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Written By Urvashi Bharti , MBBS
Reviewed By Sunny S , MBBS
Non returnable*
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Composition :

LEUPROLIDE-3.75MG

Manufacturer/Marketer :

Nivian Pharma Llp

Consume Type :

PARENTERAL

Return Policy :

Not Returnable

About Luprovian 3.75mg One Combipack Depot Injection

Luprovian 3.75mg One Combipack Depot Injection belongs to the class of 'anticancer or anti-neoplastic agents', primarily used to treat prostate cancer in men, breast cancer and endometriosis in women and precocious puberty (early puberty) in children. Prostate cancer is the prostate gland's cancer (a small gland under the bladder secretes fluid that nourishes and protects sperm) found only in men. Breast cancer is a type of cancer that develops in breast cells stimulated by a female sex hormone called oestrogen. Endometriosis is a disorder in which tissue lining the uterus grows outside the uterine cavity. Precocious puberty occurs when a child's body changes into that of an adult or experiences puberty too soon.

Luprovian 3.75mg One Combipack Depot Injection contains Leuprolide that belongs to the class of gonadotropin-releasing hormone (GnRH) agonists. It is a synthetic hormone that acts similar to the GnRH, produced by the hypothalamus gland in the brain. It works by inhibiting the synthesis of the natural male hormone, testosterone in men and oestrogen in women. This process of lowering hormone levels can decrease cancer cell's growth in prostate cancer in men and shrinks endometriosis and breast cancer in women.

Take Luprovian 3.75mg One Combipack Depot Injection as prescribed by your doctor. Your doctor will decide the dosage depending on your medical condition. The common side effects of Luprovian 3.75mg One Combipack Depot Injection include hot flashes, decreased sexual interest, shrinking of the testicles, breast tenderness or swelling, dizziness, headache, nausea, vomiting, diarrhoea, upset stomach and injection site pain reaction. These side effects are not familiar to everyone and vary individually. If you notice any side effects that are not manageable, please consult your doctor.

To treat your condition effectually continue taking Luprovian 3.75mg One Combipack Depot Injection for as long as your doctor has prescribed. Do not stop Luprovian 3.75mg One Combipack Depot Injection midway.  Avoid taking Luprovian 3.75mg One Combipack Depot Injection if you are pregnant or breastfeeding because this Luprovian 3.75mg One Combipack Depot Injection can cause harmful effects on the unborn baby. Both women and men using this Luprovian 3.75mg One Combipack Depot Injection should use birth control to avoid pregnancy. Luprovian 3.75mg One Combipack Depot Injection may also affect fertility in men, hence discuss with your doctor if you have any plans to start a family in the future. Luprovian 3.75mg One Combipack Depot Injection is not recommended for children below two years of age. Luprovian 3.75mg One Combipack Depot Injection may make you feel dizzy, hence drive when you are alert only.

Uses of Luprovian 3.75mg One Combipack Depot Injection

Prostate cancer, Breast cancer, Endometriosis, Precocious puberty

Directions for Use

Luprovian 3.75mg One Combipack Depot Injection will be administered by a healthcare professional. Do not self-administer.

Medicinal Benefits

Luprovian 3.75mg One Combipack Depot Injection contains Leuprolide, a gonadotropin-releasing hormone (GnRH) agonist. It treats prostate cancer in men, endometriosis in women and precocious puberty (early puberty) in children. Luprovian 3.75mg One Combipack Depot Injection is a synthetic hormone that acts similar to the GnRH, produced by the hypothalamus gland in the brain. Being an anti-neoplastic or anticancer agent, Luprovian 3.75mg One Combipack Depot Injection works by lowering testosterone levels in men that help stop the growth of cancer cells in prostate cancer. Luprovian 3.75mg One Combipack Depot Injection reduces oestrogen (a hormone required for the development and regulation of the female reproductive system and secondary sexual characteristics) levels in women, thus helps in shrinking of endometriosis and breast cancer.

Storage

Store in a cool and dry place away from sunlight

Drug Warnings

If you are allergic to Luprovian 3.75mg One Combipack Depot Injection or any other medicines, please tell your doctor. Luprovian 3.75mg One Combipack Depot Injection can affect the unborn baby when used in pregnancy. Hence, Luprovian 3.75mg One Combipack Depot Injection is not indicated for use in pregnancy and breastfeeding women. If you are using Luprovian 3.75mg One Combipack Depot Injection, make sure to use reliable forms of contraception to prevent pregnancy during the course. Luprovian 3.75mg One Combipack Depot Injection may also affect fertility in men, hence discuss with your doctor if you have any plans to start a family in the future. Use the Luprovian 3.75mg One Combipack Depot Injection with caution in elderly patients and children. Luprovian 3.75mg One Combipack Depot Injection is not recommended for children younger than two years of age. Your symptoms may become temporarily worse when you first start taking Luprovian 3.75mg One Combipack Depot Injection. Inform your doctor if this continues for longer than 2 months. If you have a seizure or unusual changes in mood or behaviour, inform your doctor immediately. Before starting Luprovian 3.75mg One Combipack Depot Injection, let your doctor know if you have any medical history of liver or kidney diseases, heart diseases, recent heart attack, depression, brain tumours, electrolyte imbalance, diabetes, fits, weak bones and high cholesterol levels. Luprovian 3.75mg One Combipack Depot Injection may cause QT prolongation (heart muscle takes longer than normal to recharge between beats) and may affect heart rhythm, hence heart patients should be cautious while taking Luprovian 3.75mg One Combipack Depot Injection. Luprovian 3.75mg One Combipack Depot Injection can make you feel dizzy and affects your mental ability to drive. Do not drive or operate machinery if you are not mentally alert and focused.

Drug-Drug Interactions

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Drug-Drug Interactions

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How does the drug interact with Luprovian 3.75mg One Combipack Depot Injection:
Taking leuprolide with cisapride can increase the risk of an irregular heart rhythm that may be serious.

How to manage the interaction:
Although taking Luprovian 3.75mg One Combipack Depot Injection with Cisapride is not recommended, it can be taken if prescribed by a doctor. However, contact your doctor if you experience drowsiness, lightheadedness, fainting, shortness of breath, or an irregular heartbeat. Do not stop taking any medications without consulting a doctor.
How does the drug interact with Luprovian 3.75mg One Combipack Depot Injection:
Coadministration of Luprovian 3.75mg One Combipack Depot Injection and citalopram can increase the risk of an irregular heart rhythm that may be serious.

How to manage the interaction:
Taking Luprovian 3.75mg One Combipack Depot Injection and citalopram together can possibly result in an interaction; they can be taken together if advised by your doctor. However, contact your doctor if you experience drowsiness, lightheadedness, fainting, shortness of breath, or an irregular heartbeat. Do not stop taking any medications without consulting a doctor.
LeuprorelinSaquinavir
Critical
How does the drug interact with Luprovian 3.75mg One Combipack Depot Injection:
Taking leuprolide with Saquinavir together can raise the risk of an abnormal heart rhythm.

How to manage the interaction:
Taking Luprovian 3.75mg One Combipack Depot Injection with Saquinavir together can possibly result in an interaction, they can be taken together if advised by your doctor. However, contact your doctor if you experience drowsiness, lightheadedness, fainting, shortness of breath, or irregular heartbeat. Do not stop taking any medications without consulting a doctor.
LeuprorelinEliglustat
Critical
How does the drug interact with Luprovian 3.75mg One Combipack Depot Injection:
Taking Leuprolide and Eliglustat together can raise the risk of an abnormal heart rhythm that may be serious.

How to manage the interaction:
Taking Luprovian 3.75mg One Combipack Depot Injection with Eliglustat together can possibly result in an interaction, they can be taken together if prescribed by a doctor. However, consult your doctor if you experience any unusual symptoms. Do not discontinue any medications without consulting a doctor.
LeuprorelinDofetilide
Critical
How does the drug interact with Luprovian 3.75mg One Combipack Depot Injection:
Taking leuprolide with dofetilide together can raise the risk of an abnormal heart rhythm.

How to manage the interaction:
Taking Luprovian 3.75mg One Combipack Depot Injection with Dofetilide together can possibly result in an interaction, they can be taken together if prescribed by a doctor. However, consult your doctor if you experience sudden dizziness, lightheadedness, fainting, or shortness of breath. Do not discontinue any medications without consulting a doctor.
How does the drug interact with Luprovian 3.75mg One Combipack Depot Injection:
Taking Luprovian 3.75mg One Combipack Depot Injection with Pimozide together can raise the risk of an abnormal heart rhythm.

How to manage the interaction:
Taking Luprovian 3.75mg One Combipack Depot Injection with Pimozide together can possibly result in an interaction, they can be taken together if advised by your doctor. However, contact your doctor if you experience drowsiness, lightheadedness, fainting, shortness of breath, or irregular heartbeat. Do not stop taking any medications without consulting a doctor.
How does the drug interact with Luprovian 3.75mg One Combipack Depot Injection:
Using nilotinib together with leuprolide can increase the risk of an irregular heart rhythm that may be serious

How to manage the interaction:
Taking Luprovian 3.75mg One Combipack Depot Injection with Nilotinib is not recommended, as it can result in an interaction. It can be taken if your doctor has suggested it. However, if you experience prolonged diarrhea, vomiting, dizziness, lightheadedness, fainting, or difficulty breathing, contact your doctor immediately. Do not stop using any medications without talking to your doctor.
LeuprorelinIbutilide
Critical
How does the drug interact with Luprovian 3.75mg One Combipack Depot Injection:
Using ibutilide together with leuprolide can increase the risk of an irregular heart rhythm that may be serious.

How to manage the interaction:
Taking Luprovian 3.75mg One Combipack Depot Injection with Ibutilide together can possibly result in an interaction, they can be taken together if advised by your doctor. However, contact your doctor if you experience drowsiness, lightheadedness, fainting, shortness of breath, or irregular heartbeat. Do not stop taking any medications without consulting a doctor.
LeuprorelinVandetanib
Critical
How does the drug interact with Luprovian 3.75mg One Combipack Depot Injection:
Taking Luprovian 3.75mg One Combipack Depot Injection with Vandetanib together can increase the risk of an irregular heart rhythm that may be serious.

How to manage the interaction:
Taking Luprovian 3.75mg One Combipack Depot Injection with Vandetanib together can possibly result in an interaction, they can be taken together if advised by your doctor. However, contact your doctor if you experience drowsiness, lightheadedness, fainting, shortness of breath, or irregular heartbeat. Do not stop taking any medications without consulting a doctor.
How does the drug interact with Luprovian 3.75mg One Combipack Depot Injection:
Taking Luprovian 3.75mg One Combipack Depot Injection and Ceritinib together can raise the risk of an abnormal heart rhythm.

How to manage the interaction:
Although there is an interaction between Luprovian 3.75mg One Combipack Depot Injection and Ceritinib, you can take these medicines together if prescribed by your doctor. If you experience symptoms like irregular heart rhythm, dizziness, fainting, or difficulty breathing, you must contact your doctor immediately. Do not discontinue any medications without consulting a doctor.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

  • Take the medication as directed by the doctor and at regular intervals. 
  • Maintain a fibre-rich diet and include healthy carbohydrates from fruits, vegetables and whole grains.
  • Include fish, soy, tomatoes, Brussels sprouts, kale, broccoli and oils containing omega-3 fatty acids such as olive oil as these foods may reduce the risk of prostate cancer.
  • Avoid grilled meat, red meat, saturated fat found in animal products, milk and dairy products.
  • Exercise regularly to lose weight as obesity is also considered a risk factor for prostate cancer.
  • Eat at regular intervals.
  • Keep your weight under control with BMI 19.5-24.9.
  • Opt for a diet rich in whole grains, fruits, veggies and low-fat dairy products.

Habit Forming

No

Therapeutic Class

ANTINEOPLASTIC

Author Details

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Drug-Diseases Interactions

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No Drug - Disease interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Diseases Interactions

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FAQs

Luprovian 3.75mg One Combipack Depot Injection contains Leuprolide, a synthetic hormone that helps reduce the testosterone and oestrogen hormones in men and women, respectively. This process of lowering hormone levels can decrease cancer cell's growth in prostate cancer in men and shrinks endometriosis in women.

Yes, Luprovian 3.75mg One Combipack Depot Injection commonly affects the hair by making them thin which further causes loss of hair. However, it is not very common. Hair reduction possibly happens due to the estrogen lowering effect of Luprovian 3.75mg One Combipack Depot Injection. These effects are not long-lasting and may return after some time. If it matters to you then inform your doctor for further advice.

Luprovian 3.75mg One Combipack Depot Injection may cause impotence and affect fertility in men. It is advised to speak to your doctor if you plan to have a family in the future before starting Luprovian 3.75mg One Combipack Depot Injection.

Luprovian 3.75mg One Combipack Depot Injection should be used with caution in diabetic patients as it may increase the risk of high blood sugar levels. Therefore, regular monitoring of blood sugar levels is recommended while taking Luprovian 3.75mg One Combipack Depot Injection and inform your doctor if you have diabetes before taking Luprovian 3.75mg One Combipack Depot Injection.

Luprovian 3.75mg One Combipack Depot Injection may worsen your mood disorders like depression. Hence it is advised to use Luprovian 3.75mg One Combipack Depot Injection only when you are free from any kind of mental problems. Please consult your doctor for more information.

Luprovian 3.75mg One Combipack Depot Injection is not recommended for patients suffering from heart rhythm problems such as arrhythmia (irregular heartbeat) as it may increase the risk of heart rhythm problems. Therefore, inform your doctor if you have any heart problems before taking Luprovian 3.75mg One Combipack Depot Injection.

Luprovian 3.75mg One Combipack Depot Injection may cause osteoporosis (bone thinning) due to the reduction of estrogen in the body. Regular bone density tests may help you monitor osteoporosis. Contact your doctor if you observe any sign of tendon pain or swelling while taking Luprovian 3.75mg One Combipack Depot Injection.

Drug-Drug Interactions Checker List

  • QUINIDINE
  • PROCAINAMIDE
  • DISOPYRAMIDE
  • AMIODARONE
  • DEXAMETHASONE
  • METHYLPREDNISOLONE
  • PREDNISOLONE
  • MOXIFLOXACIN
  • METHADONE
  • CITALOPRAM
  • ESCITALOPRAM
  • FLUOXETINE
  • FLUVOXAMINE
  • PAROXETINE
  • SERTRALINE

Special Advise

  • Your doctor may advise liver function tests to monitor your liver health since Luprovian 3.75mg One Combipack Depot Injection may cause increased liver enzymes (alanine aminotransferase, serum aspartate and serum transaminases).
  • Luprovian 3.75mg One Combipack Depot Injection may cause increased serum glucose levels (hyperglycaemia), hence inform your doctor if you have diabetes before starting Luprovian 3.75mg One Combipack Depot Injection.
  • Your doctor may advise blood tests, electrolyte levels and regular examinations of the prostate.
  • It is advised to get an electrocardiogram (ECG) done timely to monitor your heart health.

Disease/Condition Glossary

Prostate cancer: It is the cancer of the prostate gland (a small gland under the bladder secretes fluid that nourishes and protects sperm) found only in men. The symptoms include difficulty in urination, pain, numbness or sexual problems. It is the most common type of cancer in men.

Breast cancer: It is a type of cancer that develops in breast cells stimulated by a female sex hormone called oestrogen. Breast cancer may form in lobules (glands that produce milk), ducts of the breast (the pathway that brings milk from glands to the nipple), the fatty tissue or the fibrous connective tissue within the breast. The tumour cells invade other healthy breast cells and travel to lymph nodes, a primary pathway for the cancer cells to move to other parts of the body.

Endometriosis: It is a disorder in which tissue lining the uterus grows outside the uterine cavity. It commonly involves ovaries, fallopian tubes and the tissue lining the pelvis. Symptoms of endometriosis include pain and irregular periods.

Precocious puberty occurs when a child's body changes into that of an adult or experiences puberty too soon. If puberty begins before age 8 in girls and before age 9 in boys, it is considered precocious puberty. Symptoms in a girl include first period and breast development, whereas, in a boy, it causes enlarged testicles and penis, deepening voice and facial hair.

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