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Written By Bayyarapu Mahesh Kumar , M Pharmacy
Reviewed By Santoshini Reddy G , M Pharmacy
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Composition :

DIAZEPAM-5MG

Consume Type :

PARENTERAL

Return Policy :

Not Returnable

Expires on or after :

About Lori Injection 2 ml

Lori Injection 2 ml belongs to a group of medications called benzodiazepine used to treat anxiety, muscle spasms, and epilepsy/seizures/fits. It can also be used as a sedative during surgery or dental procedure. Besides this, it is also used to manage alcohol withdrawal symptoms like agitation, tremor, or hallucinations. An anxiety disorder is a mental condition characterized by feelings of excessive fear or worry that affect an individual's daily activities.

Lori Injection 2 ml contains diazepam, which works by increasing levels of the calming chemical mediator known as gamma-aminobutyric acid (GABA) in the brain; this helps relieve anxiety, stops seizure attacks (fits) and relaxes the tense muscles.

Lori Injection 2 ml will be administered by a healthcare professional; do not self-administer. Sometimes, Lori Injection 2 ml may cause side effects, such as drowsiness, fatigue, confusion, unsteadiness, or dizziness. Most of these side effects of Lori Injection 2 ml do not require medical attention and gradually resolve over time. However, if the side effects are persistent, reach out to your doctor.

Inform your doctor if you have lung disease, muscle weakness (myasthenia gravis), sleeping disorder, severe liver disease, or problems with alcohol consumption or other prescription recreational drugs. Inform your doctor if you are pregnant or breastfeeding. Do not drive or operate machinery as Lori Injection 2 ml may reduce mental alertness. It is advisable to avoid alcohol after taking this medicine to prevent adverse effects such as dizziness, drowsiness, and difficulty concentrating.

Uses of Lori Injection 2 ml

Anxiety, muscle spasms, epilepsy/seizures/fits, sedation, alcohol withdrawal syndrome.

Directions for Use

Lori Injection 2 ml will be administered by a qualified healthcare professional. Kindly do not self-administer.

Medicinal Benefits

Lori Injection 2 ml belongs to a group of medications called benzodiazepine used to treat anxiety, muscle spasms, and epilepsy/seizures/fits. It can also be used as a sedative during surgery or dental procedure. Besides this, it is also used to manage alcohol withdrawal symptoms like agitation, tremor, or hallucinations. Lori Injection 2 ml contains diazepam, which works by increasing levels of the calming chemical mediator known as gamma-aminobutyric acid (GABA) in the brain; this helps relieve anxiety, stops seizure attacks (fits) and relaxes the tense muscles.

Storage

Keep out of sight and reach of children.
Side effects of Lori Injection 2 ml
  • Get enough sleep. Maintain a regular sleep cycle.
  • Eat a healthy diet and exercise regularly.
  • Manage stress with yoga or meditation.
  • Limit alcohol and caffeine.
  • Avoid driving or operating machinery unless you are alert.
  • Confusion is a major psychotic disorder that needs immediate medical attention.
  • Acknowledge your experience and put effort to control confusion.
  • Avoid smoking and alcohol intake as it can worsen the condition and increase your confusion.
  • Practice meditation and yoga to avoid anxiety, which can be one of the leading causes.
  • Talk to your dietician and consume food that can improve your mental health.
  • Uncoordinated muscle movements need immediate medical attention.
  • Observe your movements and try to understand and control the particular movement.
  • Regularly do strengthening exercises to improve blood flow throughout the body and avoid involuntary movements.
  • Implement massage techniques to enhance blood flow to organs.
  • Take a balanced diet and quit smoking.
  • Practice yoga and meditation to improve thought processes and reduce uncontrolled and involuntary movements.
Here are the steps to manage medication-triggered tremors or involuntary shaking:
  • Notify your doctor immediately if you experience tremors or involuntary shaking after taking medication or adjusting your medication regimen.
  • Your doctor may adjust your medication regimen or recommend alternative techniques like relaxation, meditation, or journaling to alleviate tremor symptoms.
  • Your doctor may direct you to practice stress-reducing techniques, such as deep breathing exercises, yoga, or journaling.
  • Regular physical activity, such as walking or jogging, can help reduce anxiety and alleviate tremor symptoms.
  • Your doctor may recommend lifestyle changes, such as avoiding caffeine, getting enough sleep, and staying hydrated, to help manage tremors.
  • Maintain regular follow-up appointments with your doctor to monitor tremor symptoms and adjust treatment plans as needed.
  • Rest well; get enough sleep.
  • Eat a balanced diet and drink enough water.
  • Manage stress with yoga and meditation.
  • Limit alcohol and caffeine.
  • Physical activities like walking or jogging might help boost energy and make you feel less tired.

Drug Warnings

Lori Injection 2 ml is not recommended for people with hypersensitivity to diazepam, other related benzodiazepines or any components present in Lori Injection 2 ml, people with a phobia (a fear of a particular object or situation), difficulty breathing, porphyria (a disorder of the blood brought on by a buildup of specific substances connected to the proteins in red blood cells), liver impairment, muscle weakness (myasthenia gravis), open-angle glaucoma or acute narrow-angle glaucoma unless patients are receiving appropriate therapy. Inform your doctor if you have suicidal thoughts, difficulty concentrating, sleep disorders, depression, breathing problems, history of alcohol/drug abuse, arteriosclerosis (narrowing of the blood vessels), lung, kidney, liver or heart problems. Concomitant use of opioids and benzodiazepines may result in profound sedation, respiratory depression, coma, and death.

Drug-Drug Interactions

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Drug-Drug Interactions

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How does the drug interact with Lori Injection 2 ml:
Co-administration of Tapentadol together with Lori Injection 2 ml can increase the risk or severity of side effects like decreased breathing rate, irregular heart rhythms, or problems with movement and memory.

How to manage the interaction:
Taking Lori Injection 2 ml with Tapentadol can result in an interaction, it can be taken if your doctor has advised it. Contact a doctor immediately if you experience signs such as drowsiness, lightheadedness, palpitations, confusion, severe weakness, or difficulty breathing. Do not discontinue any medications without consulting a doctor.
How does the drug interact with Lori Injection 2 ml:
Co-administration of Lori Injection 2 ml with clozapine may increase the effects of both medicines.

How to manage the interaction:
Although there is a possible interaction, Lori Injection 2 ml can be taken with clozapine if prescribed by the doctor. Consult the prescriber if you experience side effects like low blood pressure, confusion, drowsiness, shallow breathing, incoordination, and weak pulse. Your doctor may advise dose adjustment or frequent monitoring to safely use both medicines. Do not discontinue the medications without consulting a doctor.
DiazepamCodeine
Severe
How does the drug interact with Lori Injection 2 ml:
Co-administration of Lori Injection 2 ml with codeine may cause serious side effects.

How to manage the interaction:
Consult your doctor if you are using Lori Injection 2 ml and codeine. The doctor may prescribe alternatives that do not interact, dose adjustment, or more frequent monitoring to safely use both medications. Do not discontinue the medication without consulting a doctor.
How does the drug interact with Lori Injection 2 ml:
Co-administration of Lori Injection 2 ml with tramadol may cause serious side effects like respiratory distress or coma.

How to manage the interaction:
Consult the doctor if you are taking Lori Injection 2 ml and tramadol. The doctor may prescribe alternatives that do not interact, dose adjustment, or more frequent monitoring to safely use both medications. Do not discontinue the medication without consulting a doctor.
DiazepamRemifentanil
Severe
How does the drug interact with Lori Injection 2 ml:
Co-administration of Remifentanil with Lori Injection 2 ml can increase the seriousness of side effects.

How to manage the interaction:
Although taking Lori Injection 2 ml and Remifentanil together can evidently cause an interaction, it can be taken if your doctor has suggested it. It's important to keep an eye on your health and talk to your doctor about any concerns. They can recommend different options that won't cause any problems. If you notice any symptoms like feeling dizzy, having trouble breathing, or feeling very tired, make sure to call your doctor right away. Do not stop using any medications without a doctor's advice.
DiazepamHydromorphone
Severe
How does the drug interact with Lori Injection 2 ml:
Taking of Lori Injection 2 ml with hydromorphone may cause serious side effects like respiratory depression.

How to manage the interaction:
Although there is a possible interaction, Lori Injection 2 ml should be taken with hydromorphone only if prescribed by the doctor. Consult the doctor if you have any concerns, doctor may prescribe alternatives that do not interact. Do not discontinue the medication without consulting a doctor.
DiazepamSufentanil
Severe
How does the drug interact with Lori Injection 2 ml:
Co-administration of Sufentanil with Lori Injection 2 ml can increase the risk of adverse effects.

How to manage the interaction:
Co-administration of Lori Injection 2 ml with Sufentanil can possibly result in an interaction, but it can be taken if your doctor has advised it. If you notice any of these symptoms - feeling tired or sleepy, having trouble breathing, or a slower heartbeat - make sure to contact your doctor right away. Do not stop using any medications without first talking to your doctor.
DiazepamEsketamine
Severe
How does the drug interact with Lori Injection 2 ml:
Co-administration of Lori Injection 2 ml with esketamine may increase side effects such as confusion, drowsiness, difficulty concentrating, and impairment in thinking, judgment, reaction speed, and motor coordination.

How to manage the interaction:
Although there is a possible interaction, Lori Injection 2 ml should be taken with esketamine if prescribed by the doctor. However, avoid driving or operating heavy machinery after treatment with esketamine as you may experience drowsiness. Do not discontinue the medication without consulting a doctor.
How does the drug interact with Lori Injection 2 ml:
Taking Lori Injection 2 ml together with fluvoxamine may cause an increase in side effects such as drowsiness, confusion, muscle weakness, and fainting.

How to manage the interaction:
Although there is a possible interaction, Lori Injection 2 ml can be taken with fluvoxamine if prescribed by the doctor. However, if you experience any unusual symptoms consult your doctor. Do not discontinue any medications without consulting a doctor.
How does the drug interact with Lori Injection 2 ml:
Taking Lori Injection 2 ml together with olanzapine can cause low blood pressure, weak pulse, shallow breathing, muscle weakness, drowsiness, dizziness and slurred speech.

How to manage the interaction:
Combining Olanzapine and Lori Injection 2 ml can lead to an interaction, it can be taken if your doctor has suggested it. If you experience any symptoms consult the doctor immediately. Avoid activities requiring mental alertness until you know how these medications will affect you. Do not stop using any medications without first talking to your doctor.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

  • Yoga, meditation, mindfulness-based cognitive therapy, and mindfulness-based stress reduction can help improve your mindfulness.
  • De-stress by meditating, reading books, taking a nice bubble bath, or listening to relaxing music.
  • Regular exercise can help reduce anxiety by generating endorphins and enhancing your sleep and self-image.
  • Drink plenty of water to keep hydrated.
  • Include a diet rich in whole grains, vegetables, and fruits.
  • Limit your consumption of alcohol, coffee, added sugar, salt, and fat.

Side Effects of Lori Injection 2 ml

  • Drowsiness
  • Feeling sleepy (sedation)
  • Light-headedness
  • Unsteadiness, or dizziness
  • Confusion

Habit Forming

Yes

Therapeutic Class

ANXIOLYTICS

Lori Injection 2 ml Substitute

Substitutes safety advice

Author Details

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Drug-Diseases Interactions

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DIAZEPAM-5MGMyasthenia gravis and other myoneural disorders
Severe
DIAZEPAM-5MGEssential (primary) hypertension
Severe

Drug-Diseases Interactions

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DIAZEPAM-5MGMyasthenia gravis and other myoneural disorders
Severe
How does the disease interact with Lori Injection 2 ml:
Lori Injection 2 ml shouldn't be used by people with myasthenia gravis.

How to manage the interaction:
The use of Lori Injection 2 ml is not recommended in patients with myasthenia gravis (an autoimmune disease).
DIAZEPAM-5MGEssential (primary) hypertension
Severe
How does the disease interact with Lori Injection 2 ml:
Injecting benzodiazepines into individuals who are in shock or a coma is not advised. In these patients, the hypnotic and hypotensive effects of these drugs may last longer and be more potent.

How to manage the interaction:
The hypnotic (sleep-inducing) and hypotensive (lowering blood pressure) effects of these agents may be prolonged and intensified. The medicine should not be administered to patients in shock or coma.
DIAZEPAM-5MGEpilepsy
Severe
How does the disease interact with Lori Injection 2 ml:
The incidence of generalised tonic-clonic seizures (grand mal) or their onset may be accelerated in people with seizure disorders who use benzodiazepines.

How to manage the interaction:
Benzodiazepines may increase the occurrence of seizures. Dose adjustment or initiation of appropriate anticonvulsant medication may be needed. Do not discontinue medication without first consulting with the physician.
DIAZEPAM-5MGAbnormalities of breathing
Severe
How does the disease interact with Lori Injection 2 ml:
When administered in large doses and/or by intravenous administration, benzodiazepines have the potential to cause respiratory depression and apnea.

How to manage the interaction:
Usually when given in high dosages and/or by intravenous administration, benzodiazepines may cause respiratory depression and apnea. Therapy with benzodiazepines should be administered cautiously in these patients.
DIAZEPAM-5MGOther diseases of liver
Severe
How does the disease interact with Lori Injection 2 ml:
The liver breaks down benzodiazepines, and the metabolites are then eliminated in the urine. The oxidative N-dealkylation of chlordiazepoxide, clorazepate, Lori Injection 2 ml, flurazepam, and quazepam results in active metabolites that have significantly longer half-lives than the parent substance.

How to manage the interaction:
Benzodiazepines are metabolized by the liver. Therapy with benzodiazepines should be administered cautiously at lower initial dosages in patients with impaired liver function.
DIAZEPAM-5MGMental and behavioural disorders due to multiple drug use and use of other psychoactive substances
Severe
How does the disease interact with Lori Injection 2 ml:
It is possible for benzodiazepines to lead to abuse and dependence. Particularly with repeated usage and/or high dosages, tolerance and physical and psychological dependence may develop.

How to manage the interaction:
Benzodiazepines have the potential to cause dependence and abuse. It should be used with caution in patients with addiction- prone individuals, such as those with a history of alcohol or substance abuse. The dose should be gradually reduced if dependency is suspected.
DIAZEPAM-5MGGlaucoma
Severe
How does the disease interact with Lori Injection 2 ml:
The makers believe that using benzodiazepines while a patient has acute angle-closure glaucoma or untreated open-angle glaucoma is contraindicated.

How to manage the interaction:
Benzodiazepine is not recommended in patients with acute angle-closure glaucoma or untreated open-angle glaucoma.
DIAZEPAM-5MGMental and behavioural disorders due to use of alcohol
Severe
How does the disease interact with Lori Injection 2 ml:
Alcohol and benzodiazepines should not be combined. Vital signs are decreased in alcohol-intoxicated patients.

How to manage the interaction:
The use of benzodiazepines with alcohol is not recommended. Therapy with benzodiazepines should be administered cautiously in patients who might be prone to acute alcohol intake.

FAQs

Lori Injection 2 ml works by increasing levels of a calming chemical known as gamma-aminobutyric acid (GABA) in the brain. This helps to relieve anxiety and stops seizure attacks (fits), and relaxes tense muscles.

Using Lori Injection 2 ml in patients with sleep apnoea syndrome (a condition where breathing stops for a short period of time when a person is sleeping) is contraindicated. So, it is advisable to inform the doctor if you are suffering from sleep apnoea syndrome.

Caffeine is a stimulant that may reduce the calming effects of Lori Injection 2 ml. So, it is advisable to avoid the intake of caffeinated beverages like coffee, tea, cola or chocolate that contain caffeine. Avoid grapefruit juice as it may increase the amount of Lori Injection 2 ml in blood.

Lori Injection 2 ml usage is not recommended in people with hypersensitivity to diazepam, people with a phobia (a fear of a particular object or situation), difficulty breathing, porphyria (a disorder of the blood), sleep apnoea syndrome, acute narrow-angle glaucoma, and open-angle glaucoma unless the patient is receiving appropriate treatment.

Drug-Drug Interactions Checker List

  • FLUOXETINE
  • CLOZAPINE
  • CETIRIZINE
  • ERYTHROMYCIN
  • SUXAMETHONIUM
  • TUBOCURARINE
  • MORPHINE
  • PHENOBARBITAL
  • HYDROCHLOROTHIAZIDE
  • HYDRALAZINE
  • CIMETIDINE
  • OMEPRAZOLE
  • CARBAMAZEPINE
  • PRIMIDONE
  • AMPRENAVIR
  • RITONAVIR
  • LEVODOPA
  • KETAMINE
  • THEOPHYLLINE
  • LOFEXIDINE
  • NABILONE
  • RIFAMPICIN
  • DISULFIRAM
  • PHENYTOIN

Special Advise

  • The use of Lori Injection 2 ml may increase the risk of misuse, abuse, and addiction.  Therefore, before prescribing Lori Injection 2 ml and throughout the treatment, the patient's risk for misuse, abuse, and addiction should be assessed.
  • Lori Injection 2 ml may cause withdrawal symptoms if treatment is stopped suddenly. Therefore, the dose should be gradually reduced to prevent withdrawal symptoms.

 

Disease/Condition Glossary

Anxiety Disorder: An anxiety disorder is a mental health disorder characterised by feelings of excessive fear or worry that affect an individual's daily activities. Anxiety disorders differ from normal feelings of anxiety and nervousness, involving excessive anxiety, fear or worry. Anxiety disorders can affect an individual’s job performance, school work and personal relationships.

Muscle spasms: Muscle spasms are sudden, uncontrollable movements of the muscle that can be unpleasant and painful. Muscle spasms can occur when the nerve impulses that regulate muscle action are damaged or disrupted. Symptoms include stiff joints, strange postures, trouble moving, and pain in the affected muscles and joints. Muscle spasms can be triggered by fatigue (weakness), stress, extreme heat or cold, infection, and tight clothing.

Epilepsy/seizures/fits: Epilepsy is a chronic disorder characterised by seizures (fits) episodes. In this condition, a chemical change in the brain cells (neurons) leads to a sudden surge of electrical activity in the brain, followed by sudden jerky movements of limbs or a part of the body.

Sedation: Sedation is a state of sleep, relaxation or drowsiness brought on by an external substance such as a drug. Sedation is the alleviation of irritation, anxiety or agitation by administering a sedative drug. It is generally carried out to ease the process of a diagnostic procedure or surgery.

Alcohol withdrawal syndrome: After a period of heavy drinking, someone who stops consuming alcohol may experience symptoms of alcohol withdrawal. The severity of alcohol withdrawal symptoms might vary greatly. Symptoms could appear anywhere between two hours to four days after a person stops drinking. Symptoms include hallucinations, seizures, tremors, nausea, and migraine. Alcohol withdrawal frequently necessitates both medical attention and hospitalisation.

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Alcohol

Unsafe

Intake of alcohol can increase the side effects of Lori Injection 2 ml, like dizziness, drowsiness, and difficulty concentrating. In a few cases, people may also experience impaired thinking and judgment. Hence, avoid consuming alcohol while being treated with Lori Injection 2 ml.

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Pregnancy

Unsafe

Lori Injection 2 ml is recommended in pregnancy if clearly necessary, Inform your doctor if you are pregnant or suspect pregnancy. Your doctor will weigh the benefits and potential risks before prescribing Lori Injection 2 ml.

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Breast Feeding

Unsafe

Lori Injection 2 ml may not be recommended in breastfeeding as it may harm your infant. Inform your doctor if you are breastfeeding. Your doctor will weigh the benefits and potential risks before prescribing Lori Injection 2 ml.

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Driving

Unsafe

Lori Injection 2 ml may cause a reduction in mental awareness, affect concentration and may cause dizziness. Hence, avoid driving after receiving Lori Injection 2 ml.

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Liver

Unsafe

Lori Injection 2 ml is not recommended for use in people with severe liver disease. Inform your doctor if you have a history of liver disease or an ongoing liver problem. Your doctor may adjust the dose of Lori Injection 2 ml if necessary.

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Kidney

Caution

Inform your doctor if you have kidney problems or a history of kidney disease. Your doctor may adjust your dose depending upon your kidney condition.

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Children

Caution

The safety and effectiveness of Lori Injection 2 ml in neonates (30 days or less) have not been established. Your paediatrician will recommend this medicine based on the condition of your child.

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