Loco Mr Tablet belongs to the class of drugs known as 'non-steroidal anti-inflammatory drug' (NSAID). Loco Mr Tablet is used in the reduction of musculoskeletal pain due to tissue injury, resolution of post surgery inflammation and oedema (swollen tissue with fluid). Pain can be temporary (acute) or long term(chronic) in nature. Musculoskeletal pain can be caused due to soft tissues (muscle, tendon, and ligaments) injury. Extreme tissue pain and inflammation caused due to sprains, strains or trauma or post-surgery may require a prolonged amount of time to heal.

Loco Mr Tablet is a fixed-dose combination composed of three medicines namely: Diclofenac, Paracetamol and Chlorzoxazone. Diclofenac works by blocking the action of a chemical messenger known as cyclo-oxygenase (COX) which causes pain and swelling at the injured or damaged tissue site. Paracetamol acts as a mild analgesic (mild pain reducer) and antipyretic (fever reducer) which enhances the pain relief action of Diclofenac. Third medicine i.e. Chlorzoxazone is a muscle relaxant, helps by blocking nerve impulses or pain sensations sent by the brain and causes relaxation of muscles.

Loco Mr Tablet can be taken with or after the meal. To avoid stomach upset Loco Mr Tablet can be taken with food or milk. It should be swallowed whole with a glass of water. Do not take Loco Mr Tablet if your pain lasts for more than ten days or fever lasting for more than three days. Do not take a double dose if you missed one dose. Like all medicines, Loco Mr Tablet may cause side effects, although not everybody gets them. Most of the side effects of Loco Mr Tablet are drowsiness, constipation, diarrhoea, stomach upset, slight discolouration of urine, and ringing or buzzing sounds in the ears. In case of any discomfort, speak with your doctor. 

Do not take Loco Mr Tablet if you are allergic to painkillers like aspirin, paracetamol, naproxen or diclofenac. It is not recommended for use in children, people with liver disease, heart disease or gastric ulcers/bleeding problems. Loco Mr Tablet may be associated with a small increase in the risk of heart attack (myocardial infarction). Avoid consumption of alcohol as it may damage your liver and cause even more side effects on taking this drug. Consult your doctor if your symptoms of pain, inflammation and fever do not disappear even after ten days.

Loco Mr Tablet is composed of three medicines namely: Diclofenac, Paracetamol and Chlorzoxazone. Diclofenac works by blocking the action of a chemical messenger known as cyclo-oxygenase (COX) which causes pain and swelling at the injured or damaged tissue site. Paracetamol acts as a mild analgesic (mild pain reducer) and antipyretic (fever reducer) which enhances the pain relief action of Diclofenac. Third medicine i.e. Chlorzoxazone is a muscle relaxant, helps by blocking nerve impulses or pain sensations sent by the brain and causes relaxation of muscles.

• Drowsiness
• Constipation
• Diarrhoea
• Stomach upset
• Slight discolouration of urine
• Ringing or buzzing sounds in the ears

Intake of Loco Mr Tablet should be avoided in liver disease (like jaundice) and cardiovascular disease (like coronary heart disease). Contact your doctor if you have signs of liver disease like feeling exhausted, dark urine, not feeling hungry, stomach pain or upset, light coloured stools or yellow skin/eyes. After taking if you have possible allergic symptoms like difficulty in breathing, difficulty in swallowing, lips/face/throat swelling, chest tightness, or skin rash, contact the doctor immediately. Ensure your doctor is aware if you are pregnant or planning to get pregnant, breastfeeding, allergic to Loco Mr Tablet or any other painkillers like aspirin, the problem of stomach ulcer or gastric bleeding, or taking any other OTC multivitamins, multi-minerals supplements.

Drug-Drug Interaction: Loco Mr Tablet is shown to interact with various drugs. Some of them include pain killers (naproxen, aspirin, ibuprofen, tramadol, hydrocodone, oxycodone), blood pressure-related drugs (lisinopril, hydrochlorothiazide), blood thinner (rivaroxaban, warfarin), anti-depressant (duloxetine), acidity lowering drug (cimetidine), and steroids (prednisone). These drugs may affect the working of Loco Mr Tablet and may alter its efficacy.

Drug-Food Interaction: Excessive intake of caffeine-containing food or drinks like coffee, tea, chocolate and some fizzy drinks should be avoided while taking Loco Mr Tablet. Taking together may lead to drowsiness and dizziness and sleepiness.

Drug-Disease Interaction: Loco Mr Tablet should not recommend for people having bleeding disorders, like haemophilia, von Willebrand disease or low blood platelets. Besides this, it should not be given in the condition of liver disease like jaundice, alcoholism and PKU phenylketonuria (birth defect with an excess of protein in the body).

• NAPROXEN
• ASPIRIN
• IBUPROFEN
• TRAMADOL
• HYDROCODONE
• OXYCODONE
• LISINOPRIL
• HYDROCHLOROTHIAZIDE
• RIVAROXABAN
• WARFARIN
• DULOXETINE
• CIMETIDINE
• PREDNISONE

• Loco Mr Tablet is commonly prescribed for relieving pain in both acute and chronic conditions and in cases of fever. Do not take the drug beyond its suggested dose and frequency.
• Avoid driving while consuming Loco Mr Tablet as it can cause dizziness in some individuals and hamper your focus and reflexes.
• Avoid concomitant consumption of drugs containing the same chemicals as Loco Mr Tablet as it can lead to overdosage and unwanted side effects.
• Immediately consult your doctor in case of persistent side effects like stomach pain on consumption of Loco Mr Tablet.
• Avoid consuming alcohol while you are on Loco Mr Tablet.

• Loco Mr Tablet is prescribed for relief from muscle pain and spasms.
• It can cause drowsiness and hence activities involving focus and attention like driving must be avoided while on this medication.
• Concomitant usage of alcohol with this medicine increase the risk of damage to liver and other side effects and hence alcohol consumption should be avoided while consuming this medication
• Avoid simultaneous consumption of other painkillers or cough and cold medicines with this Loco Mr Tablet as it may lead to overdose.

Musculoskeletal pain is generally caused by disorders of bones, joints, muscles, tendons, ligaments, or a combination. Injuries (mostly sports related injury) are the most common cause of musculoskeletal pain. Muscle pain (myalgia) can be caused due to injury, infection, loss of blood flow to the muscle, infection, or a tumour. Extreme tissue pain and inflammation caused due to sprains, strains, or trauma or post-surgery may require a prolonged amount of time to heal