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Written By Santoshini Reddy G , M Pharmacy
Reviewed By Veda Maddala , M Pharmacy
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Composition :

BACLOFEN-500MCG

Manufacturer/Marketer :

Sun Pharmaceutical Industries Ltd

Consume Type :

PARENTERAL

Return Policy :

Not Returnable

Expires on or after :

About Liofen 500mcg Injection

Liofen 500mcg Injection belongs to the group of medicines called 'skeletal muscle relaxants' used to reduce and relieve the muscle spasms (excessive tension in the muscles) occurring in various illnesses. It is used in the management of severe spasticities such as spasticity of spinal cord origin, and spasticity of cerebral origin. Muscle spasm is the sudden involuntary contractions of the muscle, which can be painful and uncomfortable. Spasticity is the abnormal muscle tightness occurring due to prolonged muscle contraction.

Liofen 500mcg Injection works by inhibiting the reflexes at the spinal level and helps in relieving pain and improves muscle movements. Liofen 500mcg Injection works on the spinal cord and brain, thereby helps in maintaining muscle strength and relieves muscle spasms or stiffness. Thus Liofen 500mcg Injection reduces muscle spasm in the conditions of multiple sclerosis (a disorder that affects the brain and spinal cord), cerebrovascular accidents (damage to the brain due to lack of blood supply), cerebral palsy (a disorder of movement, posture and muscle tone), spinal cord diseases and other nervous system disorders.

Liofen 500mcg Injection will be administered by a healthcare professional; do not self-administer. In some cases, Liofen 500mcg Injection may cause certain common side-effects such as constipation, dizziness, nausea, headache, weakness, and dry mouth. Most of these side effects do not require medical attention and will resolve gradually over time. However, you are suggested to talk to your doctor if you experience these side effects persistently.

Liofen 500mcg Injection should not be stopped suddenly as it could lead to unpleasant side-effects such as rigidity, increased heart rate, changes in mood, fever, mental disorders, confusion, hallucinations, and fits (seizures). Consult your doctor before taking Liofen 500mcg Injection if you are pregnant or breastfeeding. Liofen 500mcg Injection is not recommended for children below 4 years of age and those who weigh below 33kgs. Inform your doctor about all the current medicines you are taking and about your health condition to rule out any unpleasant side effects. Please speak to your doctor immediately if you experience mood swings, depression, or if you have any suicidal thoughts.

Uses of Liofen 500mcg Injection

Muscle spasm, spasticity

Directions for Use

Liofen 500mcg Injection will be administered by a healthcare professional; do not self-administer.

Medicinal Benefits

Liofen 500mcg Injection belongs to the group of medicines called muscle relaxants used to reduce and relieve the muscle spasms/spasticity (excessive tension in the muscles) occurring in various illnesses such as multiple sclerosis (a disorder that affects the brain and spinal cord), cerebrovascular accidents (damage to the brain due to lack of blood supply), cerebral palsy (a disorder of movement, posture and muscle tone), spinal cord diseases and other nervous system disorders. Liofen 500mcg Injection works by inhibiting the reflexes at the spinal level and helps in relieving pain and improves muscle movements.

Storage

Store in a cool and dry place away from sunlight

Drug Warnings

Do not take Liofen 500mcg Injection if you are allergic to any of its contents or if you ever had a stomach ulcer. Talk to your doctor before taking Liofen 500mcg Injection if you have kidney or liver problems, infections, Parkinson's disease, epilepsy, diabetes, breathing problems, blood circulation problems, high blood pressure, anxiety, pounding headache, slow heart rate, excessive sweating, or if you ever had a stroke. Consult your doctor before taking Liofen 500mcg Injection if you are pregnant or breastfeeding. Liofen 500mcg Injection is not recommended for children below 4 years of age and those who weigh below 33 kg. 

Drug-Drug Interactions

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BaclofenSodium oxybate
Severe

Drug-Drug Interactions

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BaclofenSodium oxybate
Severe
How does the drug interact with Liofen 500mcg Injection:
Co-administration of Sodium oxybate with Liofen 500mcg Injection may increase side effects.

How to manage the interaction:
Although there is an interaction, Liofen 500mcg Injection can be used with Sodium oxybate if prescribed by the doctor. Consult the prescriber if you experience drowsiness, dizziness, lightheadedness, confusion, depression, low blood pressure, slow or shallow breathing, and impairment in thinking, judgment, and motor coordination.
How does the drug interact with Liofen 500mcg Injection:
Co-administration of Liofen 500mcg Injection with Butorphanol can increase the risk of developing side effects.

How to manage the interaction:
Although there is a possible interaction between Liofen 500mcg Injection and Butorphanol, you can take these medicines together if prescribed by your doctor. If you notice any symptoms like dizziness, shortness of breath, palpitations, or chest discomfort, consult a doctor immediately. Do not stop using any medications without a doctor's advice.
BaclofenOxycodone
Severe
How does the drug interact with Liofen 500mcg Injection:
Co-administration of Liofen 500mcg Injection can enhance the sedative effects of Oxycodone on the central nervous system and can lead to serious side effects such as respiratory distress (a condition in which fluid builds up in the lungs).

How to manage the interaction:
Although there is a possible interaction between Oxycodone and Liofen 500mcg Injection, you can take these medicines together if prescribed by a doctor. Do not stop using any medications without first talking to your doctor.
BaclofenCodeine
Severe
How does the drug interact with Liofen 500mcg Injection:
Co-administration of Liofen 500mcg Injection with Codeine can increase the risk of side effects.

How to manage the interaction:
Although there is an interaction, Liofen 500mcg Injection can be used with Codeine if prescribed by the doctor. These medications may cause dizziness, drowsiness, shortness of breath, or palpitations, consult a doctor immediately. Do not stop any medication without a doctor's advice.
How does the drug interact with Liofen 500mcg Injection:
Co-administration of Liofen 500mcg Injection with Morphine may increase the risk or severity of side effects such as respiratory distress (a condition in which fluid builds up in the lungs).

How to manage the interaction:
Taking Liofen 500mcg Injection with Morphine together can result in an interaction, it can be taken if a doctor has advised it. However, contact a doctor immediately if you notice any sudden dizziness, lightheadedness, severe headache, shortness of breath, chest pain or tightness, or weakness. Do not stop using any medications without consulting a doctor.
How does the drug interact with Liofen 500mcg Injection:
Co-administration of Tapentadol together with Liofen 500mcg Injection can increase the risk or severity of side effects like decreased breathing rate, irregular heart rhythms, or problems with movement and memory.

How to manage the interaction:
Taking Liofen 500mcg Injection with Tapentadol can result in an interaction, it can be taken if a doctor has advised it. Contact a doctor immediately if you experience signs such as drowsiness, lightheadedness, palpitations, confusion, severe weakness, or difficulty breathing. Do not discontinue any medications without consulting a doctor.
BaclofenPotassium hydrogencarbonate
Severe
How does the drug interact with Liofen 500mcg Injection:
Co-administration of Liofen 500mcg Injection may decrease the excretion rate of Potassium hydrogencarbonate which could result in a higher serum level.

How to manage the interaction:
Although there is an interaction, Liofen 500mcg Injection can be used with Potassium hydrogencarbonate if prescribed by the doctor. Regular monitoring of serum potassium levels is advised.
BaclofenDezocine
Severe
How does the drug interact with Liofen 500mcg Injection:
Co-administration of Liofen 500mcg Injection with Dezocine can increase the risk of side effects.

How to manage the interaction:
Although there is an interaction, Liofen 500mcg Injection can be used with Dezocine if prescribed by the doctor. These may cause dizziness, drowsiness, palpitations, or chest discomfort. Do not stop taking the medications without a doctor's advice.
How does the drug interact with Liofen 500mcg Injection:
Co-administration of Liofen 500mcg Injection can enhance the effects of Nalbuphine, which depresses the central nervous system and can lead to serious side effects such as respiratory distress (a condition in which fluid builds up in the lungs).

How to manage the interaction:
Although there is a possible interaction between Liofen 500mcg Injection and Nalbuphine, you can take these medicines together if prescribed by a doctor. If you notice any symptoms like feeling tired, dizzy, or having trouble focusing, make sure to contact a doctor right away. Do not stop using any medications without talking to a doctor.
BaclofenAlfentanil
Severe
How does the drug interact with Liofen 500mcg Injection:
Co-administration of Liofen 500mcg Injection with Alfentanil can increase the risk of developing side effects.

How to manage the interaction:
Although there is a possible interaction between Liofen 500mcg Injection and Alfentanil, you can take these medicines together if prescribed by a doctor. If you notice any symptoms like dizziness, trouble breathing, drowsiness, or palpitations, let the doctor know. Do not stop using any medications without a doctor's advice.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

  • Exercising regularly helps in muscle stretching so that they are less likely to spasm, tear, and sprain. Mild exercises such as jogging and walking are helpful for muscle stretching. Massages can also be helpful.
  • Avoid extremely cold and hot temperatures.
  • Avoid wearing tight-fitting clothes. Instead, wear loose garments.
  • Rest well, and get plenty of sleep.
  • To avoid developing pressure sores, change your position at least every two hours.
  • Stay hydrated, drink plenty of water.

Habit Forming

No

Therapeutic Class

SKELETAL MUSCLE RELAXANTS

Author Details

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Drug-Diseases Interactions

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BACLOFEN-500MCGOther disorders of kidney and ureter, not elsewhere classified
Severe
BACLOFEN-500MCGDisorders of autonomic nervous system
Moderate

Drug-Diseases Interactions

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BACLOFEN-500MCGOther disorders of kidney and ureter, not elsewhere classified
Severe
How does the disease interact with Liofen 500mcg Injection:
The kidney is the main organ used to remove Liofen 500mcg Injection. Liofen 500mcg Injection side effects may be more likely to occur in patients with poor renal function due to decreased medication clearance. In these patients, Liofen 500mcg Injection therapy should be used with caution. It could be required to modify the dosage.

How to manage the interaction:
Therapy with Liofen 500mcg Injection should be administered cautiously in such patients. Dosage adjustments may be necessary.
BACLOFEN-500MCGDisorders of autonomic nervous system
Moderate
How does the disease interact with Liofen 500mcg Injection:
Patients with a history of autonomic dysreflexia should be treated with intrathecal Liofen 500mcg Injection with caution because the drug's rapid withdrawal or the presence of nociceptive stimuli can cause an episode of dysreflexia.

How to manage the interaction:
Liofen 500mcg Injection should be administered cautiously in patients with autonomic dysreflexia.
BACLOFEN-500MCGMental disorder, not otherwise specified
Moderate
How does the disease interact with Liofen 500mcg Injection:
Both during therapy and after an abrupt withdrawal from the drug, Liofen 500mcg Injection may cause or aggravate psychotic symptoms. Patients having a history of psychiatric illnesses should be treated with Liofen 500mcg Injection with caution.

How to manage the interaction:
Liofen 500mcg Injection may precipitate or exacerbate psychotic symptoms, both during therapy and following abrupt withdrawal of the drug. Therapy with Liofen 500mcg Injection should be administered cautiously in patients with a history of psychiatric disorders.
BACLOFEN-500MCGConvulsions, not elsewhere classified
Moderate
How does the disease interact with Liofen 500mcg Injection:
Liofen 500mcg Injection treatment for epilepsy has occasionally been associated with electroencephalographic (EEG) abnormalities and a decline in seizure control. Patients having a history of seizures should receive Liofen 500mcg Injection therapy with caution. Throughout treatment, clinical conditions and EEG should be monitored often.

How to manage the interaction:
Liofen 500mcg Injection may occasionally cause decrease in seizure control. Therapy with Liofen 500mcg Injection should be administered cautiously in patients with a history of seizures.

FAQs

Liofen 500mcg Injection works on the centres of the spinal cord and brain, thereby helps in maintaining muscle strength and relieves muscle spasms or stiffness.

Dry mouth could be a side-effect of Liofen 500mcg Injection. Limiting caffeine intake, avoiding smoking and mouthwashes containing alcohol, drinking water regularly, and chewing sugar-free gum/candy might help in stimulating saliva and thereby prevents drying of the mouth.

Liofen 500mcg Injection should not be stopped abruptly. Abrupt discontinuation of Liofen 500mcg Injection may cause altered mental status, high fever, muscle rigidity, and exaggerated rebound spasticity. In rare cases, it might even lead to multiple organ-system failures, rhabdomyolysis (breakdown of muscle tissue that releases a damaging protein into the blood) and death.

Liofen 500mcg Injection may cause suicidal thoughts, hallucinations, euphoric mood (extreme happiness), and paranoid thoughts. Consult your doctor immediately if you experience any of these symptoms.

Drug-Drug Interactions Checker List

  • IBUPROFEN
  • LITHIUM

Special Advise

  • Your doctor may advise you to undergo regular blood tests to monitor liver function.
  • Inform your doctor that you are taking Liofen 500mcg Injection if you are due to undergo any surgery which requires a general anesthetic.
  • Please talk to your doctor immediately if you experience mood swings, depression, or if you have any suicidal thoughts.

Disease/Condition Glossary

Muscle spasm: It is the sudden involuntary contractions of the muscle, which can be painful and uncomfortable. When the nerve impulses that control the muscle movements are damaged or interrupted, it could lead to muscle spasms. Symptoms include muscle tightness, joint stiffness, unusual posture, difficulty in moving, pain in affected muscles, and joints. Fatigue (weakness), stress, extreme heat or cold, infection, and tight clothing can trigger muscle spasms. Muscle relaxants and exercise can treat muscle spasms. Muscle relaxants sedate the muscle and help in inhibiting painful contractions. Exercise helps in muscle stretching so that they are less likely to spasm, tear, and sprain.

Spasticity: Spasticity is the abnormal muscle tightness occurring due to prolonged muscle contraction associated with damage to the spinal cord, brain, and motor nerves, or due to neurological conditions such as cerebral palsy. Spasticity causes the muscles to become stiff and tight, this prevents normal fluid movement. Symptoms include abnormal posture, deep tendon reflexes, repetitive jerky movements, and pain.

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