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Written By Santoshini Reddy G , M Pharmacy
Reviewed By Sunny S , MBBS
Non returnable*
COD available

Online payment accepted

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Whats That

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Composition

BACLOFEN-20MG

Manufacturer/Marketer

Esteem Pharmaceuticals Pvt Ltd

Consume Type

ORAL

Return Policy

Not Returnable

Expires on or after

Jan-27

for this medicine

About Liosyn 20 mg Tablet

Liosyn 20 mg Tablet belongs to the group of medicines called 'muscle relaxants' used to reduce and relieve the muscle spasms (excessive tension in the muscles) occurring in various illnesses. Muscle spasm is the sudden involuntary contractions of the muscle, which can be painful and uncomfortable. When the nerve impulses that control the muscle movements are damaged or interrupted, it could lead to muscle spasms.

Liosyn 20 mg Tablet works by inhibiting the reflexes at the spinal level and helps in relieving pain and improves muscle movements. Liosyn 20 mg Tablet works on the spinal cord and brain, thereby helps in maintaining muscle strength and relieves muscle spasms or stiffness. Thus Liosyn 20 mg Tablet reduces muscle spasm in the conditions of multiple sclerosis (a disorder which affects the brain and spinal cord), cerebrovascular accidents (damage to the brain due to lack of blood supply), cerebral palsy (a disorder of movement, posture and muscle tone), spinal cord diseases and other nervous system disorders.

Take Liosyn 20 mg Tablet with food. You are advised to take Liosyn 20 mg Tablet for as long as your doctor has prescribed it for you, depending on your medical condition. In some cases, you may experience certain common side-effects such as sleepiness, drowsiness, nausea, headache, weakness, and dry mouth. Most of these side-effects do not require medical attention and will resolve gradually over time. However, you are suggested to talk to your doctor if you experience these side-effects persistently.

Do not discontinue Liosyn 20 mg Tablet suddenly as it could lead to unpleasant side-effects such as rigidity, increased heart rate, changes in mood, fever, mental disorders, confusion, hallucinations, and fits (seizures). Consult your doctor before taking Liosyn 20 mg Tablet if you are pregnant or breastfeeding. Liosyn 20 mg Tablet is not recommended for children below 4 years of age and those who weigh below 33kgs. Inform your doctor about all the current medicines you are taking and about your health condition to rule out any unpleasant side-effects. Please speak to your doctor immediately if you experience mood swings, depression, or if you have any suicidal thoughts.

Uses of Liosyn 20 mg Tablet

Muscle spasm

Directions for Use

Tablet/Capsule: Swallow it as a whole with a glass of water or milk; do not crush, chew, or break the tablet/capsule. Liquid: Shake the bottle well and take the prescribed dose/quantity by mouth using the measuring cup/dosing syringe.

Medicinal Benefits

Liosyn 20 mg Tablet belongs to the group of medicines called muscle relaxants used to reduce and relieve the muscle spasms (excessive tension in the muscles) occurring in various illnesses such as multiple sclerosis (a disorder which affects the brain and spinal cord), cerebrovascular accidents (damage to the brain due to lack of blood supply), cerebral palsy (a disorder of movement, posture and muscle tone), spinal cord diseases and other nervous system disorders. Liosyn 20 mg Tablet works by inhibiting the reflexes at the spinal level and helps in relieving pain and improves muscle movements. Liosyn 20 mg Tablet is particularly effective for relieving involuntary muscle spasms in the ankle, hip, and knee. Liosyn 20 mg Tablet also helps in restoring muscle function; however, Liosyn 20 mg Tablet is not effective for muscle spasms caused by stroke, Parkinson’s disease, or rheumatoid arthritis. Liosyn 20 mg Tablet works on the centres of the spinal cord and brain, thereby helps in maintaining muscle strength and relieving muscle spasms or stiffness. Liosyn 20 mg Tablet is used off-label to treat hiccups or Tourette’s syndrome (a nervous problem which causes people to make uncontrollable sudden movements or sounds).

Storage

Store in a cool and dry place away from sunlight

Side Effects of Liosyn 20 mg Tablet

  • Sleepiness
  • Drowsiness
  • Nausea
  • Headache
  • Weakness
  • Dry mouth

Drug Warnings

Do not take Liosyn 20 mg Tablet if you are allergic to any of its contents or if you ever had a stomach ulcer. Talk to your doctor before taking Liosyn 20 mg Tablet if you have kidney or liver problems, mental disorders, breathing difficulty or lung disease, diabetes, difficulty in urination, high blood pressure, Parkinson’s disease, or if you ever had a stroke. Consult your doctor before taking Liosyn 20 mg Tablet if you are pregnant or breastfeeding. Liosyn 20 mg Tablet is not recommended for children below four years of age and those who weigh below 33 kg.

Drug-Drug Interactions

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BaclofenBuprenorphine
Severe
BaclofenHydrocodone
Severe

Drug-Drug Interactions

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BaclofenBuprenorphine
Severe
How does the drug interact with Liosyn 20 mg Tablet:
Co-administration of Buprenorphine with Liosyn 20 mg Tablet can increase the risk of side effects.

How to manage the interaction:
Co-administration of Buprenorphine alongside Liosyn 20 mg Tablet can result in an interaction. However, it can be taken if a doctor has advised it. If you experience shortness of breath, chest discomfort, dizziness, or palpitations consult a doctor immediately. Do not discontinue any medications without consulting a doctor.
BaclofenHydrocodone
Severe
How does the drug interact with Liosyn 20 mg Tablet:
Co-administration of Liosyn 20 mg Tablet with Hydrocodone may increase sedation and respiratory distress (fluid collects in the air sacs of the lungs)

How to manage the interaction:
Although there is an interaction, Liosyn 20 mg Tablet can be used with Hydrocodone if prescribed by the doctor. Co-administration of these medications may cause dizziness, drowsiness, difficulty in concentrating, and impaired judgment. Do not stop any medication without doctor's consultation.
BaclofenRemifentanil
Severe
How does the drug interact with Liosyn 20 mg Tablet:
Co-administration of Liosyn 20 mg Tablet can enhance the sedative effects of Remifentanil on the central nervous system which can lead to serious side effects such as respiratory distress (a condition in which fluid builds up in the lungs).

How to manage the interaction:
Co-administration of Liosyn 20 mg Tablet with Remifentanil can possibly result in an interaction, but it can be taken if a doctor has advised it. They can recommend other options that won't cause any problems. If you notice any symptoms like feeling tired, dizzy, or having trouble focusing, make sure to contact a doctor right away. Do not stop using any medications without talking to a doctor.
BaclofenMorphine
Severe
How does the drug interact with Liosyn 20 mg Tablet:
Co-administration of Liosyn 20 mg Tablet with Morphine may increase the risk or severity of side effects such as respiratory distress (a condition in which fluid builds up in the lungs).

How to manage the interaction:
Taking Liosyn 20 mg Tablet with Morphine together can result in an interaction, it can be taken if a doctor has advised it. However, contact a doctor immediately if you notice any sudden dizziness, lightheadedness, severe headache, shortness of breath, chest pain or tightness, or weakness. Do not stop using any medications without consulting a doctor.
BaclofenButorphanol
Severe
How does the drug interact with Liosyn 20 mg Tablet:
Co-administration of Liosyn 20 mg Tablet with Butorphanol can increase the risk of developing side effects.

How to manage the interaction:
Although there is a possible interaction between Liosyn 20 mg Tablet and Butorphanol, you can take these medicines together if prescribed by your doctor. If you notice any symptoms like dizziness, shortness of breath, palpitations, or chest discomfort, consult a doctor immediately. Do not stop using any medications without a doctor's advice.
BaclofenMethadone
Severe
How does the drug interact with Liosyn 20 mg Tablet:
Co-administration of Liosyn 20 mg Tablet with Methadone may cause serious side effects such as central nervous system depression can lead to serious side effects including respiratory distress (a condition in which fluid builds up in the lungs).

How to manage the interaction:
Although there is an interaction, Liosyn 20 mg Tablet can be used with Methadone if prescribed by the doctor. Inform the prescriber if you are taking these two medicines, the doctor may prescribe alternate medicines a dose adjustment, or more frequent monitoring to safely use both medications. Do not discontinue any medications without consulting a doctor.
BaclofenSodium oxybate
Severe
How does the drug interact with Liosyn 20 mg Tablet:
Co-administration of Sodium oxybate with Liosyn 20 mg Tablet may increase side effects.

How to manage the interaction:
Although there is an interaction, Liosyn 20 mg Tablet can be used with Sodium oxybate if prescribed by the doctor. Consult the prescriber if you experience drowsiness, dizziness, lightheadedness, confusion, depression, low blood pressure, slow or shallow breathing, and impairment in thinking, judgment, and motor coordination.
BaclofenHydromorphone
Severe
How does the drug interact with Liosyn 20 mg Tablet:
Co-administration of Liosyn 20 mg Tablet with Hydromorphone may increase the central nervous system and can lead to serious side effects including respiratory distress (a condition in which fluid builds up in the lungs).

How to manage the interaction:
Although there is an interaction, Liosyn 20 mg Tablet can be used with Hydromorphone if prescribed by the doctor. Inform the prescriber if you are taking these two medicines, the doctor may prescribe alternate medicines or a dose adjustment, or more frequent monitoring to safely use both medications. Do not discontinue any medications without consulting a doctor.
BaclofenNalbuphine
Severe
How does the drug interact with Liosyn 20 mg Tablet:
Co-administration of Liosyn 20 mg Tablet can enhance the effects of Nalbuphine, which depresses the central nervous system and can lead to serious side effects such as respiratory distress (a condition in which fluid builds up in the lungs).

How to manage the interaction:
Although there is a possible interaction between Liosyn 20 mg Tablet and Nalbuphine, you can take these medicines together if prescribed by a doctor. If you notice any symptoms like feeling tired, dizzy, or having trouble focusing, make sure to contact a doctor right away. Do not stop using any medications without talking to a doctor.
BaclofenPentazocine
Severe
How does the drug interact with Liosyn 20 mg Tablet:
Co-administration of Liosyn 20 mg Tablet can enhance the sedative effects of Pentazocine on the central nervous system which can lead to side effects such as respiratory distress (a condition in which fluid builds up in the lungs).

How to manage the interaction:
Although there is a possible interaction between Pentazocine and Liosyn 20 mg Tablet, you can take these medicines together if prescribed by a doctor. Do not stop using any medications without talking to a doctor.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

  • Exercising regularly helps in muscle stretching so that they are less likely to spasm, tear, and sprain. Mild exercises such as jogging and walking are helpful for muscle stretching.
  • Massages can also be helpful.
  • Avoid extremely cold and hot temperatures.
  • Avoid wearing tight-fitting clothes, instead, wear loose garments.
  • Rest well, get plenty of sleep.
  • To avoid developing pressure sores, change your position at least every two hours.
  • Hot or cold therapy can be helpful in treating muscle spasms. Apply an ice-pack or hot-pack on the muscle for 15-20minutes.
  • Stay hydrated, drink plenty of water.

Habit Forming

No

Therapeutic Class

SKELETAL MUSCLE RELAXANTS

Liosyn 20 mg Tablet Substitute

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Author Details

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Drug-Diseases Interactions

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BACLOFEN-20MGOther disorders of kidney and ureter, not elsewhere classified
Severe
BACLOFEN-20MGDisorders of autonomic nervous system
Moderate

Drug-Diseases Interactions

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BACLOFEN-20MGOther disorders of kidney and ureter, not elsewhere classified
Severe
How does the disease interact with Liosyn 20 mg Tablet:
The kidney is the main organ used to remove Liosyn 20 mg Tablet. Liosyn 20 mg Tablet side effects may be more likely to occur in patients with poor renal function due to decreased medication clearance. In these patients, Liosyn 20 mg Tablet therapy should be used with caution. It could be required to modify the dosage.

How to manage the interaction:
Therapy with Liosyn 20 mg Tablet should be administered cautiously in such patients. Dosage adjustments may be necessary.
BACLOFEN-20MGDisorders of autonomic nervous system
Moderate
How does the disease interact with Liosyn 20 mg Tablet:
Patients with a history of autonomic dysreflexia should be treated with intrathecal Liosyn 20 mg Tablet with caution because the drug's rapid withdrawal or the presence of nociceptive stimuli can cause an episode of dysreflexia.

How to manage the interaction:
Liosyn 20 mg Tablet should be administered cautiously in patients with autonomic dysreflexia.
BACLOFEN-20MGMental disorder, not otherwise specified
Moderate
How does the disease interact with Liosyn 20 mg Tablet:
Both during therapy and after an abrupt withdrawal from the drug, Liosyn 20 mg Tablet may cause or aggravate psychotic symptoms. Patients having a history of psychiatric illnesses should be treated with Liosyn 20 mg Tablet with caution.

How to manage the interaction:
Liosyn 20 mg Tablet may precipitate or exacerbate psychotic symptoms, both during therapy and following abrupt withdrawal of the drug. Therapy with Liosyn 20 mg Tablet should be administered cautiously in patients with a history of psychiatric disorders.
BACLOFEN-20MGConvulsions, not elsewhere classified
Moderate
How does the disease interact with Liosyn 20 mg Tablet:
Liosyn 20 mg Tablet treatment for epilepsy has occasionally been associated with electroencephalographic (EEG) abnormalities and a decline in seizure control. Patients having a history of seizures should receive Liosyn 20 mg Tablet therapy with caution. Throughout treatment, clinical conditions and EEG should be monitored often.

How to manage the interaction:
Liosyn 20 mg Tablet may occasionally cause decrease in seizure control. Therapy with Liosyn 20 mg Tablet should be administered cautiously in patients with a history of seizures.

FAQs

Liosyn 20 mg Tablet works on the centres of the spinal cord and brain, thereby helps in maintaining muscle strength and relieves muscle spasms or stiffness.

Liosyn 20 mg Tablet causes sleepiness and drowsiness. So, drive only if you are alert and omit driving or operating machinery if you feel sleepy or drowsy.

Dry mouth could be a side-effect of Liosyn 20 mg Tablet . Limiting caffeine intake, avoiding smoking and mouthwashes containing alcohol, drinking water regularly, and chewing sugar-free gum/candy might help in stimulating saliva and thereby prevents drying of the mouth.

Do not discontinue Liosyn 20 mg Tablet without consulting your doctor. Discontinuing Liosyn 20 mg Tablet suddenly might cause muscle rigidity, increased heart rate, changes in mood, fever, mental disorders, confusion, hallucinations, and fits (seizures). Talk to your doctor if you feel any difficulty while taking Liosyn 20 mg Tablet ; your doctor will reduce the dose gradually.

Do not use Liosyn 20 mg Tablet at a time when muscle tone is required for safe balance and movement during certain activities. In some conditions, it may be dangerous for you to have low or reduced muscle tone. Please do not drink alcohol with Liosyn 20 mg Tablet as it can cause side effects. Avoid driving or performing hazardous tasks until you know how Liosyn 20 mg Tablet will affect you and your reactions could be impaired.

Drug-Drug Interactions Checker List

  • HYDROCODONE
  • ACETAMINOPHEN
  • IBUPROFEN
  • MORPHINE
  • FENTANYL
  • TRAMADOL
  • NALOXONE
  • TIZANIDINE
  • LITHIUM
  • AMITRIPTYLINE
  • DILTIAZEM
  • LEVODOPA
  • PROMETHAZINE
  • CARBAMAZEPINE

Special Advise

  • Your doctor may advise you to undergo regular blood tests to monitor liver function.
  • Inform your doctor that you are taking Liosyn 20 mg Tablet if you are due to undergo any surgery which requires a general anaesthetic.
  • Please talk to your doctor immediately if you experience mood swings, depression, or if you have any suicidal thoughts.

Disease/Condition Glossary

Muscle spasm: It is the sudden involuntary contractions of the muscle, which can be painful and uncomfortable. When the nerve impulses that control the muscle movements are damaged or interrupted, it could lead to muscle spasms. Symptoms include muscle tightness, joint stiffness, unusual posture, difficulty in moving, pain in affected muscles, and joints. Fatigue (weakness), stress, extreme heat or cold, infection, and tight clothing can trigger muscle spasms. Muscle relaxants and exercise can treat muscle spasms. Muscle relaxants sedate the muscle and help in inhibiting painful contractions. Exercise helps in muscle stretching so that they are less likely to spasm, tear, and sprain.

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