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Written By Divya L , PharmaD
Reviewed By Bayyarapu Mahesh Kumar , M Pharmacy
Non returnable*
COD available

Online payment accepted

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Manufacturer/Marketer :

Corvin Pharmaceuticals

Consume Type :

ORAL

Return Policy :

Not Returnable

About Luminate 80mg/480mg Tablet

Luminate 80mg/480mg Tablet belongs to the class of 'anti-malarial drugs', primarily used to treat and prevent malaria. Malaria is a disease caused by a plasmodium parasite, transmitted by the bite of infected Anopheles mosquitoes. When an infected mosquito bites a healthy person, it transmits the 'Plasmodium parasite' into the bloodstream, which affects the red blood cells and liver cells. Malaria symptoms usually start in 10 days to 4 weeks after the infection. They include chills, high fever, profuse sweating, headache, nausea, vomiting, abdominal pain, diarrhoea, anaemia, muscle pain, convulsions, coma and bloody stools.

Luminate 80mg/480mg Tablet contains two medicines, namely: Artemether and Lumefantrine. These are anti-malarial drugs that interfere with Plasmodium parasite's growth in the red blood cells of the human body. Luminate 80mg/480mg Tablet is a combination that is used to treat non-severe malaria caused by a parasite called 'Plasmodium falciparum,' other Plasmodium species. It works by inhibiting nucleic acid and protein synthesis in Plasmodium falciparum. Artemether is known to reduce parasite biomass and Lumefantrine eliminates residual parasites.

Your doctor will decide the dose and duration based on your medical condition. Common side effects of Luminate 80mg/480mg Tablet include headache, dizziness, loss of appetite, weakness, fever, chills, tiredness, muscle/joint pain, nausea, vomiting, abdominal pain, cough and trouble sleeping. These side effects are not familiar to everyone and vary individually. If you notice any side effects that are not manageable, please consult your doctor.

Before using Luminate 80mg/480mg Tablet, inform your doctor if you recently used any prescription and non-prescription medications, including other anti-malarial or antibiotic drugs. Let your doctor know if you are allergic to Luminate 80mg/480mg Tablet or its components. Inform your doctor if you have any liver or kidney problems, severe heart diseases and electrolyte imbalance. It is essential to let your doctor know if you are pregnant, planning to conceive or a breastfeeding mother. Avoiding alcohol is recommended to rule out any possibility of side effects.

Uses of Luminate 80mg/480mg Tablet

Malaria.

Directions for Use

Tablet: Swallow it as a whole with a glass of water, do not chew or break the tablet.For patients like infants and children who cannot swallow the tablets, crush the tablet and mix it with 1 to 2 teaspoons of water in a clean container and administer it. Rinse the container with more water and swallow the contents. You can also give the crushed tablet preparation with food/drink like milk, formula, pudding, broth and porridge.Syrup/suspension: Shake the bottle well before use. Take the prescribed dose by mouth using the measuring cup/dosing syringe/dropper provided by the pack.

Medicinal Benefits

Luminate 80mg/480mg Tablet contains two anti-malarial drugs, namely: Artemether and Lumefantrine. It is a combination that treats non-severe malaria caused by a parasite called 'Plasmodium falciparum', other Plasmodium species. It interferes with the growth of Plasmodium parasites in the red blood cells of the human body. Luminate 80mg/480mg Tablet works by inhibiting nucleic acid and protein synthesis in Plasmodium falciparum. Artemether reduces parasite biomass and Lumefantrine eliminates residual parasites.

Storage

Store in a cool and dry place away from sunlight

Drug Warnings

Let your doctor know if you use any antibiotic drugs or have recently undergone treatment with other anti-malarial drugs. Brief your medical history to the doctor if you have any liver or kidney problems, malarial infection of the brain, lungs or kidneys, severe heart diseases and electrolyte imbalance. It is essential to inform your doctor if you have hypokalemia (low potassium levels) or hypomagnesemia (low magnesium levels) before starting Luminate 80mg/480mg Tablet. Luminate 80mg/480mg Tablet may affect QT prolongation that can cause serious fast/irregular heartbeat. Hence it is advised to inform your doctor if you have any heart-related problems like heart failure, slow heartbeat, QT prolongation in EKG or ECG (electrocardiogram), and a family history of heart diseases. It is essential to let your doctor know if you are pregnant, planning to conceive or a breastfeeding mother before starting Luminate 80mg/480mg Tablet. Avoiding alcohol is recommended to rule out any possibility of side effects like dizziness or drowsiness.

Drug-Drug Interactions

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Drug-Drug Interactions

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How does the drug interact with Luminate 80mg/480mg Tablet:
Using Carbamazepine with Luminate 80mg/480mg Tablet may decrease the blood levels of Luminate 80mg/480mg Tablet, which may make Luminate 80mg/480mg Tablet less effective in treating your malaria.

How to manage the interaction:
Taking Carbamazepine with Luminate 80mg/480mg Tablet is not recommended, but can be taken if prescribed by the doctor. However, if you experience any unusual symptoms, consult the doctor. Do not discontinue any medications without consulting a doctor.
How does the drug interact with Luminate 80mg/480mg Tablet:
Both Metoprolol and Luminate 80mg/480mg Tablet may increase the blood levels and effects of metoprolol activity.

How to manage the interaction:
Taking Metoprolol and Luminate 80mg/480mg Tablet together can possibly result in an interaction, it can be taken if your doctor has advised it. However, if you experience blurry vision, confusion, dizziness, fainting, lightheadedness, nausea or vomiting, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.

Drug-Food Interactions

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ARTEMETHER-80MG+LUMEFANTRINE-480MGGrapefruit and Grapefruit Juice
Moderate

Drug-Food Interactions

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ARTEMETHER-80MG+LUMEFANTRINE-480MGGrapefruit and Grapefruit Juice
Moderate
Common Foods to Avoid:
Grapefruit, Grapefruit Juice

How to manage the interaction:
Coadministration with grapefruit juice may increase the plasma concentrations of artemether and lumefantrine. Avoid consumption of grapefruit juice and grape fruit.

Diet & Lifestyle Advise

  • Take nutritious food, including fresh fruits and vegetables that help in recovering from malarial fever.
  • During malarial fever, the patient may experience appetite loss. In such cases, drink glucose water, fresh fruit juices and coconut water.
  • Include high fibre foods like green leafy vegetables and fruits to aid digestion.
  • Take proper rest to help your body relax and heal faster.
  • Avoid or limit the intake of alcohol and caffeine.

Habit Forming

No

Therapeutic Class

ANTI- MALARIALS

Author Details

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Drug-Diseases Interactions

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No Drug - Disease interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Diseases Interactions

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FAQs

Drug-Drug Interactions Checker List

  • MEFLOQUINE
  • QUININE
  • QUINIDINE
  • FLECAINIDE
  • AMIODARONE
  • SOTALOL
  • PROCAINAMIDE
  • DISOPYRAMIDE
  • PIMOZIDE
  • ZIPRASIDONE
  • ERYTHROMYCIN
  • CIPROFLOXACIN
  • MOXIFLOXACIN
  • RIFABUTIN
  • RIFAMPICIN
  • CARBAMAZEPINE
  • PHENOBARBITAL
  • PHENYTOIN
  • KETOCONAZOLE
  • ITRACONAZOLE
  • DELAVIRDINE
  • EFAVIRENZ
  • NELFINAVIR
  • RITONAVIR
  • CLOMIPRAMINE
  • AMITRIPTYLINE
  • IMIPRAMINE
  • METOPROLOL

Special Advise

  • Let your doctor know that you are taking Luminate 80mg/480mg Tablet if you are undergoing any medical tests.
  • Regular monitoring of heart function with ECG or EKG is necessary.
  • Liver and kidney function tests are recommended to rule out any chances of kidney or liver impairment.
  • Luminate 80mg/480mg Tablet may decrease the effectiveness of hormonal birth control such as pills, patch, or ring. This could cause pregnancy. 

Disease/Condition Glossary

Malaria: It is a life-threatening disease caused by parasites that enter the body through a mosquito's bite. This is a common disease in countries like Africa, South America and Southern Asia. This disease usually occurs when an Anopheles mosquito (infected with parasite 'Plasmodium') bites a healthy individual and transfers the parasite into the bloodstream. Parasites that cause malaria include Plasmodium vivax, P. ovale, P. malaria and P. falciparum. Malaria symptoms usually start in 10 days to 4 weeks after the infection. They include chills, high fever, profuse sweating, headache, nausea, vomiting, abdominal pain, diarrhoea, anaemia, muscle pain, convulsions, coma and bloody stools.

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