainePhenobarbital
Severe
How does the drug interact with Levo-Anawin 0.5% Injection 20 ml:
Taking Phenobarbital with Levo-Anawin 0.5% Injection 20 ml can increase the risk of methemoglobinemia (a condition in which the iron in the hemoglobin molecule is defective, making it unable to carry oxygen effectively to the tissues).

How to manage the interaction:
Although there is a possible interaction between Levo-Anawin 0.5% Injection 20 ml and Phenobarbital, you can take these medicines together if prescribed by a doctor. Seek immediate medical attention if they develop gray discoloration of the skin, abnormal blood coloration, nausea, headache, dizziness, lightheadedness, fatigue, shortness of breath, rapid or shallow breathing, a rapid heartbeat, palpitation, anxiety, or confusion. Do not stop using any medications without talking to a doctor.
LevobupivacaineNitrofurantoin
Severe
How does the drug interact with Levo-Anawin 0.5% Injection 20 ml:
Combining Nitrofurantoin with Levo-Anawin 0.5% Injection 20 ml can increase the risk of methemoglobinemia (a condition in which the iron in the hemoglobin molecule (the red blood pigment) is defective, making it unable to carry oxygen effectively to the tissues).

How to manage the interaction:
There may be a possibility of interaction between Nitrofurantoin and Levo-Anawin 0.5% Injection 20 ml, but it can be taken if prescribed by a doctor. If you have any of these symptoms, it's important to contact a doctor right away. These symptoms include a condition called methemoglobinemia, problems with your heart or lungs, your skin turning gray, feeling sick to your stomach, having a headache, feeling dizzy or lightheaded, being very tired, having trouble breathing, breathing quickly or not deeply enough, a fast heartbeat, feeling your heart pounding, feeling anxious or confused. Do not stop using any medications without a doctor's advice.
LevobupivacaineHydroxycarbamide
Severe
How does the drug interact with Levo-Anawin 0.5% Injection 20 ml:
Levo-Anawin 0.5% Injection 20 ml has the potential to cause methemoglobinemia (a rare disorder in which the iron in the haemoglobin molecule (the red blood pigment) is defective, preventing it from carrying oxygen to the tissues adequately). This risk increases when used with hydroxycarbamide, which may lead to methemoglobinemia. When taking these drugs, those who are extremely young (particularly newborns and babies), have heart or lung conditions, certain genetic predispositions, or have a glucose-6-phosphate dehydrogenase deficit may be more likely to develop methemoglobinemia.

How to manage the interaction:
Although taking hydroxycarbamide and Levo-Anawin 0.5% Injection 20 ml together can possibly result in an interaction, it can be taken if your doctor has advised it. However, if you experience symptoms such as grey discolouration of the skin, abnormal blood colouration, nausea, headache, dizziness, lightheadedness, fatigue, shortness of breath, rapid or shallow breathing, a rapid heartbeat, palpitation, anxiety, or confusion, consult a doctor immediately. Do not discontinue any medications without consulting a doctor.
LevobupivacainePhenazopyridine
Severe
How does the drug interact with Levo-Anawin 0.5% Injection 20 ml:
Taking phenazopyridine with Levo-Anawin 0.5% Injection 20 ml can increase the risk of methemoglobinemia(a blood disorder in which too little oxygen is delivered to the cells).

How to manage the interaction:
Although there is a drug interaction between phenazopyridine and Levo-Anawin 0.5% Injection 20 ml but can be taken together if advised by a doctor. If experience nausea, headache, dizziness, lightheadedness, fatigue, shortness of breath, fast breathing, fast heartbeat, anxiety and confusion contact doctor immediately. Do not discontinue medications without consulting a doctor.
LevobupivacaineBupivacaine
Severe
How does the drug interact with Levo-Anawin 0.5% Injection 20 ml:
C0administration of bupivacaine with Levo-Anawin 0.5% Injection 20 ml can have additive toxic effects, so using them together increases the risk of serious side effects like methemoglobinemia (a condition that can deprive tissues and organs of oxygen), reactions in the central nervous system (e.g-convulsions, unconsciousness, coma, respiratory arrest), and cardiovascular disorders (e.g- low blood pressure, heart block, irregular heart rhythm).

How to manage the interaction:
There may be a possibility of interaction between Bupivacaine and Levo-Anawin 0.5% Injection 20 ml, but it can be taken if prescribed by a doctor. However, if you experience pale, grey, or blue-coloured skin, headache, rapid heart rate, shortness of breath, lightheadedness, or fatigue, consult a doctor. Do not stop using any medications without a doctor's advice.
LevobupivacaineChloroquine
Severe
How does the drug interact with Levo-Anawin 0.5% Injection 20 ml:
Taking Chloroquine with Levo-Anawin 0.5% Injection 20 ml can increase the risk of methemoglobinemia( blood disorder that affects how red blood cells deliver oxygen throughout your body).

How to manage the interaction:
Co-administration of Levo-Anawin 0.5% Injection 20 ml with Chloroquine can possibly result in an interaction, but it can be taken together if prescribed by a doctor. However, consult your doctor if you experience gray discoloration of the skin, abnormal blood coloration, nausea, headache, dizziness, lightheadedness, fatigue, shortness of breath, rapid or shallow breathing, a rapid heartbeat, palpitation, anxiety, or confusion. Do not discontinue any medications without consulting a doctor.
LevobupivacaineNitroprusside
Severe
How does the drug interact with Levo-Anawin 0.5% Injection 20 ml:
Co-administration of Levo-Anawin 0.5% Injection 20 ml and Nitroprusside can rarely cause methemoglobinemia(a condition that can reduce oxygen-carrying capacity of the blood).

How to manage the interaction:
Co-administration of Levo-Anawin 0.5% Injection 20 ml and Nitroprusside can lead to an interaction, but it can be taken if your doctor advises. However, if you experience any symptoms like grey discoloration of the skin, abnormal blood coloration, nausea, headache, dizziness, lightheadedness, fatigue, shortness of breath, rapid or shallow breathing, a rapid heartbeat, palpitation, anxiety, or confusion, contact your doctor immediately. Do not discontinue any medications without consulting your doctor.
LevobupivacaineSulfasalazine
Severe
How does the drug interact with Levo-Anawin 0.5% Injection 20 ml:
Coadministration of Levo-Anawin 0.5% Injection 20 ml with Sulfasalazine can increase the risk of methemoglobinemia (a rare red blood cell disorder).

How to manage the interaction:
Taking Levo-Anawin 0.5% Injection 20 ml with Sulfasalazine together can result in an interaction, but it can be taken if your doctor has advised it. It is important to keep a close eye on any signs or symptoms of Methemoglobinemia. If you notice any of these symptoms like gray discoloration, nausea, headache, dizziness, fatigue, or shortness of breath, it's best to contact a doctor right away. They can help determine the cause and provide appropriate treatment. Do not discontinue any medications without consulting a doctor.
LevobupivacaineGlyceryl trinitrate
Severe
How does the drug interact with Levo-Anawin 0.5% Injection 20 ml:
Coadministration of Levo-Anawin 0.5% Injection 20 ml and glyceryl trinitrate can increase the risk of developing methemoglobinemia (a rare condition where red blood cells are unable to carry oxygen effectively to the tissues).

How to manage the interaction:
Although taking Levo-Anawin 0.5% Injection 20 ml and glyceryl trinitrate together can possibly result in an interaction, it can be taken if your doctor has advised it. However, consult your doctor immediately if you experience symptoms such as grey discolouration of the skin, nausea, headache, dizziness, lightheadedness, fatigue, shortness of breath, rapid or shallow breathing, a rapid heartbeat, palpitation, anxiety, or confusion. Do not discontinue any medications without consulting your doctor.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Drug-Diseases Interactions

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No Drug - Disease interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Diseases Interactions

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Drug-Drug Interactions Checker List

  • LIDOCAINE
  • PHENYLEPHRINE
  • VASOPRESSIN
  • AMIODARONE

Diet & Lifestyle Advise

  • Physical activity helps in strengthening muscles and relieves joint stiffness. Gentle exercises like 20-30 minutes of walking or swimming would be helpful.
  • Maintain a healthy weight by performing regular low-strain exercises and eating healthy food.
  • Get adequate sleep, as resting the muscles can help in reducing inflammation and swelling.
  • Follow heat or cold therapy, and apply a cold or hot compress on the painful areas for 15-20 minutes regularly.
  • Eat food rich in antioxidants such as berries, spinach, kidney beans, dark chocolate, etc.
  • Foods containing flavonoids help in reducing inflammation. These include soy, berries, broccoli, grapes and green tea.
  • Avoid smoking and alcohol consumption.

Habit Forming

No

Special Advise

  • Monitor your blood pressure regularly since Levo-Anawin 0.5% Injection 20 ml may affect your blood pressure.
  • Careful monitoring of respiratory functions is needed while on treatment with Levo-Anawin 0.5% Injection 20 ml.

Disease/Condition Glossary

Surgical Anaesthesia: Anesthesia prevents the feeling of pain during medical procedures by using medications known as anaesthetics. A particular part of the body is rendered numb by local or regional anaesthesia. In order to undergo more invasive surgeries, general anaesthesia causes one to become unconscious or sleep momentarily.
Pain: This is not a disease but a symptom triggered by the nervous system, causing uncomfortable sensations in the body. Pain may be dull or sharp; it might be constant or intermittent. The tolerance level of pain might vary from person to person. Pain can be generalized (overall body aches) or localized (affecting a specific area of the body). Pain can be considered a good thing as it helps us know that something is wrong in the body and thereby helps diagnose the condition. The common causes of pain include headache, muscle strain, cramps, cuts, bone fractures, arthritis and stomach aches.

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