Lotegate Eye Drops 5 ml consists of a combination of an eye medication containing antibiotic and corticosteroid, primarily used to treat bacterial infections, including conjunctivitis/pink eye. It also decreases the risk of eye infections such as conjunctivitis (inflammation of the conjunctiva) and other eye inflammatory conditions (cornea, iris, and connective tissue) in postoperative patients. A bacterial eye infection occurs when bacteria invade any part of the eyeball or its surrounding tissues, including the cornea (clear front surface of the eye) and the conjunctiva (thin membrane lining the outer eye and inner eyelids). A bacterial eye infection symptoms include red eyes, pain, swelling of eyes, watery eyes, itching, and blurry vision.

Lotegate Eye Drops 5 ml contains Gatifloxacin (antibiotic) and Loteprednol (corticosteroid). Gatifloxacin is an antibiotic that helps treat and prevent a wide range of bacterial infections. It kills bacteria (bactericidal action) by preventing the synthesis of enzymes, namely DNA gyrase and Topoisomerase IV, which is essential for the growth and survival of the bacterial cell. Loteprednol is a corticosteroid with anti-inflammatory properties and acts by inhibiting the chemicals such as prostaglandins production (chemical messengers) that make the eye red, swollen, and itchy. It reduces symptoms associated with infection, such as redness and irritation of the eye, and decreases the risk of infections.

Lotegate Eye Drops 5 ml is for external use only. Use Lotegate Eye Drops 5 ml as prescribed by your doctor. Lotegate Eye Drops 5 ml is only for use in the eyes. Do not swallow or inject Lotegate Eye Drops 5 ml. You are advised to use Lotegate Eye Drops 5 ml for as long as your doctor has prescribed it based on your medical condition. If you wear contact lenses or are wearing them, remove them before using Lotegate Eye Drops 5 ml, and you can put them back 15 minutes after using Lotegate Eye Drops 5 ml. You may experience watery eyes, irritation in the eyes, and eye itching, in some cases. Most of these side effects of Lotegate Eye Drops 5 ml are temporary, do not require medical attention, and gradually resolve over time. However, if the side effects are persistent, reach out to your doctor.

Do not take Lotegate Eye Drops 5 ml if you are allergic to antibiotics, corticosteroids or any ingredient of Lotegate Eye Drops 5 ml. Put Lotegate Eye Drops 5 ml only if the doctor prescribes you. It would help if you did not stop taking Lotegate Eye Drops 5 ml abruptly, as it may worsen your symptoms. Also, do not put more than the prescribed dose of Lotegate Eye Drops 5 ml, as it may cause glaucoma or optic nerve damage. Do not take any other eye medication with Lotegate Eye Drops 5 ml without consulting your doctor. The use of loteprednol in Lotegate Eye Drops 5 ml after cataract surgery is known to slow the surgery's healing process, so it is given in a very minimum dose. If you have or ever had glaucoma (increased eye pressure), herpes simplex infection, or any other eye problem, are pregnant or breastfeeding, do not take Lotegate Eye Drops 5 ml until prescribed by your doctor.

Lotegate Eye Drops 5 ml is a combination of two drugs: Gatifloxacin (antibiotic) and Loteprednol (corticosteroid). Gatifloxacin belongs to the group of medicines called fluoroquinolone antibiotics used to treat bacterial infections, including conjunctivitis (pinkeye). It kills bacteria (bactericidal action) by preventing the synthesis of enzymes, namely DNA gyrase and Topoisomerase IV, which is essential for the growth and survival of the bacterial cell. Lotegate Eye Drops 5 ml has a broad spectrum of antibacterial activity against aerobic gram-positive and aerobic gram-negative bacteria (that live in oxygen). Loteprednol is a corticosteroid that works by blocking prostaglandins (a chemical messenger) in the brain, making the eye red, swollen and itchy. As a result, it reduces symptoms associated with infection, such as redness and irritation of the eye, and decreases the risk of infections. Lotegate Eye Drops 5 ml is used to prevent or treat only bacterial eye infections.

• Eye irritation
• Eye redness
• Pain on the administration of medicine
• Blurred vision
• Decreases in taste sensitivity (dysgeusia) 
• Anterior chamber inflammation

Do not take Lotegate Eye Drops 5 ml if you are allergic or have had a severe reaction to the quinolone or fluoroquinolone antibiotics and corticosteroids or any of the ingredients of Lotegate Eye Drops 5 ml. Please inform your doctor if you are pregnant or breastfeeding before starting Lotegate Eye Drops 5 ml. Lotegate Eye Drops 5 ml is not recommended for children below one year of age as safety and effectiveness have not been established. Do not stop taking Lotegate Eye Drops 5 ml even if you feel better without asking your doctor, as your symptoms may come back and may even worsen your condition. Please do not take more than the prescribed dose of Lotegate Eye Drops 5 ml as it may cause glaucoma, increase the risk of cataracts (clouding of the eye), and secondary infection. To avoid any contamination, avoid touching the tip of the dropper. Do not put to eye medication simultaneously; wait for at least 10 minutes before putting in the second medication. If you have or have ever had glaucoma (increased eye pressure), herpes simplex infection, or any other eye problem, do not take Lotegate Eye Drops 5 ml until prescribed by your doctor. Prolonged use of corticosteroids may result in glaucoma with damage to the optic nerve and defects in visual acuity and fields of vision. If this product is used for ten days or longer, intraocular pressure (IOP) should be monitored.

Drug-drug interactions: Lotegate Eye Drops 5 ml may interact with other ophthalmic medications (bromfenac, diclofenac, flurbiprofen, ketorolac, nepafenac, suprofen, bimatoprost, latanoprost, tafluprost), HIV medicines (ritonavir, cobicistat, darunavir, nelfinavir), antibiotic medication (clarithromycin), and vaccine (smallpox vaccine).

Drug-Food Interactions:  No interaction found.

Drug-Disease Interactions: Lotegate Eye Drops 5 ml should not be used in patients with fungal infections, viral infections such as herpes simplex or varicella, or parasitic infections such as amoebiasis, tuberculosis, damaged cornea, ulceration, and glaucoma (increased pressure inside the eye).

• BROMFENAC
• DICLOFENAC
• FLURBIPROFEN
• KETOROLAC
• BIMATOPROST
• LATANOPROST
• TAFLUPROST
• RITONAVIR
• COBICISTAT
• DARUNAVIR
• NELFINAVIR
• CLARITHROMYCIN
• SMALLPOX VACCINE

• Try to maintain good hygiene to keep your eyes clean and irritant-free.
• Do not rub your eyes even though some ophthalmic drugs make your eye itchy.
• Know your allergy triggers, such as pollen, dust, and other factors.
• Sleep for at least six to eight hours to rejuvenate your eyes naturally.
• Wash your eyes with clean water at least two to three times a day
• Manage stress, eat healthily, drink plenty of water, exercise regularly, and get plenty of sleep.
• Wash your hands thoroughly and do not touch the dropper before using drops to avoid contamination.
• Reduce screen time (by avoiding watching tv, or phone) and use sunglasses while going out into the sunlight.
• Avoid alcoholic beverages as it can make you dehydrated and affect the eye's pressure. This effect can also affect your body’s ability in fighting off infections.

• Do not take Lotegate Eye Drops 5 ml on your own, as self-medication may lead to antibiotic resistance in which antibiotics fail to act against specific bacterial infections.
• Using Lotegate Eye Drops 5 ml for prolonged may result in a new fungal eye infection (secondary infection). Do not use Lotegate Eye Drops 5 ml for longer than prescribed.
• Lotegate Eye Drops 5 ml should not be administered directly into the eye's anterior chamber. 
• Please consult an eye specialist if your eye infection persists or worsens after using Lotegate Eye Drops 5 ml for a week.
• Have frequent follow-up check-ups with your doctor to check for any problems such as cataracts, an increase in pressure, or infections if you are using it is prescribed for long-term use.

Bacterial eye infection: A bacterial eye infection occurs when bacteria invade any part of the eyeball or surrounding tissues, including the cornea (clear front surface of the eye) and the conjunctiva (thin membrane lining the outer eye inner eyelids). A bacterial eye infection symptoms include red eyes, pain, swelling of eyes, watery eyes, itching, and blurry vision. Some prevalent/very common eye infections are Conjunctivitis (pink eye) and Stye.

Conjunctivitis: A condition caused by the inflammation and irritation of the eye's mucous membrane (conjunctiva). 

Stye: Formation of a bump on the eyelid that happens when bacteria from the skin get into an eyelash's hair follicle.