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Written By Urvashi Bharti , MBBS
Reviewed By Sunny S , MBBS
Non returnable*
COD available

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Whats That

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Composition :

ERLOTINIB-150MG

Manufacturer/Marketer :

RPG Life Sciences Ltd

Consume Type :

ORAL

Return Policy :

Not Returnable

About Lortinib 150mg Tablet

Lortinib 150mg Tablet belongs to the group of medicine called ‘anti-cancer’ primarily used for lung and pancreatic cancer treatment. Lung cancer is the uncontrolled growth of abnormal cells in one or both lungs. These abnormal cells do not carry out normal lung cell functions and do not develop into healthy lung tissue. In this disease, cells of the lung grow uncontrollably, and if not detected at an early stage may spread to other body parts, including the brain. Pancreatic cancer is an uncontrolled cancerous growth in the pancreas, usually in the cells that produce insulin.

Lortinib 150mg Tablet contains 'Erlotinib' that belongs to the group of medicines known as 'kinase inhibitors'. It works by stopping the action of an abnormal protein that causes the multiplication of cancerous cells. In this way, it prevents the spread of cancerous cells.

Take Lortinib 150mg Tablet as prescribed by your doctor. You are suggested to take Lortinib 150mg Tablet as long as your doctor has prescribed it after checking your medical condition.  In some cases, you may experience certain common side-effects such as abdominal pain, bone pain, breathlessness, constipation, cough, diarrhea, edema (swelling), fatigue, fever, infection, muscle pain, nausea, rash, stomatitis (inflammation of the mouth), vomiting, weight loss abnormal blood tests for the liver function. Most of these side-effects do not require medical attention and will resolve gradually over time. However, you are advised to talk to your doctor if you experience these side-effects persistently.

To treat your condition effectually, continue taking Lortinib 150mg Tablet for as long as your doctor has prescribed. Do not take Lortinib 150mg Tablet if you are pregnant or planning for pregnancy and breastfeeding as Lortinib 150mg Tablet causes serious congenital disabilities. Older adults are more sensitive to medicine so that they may adjust the dosage according to the condition. While taking Lortinib 150mg Tablet, you might become more sensitive to sunlight, so it is important to protect your skin with a high sun protection factor (SPF). Regular blood tests are required to monitor liver function and blood cells in the blood while taking Lortinib 150mg Tablet. Avoid consuming alcohol along with Lortinib 150mg Tablet as it could lead to increased dizziness.

Uses of Lortinib 150mg Tablet

Lung cancer, Pancreatic cancer

Directions for Use

Swallow it as a whole with water; do not crush, break or chew it.

Medicinal Benefits

Lortinib 150mg Tablet is prescribed to the patients dealing with nonsmall cell lung cancer and pancreatic cancer. Cancer of this type tends to spread quickly in other parts of the body. Lortinib 150mg Tablet travel through the bloodstream and effectively destroy cancerous cells of the lung, pancreas, and other body parts. Lortinib 150mg Tablet contains Erlotinib is a 'tyrosine kinase inhibitor (TKI)' that stops the uncontrolled growth and spread of cancerous cells. It acts by blocking the abnormal protein's action that is responsible for the multiplication of cancerous cells. Whenever a new healthy cell is formed, it undergoes a usual process of maturity. Cancerous cells form new cells more quickly, so Lortinib 150mg Tablet targets cancerous cells and block the action of Tyrosine kinases enzymes (responsible for causing cancer). It also decreases the blood supply to cancer tumors to slow down the growth of the tumor. In this way, Lortinib 150mg Tablet stops the production, spread, and growth of cancerous cells in the body. 

Storage

Store in a cool and dry place away from sunlight

Side Effects of Lortinib 150mg Tablet

  • ​​​​Stomach pain
  • Bone pain
  • Breathlessness
  • Constipation
  • Cough
  • Diarrhea
  • Loss of appetite
  • Edema (swelling)
  • Fatigue
  • Fever
  • Infection
  • Muscle pain
  • Nausea
  • Rash
  • Changes in vision
  • Partial hair loss (by strands, not typically in clumps)
  • Stomatitis (Inflammation of the mouth)
  • Weight loss
  • Abnormal blood tests for the liver function

Drug Warnings

Do not take Lortinib 150mg Tablet if you are allergic to Lortinib 150mg Tablet or any of its ingredients. While taking Lortinib 150mg Tablet, you might become more sensitive to sunlight, so it is important to protect your skin with a high sun protection factor (SPF) while going out as it can lead to a skin rash if you are not using a strong SPF. Lortinib 150mg Tablet can cause leg swelling and water retention or fluid overload (edema), so if you have unexpected rapid weight gain, please consult your doctor. Do not take Lortinib 150mg Tablet if you are pregnant or planning to get pregnant and breastfeeding as it could harm the unborn baby. Use effective birth control measures while taking this medication and for at least 1 month after your last dose. Lortinib 150mg Tablet is not recommended for children and adolescents. You are advised to stop smoking while taking Lortinib 150mg Tablet as smoking could decrease this medication's effect. Lortinib 150mg Tablet may make you more susceptible to infections, consult your doctor if you develop any signs of infections, fever, sore throat, breathlessness, jaundice, unexplained bleeding, or bruising.  Lortinib 150mg Tablet may cause blurry vision and dizziness, so do not drive or operate any machinery which requires concentration. Before undergoing any surgery, it is advised to tell the medical professional who performs the procedure about all the medicines you are taking. 

Drug-Drug Interactions

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ErlotinibRabeprazole
Critical
ErlotinibOmeprazole
Critical

Drug-Drug Interactions

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ErlotinibRabeprazole
Critical
How does the drug interact with Lortinib 150mg Tablet:
When used in combination with Lortinib 150mg Tablet, Rabeprazole may prevent the absorption of Lortinib 150mg Tablet into the circulation, which might make Lortinib 150mg Tablet less effective in treating cancer.

How to manage the interaction:
Taking Rabeprazole with Lortinib 150mg Tablet is not recommended as it can result in an interaction, it should be taken only if a doctor has advised it. Do not stop using any medications without consulting a doctor.
ErlotinibOmeprazole
Critical
How does the drug interact with Lortinib 150mg Tablet:
Omeprazole can make Lortinib 150mg Tablet less effective by reducing its absorption in the body. This can lead to low treatment outcomes.

How to manage the interaction:
Taking Omeprazole and Lortinib 150mg Tablet together is not recommended as it can result in an interaction; it should be taken only if a doctor has advised it. Do not stop using any medications without talking to a doctor.
ErlotinibLansoprazole
Severe
How does the drug interact with Lortinib 150mg Tablet:
The combination of Lortinib 150mg Tablet with lansoprazole is commonly not advised. Lortinib 150mg Tablet may be less effective at treating your cancer as lansoprazole may interfere with Lortinib 150mg Tablet's absorption into the bloodstream.

How to manage the interaction:
Although taking Lansoprazole and Lortinib 150mg Tablet together can possibly result in an interaction, it can be taken if your doctor has prescribed it. Without consulting a doctor, never stop taking any drugs.
ErlotinibLomitapide
Severe
How does the drug interact with Lortinib 150mg Tablet:
Taking Lortinib 150mg Tablet and Lomitapide can increase the risk or severity of liver damage.

How to manage the interaction:
Taking Lortinib 150mg Tablet and Lomitapide is generally avoided as it can possibly result in an interaction, it can be taken if your doctor has advised it. However, if you notice any symptoms of fever, chills, joint pain or swelling, unusual bleeding or bruising, skin rash, itching, loss of appetite, fatigue, nausea, vomiting, abdominal pain, dark-colored urine, light-colored stools, and/or yellowing of the skin or eyes, you should contact a doctor immediately. Do not stop using any medications without talking to a doctor.
ErlotinibEsomeprazole
Severe
How does the drug interact with Lortinib 150mg Tablet:
Coadministration of Lortinib 150mg Tablet and esomeprazole can reduce effects of Lortinib 150mg Tablet.

How to manage the interaction:
Taking Lortinib 150mg Tablet and Esomeprazole together is generally avoided as it can possibly result in an interaction. It can be taken if your doctor has advised it. Do not stop using any medications without first talking to your doctor.
ErlotinibMitotane
Severe
How does the drug interact with Lortinib 150mg Tablet:
When Lortinib 150mg Tablet is taken with mitotane, it reduces the blood levels of Lortinib 150mg Tablet.This can lead to low treatment outcomes.

How to manage the interaction:
Co-administration of Lortinib 150mg Tablet with Mitotane can possibly result in an interaction, but it can be taken if your doctor has advised it. Do not stop using any medications without a doctor's advice.
ErlotinibTeriflunomide
Severe
How does the drug interact with Lortinib 150mg Tablet:
Taking Lortinib 150mg Tablet with Teriflunomide can increase the risk or severity of liver damage.

How to manage the interaction:
Taking Lortinib 150mg Tablet with Teriflunomide together is generally avoided as it can result in an interaction, it can be taken if your doctor has advised it. However, if you notice any symptoms of fever, chills, joint pain or swelling, unusual bleeding or bruising, skin rash, itching, loss of appetite, fatigue, nausea, vomiting, abdominal pain, dark-colored urine, light-colored stools, and/or yellowing of the skin or eyes, you should contact a doctor immediately. Do not stop using any medications without talking to a doctor.
ErlotinibRifapentine
Severe
How does the drug interact with Lortinib 150mg Tablet:
When Lortinib 150mg Tablet is taken with rifapentine, it reduces the blood levels of Lortinib 150mg Tablet.

How to manage the interaction:
Although there is a possible interaction between Lortinib 150mg Tablet and Rifapentine, you can take these medicines together if advised by a doctor. Do not discontinue any medications without first consulting a doctor.
ErlotinibRanitidine bismuth citrate
Severe
How does the drug interact with Lortinib 150mg Tablet:
Coadministration of Ranitidine bismuth citrate with Lortinib 150mg Tablet can interfere with the absorption of Lortinib 150mg Tablet and reduce its effectiveness.

How to manage the interaction:
Taking Ranitidine bismuth citrate with Lortinib 150mg Tablet together can result in an interaction, but it can be taken if your doctor has advised it. When taken together, your doctor can recommend other options that won't cause any problems. Do not stop using any medications without talking to a doctor.
ErlotinibPrimidone
Severe
How does the drug interact with Lortinib 150mg Tablet:
When Lortinib 150mg Tablet is taken with primidone, it reduces the blood levels of Lortinib 150mg Tablet. This can lead to low treatment outcomes.

How to manage the interaction:
Taking Lortinib 150mg Tablet with Primidone together can possibly result in an interaction, but it can be taken if your doctor has advised it. Do not stop using any medications without talking to a doctor.

Drug-Food Interactions

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ERLOTINIB-150MGGrapefruit and Grapefruit Juice
Moderate

Drug-Food Interactions

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ERLOTINIB-150MGGrapefruit and Grapefruit Juice
Moderate
Common Foods to Avoid:
Grapefruit Juice

How to manage the interaction:
Grapefruit juice can increase the absorption of Lortinib 150mg Tablet which may lead to higher blood levels of Lortinib 150mg Tablet and possibly increased side effects. Avoid or limit the consumption of Grapefruit juice or Grapefruit while taking Lortinib 150mg Tablet as it can lead to increased risk or severity of side effects. However, if you notice any Burning, tingling, numbness or pain in the hands, arms, feet, or legs, cough or hoarseness, or severe diarrhea, you should contact your doctor immediately. Do not stop using any medications without first talking to your doctor.

Diet & Lifestyle Advise

  • ​​​​​​Physical activity helps in strengthening muscles, reduce fatigue, aids in weight loss, and give strength. Gentle exercises like 20-30 minutes of walking or swimming would be helpful.
  • Performing yoga and other relaxation techniques may also improve physical and mental health and reduce stress levels.
  • Maintain a healthy weight by performing regular low-strain exercises and eating healthy food.
  • Get adequate sleep as resting helps in improving your health, mental ability and improves attention.
  • De-stress yourself by meditating, reading books, taking a warm bubble bath, or listen to soothing music.
  • Eat food rich in antioxidants such as berries, spinach, kidney beans, dark chocolate, etc.
  • Foods containing fiber help in better digestion. These include beans, peas, lentils, whole grains,  nuts, and seeds.
  • Avoid smoking and alcohol consumption. 

Habit Forming

No

Therapeutic Class

ANTINEOPLASTIC

Lortinib 150mg Tablet Substitute

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Author Details

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Drug-Diseases Interactions

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No Drug - Disease interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Diseases Interactions

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FAQs

Lortinib 150mg Tablet contains Erlotinib, an anti-cancer medication that works by preventing the activity of a protein called epidermal growth factor receptor (EGFR) and hence induces cell death (apoptosis). As a result, the growth and spread of cancer cells in stopped or slowed down.

The most common sign of lung cancer is a cough that lasts long and gets worse with time. Sometimes, a patient may notice blood in the cough. Chest pain is also a sign of lung cancer followed by coughing.

Lortinib 150mg Tablet is safe to be taken by a diabetic person. However, take Lortinib 150mg Tablet only after asking with a doctor as they may adjust the dosing according to the patient's condition.

In elderly patients, the risk of side effects is more if you are taking Lortinib 150mg Tablet. For the patients who are elderly, dose adjustment might be required or your doctor might prescribe any other medication safe for the elderly.

Lortinib 150mg Tablet can make you more likely to get infections or may worsen any current infections. Avoid contact with people who have infections that may spread to others (such as chickenpox, measles, flu). Consult your doctor if you have been exposed to an infection or for more details.

No, It is advised to maintain a gap between both the medicines, as use of antacids along with Lortinib 150mg Tablet may affect the way the Lortinib 150mg Tablet works. Consult your doctor for further information.

Lortinib 150mg Tablet should be used with caution in patients using anticoagulants. Lortinib 150mg Tablet may increase your tendency to bleed. Talk to your doctor, he will need to regularly monitor you with some blood tests.

Drug-Drug Interactions Checker List

  • WARFARIN
  • ASPIRIN
  • AMLODIPINE
  • METOPROLOL
  • NIFEDIPINE
  • QUINIDINE
  • ATORVASTATIN
  • FLUVASTATIN
  • PRAVASTATIN
  • ROSUVASTATIN
  • SIMVASTATIN
  • CYCLOSPORINE
  • ERYTHROMYCIN
  • TELITHROMYCIN
  • CLARITHROMYCIN
  • RIFAMPICIN
  • CIPROFLOXACIN
  • ITRACONAZOLE
  • VORICONAZOLE
  • KETOCONAZOLE
  • TRIAZOLAM
  • ALPRAZOLAM
  • ESTAZOLAM
  • PRIMIDONE
  • PHENOBARBITAL
  • PHENYTOIN
  • CARBAMAZEPINE
  • SAQUINAVIR
  • RITONAVIR
  • SILDENAFIL
  • OMEPRAZOLE
  • RANITIDINE

Special Advise

  • ​​​​​​Regular blood test is required to monitor liver function and blood cells in blood while taking Lortinib 150mg Tablet.
  • While taking Lortinib 150mg Tablet, you might become more sensitive to sunlight, so it is important to protect your skin with a high sun protection factor (SPF) while going out as it can lead to a skin rash if you are not using a strong SPF.
  • Always take it with food and a full glass of water to prevent nausea.
  • Lortinib 150mg Tablet can cause swelling and water retention, so if you have unexpected rapid weight gain, please consult your doctor. 
  • Do not have immunizations with live vaccines (for mumps, rubella, measles and BCG, yellow fever and shingles or pox chicken) while you’re having treatment and for up to 12 months afterward. 
  • Contact your doctor immediately if you experience any infection signs, including a temperature above 37.5 C or below 36 C.

Disease/Condition Glossary

Lung cancer: It happens when cells in the lung begin to grow in an uncontrolled manner. The most common form of lung cancer is non-small cell lung cancer (NSCLC). It happens when cells that form the lining of the lung start growing uncontrollably. Persons who smoke are at high risk of lung cancer. A common symptom of NSCLC is a cough that does not go quickly followed by shortness of breath. Cancerous cells of the lung spread off and travel through the bloodstream to distant regions of the body and grow.

Pancreatic cancer: It is a type of tumor in the pancreas that usually begins in the juice's cells. It is a gland behind your stomach that produces juices that help break down food and the hormones that help control blood sugar levels.

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