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Written By Lakshmithulasi Yarragunta , Pharm-D (PB)
Reviewed By Santoshini Reddy G , M Pharmacy

About Mabthera 100 mg Injection 1's

Mabthera 100 mg Injection 1's belongs to a class of medicines called monoclonal antibodies used in the treatment of non-Hodgkin’s disease and chronic lymphocytic leukaemia. This medicine is also used in treating rheumatoid arthritis in combination with methotrexate and granulomatosis in combination with glucocorticoids. It is also used to treat Pemphigus Vulgaris (PV) and mature B-cell acute leukaemia (B-AL).

Mabthera 100 mg Injection 1's contains Rituximab, which works by inhibiting the DNA and RNA transcription that is essential for cancer cell growth. This helps prevent the growth and further spread of cancerous or non-cancerous cells. On the other hand, Mabthera 100 mg Injection 1's works by interfering with the immune system process that causes inflammation in the joint tissues. Thus, it reduces pain and inflammation and prevents joint damage and disease progression over time

Mabthera 100 mg Injection 1's may cause certain side effects, such as pale skin, painful urination, night sweats, flushing, back pain, nausea, vomiting, diarrhoea, stomach pain, mouth sores, peeling of skin, injection site reactions and pain at the site of injection. These side effects do not require medical attention and gradually resolve over time. However, if the side effects persist or worsen, please consult your doctor. Mabthera 100 mg Injection 1's is a parenteral preparation. A trained healthcare professional will administer it. Hence, do not self-administer.

Mabthera 100 mg Injection 1's should be avoided if you are allergic to it or any other components present in it. Let your doctor know about your complete medical history, including current medication, to rule out any side effects/interactions. Also, inform your doctor if you have liver/kidney disease, hepatitis B virus infection, cardiac disorders, any active infections, or gastrointestinal disorders before receiving this injection. Mabthera 100 mg Injection 1's may cause bowel obstruction and perforation, reactivation of Hepatitis B infection, Cardiac arrhythmias, tumour lysis syndrome, and angina in some patients. Hence, careful monitoring should be done during the entire treatment. Inform your doctor if you are pregnant, planning to become pregnant, or breastfeeding.

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Whats That

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Non returnable*
COD available

Online payment accepted

Composition

RITUXIMAB-100MG

Consume Type

PARENTERAL

Return Policy

Not Returnable

Expires on or after

Apr-24

for this medicine

Uses of Mabthera 100 mg Injection 1's

Non-Hodgkin’s disease, rheumatoid arthritis, chronic lymphocytic leukaemia, granulomatosis, pemphigus vulgaris

Medicinal Benefits

Mabthera 100 mg Injection 1's contains Rituximab, which belongs to the class of monoclonal antibodies. It works by inhibiting the DNA and RNA transcription that is essential for cancer cell growth. This helps prevent the growth and further spread of cancerous or non-cancerous cells. On the other hand, Mabthera 100 mg Injection 1's works by interfering with the immune system process that causes inflammation in the joint tissues. Thus, it reduces pain and inflammation and prevents joint damage and disease progression over time.

Side Effects of Mabthera 100 mg Injection 1's

  • Pale skin
  • Diarrhoea
  • Painful urination
  • Night sweats
  • Flushing
  • Back pain
  • Vomiting
  • Diarrhoea
  • Stomach pain
  • Mouth sores
  • Peeling of skin
  • Cough
  • Bruising or bleeding gums
  • Pain at the site of injection

Directions for Use

Mabthera 100 mg Injection 1's will be administered by a trained healthcare professional. Hence, do not self-administer. 

Storage

Store in a cool and dry place away from sunlight

Drug Warnings

Mabthera 100 mg Injection 1's should be avoided if you are allergic to it or any other components present in it. Let your doctor know about your complete medical history, including current medication, to rule out any side effects/interactions. Before administration, inform your doctor if you have liver/kidney disease, hepatitis B Virus infection, cardiac disorders, any active infections, or gastrointestinal disorders. Mabthera 100 mg Injection 1's may cause bowel obstruction and perforation, reactivation of Hepatitis B infection, Cardiac arrhythmias, tumour lysis syndrome (tumour cells release their contents into the bloodstream), and angina in some patients. Hence, careful monitoring should be done during the entire treatment. Inform your doctor if you are pregnant, planning to become pregnant, or breastfeeding.

Therapeutic Class

CHEMOTHERAPY

Drug-Drug Interactions

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RituximabRotavirus vaccine
Critical
RituximabClozapine
Severe

Drug-Drug Interactions

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RituximabRotavirus vaccine
Critical
How does the drug interact with Mabthera 100 mg Injection 1's:
Taking Mabthera 100 mg Injection 1's and Rotavirus vaccine together may increase risk of side effects.

How to manage the interaction:
Taking Mabthera 100 mg Injection 1's with Rotavirus vaccine is not recommended as it can possibly result in an interaction, it can be taken if a doctor has prescribed it. In case you experience any unusual symptoms, consult a doctor. Do not stop using any medications without consulting a doctor.
RituximabClozapine
Severe
How does the drug interact with Mabthera 100 mg Injection 1's:
Taking Mabthera 100 mg Injection 1's with Clozapine can increase the risk of infections.

How to manage the interaction:
Although taking Mabthera 100 mg Injection 1's and Clozapine together can evidently cause an interaction, it can be taken if your doctor has suggested it. However, consult your doctor if you experience fever, chills, loose stools, sore throat, muscle aches, shortness of breath, blood in phlegm, red or inflamed skin, body sores, and pain or burning during urination. Do not discontinue any medications without consulting a doctor.
RituximabDeferiprone
Severe
How does the drug interact with Mabthera 100 mg Injection 1's:
Taking Mabthera 100 mg Injection 1's with Deferiprone may increase the risk of infections.

How to manage the interaction:
Taking Mabthera 100 mg Injection 1's with Deferiprone together can possibly result in an interaction, but it can be taken if your doctor has advised it. However, consult the doctor immediately if you experience symptoms such as fever, chills, loose stools, sore throat, muscle aches, shortness of breath, blood in phlegm, red or inflamed skin, body sores, and pain or burning during urination. Do not stop using any medications without consulting a doctor.
RituximabProcarbazine
Severe
How does the drug interact with Mabthera 100 mg Injection 1's:
Combining Mabthera 100 mg Injection 1's with Procarbazine can increase risk of side effects.

How to manage the interaction:
There may be a possibility of interaction between Procarbazine and Mabthera 100 mg Injection 1's, but it can be taken if prescribed by a doctor. However, consult the doctor immediately if you experience any unusual symptoms. Do not discontinue any medications without consulting a doctor.
RituximabNatalizumab
Severe
How does the drug interact with Mabthera 100 mg Injection 1's:
Combining Mabthera 100 mg Injection 1's with Natalizumab may increase the risk of infections.

How to manage the interaction:
Although taking Mabthera 100 mg Injection 1's and Natalizumab together can evidently cause an interaction, it can be taken if your doctor has suggested it. However, consult the doctor immediately if you experience symptoms such as fever, chills, loose stools, sore throat, muscle aches, shortness of breath, blood in phlegm, red or inflamed skin, body sores, and pain or burning during urination. Do not stop using any medications without consulting a doctor.
RituximabAdalimumab
Severe
How does the drug interact with Mabthera 100 mg Injection 1's:
Taking adalimumab with Mabthera 100 mg Injection 1's may increase the risk of infections.

How to manage the interaction:
Co-administration of Mabthera 100 mg Injection 1's with Adalimumab can result in an interaction, but it can be taken if your doctor has advised it. However, consult the doctor immediately if you experience symptoms such as fever, chills, loose stools, sore throat, muscle aches, shortness of breath, red or inflamed skin, body sores, and pain or burning during urination. Do not stop using any medications without consulting a doctor.
RituximabInfliximab
Severe
How does the drug interact with Mabthera 100 mg Injection 1's:
Taking Infliximab with Mabthera 100 mg Injection 1's may increase the risk of infections.

How to manage the interaction:
Taking Mabthera 100 mg Injection 1's with Infliximab together can result in an interaction, but it can be taken if your doctor has advised it. However, consult the doctor immediately if you experience symptoms such as fever, chills, loose stools, sore throat, muscle aches, shortness of breath, blood in phlegm, red or inflamed skin, body sores, and pain or burning during urination. Do not stop using any medications without talking to a doctor.
RituximabTofacitinib
Severe
How does the drug interact with Mabthera 100 mg Injection 1's:
Taking Mabthera 100 mg Injection 1's and Tofacitinib may increase the risk infections.

How to manage the interaction:
Taking Tofacitinib with Mabthera 100 mg Injection 1's together can possibly result in an interaction, but it can be taken if your doctor has advised it. However, consult the doctor immediately if you experience symptoms such as fever, chills, loose stools, sore throat, muscle aches, shortness of breath, blood in phlegm, red or inflamed skin, body sores, and pain or burning during urination. Do not stop using any medications without consulting a doctor.
RituximabBaricitinib
Severe
How does the drug interact with Mabthera 100 mg Injection 1's:
Taking Mabthera 100 mg Injection 1's with Baricitinib may significantly increases the risk of infections.

How to manage the interaction:
Although taking Mabthera 100 mg Injection 1's and Baricitinib together can cause an interaction, it can be taken if A doctor has suggested it. However, consult the doctor immediately if you experience symptoms such as fever, chills, loose stools, sore throat, muscle aches, breathing difficulty, red or inflamed skin, body sores, and pain or burning during urination. Do not stop using any medications without consulting a doctor.
RituximabLeflunomide
Severe
How does the drug interact with Mabthera 100 mg Injection 1's:
Taking Mabthera 100 mg Injection 1's with Leflunomide can increase the risk of infections.

How to manage the interaction:
Taking Mabthera 100 mg Injection 1's with Leflunomide together can result in an interaction, it can be taken if your doctor has advised it. However, consult the doctor immediately if you experience fatigue, dizziness, lightheadedness, unusual bleeding or bruising, fever, chills, loose stools, sore throat, muscle aches, shortness of breath, blood in phlegm, red or inflamed skin, body sores, and pain or burning during urination. Do not stop using any medications without a doctor's advice.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Drug-Diseases Interactions

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No Drug - Disease interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Diseases Interactions

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Drug-Drug Interactions Checker List

  • CISPLATIN
  • TYPHOID VACCINE
  • CHOLERA VACCINE

Diet & Lifestyle Advise

  • After your treatment begins, dietary adjustments can help you control side effects.
  • Anyone suffering from a chronic illness, including cancer, should consume foods high in protein, healthy fats, whole grains, and vitamins and minerals.
  • Plant-based proteins are among the greatest meals to take during chemotherapy or other cancer treatments. They have the highest concentrations of vitamins and minerals, such as nuts, seeds, beans, and legumes.
  • Eat a healthy diet and exercise regularly to maintain proper weight.
  • Include leafy vegetables, citrus fruits, fatty fish, berries, yoghurt, apples, peaches, cauliflower, cabbage, broccoli, beans, and herbs.
  • De-stress yourself by meditating, reading books, taking a warm bubble bath or listening to soothing music.
  • Get optimal sleep; rest well.
  • Avoid smoking and alcohol consumption.
  • Avoid fast and fried food, processed meats, refined carbs and added sugars.

Habit Forming

No

Special Advise

  • A blood test should be performed such as liver function test, renal function test, and pulmonary function test, to check for liver/kidney function and pulmonary function.
  • Weekly blood tests should be done during the treatment to check for CBC (Complete blood count).

Disease/Condition Glossary

Non-Hodgkin’s Disease: Non-Hodgkin’s disease or Non-Hodgkin’s lymphoma is a blood cancer that affects your lymph system. It causes the uncontrollable growth of cancer cells in the lymph nodes. The lymph system is a part of the immune system which protects your body from disease and infections. Symptoms include lymph node swelling, abdominal pain, chest pain, cough, fever, and night sweats.

Rheumatoid arthritis: It is an auto-immune disease (the body's immune system attacks its tissue) that causes joint pain and damage. It occurs when the immune system does not work properly. Symptoms of rheumatoid arthritis include pain, swelling, stiffness, deformities, and loss of joint function. Mabthera 100 mg Injection 1's is used in combination with methotrexate for the treatment of rheumatoid arthritis.

Chronic lymphocytic leukaemia: It is a type of cancer that occurs in the bone marrow and blood. It increases the number of lymphocytes (a type of white blood cell). The symptoms include fever, enlarged liver, bone or joint pain, shortness of breath, weakness, and bleeding from gums or bruises.

Pemphigus Vulgaris: It is a condition that causes painful blisters on the skin and the lining of the mouth, nose, throat and genitals.

Mabthera 100 mg Injection 1's Substitute

Substitutes safety advice
  • MABTAS 100MG INJECTION

    6996.20per tablet
  • Reditux 100 Injection 1's

    6995.80per tablet
  • Rituxem 100 mg/10 ml Injection 10 ml

    699.62per tablet
  • Enfiera 100 Injection 10 ml

    699.58per tablet
  • Maball 100 mg Injection 10 ml

    664.20per tablet
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